{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:46:47Z","timestamp":1792043207479,"version":"4.4.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.celrep.2023.112879","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:01:18Z","timestamp":1690934478000},"page":"112879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma"],"prefix":"10.1016","volume":"42","author":[{"given":"Miriam I.","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Greenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Buchkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Peres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Santoni-Rugiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mikl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zalman","family":"Vaksman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Reshef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Salovin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Naranjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Ulitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"de Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine K.","family":"Matthay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Weigman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gur","family":"Yaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Panzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Maris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112879_bib1","series-title":"Ueber den jetzigen Stand der Karzinomforschung","author":"Ehrlich","year":"1908"},{"key":"10.1016\/j.celrep.2023.112879_bib2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI31405","article-title":"Immune surveillance of tumors","volume":"117","author":"Swann","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2023.112879_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/00313027509092702","article-title":"Spontaneous regression of melanoma","volume":"7","author":"McGovern","year":"1975","journal-title":"Pathology"},{"key":"10.1016\/j.celrep.2023.112879_bib4","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(19)30244-3","article-title":"An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models","volume":"18","author":"Dalmau","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2023.112879_bib5","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1038\/s41598-018-25294-y","article-title":"Paraneoplastic limbic encephalitis associated with lung cancer","volume":"8","author":"Shen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112879_bib6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/jnnp.2003.034447","article-title":"Recommended diagnostic criteria for paraneoplastic neurological syndromes","volume":"75","author":"Graus","year":"2004","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2023.112879_bib7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.18632\/oncotarget.323","article-title":"New perspectives on the role of vitiligo in immune responses to melanoma","volume":"2","author":"Byrne","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2023.112879_bib8","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMra023009","article-title":"Paraneoplastic syndromes involving the nervous system","volume":"349","author":"Darnell","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2023.112879_bib9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0190-9622(83)70182-9","article-title":"Vitiligo in patients with metastatic melanoma: a good prognostic sign","volume":"9","author":"Nordlund","year":"1983","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2023.112879_bib10","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/1097-0142(196511)18:11<1399::AID-CNCR2820181104>3.0.CO;2-R","article-title":"Spontaneous regression of primary malignant melanomas with regional metastases","volume":"18","author":"Smith","year":"1965","journal-title":"Cancer"},{"key":"10.1016\/j.celrep.2023.112879_bib11","doi-asserted-by":"crossref","first-page":"642800","DOI":"10.3389\/fneur.2021.642800","article-title":"Paraneoplastic Neurological Syndromes and Beyond Emerging With the Introduction of Immune Checkpoint Inhibitor Cancer Immunotherapy","volume":"12","author":"Valencia-Sanchez","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.celrep.2023.112879_bib12","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.mayocp.2019.02.003","article-title":"Neurologic Autoimmunity in the Era of Checkpoint Inhibitor Cancer Immunotherapy","volume":"94","author":"Zekeridou","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.celrep.2023.112879_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ncpneuro0493","article-title":"A patient with encephalitis associated with NMDA receptor antibodies","volume":"3","author":"Sansing","year":"2007","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.celrep.2023.112879_bib14","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.celrep.2019.04.098","article-title":"The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer","volume":"27","author":"De Mattos-Arruda","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.112879_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/jnnp.25.3.271","article-title":"Myoclonic encephalopathy of infants","volume":"25","author":"Kinsbourne","year":"1962","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2023.112879_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0092-8674(86)90509-X","article-title":"N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma","volume":"47","author":"Bernards","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112879_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPH.0000000000000976","article-title":"Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome","volume":"40","author":"Hero","year":"2018","journal-title":"J.\u00a0Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2023.112879_bib18","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/1097-0142(197602)37:2<846::AID-CNCR2820370233>3.0.CO;2-L","article-title":"Favorable prognosis for survival in children with coincident opso-myoclonus and neuroblastoma","volume":"37","author":"Altman","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.celrep.2023.112879_bib19","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/mpo.1138","article-title":"Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies-a report from the Children's Cancer Group Study","volume":"36","author":"Rudnick","year":"2001","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.celrep.2023.112879_bib20","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1158\/0008-5472.CAN-21-0691","article-title":"Neuroblastoma Formation Requires Unconventional CD4\u00a0T Cells and Arginase-1-Dependent Myeloid Cells","volume":"81","author":"Van de Velde","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112879_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S2352-4642(17)30130-X","article-title":"Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial","volume":"2","author":"de Alarcon","year":"2018","journal-title":"Lancet. Child Adolesc. Health"},{"key":"10.1016\/j.celrep.2023.112879_bib22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s12864-017-3827-y","article-title":"A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples","volume":"18","author":"Schuierer","year":"2017","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2023.112879_bib23","doi-asserted-by":"crossref","first-page":"eabb9726","DOI":"10.1126\/sciimmunol.abb9726","article-title":"T cell factor 1: A master regulator of the T\u00a0cell response in disease","volume":"5","author":"Escobar","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib24","doi-asserted-by":"crossref","first-page":"e714","DOI":"10.1212\/WNL.0000000000006035","article-title":"Glutamate receptor delta2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome","volume":"91","author":"Berridge","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2023.112879_bib25","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.4049\/jimmunol.1900620","article-title":"Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus","volume":"203","author":"Kulik","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib26","first-page":"425","article-title":"Transformation and model choice for RNA-seq co-expression analysis","volume":"19","author":"Rau","year":"2018","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.celrep.2023.112879_bib27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/02664763.2018.1454894","article-title":"Clustering transformed compositional data using K-means, with applications in gene expression and bicycle sharing system data","volume":"46","author":"Godichon-Baggioni","year":"2019","journal-title":"J.\u00a0Appl. Stat."},{"key":"10.1016\/j.celrep.2023.112879_bib28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2023.112879_bib29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3390\/cancers12030620","article-title":"RNA Immune Signatures from Pan-Cancer Analysis Are Prognostic for High-Grade Serous Ovarian Cancer and Other Female Cancers","volume":"12","author":"Jones","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.celrep.2023.112879_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/mpo.1139","article-title":"Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: histopathologic features-a report from the Children's Cancer Group","volume":"36","author":"Cooper","year":"2001","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.celrep.2023.112879_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/pin.12591","article-title":"Clinicopathological features of neuroblastic tumors with opsoclonus-myoclonus-ataxia syndrome: Follicular structure predicts a better neurological outcome","volume":"67","author":"Fukushima","year":"2017","journal-title":"Pathol. Int."},{"key":"10.1016\/j.celrep.2023.112879_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00428-002-0747-1","article-title":"Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases","volume":"442","author":"Gambini","year":"2003","journal-title":"Virchows Arch."},{"key":"10.1016\/j.celrep.2023.112879_bib33","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","article-title":"The Immune Landscape of Cancer","volume":"48","author":"Thorsson","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.112879_bib34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1158\/1541-7786.MCR-18-0601","article-title":"Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas","volume":"17","author":"Chen","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.celrep.2023.112879_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.112879_bib36","article-title":"XGBoost: A Scalable Tree Boosting System","author":"Chen","year":"2016","journal-title":"arXiv"},{"key":"10.1016\/j.celrep.2023.112879_bib37","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1038\/s41467-020-18987-4","article-title":"Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations","volume":"11","author":"Brady","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112879_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng.2529","article-title":"The genetic landscape of high-risk neuroblastoma","volume":"45","author":"Pugh","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.112879_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-0029-1237723","article-title":"Long-term follow-up of neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome","volume":"40","author":"De Grandis","year":"2009","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.celrep.2023.112879_bib40","doi-asserted-by":"crossref","first-page":"106296","DOI":"10.18632\/oncotarget.22435","article-title":"Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes","volume":"8","author":"Su","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2023.112879_bib41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri.2017.143","article-title":"HLA variation and disease","volume":"18","author":"Dendrou","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib42","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13073-017-0473-6","article-title":"HLAProfiler utilizes k-mer profiles to improve HLA calling accuracy for rare and common alleles in RNA-seq data","volume":"9","author":"Buchkovich","year":"2017","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2023.112879_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/351485a0","article-title":"A novel class II MHC molecule with unusual tissue distribution","volume":"351","author":"Karlsson","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112879_bib44","series-title":"Pediatric Blood\u00a0& Cancer 45","first-page":"365","article-title":"Opsomyoclonus Syndrome in infancy with or without neuroblastoma is associated with HLA-DRB1\u221701","author":"Hero","year":"2005"},{"key":"10.1016\/j.celrep.2023.112879_bib45","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1038\/ncomms3680","article-title":"Using synthetic templates to design an unbiased multiplex PCR assay","volume":"4","author":"Carlson","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112879_bib46","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1182\/blood-2009-04-217604","article-title":"Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T\u00a0cells","volume":"114","author":"Robins","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.112879_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature22383","article-title":"Quantifiable predictive features define epitope-specific T\u00a0cell receptor repertoires","volume":"547","author":"Dash","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112879_bib48","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.it.2015.09.006","article-title":"Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires","volume":"36","author":"Greiff","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib49","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ng.3822","article-title":"Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T\u00a0cell repertoire","volume":"49","author":"Emerson","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.112879_bib50","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.4049\/jimmunol.1001323","article-title":"CD20+ B cells: the other tumor-infiltrating lymphocytes","volume":"185","author":"Nelson","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/01.mph.0000212991.64435.f0","article-title":"Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome","volume":"28","author":"Pranzatelli","year":"2006","journal-title":"J.\u00a0Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2023.112879_bib52","doi-asserted-by":"crossref","first-page":"e27776","DOI":"10.1002\/pbc.27776","article-title":"An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome","volume":"66","author":"Wilbur","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.celrep.2023.112879_bib99","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1158\/0008-5472.CAN-10-3810","article-title":"MMSET is highly expressed and associated with aggressiveness in neuroblastoma","volume":"71","author":"Hudlebusch","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.112879_bib53","doi-asserted-by":"crossref","first-page":"eaaw0044","DOI":"10.1126\/scitranslmed.aaw0044","article-title":"Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors","volume":"11","author":"Jones","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2023.112879_bib54","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","article-title":"Tertiary lymphoid structures improve immunotherapy and survival in melanoma","volume":"577","author":"Cabrita","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112879_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112879_bib56","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/imr.12405","article-title":"Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers","volume":"271","author":"Dieu-Nosjean","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2023.112879_bib57","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1038\/s41467-021-23355-x","article-title":"B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma","volume":"12","author":"Ruffin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112879_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41568-019-0144-6","article-title":"Tertiary lymphoid structures in the era of cancer immunotherapy","volume":"19","author":"Saut\u00e8s-Fridman","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.112879_bib59","doi-asserted-by":"crossref","first-page":"674565","DOI":"10.3389\/fimmu.2021.674565","article-title":"Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies","volume":"12","author":"Tr\u00fcb","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib60","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fendo.2019.00471","article-title":"CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond","volume":"10","author":"Kazanietz","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.celrep.2023.112879_bib61","doi-asserted-by":"crossref","first-page":"105348","DOI":"10.1016\/j.oraloncology.2021.105348","article-title":"Single-cell profiling of tumor-infiltrating TCF1\/TCF7(+) T\u00a0cells reveals a T lymphocyte subset associated with tertiary lymphoid structures\/organs and a superior prognosis in oral cancer","volume":"119","author":"Peng","year":"2021","journal-title":"Oral Oncol."},{"key":"10.1016\/j.celrep.2023.112879_bib62","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1038\/s41467-021-24343-x","article-title":"The T\u00a0cell receptor repertoire of tumor infiltrating T\u00a0cells is predictive and prognostic for cancer survival","volume":"12","author":"Valpione","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112879_bib63","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.immuni.2021.02.014","article-title":"Global analysis of shared T\u00a0cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery","volume":"54","author":"Chiou","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.112879_bib64","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-018-0130-2","article-title":"Bystander CD8(+) T\u00a0cells are abundant and phenotypically distinct in human tumour infiltrates","volume":"557","author":"Simoni","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112879_bib65","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1212\/NXI.0000000000000419","article-title":"Phenotypic and functional complexity of brain-infiltrating T\u00a0cells in Rasmussen encephalitis","volume":"5","author":"Al Nimer","year":"2018","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.celrep.2023.112879_bib66","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3389\/fimmu.2016.00608","article-title":"Shared HLA Class I and II Alleles and Clonally Restricted Public and Private Brain-Infiltrating alphabeta T Cells in a Cohort of Rasmussen Encephalitis Surgery Patients","volume":"7","author":"Dandekar","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib67","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.1038\/ncomms11153","article-title":"CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing","volume":"7","author":"Schneider-Hohendorf","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.112879_bib68","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/imm.12554","article-title":"Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues","volume":"147","author":"Jones","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2023.112879_bib69","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/brain\/awm038","article-title":"Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology","volume":"130","author":"Magliozzi","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2023.112879_bib70","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.4049\/jimmunol.176.12.7676","article-title":"CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis","volume":"176","author":"Bagaeva","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib71","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1093\/rheumatology\/keu163","article-title":"High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease","volume":"53","author":"Bugatti","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2023.112879_bib72","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1038\/s41598-017-08935-6","article-title":"T cell specific Cxcr5 deficiency prevents rheumatoid arthritis","volume":"7","author":"Moschovakis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112879_bib73","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1002\/art.22939","article-title":"CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis","volume":"56","author":"Wengner","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2023.112879_bib74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2011.12.014","article-title":"Key role of CXCL13\/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS","volume":"243","author":"Pranzatelli","year":"2012","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.celrep.2023.112879_bib75","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3389\/fimmu.2018.01952","article-title":"Tertiary Lymphoid Structures: Autoimmunity Goes Local","volume":"9","author":"Pipi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib76","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","article-title":"Germinal center selection and the development of memory B and plasma cells","volume":"247","author":"Shlomchik","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2023.112879_bib77","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.4049\/jimmunol.1500792","article-title":"B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus","volume":"195","author":"Giles","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib78","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1084\/jem.20130699","article-title":"MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies","volume":"210","author":"Molnarfi","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.112879_bib79","doi-asserted-by":"crossref","first-page":"13877","DOI":"10.1038\/s41598-019-50455-y","article-title":"Synergy between B cell receptor\/antigen uptake and MHCII peptide editing relies on HLA-DO tuning","volume":"9","author":"Jiang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112879_bib80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.coi.2020.05.007","article-title":"The love and hate relationship of HLA-DM\/DO in the selection of immunodominant epitopes","volume":"64","author":"Welsh","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2023.112879_bib97","article-title":"A Unified Approach to Interpreting Model Predictions","author":"Lundberg","year":"2017","journal-title":"arXiv"},{"key":"10.1016\/j.celrep.2023.112879_bib94","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale\u00a0B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib95","doi-asserted-by":"crossref","first-page":"W34","DOI":"10.1093\/nar\/gkt382","article-title":"IgBLAST: an immunoglobulin variable domain sequence analysis tool","volume":"41","author":"Ye","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.112879_bib92","article-title":"Robust Classification of Immune Subtypes in Cancer","volume":"2001","author":"Gibbs","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2023.112879_bib96","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1093\/bioinformatics\/btz481","article-title":"RAbHIT: R Antibody Haplotype Inference Tool","volume":"35","author":"Peres","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib87","doi-asserted-by":"crossref","first-page":"e12776","DOI":"10.1371\/journal.pone.0012776","article-title":"Inferring regulatory networks from expression data using tree-based methods","volume":"5","author":"Huynh-Thu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112879_bib89","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2023.112879_bib83","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.112879_bib84","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.112879_bib85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib86","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/bioinformatics\/btt087","article-title":"EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments","volume":"29","author":"Leng","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib81","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib82","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13059-019-1842-9","article-title":"Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods","volume":"20","author":"Haas","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.112879_bib88","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.112879_bib90","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.112879_bib91","first-page":"115717","article-title":"The Sentieon Genomics Tools - A Fast and Accurate Solution to Variant Calling from Next-Generation Sequence Data","author":"Freed","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2023.112879_bib93","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2018.03.022","article-title":"Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer","volume":"173","author":"Hoadley","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.112879_bib98","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7","article-title":"The International Neuroblastoma Pathology Classification (the Shimada system)","volume":"86","author":"Shimada","year":"1999","journal-title":"Cancer"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723008902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723008902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:05:53Z","timestamp":1759957553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723008902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":99,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2211124723008902"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112879","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.14.471886","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"112879"}}