{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:38:36Z","timestamp":1780504716028,"version":"3.54.1"},"reference-count":75,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2015-00218"],"award-info":[{"award-number":["2015-00218"]}],"id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2018-00648"],"award-info":[{"award-number":["2018-00648"]}],"id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2020-00789"],"award-info":[{"award-number":["2020-00789"]}],"id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018850","name":"Gunvor och Josef An\u00e9rs Siftelse","doi-asserted-by":"publisher","award":["FB19-0054"],"award-info":[{"award-number":["FB19-0054"]}],"id":[{"id":"10.13039\/100018850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS- 593371"],"award-info":[{"award-number":["SLS- 593371"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013710","name":"European Federation of Immunological Societies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"Horizon 2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["754412"],"award-info":[{"award-number":["754412"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010822","name":"Axel Linders Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2019-1789"],"award-info":[{"award-number":["075-15-2019-1789"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","award":["2018-2300"],"award-info":[{"award-number":["2018-2300"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","award":["2019-2986"],"award-info":[{"award-number":["2019-2986"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","award":["2020-3395"],"award-info":[{"award-number":["2020-3395"]}],"id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32953"],"award-info":[{"award-number":["P32953"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF2013-02358960"],"award-info":[{"award-number":["RF2013-02358960"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.celrep.2023.112446","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T17:30:42Z","timestamp":1682616642000},"page":"112446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations"],"prefix":"10.1016","volume":"42","author":[{"given":"Vanda","family":"Friman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Quinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey N.","family":"Davydov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-7942","authenticated-orcid":false,"given":"Mikhail","family":"Shugay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Farroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Pour Akaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Barresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-1527","authenticated-orcid":false,"given":"Ahmed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pulvirenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Milito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Giorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Marasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Marcellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Cascioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Scarsella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-6899","authenticated-orcid":false,"given":"Ganesh","family":"Phad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Tilevik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Bemark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-790X","authenticated-orcid":false,"given":"Dmitriy M.","family":"Chudakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Carsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-2556","authenticated-orcid":false,"given":"Ola","family":"Grimsholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112446_bib1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1084\/jem.177.4.999","article-title":"Receptor editing: an approach by autoreactive B cells to escape tolerance","volume":"177","author":"Gay","year":"1993","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ni1076","article-title":"Receptor editing is the main mechanism of B cell tolerance toward membrane antigens","volume":"5","author":"Halverson","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nri1939","article-title":"Receptor editing in lymphocyte development and central tolerance","volume":"6","author":"Nemazee","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib4","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.177.4.1165","article-title":"B lymphocytes may escape tolerance by revising their antigen receptors","volume":"177","author":"Radic","year":"1993","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1084\/jem.177.4.1009","article-title":"Receptor editing in self-reactive bone marrow B cells","volume":"177","author":"Tiegs","year":"1993","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","article-title":"Germinal centers","volume":"12","author":"MacLennan","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib7","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.112446_bib8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000019068","article-title":"The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments","volume":"15","author":"Barbi\u00e9","year":"1998","journal-title":"Exp. Clin. Immunogenet."},{"key":"10.1016\/j.celrep.2023.112446_bib9","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/hmg\/4.6.983","article-title":"Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2","volume":"4","author":"Frippiat","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.112446_bib10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/1521-4141(200104)31:4<1017::AID-IMMU1017>3.0.CO;2-3","article-title":"Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes","volume":"31","author":"Kawasaki","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1101\/gr.7.3.250","article-title":"One-megabase sequence analysis of the human immunoglobulin lambda gene locus","volume":"7","author":"Kawasaki","year":"1997","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2023.112446_bib12","series-title":"The Immunoglobulin Factsbook","author":"Lefranc","year":"2001"},{"key":"10.1016\/j.celrep.2023.112446_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000019054","article-title":"The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments","volume":"15","author":"Pallar\u00e8s","year":"1998","journal-title":"Exp. Clin. Immunogenet."},{"key":"10.1016\/j.celrep.2023.112446_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/294173a0","article-title":"Assignment of the genes for human lambda immunoglobulin chains to chromosome 22","volume":"294","author":"Erikson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112446_bib15","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1073\/pnas.79.16.4957","article-title":"Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in\u00a0situ hybridization","volume":"79","author":"Malcolm","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112446_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.molimm.2012.03.028","article-title":"B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients","volume":"51","author":"Schoettler","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/infdis\/jiv448","article-title":"Lambda light chain bias associated with enhanced binding and function of anti-HIV env glycoprotein antibodies","volume":"213","author":"Sajadi","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2023.112446_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fimmu.2016.00388","article-title":"Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions","volume":"7","author":"Townsend","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib19","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1016\/j.celrep.2020.02.022","article-title":"The interplay between CD27(dull) and CD27(bright) B cells ensures the flexibility, stability, and resilience of human B cell memory","volume":"30","author":"Grimsholm","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112446_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/eji.201646642","article-title":"Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events","volume":"47","author":"Aranburu","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib21","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.4049\/jimmunol.1500753","article-title":"A reassessment of IgM memory subsets in humans","volume":"195","author":"Bagnara","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib22","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1084\/jem.188.9.1679","article-title":"Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells","volume":"188","author":"Klein","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib23","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1084\/jem.20091087","article-title":"Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation","volume":"206","author":"Seifert","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International consensus document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J.\u00a0Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.celrep.2023.112446_bib25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s10875-012-9856-z","article-title":"Quantification of IgM and IgA anti-pneumococcal capsular polysaccharides by a new ELISA assay: a valuable diagnostic and prognostic tool for common variable immunodeficiency","volume":"33","author":"Cavaliere","year":"2013","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/ACI.0b013e32835914b9","article-title":"The many faces of the clinical picture of common variable immune deficiency","volume":"12","author":"Resnick","year":"2012","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112446_bib28","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood-2010-05-285585","article-title":"CD21low B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells","volume":"116","author":"Rakhmanov","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112446_bib29","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1182\/blood-2011-09-373969","article-title":"Response: common variable immunodeficiency patients with increased CD21 -\/lo B cells suffer from altered receptor editing and defective central B-cell tolerance","volume":"118","author":"Romberg","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112446_bib30","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1084\/jem.20082053","article-title":"RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes","volume":"205","author":"Panigrahi","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2003-12-4359","article-title":"Deficiency of somatic hypermutation of the antibody light chain is associated with increased frequency of severe respiratory tract infection in common variable immunodeficiency","volume":"105","author":"Andersen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112446_bib32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.immuni.2017.06.013","article-title":"Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals","volume":"47","author":"Magri","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.112446_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009885","article-title":"Phylogenetic analysis of migration, differentiation, and class switching in B cells","volume":"18","author":"Hoehn","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.celrep.2023.112446_bib34","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41467-022-29450-x","article-title":"Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses","volume":"13","author":"Rodr\u00edguez-Ubreva","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112446_bib35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20042251","article-title":"Defective B cell tolerance checkpoints in systemic lupus erythematosus","volume":"201","author":"Yurasov","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1074-7613(00)00006-6","article-title":"Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities","volume":"13","author":"Xu","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.112446_bib37","doi-asserted-by":"crossref","first-page":"16671","DOI":"10.1073\/pnas.0808081105","article-title":"How the thymus designs antigen-specific and self-tolerant T\u00a0cell receptor sequences","volume":"105","author":"Kosmrlj","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112446_bib38","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ni.3491","article-title":"Hydrophobic CDR3 residues promote the development of self-reactive T\u00a0cells","volume":"17","author":"Stadinski","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib39","doi-asserted-by":"crossref","first-page":"302ra135","DOI":"10.1126\/scitranslmed.aab1216","article-title":"IgH sequences in common variable immune deficiency reveal altered B cell development and selection","volume":"7","author":"Roskin","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2023.112446_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.79254","article-title":"Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires","volume":"11","author":"Mikelov","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2023.112446_bib41","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41590-022-01230-1","article-title":"Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts","volume":"23","author":"Phad","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib42","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaci.2018.06.012","article-title":"Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses","volume":"143","author":"Romberg","year":"2019","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib43","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.3389\/fimmu.2018.02545","article-title":"Identification of CVID patients with defects in immune repertoire formation or specification","volume":"9","author":"van Schouwenburg","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib44","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112446_bib45","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1186\/ar4481","article-title":"Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjogren's syndrome","volume":"16","author":"Hershberg","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.celrep.2023.112446_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.959002","article-title":"Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency","volume":"13","author":"van Schouwenburg","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib47","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3389\/fimmu.2018.02309","article-title":"Comparative analysis of B-cell receptor repertoires induced by live yellow fever vaccine in young and middle-age donors","volume":"9","author":"Davydov","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib48","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jaci.2020.02.025","article-title":"Exhausted phenotype of follicular CD8 T\u00a0cells in CVID","volume":"146","author":"Klocperk","year":"2020","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib49","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10875-014-0052-1","article-title":"Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency","volume":"34","author":"Unger","year":"2014","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib50","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.4049\/jimmunol.1102984","article-title":"Human MSH6 deficiency is associated with impaired antibody maturation","volume":"188","author":"Gard\u00e8s","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib51","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jaci.2019.02.017","article-title":"Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies","volume":"144","author":"Blanco","year":"2019","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib52","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3389\/fimmu.2019.01913","article-title":"Repertoire sequencing of B cells elucidates the role of UNG and mismatch repair proteins in somatic hypermutation in humans","volume":"10","author":"IJspeert","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib53","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1073\/pnas.0700815104","article-title":"Role for Msh5 in the regulation of Ig class switch recombination","volume":"104","author":"Sekine","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112446_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.biochem.76.061705.090740","article-title":"Molecular mechanisms of antibody somatic hypermutation","volume":"76","author":"Di Noia","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2023.112446_bib55","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/nprot.2016.093","article-title":"High-quality full-length immunoglobulin profiling with unique molecular barcoding","volume":"11","author":"Turchaninova","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2023.112446_bib56","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmeth.2960","article-title":"Towards error-free profiling of immune repertoires","volume":"11","author":"Shugay","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.112446_bib57","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"Bolotin","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.112446_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004503","article-title":"VDJtools: unifying post-analysis of T\u00a0cell receptor repertoires","volume":"11","author":"Shugay","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.celrep.2023.112446_bib60","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib64","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1002\/cpbi.96","article-title":"Using ggtree to visualize data on tree-like structures","volume":"69","author":"Yu","year":"2020","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib59","doi-asserted-by":"crossref","first-page":"1129234","DOI":"10.3389\/fimmu.2023.1129234","article-title":"Clonal relationships of memory B cell subsets in autoimmune mice","volume":"14","author":"Aranburu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112446_bib61","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/molbev\/mst034","article-title":"CodonPhyML: fast maximum likelihood phylogeny estimation under codon substitution models","volume":"30","author":"Gil","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.celrep.2023.112446_bib62","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-59745-251-9_6","article-title":"Estimating maximum likelihood phylogenies with PhyML","volume":"537","author":"Guindon","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2023.112446_bib63","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1073\/pnas.1906020116","article-title":"Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination","volume":"116","author":"Hoehn","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112446_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib66","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.112446_bib67","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib68","series-title":"Ggplot2 Elegant Graphics for Data Analysis. Use R!","author":"Wickham","year":"2009"},{"key":"10.1016\/j.celrep.2023.112446_bib69","first-page":"1438","article-title":"From reads to genes to pathways: differential expression analysis of RNA-Seq experiments using Rsubread and the edgeR quasi-likelihood pipeline","volume":"5","author":"Chen","year":"2016","journal-title":"F1000Res."},{"key":"10.1016\/j.celrep.2023.112446_bib70","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"Durinck","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib71","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2023.112446_bib72","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.112446_bib73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112446_bib74","series-title":"org.Hs.eg.db: Genome Wide Annotation for Human","author":"Carlson","year":"2019"},{"key":"10.1016\/j.celrep.2023.112446_bib75","series-title":"GO.db: A Set of Annotation Maps Describing the Entire Gene Ontology","author":"Carlson","year":"2019"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723004576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723004576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:53:57Z","timestamp":1762602837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723004576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2211124723004576"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112446","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"112446"}}