{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:45Z","timestamp":1791270225217,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC019370"],"award-info":[{"award-number":["R01 DC019370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008235","name":"School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"School of Medicine, Stanford University","doi-asserted-by":"publisher","award":["T32 DC015209"],"award-info":[{"award-number":["T32 DC015209"]}],"id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.celrep.2023.112545","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:13:57Z","timestamp":1684869237000},"page":"112545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle"],"prefix":"10.1016","volume":"42","author":[{"given":"Maggie S.","family":"Matern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Durruthy-Durruthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Birol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Darmanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Scheibinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Groves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0490-4440","authenticated-orcid":false,"given":"Stefan","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112545_bib1","series-title":"Deafness and Hearing Loss","year":"2021"},{"key":"10.1016\/j.celrep.2023.112545_bib2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/lary.28765","article-title":"Cell type\u2013specific expression analysis of the inner ear: a technical report","volume":"131","author":"Hertzano","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.celrep.2023.112545_bib3","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.3389\/fcell.2021.730042","article-title":"Stem cell-based therapies in hearing loss","volume":"9","author":"He","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib4","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1038\/ncomms9557","article-title":"Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear","volume":"6","author":"Burns","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112545_bib5","doi-asserted-by":"crossref","first-page":"bio038083","DOI":"10.1242\/bio.038083","article-title":"Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers","volume":"7","author":"McInturff","year":"2018","journal-title":"Biol. Open"},{"key":"10.1016\/j.celrep.2023.112545_bib6","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2018.07.008","article-title":"Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system","volume":"174","author":"Sun","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112545_bib7","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2018.07.007","article-title":"Sensory neuron diversity in the inner ear is shaped by activity","volume":"174","author":"Shrestha","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112545_bib8","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1038\/s41467-018-06033-3","article-title":"Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system","volume":"9","author":"Petitpr\u00e9","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112545_bib9","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1038\/s41467-020-16113-y","article-title":"Characterization of the development of the mouse cochlear epithelium at the single cell level","volume":"11","author":"Kolla","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112545_bib10","doi-asserted-by":"crossref","first-page":"108646","DOI":"10.1016\/j.celrep.2020.108646","article-title":"Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea","volume":"34","author":"Kubota","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112545_bib11","doi-asserted-by":"crossref","first-page":"109358","DOI":"10.1016\/j.celrep.2021.109358","article-title":"Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics","volume":"36","author":"Jan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112545_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fncel.2015.00079","article-title":"Identification and characterization of mouse otic sensory lineage genes","volume":"9","author":"Hartman","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2023.112545_bib13","doi-asserted-by":"crossref","first-page":"a008409","DOI":"10.1101\/cshperspect.a008409","article-title":"Molecular mechanisms of inner ear development","volume":"4","author":"Wu","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib14","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1523\/JNEUROSCI.18-09-03327.1998","article-title":"Development of the mouse inner ear and origin of its sensory organs","volume":"18","author":"Morsli","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2023.112545_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cne.902150402","article-title":"Studies on cell migration and axon guidance in the developing distal auditory system of the mouse","volume":"215","author":"Carney","year":"1983","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2023.112545_bib16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pneurobio.2011.01.004","article-title":"Connecting the ear to the brain: molecular mechanisms of auditory circuit assembly","volume":"93","author":"Appler","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2023.112545_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ydbio.2008.07.011","article-title":"Spatial and temporal segregation of auditory and vestibular neurons in the otic placode","volume":"322","author":"Bell","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib18","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1242\/dev.009118","article-title":"Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development","volume":"134","author":"Raft","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110542","article-title":"Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages","volume":"38","author":"Sun","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112545_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/gene.20017","article-title":"Generation of pax2-cre mice by modification of a Pax2 bacterial artificial chromosome","volume":"38","author":"Ohyama","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2023.112545_bib21","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.celrep.2018.05.002","article-title":"Transcriptional dynamics of hair-bundle morphogenesis revealed with Celltrace","volume":"23","author":"Ellwanger","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112545_bib22","doi-asserted-by":"crossref","first-page":"17172","DOI":"10.1523\/JNEUROSCI.0885-12.2012","article-title":"Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning","volume":"32","author":"Miguez","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2023.112545_bib23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0896-6273(00)80728-X","article-title":"Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain","volume":"22","author":"Davenne","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2023.112545_bib24","first-page":"143","article-title":"NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell growth Differ","volume":"3","author":"G\u00f6bel","year":"1992","journal-title":"Mol. Biol. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.celrep.2023.112545_bib25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.celrep.2018.07.029","article-title":"Neuronal-specific TUBB3 is not required for normal neuronal functionbut is essential for timely axon regeneration","volume":"24","author":"Latremoliere","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112545_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons","volume":"23","author":"Gleeson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2023.112545_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00441-010-0984-6","article-title":"Neurod1 regulates survival and formation of connections in mouse ear and brain","volume":"341","author":"Jahan","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2023.112545_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/cne.20257","article-title":"Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear","volume":"477","author":"Radde-Gallwitz","year":"2004","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2023.112545_bib29","doi-asserted-by":"crossref","first-page":"845461","DOI":"10.3389\/fcell.2022.845461","article-title":"Early deletion of Neurod1 alters neuronal lineage potential and diminishes neurogenesis in the inner ear","volume":"10","author":"Filova","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib30","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1242\/dev.00628","article-title":"The role of Six1 in mammalian auditory system development","volume":"130","author":"Zheng","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.mod.2015.11.001","article-title":"Insm1 promotes neurogenic proliferation in delaminated otic progenitors","volume":"138 Pt 3","author":"Lorenzen","year":"2015","journal-title":"Mech. Dev."},{"key":"10.1016\/j.celrep.2023.112545_bib32","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/dvdy.326","article-title":"Eya2 expression during mouse embryonic development revealed by Eya2lacZ knockin reporter and homozygous mice show mild hearing loss","volume":"250","author":"Zhang","year":"2021","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.celrep.2023.112545_bib33","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.3390\/ijms22084189","article-title":"Development in the mammalian auditory system depends on transcription factors","volume":"22","author":"Elliott","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.112545_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/dbio.2000.9732","article-title":"Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures","volume":"222","author":"H\u00e9bert","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib35","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1002\/dvdy.20839","article-title":"Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear","volume":"235","author":"Pauley","year":"2006","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.celrep.2023.112545_bib36","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1242\/dev.124.15.2961","article-title":"Pax-6 is involved in the specification of hindbrain motor neuron subtype","volume":"124","author":"Osumi","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.gene.2018.04.087","article-title":"The expression and function of PAX3 in development and disease","volume":"666","author":"Boudjadi","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2023.112545_bib38","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cell.2014.03.036","article-title":"Reconstruction of the mouse otocyst and early neuroblast lineage at single cell resolution","volume":"157","author":"Durruthy-Durruthy","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112545_bib39","first-page":"1771","article-title":"Functions of EpCAM in physiological processes and diseases","volume":"42","author":"Huang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.celrep.2023.112545_bib40","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1074\/jbc.M111.301549","article-title":"Identification of novel interaction between annexin A2 and keratin 17 evidence for reciprocal regulation","volume":"287","author":"Chung","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112545_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/1523-1747.ep12286470","article-title":"Differential expression of the calpactin I subunits annexin II and p11 in cultured keratinocytes and during wound repair","volume":"108","author":"Munz","year":"1997","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2023.112545_bib42","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/dvdy.21099","article-title":"Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression","volume":"236","author":"Bazzi","year":"2007","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.celrep.2023.112545_bib43","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00018-017-2701-z","article-title":"Master regulatory role of p63 in epidermal development and disease","volume":"75","author":"Soares","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2023.112545_bib44","doi-asserted-by":"crossref","first-page":"dev195651","DOI":"10.1242\/dev.195651","article-title":"Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse","volume":"148","author":"Kaiser","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib45","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.devcel.2017.09.026","article-title":"ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development","volume":"43","author":"Rohacek","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2023.112545_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/dvdy.23918","article-title":"During embryogenesis, Esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes","volume":"242","author":"Revil","year":"2013","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.celrep.2023.112545_bib47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2011.04.033","article-title":"Myth\/NZF family transcription factors regulate neuronal differentiation of P19 cells","volume":"497","author":"Kameyama","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2023.112545_bib48","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1523\/JNEUROSCI.2728-18.2019","article-title":"Pou4f1 defines a subgroup of type I spiral ganglion neurons and is necessary for normal inner hair cell presynaptic Ca 2+ signaling","volume":"39","author":"Sherrill","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2023.112545_bib49","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/hmg\/ddq567","article-title":"Identification of direct downstream targets of Dlx5 during early inner ear development","volume":"20","author":"Sajan","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.112545_bib50","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1101\/gad.285452.116","article-title":"Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis","volume":"30","author":"Yang","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2023.112545_bib51","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cell.2018.06.004","article-title":"Defects in the alternative splicing-dependent regulation of REST cause deafness","volume":"174","author":"Nakano","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112545_bib52","doi-asserted-by":"crossref","first-page":"e25681","DOI":"10.7554\/eLife.25681","article-title":"Elastic force restricts growth of the murine utricle","volume":"6","author":"Gnedeva","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2023.112545_bib53","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.1073\/pnas.2000175117","article-title":"Organ of Corti size is governed by yap\/tead-mediated progenitor self-renewal","volume":"117","author":"Gnedeva","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112545_bib54","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112545_bib55","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/15384101.2015.1006048","article-title":"ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance","volume":"14","author":"Zhang","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2023.112545_bib56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.oraloncology.2012.07.012","article-title":"Epithelial-mesenchymal transition transcription factor ZEB1\/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer","volume":"49","author":"Chu","year":"2013","journal-title":"Oral Oncol."},{"key":"10.1016\/j.celrep.2023.112545_bib57","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/cam.3.1.6773","article-title":"Cell adhesion molecules in the central nervous system","volume":"3","author":"Togashi","year":"2009","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.celrep.2023.112545_bib58","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.3389\/fcell.2021.820105","article-title":"Neurofilament light regulates axon caliber, synaptic activity, and organelle trafficking in cultured human motor neurons","volume":"9","author":"Sainio","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib59","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3389\/fcell.2020.567537","article-title":"GAP-43 and BASP1 in axon regeneration: implications for the treatment of neurodegenerative diseases","volume":"8","author":"Chung","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrc1802","article-title":"Common markers of proliferation","volume":"6","author":"Whitfield","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.112545_bib61","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nprot.2015.022","article-title":"3D computational reconstruction of tissues with hollow spherical morphologies using single-cell gene expression data","volume":"10","author":"Durruthy-Durruthy","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2023.112545_bib62","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1242\/dev.01082","article-title":"Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth","volume":"131","author":"Cecconi","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib63","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nbt.4091","article-title":"Batch effects in single-cell RNA sequencing data are corrected by matching mutual nearest neighbours","volume":"36","author":"Haghverdi","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2023.112545_bib64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0959-4388(02)00287-8","article-title":"Revisiting cell fate specification in the inner ear","volume":"12","author":"Fekete","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2023.112545_bib65","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2174\/1568009621666210601114631","article-title":"Role of ZEB family members in proliferation, metastasis, and chemoresistance of prostate cancer cells: revealing signaling networks","volume":"21","author":"Soleymani","year":"2021","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.celrep.2023.112545_bib66","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.canlet.2010.09.007","article-title":"ZEB1-Responsive genes in non-small cell lung cancer","volume":"300","author":"Gemmill","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2023.112545_bib67","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2","volume":"283","author":"Korpal","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112545_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-016-0502-x","article-title":"Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications","volume":"15","author":"Serrano-Gomez","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2023.112545_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101118","article-title":"The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges","volume":"8","author":"Loh","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2023.112545_bib70","doi-asserted-by":"crossref","first-page":"1002307","DOI":"10.1371\/journal.pgen.1002307","article-title":"A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in twirler mice","volume":"7","author":"Kurima","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2023.112545_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1242\/dev.6.1.105","article-title":"Twirler: a mutant affecting the inner ear of the house mouse","volume":"6","author":"Lyon","year":"1958","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib72","doi-asserted-by":"crossref","first-page":"e1002309","DOI":"10.1371\/journal.pgen.1002309","article-title":"Cell type\u00a0\u2013 specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis","volume":"7","author":"Hertzano","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2023.112545_bib73","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1242\/dev.069849","article-title":"Dual embryonic origin of the mammalian otic vesicle forming the inner ear","volume":"138","author":"Freyer","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.112545_bib74","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ydbio.2013.11.009","article-title":"Cochleovestibular nerve development is integrated with migratory neural crest cells","volume":"385","author":"Sandell","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib75","article-title":"gEAR: gene Expression Analysis Resource portal for community-driven, multi-omic data exploration","author":"Orvis","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2023.112545_bib76","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112545_bib77","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0070-2153(08)60505-0","article-title":"Detection of multiple gene products simultaneously by in\u00a0situ hybridization and immunohistochemistry in whole mounts of avian embryos","volume":"36","author":"Stern","year":"1998","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib78","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ydbio.2014.04.014","article-title":"Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling","volume":"391","author":"Khatri","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112545_bib79","series-title":"org.Mm.eg.db: Genome Wide Annotation for Mouse","author":"Carlson","year":"2021"},{"key":"10.1016\/j.celrep.2023.112545_bib80","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112545_bib81","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nbt.3102","article-title":"Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells","volume":"33","author":"Buettner","year":"2015","journal-title":"Nat. Biotechnol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723005569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723005569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:55:20Z","timestamp":1778842520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723005569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2211124723005569"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112545","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"112545"}}