{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:12:14Z","timestamp":1790356334847,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.celrep.2023.112601","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T17:33:27Z","timestamp":1685813607000},"page":"112601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2"],"prefix":"10.1016","volume":"42","author":[{"given":"Johanna","family":"Michl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Monterisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktoria","family":"Blaszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzbeta","family":"Hulikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnar","family":"Abdullayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter F.","family":"Bodmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-9473","authenticated-orcid":false,"given":"Pawel","family":"Swietach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112601_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrc.2017.77","article-title":"Tumour acidosis: from the passenger to the driver's seat","volume":"17","author":"Corbet","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The acidic tumor microenvironment as a driver of cancer","volume":"82","author":"Boedtkjer","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2023.112601_bib3","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1158\/0008-5472.CAN-12-2796","article-title":"Acidity generated by the tumor microenvironment drives local invasion","volume":"73","author":"Estrella","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrm2820","article-title":"Sensors and regulators of intracellular pH","volume":"11","author":"Casey","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s10555-021-10004-4","article-title":"Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets","volume":"40","author":"Andersen","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.celrep.2023.112601_bib6","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41416-022-01910-7","article-title":"Autoregulation of H(+)\/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production","volume":"127","author":"Blaszczak","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2967\/jnumed.109.068981","article-title":"Tumor pH and its measurement","volume":"51","author":"Zhang","year":"2010","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.celrep.2023.112601_bib8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jmri.10181","article-title":"MRI of the tumor microenvironment","volume":"16","author":"Gillies","year":"2002","journal-title":"J.\u00a0Magn. Reson. Imaging."},{"key":"10.1016\/j.celrep.2023.112601_bib9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/sj.cdd.4401466","article-title":"Alterations of intracellular pH homeostasis in apoptosis: origins and roles","volume":"11","author":"Lagadic-Gossmann","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2023.112601_bib10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/35014006","article-title":"Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis","volume":"2","author":"Matsuyama","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib11","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1158\/0008-5472.CAN-05-4193","article-title":"Acid-mediated tumor invasion: a multidisciplinary study","volume":"66","author":"Gatenby","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1083\/jcb.200804161","article-title":"Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding","volume":"183","author":"Frantz","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib13","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1074\/jbc.M310148200","article-title":"Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor","volume":"279","author":"Pope","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112601_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.semcancer.2022.07.004","article-title":"'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - genetic deconstruction and therapeutic perspectives","volume":"86","author":"Pouyss\u00e9gur","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10555-019-09791-8","article-title":"Intracellular pH dynamics and charge-changing somatic mutations in cancer","volume":"38","author":"White","year":"2019","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.celrep.2023.112601_bib16","doi-asserted-by":"crossref","first-page":"eaam9931","DOI":"10.1126\/scisignal.aam9931","article-title":"Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins","volume":"10","author":"White","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2023.112601_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s42003-019-0393-7","article-title":"Evidence-based guidelines for controlling pH in mammalian live-cell culture systems","volume":"2","author":"Michl","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/advan.00045.2004","article-title":"Regulation of intracellular pH","volume":"28","author":"Boron","year":"2004","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.celrep.2023.112601_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/337601a0","article-title":"Cell growth factors. Bicarbonate and pHi response","volume":"337","author":"Thomas","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112601_bib20","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1038\/ncomms9752","article-title":"Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane","volume":"6","author":"Damaghi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112601_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/2159-8290.CD-19-1007","article-title":"Golgi acidification by NHE7 regulates cytosolic pH homeostasis in pancreatic cancer cells","volume":"10","author":"Galenkamp","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2023.112601_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","article-title":"The monocarboxylate transporter family--role and regulation","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.celrep.2023.112601_bib23","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/0008-5472.CAN-05-3260","article-title":"Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma","volume":"66","author":"Koukourakis","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib24","doi-asserted-by":"crossref","first-page":"13815","DOI":"10.1074\/jbc.M111.219899","article-title":"Dual role of CO2\/HCO3\u2212 buffer in the regulation of intracellular pH of three-dimensional tumor growths","volume":"286","author":"Hulikova","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112601_bib25","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1158\/0008-5472.CAN-15-1862","article-title":"Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth","volume":"76","author":"McIntyre","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mam.2012.10.008","article-title":"The SLC4 family of bicarbonate (HCO\u2083\u207b) transporters","volume":"34","author":"Romero","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.celrep.2023.112601_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/expphysiol.2005.031765","article-title":"Molecular physiology of SLC4 anion exchangers","volume":"91","author":"Alper","year":"2006","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.celrep.2023.112601_bib28","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s10555-021-10005-3","article-title":"What do cellular responses to acidity tell us about cancer?","volume":"40","author":"Blaszczak","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.celrep.2023.112601_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fphys.2015.00355","article-title":"Structure and function of SLC4 family HCO3- transporters","volume":"6","author":"Liu","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.celrep.2023.112601_bib30","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1007\/s00018-021-03890-y","article-title":"SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes","volume":"78","author":"Khosrowabadi","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2023.112601_bib31","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1021\/bi00578a012","article-title":"Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in\u00a0situ","volume":"18","author":"Thomas","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2023.112601_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrc2892","article-title":"The evolutionary dynamics of cancer prevention","volume":"10","author":"Gatenby","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib33","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/15384101.2018.1464850","article-title":"The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells","volume":"17","author":"Flinck","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2023.112601_bib34","doi-asserted-by":"crossref","first-page":"44645","DOI":"10.1074\/jbc.M308099200","article-title":"Na-H exchange-dependent increase in intracellular pH times G2\/M entry and transition","volume":"278","author":"Putney","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.112601_bib35","article-title":"GMMchi: gene expression clustering using Gaussian mixture modeling","author":"Liu","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2023.112601_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-5793(04)00315-1","article-title":"The AE2 anion exchanger is necessary for the structural integrity of the Golgi apparatus in mammalian cells","volume":"564","author":"Holappa","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2023.112601_bib37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0014-5793(03)00597-0","article-title":"Targeting of the AE2 anion exchanger to the Golgi apparatus is cell type-dependent and correlates with the expression of Ank(195), a Golgi membrane skeletal protein","volume":"546","author":"Holappa","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2023.112601_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12915-022-01340-0","article-title":"Proton export upregulates aerobic glycolysis","volume":"20","author":"Russell","year":"2022","journal-title":"BMC Biol."},{"key":"10.1016\/j.celrep.2023.112601_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2012.10.025","article-title":"Histone acetylation regulates intracellular pH","volume":"49","author":"McBrian","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2023.112601_bib40","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1158\/0008-5472.CAN-11-3881","article-title":"Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments","volume":"72","author":"Wojtkowiak","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.112601_bib42","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2023.112601_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cell.2018.05.009","article-title":"Acid suspends the circadian clock in hypoxia through inhibition of mTOR","volume":"174","author":"Walton","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112601_bib44","doi-asserted-by":"crossref","first-page":"e1800265","DOI":"10.1002\/bies.201800265","article-title":"mTOR senses intracellular pH through lysosome dispersion from RHEB","volume":"41","author":"Walton","year":"2019","journal-title":"Bioessays"},{"key":"10.1016\/j.celrep.2023.112601_bib45","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1016\/j.molcel.2022.06.008","article-title":"The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis","volume":"82","author":"Ali","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2023.112601_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10555-018-09778-x","article-title":"What is pH regulation, and why do cancer cells need it?","volume":"38","author":"Swietach","year":"2019","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.celrep.2023.112601_bib47","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3110","article-title":"Dysregulated pH: a perfect storm for cancer progression","volume":"11","author":"Webb","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib48","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1038\/s41598-019-54545-9","article-title":"Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): an integrative analysis of a novel therapeutic target","volume":"9","author":"Pandey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112601_bib49","first-page":"8924","article-title":"Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer","volume":"61","author":"Olive","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112601_bib50","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1186\/s12885-016-2751-x","article-title":"Expression of AE1\/p16 promoted degradation of AE2 in gastric cancer cells","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib51","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1038\/s41598-021-85499-6","article-title":"Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)\/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2","volume":"11","author":"Itoh","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112601_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12943-016-0562-y","article-title":"Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors","volume":"15","author":"Faes","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2023.112601_bib53","doi-asserted-by":"crossref","first-page":"e21549","DOI":"10.1371\/journal.pone.0021549","article-title":"Regulation of mTORC1 Signaling by pH","volume":"6","author":"Balgi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112601_bib54","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature07017","article-title":"Magnetic resonance imaging of pH in\u00a0vivo using hyperpolarized 13C-labelled bicarbonate","volume":"453","author":"Gallagher","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112601_bib55","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1038\/s41598-017-06472-w","article-title":"Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR\/p70S6K1 signaling","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112601_bib56","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2010.11.012","article-title":"Ubiquitin: same molecule, different degradation pathways","volume":"143","author":"Clague","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112601_bib57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41586-020-2545-9","article-title":"Lysosome-targeting chimaeras for degradation of extracellular proteins","volume":"584","author":"Banik","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112601_bib58","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","article-title":"PROTAC targeted protein degraders: the past is prologue","volume":"21","author":"B\u00e9k\u00e9s","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2023.112601_bib59","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.112601_bib60","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/chemosensors9060139","article-title":"Cost-effective real-time metabolic profiling of cancer cell lines for plate-based assays","volume":"9","author":"Blaszczak","year":"2021","journal-title":"Chemosensors"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723006125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723006125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T18:30:51Z","timestamp":1720722651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723006125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2211124723006125"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112601","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742670610.793598977","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"112601"}}