{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:48:20Z","timestamp":1790876900224,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.celrep.2023.112860","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T17:00:43Z","timestamp":1690304443000},"page":"112860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Single-cell transcriptomic characterization of sheep conceptus elongation and implantation"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-3210","authenticated-orcid":false,"given":"Gong-Xue","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ji","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ping","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Wu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-6996","authenticated-orcid":false,"given":"Qi-En","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112860_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"Wilcox","year":"1988","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2023.112860_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1439-0531.2008.01171.x","article-title":"Embryonic and early foetal losses in cattle and other ruminants","volume":"43","author":"Diskin","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.celrep.2023.112860_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.theriogenology.2015.08.001","article-title":"Placentation, maternal-fetal interface, and conceptus loss in swine","volume":"85","author":"Kridli","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.celrep.2023.112860_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00318976","article-title":"Electron microscopy of the initial stages of placentation in the pig","volume":"172","author":"Dantzer","year":"1985","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.celrep.2023.112860_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/jrf.0.0480257","article-title":"Studies on the equine placenta II. Ultrastructure of the placental barrier","volume":"48","author":"Samuel","year":"1976","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.celrep.2023.112860_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0143-4004(81)80042-2","article-title":"Review article: trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals","volume":"2","author":"Pijnenborg","year":"1981","journal-title":"Placenta"},{"key":"10.1016\/j.celrep.2023.112860_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2023.112860_bib8","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.3390\/ijms20184530","article-title":"Immunohistochemical examination of trophoblast syncytialization during early placentation in sheep","volume":"20","author":"Seo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.anireprosci.2012.08.007","article-title":"Conceptus elongation in cattle: genes, models and questions","volume":"134","author":"Hue","year":"2012","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","article-title":"Pig blastocyst-uterine interactions","volume":"87","author":"Bazer","year":"2014","journal-title":"Differentiation."},{"key":"10.1016\/j.celrep.2023.112860_bib11","doi-asserted-by":"crossref","first-page":"E1749","DOI":"10.1073\/pnas.1721191115","article-title":"Uterine influences on conceptus development in fertility-classified animals","volume":"115","author":"Moraes","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112860_bib12","first-page":"143","article-title":"Ultrastructural evolution of the trophoblast cells of the pre-implantation sheep blastocyst from day 8 to day 18","volume":"118","author":"Wintenberger-Torr\u00e9s","year":"1974","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.celrep.2023.112860_bib13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.1.00398","article-title":"Implantation mechanisms: insights from the sheep","volume":"128","author":"Spencer","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0143-4004(81)80021-5","article-title":"Conceptus attachment in the ewe: an ultrastructural study","volume":"2","author":"Guillomot","year":"1981","journal-title":"Placenta"},{"key":"10.1016\/j.celrep.2023.112860_bib15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1051\/rnd:19860609","article-title":"Experimental studies on the elongation of the ewe blastocyst","volume":"26","author":"Fl\u00e9chon","year":"1986","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.celrep.2023.112860_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/rep.0.1240289","article-title":"Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation","volume":"124","author":"Gray","year":"2002","journal-title":"Reproduction"},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2023.112860_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ansci\/49.Supplement_II.35","article-title":"Actions of hormones on the uterus and effect on conceptus development","volume":"49","author":"Bazer","year":"1979","journal-title":"J.\u00a0Anim. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1530\/jrf.0.0820875","article-title":"The functions of uterine secretions","volume":"82","author":"Roberts","year":"1988","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.celrep.2023.112860_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1387\/ijdb.130344ts","article-title":"Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization","volume":"58","author":"Filant","year":"2014","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1095\/biolreprod.106.052944","article-title":"Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus","volume":"75","author":"Satterfield","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib21","doi-asserted-by":"crossref","first-page":"bqaa098","DOI":"10.1210\/endocr\/bqaa098","article-title":"Steroids regulate SLC2A1 and SLC2A3 to deliver glucose into trophectoderm for metabolism via glycolysis","volume":"161","author":"Kramer","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2023.112860_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1530\/REP-17-0043","article-title":"ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion","volume":"153","author":"Frank","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1055\/s-0028-1108013","article-title":"Interferons and uterine receptivity","volume":"27","author":"Bazer","year":"2009","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.celrep.2023.112860_bib24","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1530\/REP-17-0257","article-title":"Chronicling the discovery of interferon tau","volume":"154","author":"Bazer","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.112.105684","article-title":"Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes","volume":"88","author":"Antoniazzi","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1095\/biolreprod40.2.425","article-title":"Changes in ovine conceptus and endometrial function following asynchronous embryo transfer or administration of progesterone","volume":"40","author":"Ashworth","year":"1989","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1210\/mend-3-7-1099","article-title":"In situ localization of mRNA for the interferon, ovine trophoblast protein-1, during early embryonic development of the sheep","volume":"3","author":"Farin","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.celrep.2023.112860_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0248-4900(90)90309-Q","article-title":"Cellular localization of an embryonic interferon, ovine trophoblastin and its mRNA in sheep embryos during early pregnancy","volume":"68","author":"Guillomot","year":"1990","journal-title":"Biol. Cell."},{"key":"10.1016\/j.celrep.2023.112860_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1095\/biolreprod.114.124156","article-title":"Biological roles of interferon tau (IFNT) and type I IFN receptors in elongation of the ovine conceptus","volume":"92","author":"Brooks","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s004410000316","article-title":"Expression of placental lactogen and cytokeratin in bovine placental binucleate cells in culture","volume":"303","author":"Nakano","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2023.112860_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1477-7827-2-77","article-title":"cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period","volume":"2","author":"Ushizawa","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.celrep.2023.112860_bib32","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1210\/en.2005-1310","article-title":"Effect of interferon-tau administration on endometrium of nonpregnant ewes: a comparison with pregnant ewes","volume":"147","author":"Chen","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2023.112860_bib33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1095\/biolreprod.105.046656","article-title":"Identification of endometrial genes regulated by early pregnancy, progesterone, and interferon tau in the ovine uterus","volume":"74","author":"Gray","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1152\/physiolgenomics.00001.2009","article-title":"Discovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation","volume":"39","author":"Satterfield","year":"2009","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.celrep.2023.112860_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1095\/biolreprod.111.091587","article-title":"Transcriptome changes at the initiation of elongation in the bovine conceptus","volume":"85","author":"Clemente","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.23986\/afsci.90523","article-title":"Functional profiling of the endometrium transcriptome during preimplantation development in Finnsheep, Texel and their F1 crosses","volume":"29","author":"Pokharel","year":"2020","journal-title":"AFSci."},{"key":"10.1016\/j.celrep.2023.112860_bib37","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1095\/biolreprod.111.092643","article-title":"RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation","volume":"85","author":"Mamo","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1095\/biolreprod.115.134973","article-title":"Extracellular vesicles originate from the conceptus and uterus during early pregnancy in sheep","volume":"94","author":"Burns","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158278","article-title":"Induction of IFNT-stimulated genes by conceptus-derived exosomes during the attachment period","volume":"11","author":"Nakamura","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112860_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1095\/biolreprod.116.141945","article-title":"Analysis of the uterine epithelial and conceptus transcriptome and luminal fluid proteome during the peri-implantation period of pregnancy in sheep","volume":"95","author":"Brooks","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib41","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.cell.2021.04.004","article-title":"A single-embryo, single-cell time-resolved model for mouse gastrulation","volume":"184","author":"Mittnenzweig","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112860_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41586-021-04158-y","article-title":"Single-cell transcriptomic characterization of a gastrulating human embryo","volume":"600","author":"Tyser","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112860_bib43","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.3390\/ijms22105177","article-title":"Cell-cell communication at the embryo implantation site of mouse uterus revealed by single-cell analysis","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112860_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1071\/RD16359","article-title":"Insights into conceptus elongation and establishment of pregnancy in ruminants","volume":"29","author":"Spencer","year":"2016","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.celrep.2023.112860_bib46","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","article-title":"CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data","volume":"51","author":"Hu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.112860_bib47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41586-019-1127-1","article-title":"The emergent landscape of the mouse gut endoderm at single-cell resolution","volume":"569","author":"Nowotschin","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112860_bib48","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2016.03.023","article-title":"Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos","volume":"165","author":"Petropoulos","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112860_bib49","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.crvi.2009.09.004","article-title":"Cellular organization of the trophoblastic epithelium in elongating conceptuses of ruminants","volume":"332","author":"Wang","year":"2009","journal-title":"C.\u00a0R. Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib50","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.stem.2022.06.002","article-title":"Epiblast inducers capture mouse trophectoderm stem cells in\u00a0vitro and pattern blastoids for implantation in utero","volume":"29","author":"Seong","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.112860_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.theriogenology.2016.04.037","article-title":"Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows","volume":"86","author":"Wiltbank","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.celrep.2023.112860_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2019.106251","article-title":"Pregnancy loss in beef cattle: a meta-analysis","volume":"212","author":"Reese","year":"2020","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183659","article-title":"Using transrectal ultrasound to examine the effect of exogenous progesterone on early embryonic loss in sheep","volume":"12","author":"Rickard","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112860_bib54","doi-asserted-by":"crossref","first-page":"skac123","DOI":"10.1093\/jas\/skac123","article-title":"Ruminant conceptus-maternal interactions: interferon-tau and beyond","volume":"100","author":"Mathew","year":"2022","journal-title":"J.\u00a0Anim. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib55","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002762RR","article-title":"Deciphering two rounds of cell lineage segregations during bovine preimplantation development","volume":"35","author":"Akizawa","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2023.112860_bib56","first-page":"109","article-title":"Interaction between inner cell mass and trophectoderm of the mouse blastocyst. II. The fate of the polar trophectoderm","volume":"51","author":"Copp","year":"1979","journal-title":"J.\u00a0Embryol. Exp. Morphol."},{"key":"10.1016\/j.celrep.2023.112860_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/bs.ctdb.2017.10.009","article-title":"Our first choice: cellular and genetic underpinnings of trophectoderm identity and differentiation in the mammalian embryo","volume":"128","author":"Menchero","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1017\/S0967199413000531","article-title":"Morphological changes and germ layer formation in the porcine embryos from days 7-13 of development","volume":"23","author":"Sun","year":"2015","journal-title":"Zygote"},{"key":"10.1016\/j.celrep.2023.112860_bib59","doi-asserted-by":"crossref","first-page":"16409","DOI":"10.1073\/pnas.2002008117","article-title":"On the enigmatic disappearance of Rauber's layer","volume":"117","author":"van Leeuwen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112860_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.680539","article-title":"Lineage differentiation markers as a proxy for embryo viability in farm ungulates","volume":"8","author":"P\u00e9rez-G\u00f3mez","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.celrep.2023.112860_bib61","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/humrep\/15.3.694","article-title":"Flow of cells from polar to mural trophectoderm is polarized in the mouse blastocyst","volume":"15","author":"Gardner","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/2049-1891-5-53","article-title":"Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol","volume":"5","author":"Brooks","year":"2014","journal-title":"J.\u00a0Anim. Sci. Biotechnol."},{"key":"10.1016\/j.celrep.2023.112860_bib63","first-page":"882","article-title":"Endometrial luminal epithelial cells sense embryo elongation in the roe deer independent of interferon-tau","volume":"101","author":"van der Weijden","year":"2019","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2049-1891-4-23","article-title":"Pregnancy recognition signaling mechanisms in ruminants and pigs","volume":"4","author":"Bazer","year":"2013","journal-title":"J.\u00a0Anim. Sci. Biotechnol."},{"key":"10.1016\/j.celrep.2023.112860_bib65","doi-asserted-by":"crossref","first-page":"F21","DOI":"10.1530\/REP-17-0330","article-title":"Transcriptional control of IFNT expression","volume":"154","author":"Ezashi","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib66","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1128\/MCB.21.23.7883-7891.2001","article-title":"Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4","volume":"21","author":"Ezashi","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib67","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/mrd.22212","article-title":"CDX2 regulates multiple trophoblast genes in bovine trophectoderm CT-1 cells","volume":"80","author":"Schiffmacher","year":"2013","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2023.112860_bib68","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/mrd.21082","article-title":"Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-tau gene transcription","volume":"76","author":"Bai","year":"2009","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2023.112860_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1095\/biolreprod.107.066647","article-title":"The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2","volume":"79","author":"Ezashi","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-213X-7-64","article-title":"Identification and expression analysis of genes associated with bovine blastocyst formation","volume":"7","author":"Goossens","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib71","first-page":"1908","article-title":"Fibronectin 1 inhibits the apoptosis of human trophoblasts by activating the PI3K\/Akt signaling pathway","volume":"46","author":"Ji","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.celrep.2023.112860_bib72","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/REP-09-0447","article-title":"Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface","volume":"139","author":"Massuto","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib73","first-page":"507","article-title":"Structure of trophoblast papillae on the sheep conceptus at implantation","volume":"134","author":"Wooding","year":"1982","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.celrep.2023.112860_bib74","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.110.090019","article-title":"Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?","volume":"85","author":"Forde","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.112860_bib75","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/jrf.0.0590205","article-title":"Collection, description and transfer of embryos from cattle 10-16\u00a0days after oestrus","volume":"59","author":"Betteridge","year":"1980","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.celrep.2023.112860_bib76","doi-asserted-by":"crossref","first-page":"22635","DOI":"10.1073\/pnas.1911362116","article-title":"Dynamics of trophoblast differentiation in peri-implantation-stage human embryos","volume":"116","author":"West","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112860_bib77","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1530\/REP-14-0485","article-title":"Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy","volume":"149","author":"Wallace","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2023.112860_bib78","article-title":"The Tabula Sapiens: a multiple-organ, single-cell transcriptomic atlas of humans","volume":"376","author":"Jones","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.112860_bib79","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/er.2018-00281","article-title":"Uterine glands: developmental biology and functional roles in pregnancy","volume":"40","author":"Kelleher","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.celrep.2023.112860_bib80","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1096\/fj.10-175349","article-title":"WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse","volume":"25","author":"Franco","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2023.112860_bib81","first-page":"155","article-title":"The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46","volume":"70","author":"Purcell","year":"1990","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2023.112860_bib82","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100590R","article-title":"Jagged1 regulates endometrial receptivity in both humans and mice","volume":"35","author":"Zhou","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2023.112860_bib83","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40104-015-0017-0","article-title":"Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period","volume":"6","author":"Zhao","year":"2015","journal-title":"J.\u00a0Anim. Sci. Biotechnol."},{"key":"10.1016\/j.celrep.2023.112860_bib84","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41422-021-00592-9","article-title":"Generation and characterization of stable pig pregastrulation epiblast stem cell lines","volume":"32","author":"Zhi","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2023.112860_bib85","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/s41588-021-00972-2","article-title":"Mapping the temporal and spatial dynamics of the human endometrium in\u00a0vivo and in\u00a0vitro","volume":"53","author":"Garcia-Alonso","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.112860_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112860_bib87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.112860_bib88","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2023.112860_bib89","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112860_bib90","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723008719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723008719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:55:17Z","timestamp":1759956917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723008719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2211124723008719"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112860","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptomic characterization of sheep conceptus elongation and implantation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"112860"}}