{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:53Z","timestamp":1791925313864,"version":"4.3.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["IRG-21-144-27"],"award-info":[{"award-number":["IRG-21-144-27"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["P50CA221747"],"award-info":[{"award-number":["P50CA221747"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0380"],"award-info":[{"award-number":["W81XWH-21-1-0380"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008250","name":"Northwestern University Feinberg School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50CA221747"],"award-info":[{"award-number":["P50CA221747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R03HL155249"],"award-info":[{"award-number":["R03HL155249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1K08HL143271"],"award-info":[{"award-number":["1K08HL143271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 NS124594"],"award-info":[{"award-number":["R01 NS124594"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R00 CA240896"],"award-info":[{"award-number":["R00 CA240896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002002","name":"Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001831","name":"Lynn Sage Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.celrep.2023.112127","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T20:58:31Z","timestamp":1676408311000},"page":"112127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma"],"prefix":"10.1016","volume":"42","author":[{"given":"Lizhi","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Dunterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Heimberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-9328","authenticated-orcid":false,"given":"Peiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112127_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1158\/2159-8290.CD-19-0400","article-title":"Circadian regulator CLOCK recruits immune-suppressive microglia into the GBM tumor microenvironment","volume":"10","author":"Chen","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2023.112127_bib2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ccell.2019.05.003","article-title":"Symbiotic macrophage-glioma cell interactions reveal synthetic lethality in PTEN-null glioma","volume":"35","author":"Chen","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib3","series-title":"Glioblastoma","article-title":"Current standards of care in glioblastoma therapy","author":"Fernandes","year":"2017"},{"key":"10.1016\/j.celrep.2023.112127_bib4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/neuonc\/noaa106","article-title":"Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions","volume":"22","author":"Wen","year":"2020","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2023.112127_bib5","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2023.112127_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2021.02.004","article-title":"Context-dependent glioblastoma-macrophage\/microglia symbiosis and associated mechanisms","volume":"42","author":"Xuan","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2023.112127_bib7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ccell.2020.04.001","article-title":"The glioma stem cell model in the era of single-cell genomics","volume":"37","author":"Suv\u00e0","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib8","doi-asserted-by":"crossref","first-page":"108597","DOI":"10.1016\/j.celrep.2020.108597","article-title":"Cancer stemness meets immunity: from mechanism to therapy","volume":"34","author":"Chen","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112127_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ncb3090","article-title":"Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth","volume":"17","author":"Zhou","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2023.112127_bib10","doi-asserted-by":"crossref","first-page":"e163446","DOI":"10.1172\/JCI163446","article-title":"Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy","volume":"133","author":"Khan","year":"2023","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2023.112127_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.tcb.2021.06.008","article-title":"Circadian regulation of cancer cell and tumor microenvironment crosstalk","volume":"31","author":"Xuan","year":"2021","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2023.112127_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1158\/2326-6066.CIR-21-0559","article-title":"Circadian regulator CLOCK drives immunosuppression in glioblastoma","volume":"10","author":"Xuan","year":"2022","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2023.112127_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.187922.112","article-title":"Emerging insights into the molecular and cellular basis of glioblastoma","volume":"26","author":"Dunn","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2023.112127_bib14","doi-asserted-by":"crossref","first-page":"114rv3","DOI":"10.1126\/scitranslmed.3003149","article-title":"Forty-year journey of angiogenesis translational research","volume":"3","author":"Cao","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2023.112127_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2015.10.009","article-title":"Glioblastoma: defining tumor niches","volume":"1","author":"Hambardzumyan","year":"2015","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2023.112127_bib16","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.celrep.2020.01.073","article-title":"Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells","volume":"30","author":"Lucero","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112127_bib17","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.1158\/0008-5472.CAN-06-1010","article-title":"Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor","volume":"66","author":"Bao","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112127_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2013.02.021","article-title":"Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth","volume":"153","author":"Cheng","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib19","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3892\/ijo.2017.3987","article-title":"Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal\u00a0cancer","volume":"50","author":"Wang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.celrep.2023.112127_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.celrep.2012.07.005","article-title":"Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish","volume":"2","author":"Jensen","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112127_bib21","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1158\/2159-8290.CD-19-0215","article-title":"Targeting glioblastoma stem cells through disruption of the circadian clock","volume":"9","author":"Dong","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2023.112127_bib22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2023.112127_bib23","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112127_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/ng.3711","article-title":"Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation","volume":"49","author":"Shingu","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.112127_bib25","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1182\/blood.V92.2.362","article-title":"Evidence for circulating bone marrow-derived endothelial cells","volume":"92","author":"Shi","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112127_bib26","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1046\/j.1471-4159.1996.66052026.x","article-title":"Influence of host cell infiltration on the glycolipid content of mouse brain tumors","volume":"66","author":"Seyfried","year":"1996","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2023.112127_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ccr.2013.06.004","article-title":"A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis","volume":"24","author":"Masiero","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity, and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41467-022-28372-y","article-title":"Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target","volume":"13","author":"Abdelfattah","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112127_bib30","doi-asserted-by":"crossref","first-page":"14136","DOI":"10.1074\/jbc.M109.000414","article-title":"Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation","volume":"284","author":"Clark","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112127_bib31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.phrs.2016.04.008","article-title":"Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies","volume":"111","author":"Hasan","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.celrep.2023.112127_bib32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1158\/2159-8290.CD-17-0833","article-title":"Ex\u00a0vivo profiling of PD-1 blockade using organotypic tumor spheroids","volume":"8","author":"Jenkins","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2023.112127_bib33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09002","article-title":"Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis","volume":"465","author":"Wang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112127_bib34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jnci\/95.11.825","article-title":"Night-shift work and risk of colorectal cancer in the nurses' health study","volume":"95","author":"Schernhammer","year":"2003","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.celrep.2023.112127_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-0-12-396971-2.00009-9","article-title":"The circadian clock in cancer development and therapy","volume":"119","author":"Fu","year":"2013","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.celrep.2023.112127_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2016.03.015","article-title":"Core circadian clock genes regulate leukemia stem cells in AML","volume":"165","author":"Puram","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib37","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.febslet.2013.06.018","article-title":"Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124","volume":"587","author":"Li","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2023.112127_bib38","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrendo.2014.114","article-title":"VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs","volume":"10","author":"Cao","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2023.112127_bib39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrclinonc.2010.118","article-title":"Off-tumor target--beneficial site for antiangiogenic cancer therapy?","volume":"7","author":"Cao","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.celrep.2023.112127_bib40","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.2741\/3504","article-title":"Tumor angiogenesis and molecular targets for therapy","volume":"14","author":"Cao","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.celrep.2023.112127_bib41","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/cancers11111723","article-title":"Progression-free but No overall survival benefit for adult patients with bevacizumab therapy for the treatment of newly diagnosed glioblastoma: a systematic review and meta-analysis","volume":"11","author":"Kaka","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.celrep.2023.112127_bib42","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1172\/JCI38596","article-title":"P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3","volume":"122","author":"Zerrouqi","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2023.112127_bib43","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1038\/onc.2011.563","article-title":"EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway","volume":"31","author":"Bonavia","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2023.112127_bib44","doi-asserted-by":"crossref","first-page":"40148","DOI":"10.18632\/oncotarget.9512","article-title":"Periostin promotes tumor angiogenesis in pancreatic cancer via Erk\/VEGF signaling","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2023.112127_bib45","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.celrep.2018.02.035","article-title":"Periostin limits tumor response to VEGFA inhibition","volume":"22","author":"Keklikoglou","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112127_bib46","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1158\/1535-7163.MCT-15-0427","article-title":"Periostin (POSTN) regulates tumor resistance to antiangiogenic therapy in glioma models","volume":"15","author":"Park","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2023.112127_bib47","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.matbio.2014.04.007","article-title":"Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments","volume":"37","author":"Liu","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.celrep.2023.112127_bib48","first-page":"5358","article-title":"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility","volume":"62","author":"Gillan","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112127_bib49","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1165\/rcmb.2018-0122OC","article-title":"Myeloid TBK1 signaling contributes to the immune response to influenza","volume":"60","author":"Hagan","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2023.112127_bib50","doi-asserted-by":"crossref","first-page":"15325","DOI":"10.1074\/jbc.R700002200","article-title":"Triggering the innate antiviral response through IRF-3 activation","volume":"282","author":"Hiscott","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112127_bib51","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ni.3464","article-title":"Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity","volume":"17","author":"Li","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112127_bib52","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1158\/2159-8290.CD-16-0955","article-title":"Biomarker accessible and chemically addressable mechanistic subtypes of BRAF melanoma","volume":"7","author":"Eskiocak","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2023.112127_bib53","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1158\/0008-5472.CAN-17-0829","article-title":"TBK1 provides context-selective support of the activated AKT\/mTOR pathway in lung cancer","volume":"77","author":"Cooper","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112127_bib54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12079-017-0438-y","article-title":"Assessment of TANK-binding kinase 1 as a therapeutic target in cancer","volume":"12","author":"Cruz","year":"2018","journal-title":"J.\u00a0Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2023.112127_bib55","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.stem.2016.12.001","article-title":"Glioblastoma cancer stem cells evade innate immune suppression of self-renewal through reduced TLR4 expression","volume":"20","author":"Alvarado","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.112127_bib56","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.0511319103","article-title":"Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway","volume":"103","author":"Korherr","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112127_bib57","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.2741\/3225","article-title":"Influence of TBK-1 on tumor angiogenesis and microvascular inflammation","volume":"13","author":"Czabanka","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.celrep.2023.112127_bib58","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20022156","article-title":"Fractalkine preferentially mediates arrest and migration of CD16+ monocytes","volume":"197","author":"Ancuta","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112127_bib59","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1182\/blood-2004-12-4942","article-title":"ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow","volume":"106","author":"Yang","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112127_bib60","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1158\/1078-0432.CCR-11-1354","article-title":"Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner","volume":"17","author":"Chen","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2023.112127_bib61","doi-asserted-by":"crossref","first-page":"e96801","DOI":"10.1371\/journal.pone.0096801","article-title":"IHC profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples","volume":"9","author":"Varghese","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112127_bib62","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1038\/s41467-020-17772-7","article-title":"A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis","volume":"11","author":"Barth","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723001389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723001389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:56:07Z","timestamp":1778842567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723001389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2211124723001389"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112127","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"112127"}}