{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:11:27Z","timestamp":1790745087217,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871432"],"award-info":[{"award-number":["31871432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000895"],"award-info":[{"award-number":["32000895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770312"],"award-info":[{"award-number":["81770312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771627"],"award-info":[{"award-number":["81771627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971061"],"award-info":[{"award-number":["81971061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.celrep.2023.112400","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T14:01:04Z","timestamp":1681740064000},"page":"112400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response"],"prefix":"10.1016","volume":"42","author":[{"given":"Rui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-0330","authenticated-orcid":false,"given":"Jian-Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112400_bib1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ejhf.1594","article-title":"Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis","volume":"21","author":"Jones","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.celrep.2023.112400_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15420\/cfr.2016:25:2","article-title":"Global public health burden of heart failure","volume":"3","author":"Savarese","year":"2017","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.celrep.2023.112400_bib3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jchf.2015.06.012","article-title":"Characteristics, treatments, and outcomes of hospitalized heart failure patients stratified by etiologies of cardiomyopathy","volume":"3","author":"Shore","year":"2015","journal-title":"JACC. Heart Fail."},{"key":"10.1016\/j.celrep.2023.112400_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCULATIONAHA.117.030811","article-title":"Cardioprotective role of myeloid-derived suppressor cells in heart failure","volume":"138","author":"Zhou","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2023.112400_bib5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/CIRCRESAHA.116.308687","article-title":"Acute catecholamine exposure causes reversible myocyte injury without cardiac regeneration","volume":"119","author":"Wallner","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2023.112400_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15104","article-title":"DNA single-strand break-induced DNA damage response causes heart failure","volume":"8","author":"Higo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112400_bib7","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jacc.2019.03.471","article-title":"Prevention or procrastination for heart failure?: why we need a universal definition of heart failure","volume":"73","author":"Cleland","year":"2019","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.celrep.2023.112400_bib8","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/CIRCULATIONAHA.118.034822","article-title":"DNA damage response mediates pressure overload-induced cardiomyocyte hypertrophy","volume":"139","author":"Nakada","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2023.112400_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yjmcc.2016.01.028","article-title":"Novel molecular mechanisms and regeneration therapy for heart failure","volume":"92","author":"Oka","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.celrep.2023.112400_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2023.112400_bib11","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2023.112400_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10741-014-9436-9","article-title":"Amino acids and derivatives, a new treatment of chronic heart failure?","volume":"20","author":"Carubelli","year":"2015","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.celrep.2023.112400_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tem.2019.11.009","article-title":"Metabolism, epigenetics, and causal inference in heart failure","volume":"31","author":"Kimball","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.celrep.2023.112400_bib14","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/eurheartj\/ehv305","article-title":"Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications","volume":"36","author":"M\u00fcnzel","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2023.112400_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/CIRCULATIONAHA.119.042573","article-title":"Cardiac overexpression of PDE4B blunts beta-adrenergic response and maladaptive remodeling in heart failure","volume":"142","author":"Karam","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2023.112400_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-4939-8597-5_16","article-title":"Isoproterenol-induced heart failure mouse model using osmotic pump implantation","volume":"1816","author":"Chang","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2023.112400_bib17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cmet.2020.12.003","article-title":"The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure","volume":"33","author":"Cluntun","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2023.112400_bib18","doi-asserted-by":"crossref","first-page":"8914","DOI":"10.1016\/S0021-9258(19)86787-X","article-title":"Accumulation of amino acids by lysosomes incubated with amino acid methyl esters","volume":"254","author":"Reeves","year":"1979","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112400_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2017.10.015","article-title":"Sensing and transmitting intracellular amino acid signals through reversible lysine aminoacylations","volume":"27","author":"He","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2023.112400_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2014.09.006","article-title":"Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage","volume":"56","author":"Wei","year":"2014","journal-title":"Mol. Cell."},{"key":"10.1016\/j.celrep.2023.112400_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1073\/pnas.1608488114","article-title":"Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage","volume":"114","author":"Cao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112400_bib22","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature14028","article-title":"A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol","volume":"519","author":"Sajish","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112400_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.23.1_supplement.497.1","article-title":"Is Dominant Intermediate - charcot-Marie-Tooth type C disorder due to a defect in protein synthesis?","volume":"23","author":"Froelich","year":"2009","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2023.112400_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1158\/0008-5472.CAN-19-1023","article-title":"Inactivation of the AMPK-GATA3-ECHS1 pathway induces fatty acid synthesis that promotes clear cell renal cell carcinoma growth","volume":"80","author":"Qu","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112400_bib25","article-title":"Gestational leucylation suppresses embryonic T-box transcription factor 5 signal and causes congenital heart disease","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2023.112400_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/CIRCULATIONAHA.121.054204","article-title":"Dysregulated phenylalanine catabolism plays a key role in the trajectory of cardiac aging","volume":"144","author":"Czibik","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2023.112400_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5012","article-title":"Plasma amino acid metabolomic pattern in heart failure patients with either preserved or reduced ejection fraction: the relation to established risk variables and prognosis","volume":"35","author":"Saleem","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.celrep.2023.112400_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jacc.2007.09.055","article-title":"Combined metabolomic and proteomic analysis of human atrial fibrillation","volume":"51","author":"Mayr","year":"2008","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.celrep.2023.112400_bib29","article-title":"Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112400_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJM196910092811503","article-title":"Plasma amino acid levels and insulin secretion in obesity","volume":"281","author":"Felig","year":"1969","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2023.112400_bib31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2023.112400_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jash.2017.11.004","article-title":"High dietary intake of aromatic amino acids increases risk of hypertension","volume":"12","author":"Teymoori","year":"2018","journal-title":"J.\u00a0Am. Soc. Hypertens."},{"key":"10.1016\/j.celrep.2023.112400_bib33","article-title":"Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease","volume":"4","author":"Zhao","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.celrep.2023.112400_bib34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.celrep.2018.09.022","article-title":"Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112400_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","article-title":"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112400_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/emm.2007.2","article-title":"SIRT1 promotes DNA repair activity and deacetylation of Ku70","volume":"39","author":"Jeong","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2023.112400_bib37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.molcel.2014.10.007","article-title":"A divergent role of the SIRT1-TopBP1 Axis in regulating metabolic checkpoint and DNA damage checkpoint","volume":"56","author":"Liu","year":"2014","journal-title":"Mol. Cell."},{"key":"10.1016\/j.celrep.2023.112400_bib38","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4062\/biomolther.2011.19.3.282","article-title":"Sirt1 promotes DNA damage repair and cellular survival","volume":"19","author":"Song","year":"2011","journal-title":"Biomol Ther"},{"key":"10.1016\/j.celrep.2023.112400_bib39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/onc.2012.83","article-title":"SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells","volume":"32","author":"Wang","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2023.112400_bib40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1101\/gad.188482.112","article-title":"Regulation of SIRT1 activity by genotoxic stress","volume":"26","author":"Yuan","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2023.112400_bib41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/jmcb\/mjs035","article-title":"DBC1 phosphorylation by ATM\/ATR inhibits SIRT1 deacetylase in response to DNA damage","volume":"4","author":"Zannini","year":"2012","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2023.112400_bib42","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s11427-014-4687-1","article-title":"Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure","volume":"57","author":"Mu","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.celrep.2023.112400_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205005","article-title":"Inducible cardiac-specific deletion of Sirt1 in male mice reveals progressive cardiac dysfunction and sensitization of the heart to pressure overload","volume":"20","author":"Sanz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.112400_bib44","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.yjmcc.2011.09.013","article-title":"Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice","volume":"51","author":"Kawashima","year":"2011","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.celrep.2023.112400_bib45","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2023.112400_bib46","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cmet.2011.10.001","article-title":"PPAR alpha-sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway","volume":"14","author":"Oka","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2023.112400_bib47","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004531","article-title":"Intake of different dietary proteins and risk of heart failure in men: the kuopio ischaemic heart disease risk factor study","volume":"11","author":"Virtanen","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.celrep.2023.112400_bib48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1139\/apnm-2013-0274","article-title":"Effect of a high-protein diet on development of heart failure in response to pressure overload","volume":"39","author":"Ribeiro","year":"2014","journal-title":"Appl. Physiol. Nutr. Metabol."},{"key":"10.1016\/j.celrep.2023.112400_bib49","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.numecd.2010.03.009","article-title":"Red meat consumption and risk of heart failure in male physicians","volume":"21","author":"Ashaye","year":"2011","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"key":"10.1016\/j.celrep.2023.112400_bib50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijcard.2015.05.044","article-title":"Long-term processed and unprocessed red meat consumption and risk of heart failure: a prospective cohort study of women","volume":"193","author":"Kaluza","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.celrep.2023.112400_bib51","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCHEARTFAILURE.113.000921","article-title":"Processed and unprocessed red meat consumption and risk of heart failure: prospective study of men","volume":"7","author":"Kaluza","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.celrep.2023.112400_bib52","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCULATIONAHA.106.666818","article-title":"Prevalence and prognostic significance of heart failure stages: application of the American College of Cardiology\/American Heart Association heart failure staging criteria in the community","volume":"115","author":"Ammar","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2023.112400_bib53","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A simplified, langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2023.112400_bib54","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nprot.2007.202","article-title":"Extraction, purification and analysis of histones","volume":"2","author":"Shechter","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2023.112400_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1126\/science.1238327","article-title":"Functional lysine modification by an intrinsically reactive primary glycolytic metabolite","volume":"341","author":"Moellering","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.112400_bib56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/cr.2017.158","article-title":"Cryo-EM structure of human ATR-ATRIP complex","volume":"28","author":"Rao","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2023.112400_bib57","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1021\/pr400398b","article-title":"High-fat diet induces dynamic metabolic alterations in multiple biological matrices of rats","volume":"12","author":"An","year":"2013","journal-title":"J.\u00a0Proteome Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723004114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723004114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:46:13Z","timestamp":1762602373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723004114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2211124723004114"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112400","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"112400"}}