{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:59:01Z","timestamp":1792799941969,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.celrep.2023.113012","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T07:40:48Z","timestamp":1692603648000},"page":"113012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes"],"prefix":"10.1016","volume":"42","author":[{"given":"Keren","family":"Turton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Zarodkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad A.","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dwane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana","family":"Parau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Coll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-3641","authenticated-orcid":false,"given":"Miguel A.","family":"Valvano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.113012_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1513\/AnnalsATS.201406-288FR","article-title":"Achromobacter respiratory infections","volume":"12","author":"Swenson","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.celrep.2023.113012_bib2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3390\/jcm10061275","article-title":"Bacterial re-colonization occurs early after lung transplantation in cystic fibrosis patients","volume":"10","author":"Holm","year":"2021","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.celrep.2023.113012_bib3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jcf.2022.11.001","article-title":"Clinical outcomes associated with Achromobacter species infection in people with cystic fibrosis","volume":"22","author":"Kerem","year":"2023","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.celrep.2023.113012_bib4","first-page":"268","article-title":"Achromobacter xylosoxidans bacteremia: clinical and microbiological features in a 10-year case series","volume":"31","author":"P\u00e9rez Barrag\u00e1n","year":"2018","journal-title":"Rev. Espa\u00f1ola Quimioter."},{"key":"10.1016\/j.celrep.2023.113012_bib5","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3390\/microorganisms10071449","article-title":"Achromobacter species: An emerging cause of community-onset bloodstream infections","volume":"10","author":"Isler","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.celrep.2023.113012_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/clinids\/23.3.569","article-title":"Achromobacter xylosoxidans bacteremia: report of four cases and review of the literature","volume":"23","author":"Duggan","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2023.113012_bib7","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.3390\/ijms23169265","article-title":"Achromobacter spp. adaptation in cystic fibrosis infection and candidate biomarkers of antimicrobial resistance","volume":"23","author":"Sandri","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.113012_bib8","first-page":"000582","article-title":"Achromobacter spp. genetic adaptation in cystic fibrosis","volume":"7","author":"Gabrielaite","year":"2021","journal-title":"Microb. Genom."},{"key":"10.1016\/j.celrep.2023.113012_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fmicb.2014.00138","article-title":"Outbreak of Achromobacter xylosoxidans in an Italian cystic fibrosis center: genome variability, biofilm production, antibiotic resistance, and motility in isolated strains","volume":"5","author":"Trancassini","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jcf.2011.07.004","article-title":"Marked increase in incidence of Achromobacter xylosoxidans infections caused by sporadic acquisition from the environment","volume":"10","author":"Ridderberg","year":"2011","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.celrep.2023.113012_bib11","doi-asserted-by":"crossref","first-page":"e02911","DOI":"10.1128\/JCM.02911-20","article-title":"Transmission and antibiotic resistance of Achromobacter in cystic fibrosis","volume":"59","author":"Gabrielaite","year":"2021","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1017\/S0950268816002624","article-title":"Patterns of virulence factor expression and antimicrobial resistance in Achromobacter xylosoxidans and Achromobacter ruhlandii isolates from patients with cystic fibrosis","volume":"145","author":"Pereira","year":"2017","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.celrep.2023.113012_bib13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fcimb.2017.00224","article-title":"Uncovering differences in virulence markers associated with Achromobacter species of CF and non-CF origin","volume":"7","author":"Filipic","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/microorganisms4030033","article-title":"Achromobacter species isolated from cystic fibrosis patients reveal distinctly different biofilm morphotypes","volume":"4","author":"Nielsen","year":"2016","journal-title":"Microorganisms"},{"key":"10.1016\/j.celrep.2023.113012_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jcf.2012.02.002","article-title":"A heat-stable cytotoxic factor produced by Achromobacter xylosoxidans isolated from Brazilian patients with CF is associated with in\u00a0vitro increased proinflammatory cytokines","volume":"11","author":"Mantovani","year":"2012","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.celrep.2023.113012_bib16","doi-asserted-by":"crossref","first-page":"859181","DOI":"10.3389\/fcimb.2022.859181","article-title":"Characterization of the Achromobacter xylosoxidans type VI secretion system and its implication in cystic fibrosis","volume":"12","author":"Le Goff","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib17","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1007\/s00253-013-5018-3","article-title":"Comparative genome characterization of Achromobacter members reveals potential genetic determinants facilitating the adaptation to a pathogenic lifestyle","volume":"97","author":"Li","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.celrep.2023.113012_bib18","doi-asserted-by":"crossref","first-page":"e68484","DOI":"10.1371\/journal.pone.0068484","article-title":"Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes","volume":"8","author":"Jakobsen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.113012_bib19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/gbe\/evx061","article-title":"A pan-genomic approach to understand the basis of host adaptation in Achromobacter","volume":"9","author":"Jeukens","year":"2017","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.celrep.2023.113012_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fcimb.2020.00466","article-title":"Bordetella type III secretion injectosome and effector proteins","volume":"10","author":"Kamanova","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00136-20","article-title":"Achromobacter xylosoxidans cellular pathology is correlated with activation of a Type III secretion system","volume":"88","author":"Pickrum","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.113012_bib22","doi-asserted-by":"crossref","first-page":"e0208322","DOI":"10.1128\/spectrum.02083-22","article-title":"The in\u00a0vitro replication cycle of Achromobacter xylosoxidans and identification of virulence genes associated with cytotoxicity in macrophages","volume":"10","author":"Pickrum","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2023.113012_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jcf.2009.10.005","article-title":"Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients","volume":"9","author":"Hansen","year":"2010","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.celrep.2023.113012_bib24","doi-asserted-by":"crossref","first-page":"17658","DOI":"10.1038\/s41598-017-17993-9","article-title":"Leukotriene B4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection","volume":"7","author":"Prado","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.113012_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib27","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cell.2017.02.022","article-title":"In situ molecular architecture of the Salmonella type III secretion machine","volume":"168","author":"Hu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113012_bib28","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1365-2958.2011.07830.x","article-title":"The assembly of the export apparatus (YscR,S,T,U,V) of the Yersinia type III secretion apparatus occurs independently of other structural components and involves the formation of an YscV oligomer","volume":"82","author":"Diepold","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib29","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1365-2958.2012.08146.x","article-title":"Assembly of the Yersinia injectisome: the missing pieces","volume":"85","author":"Diepold","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/mmi.14880","article-title":"Type III secretion by Yersinia pseudotuberculosis is reliant upon an authentic N-terminal YscX secretor domain","volume":"117","author":"Gurung","year":"2022","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1574-6968.2012.02561.x","article-title":"Btc22 chaperone is required for secretion and stability of the type III secreted protein Bsp22 in Bordetella bronchiseptica","volume":"331","author":"Kurushima","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.celrep.2023.113012_bib32","doi-asserted-by":"crossref","first-page":"vbab016","DOI":"10.1093\/bioadv\/vbab016","article-title":"cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters","volume":"1","author":"Gilchrist","year":"2021","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.celrep.2023.113012_bib33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrmicro.2017.20","article-title":"Assembly, structure, function and regulation of type III secretion systems","volume":"15","author":"Deng","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib34","doi-asserted-by":"crossref","DOI":"10.3791\/54406","article-title":"Implementation of a permeable membrane insert-based infection system to study the effects of secreted bacterial toxins on mammalian host cells","author":"Flaherty","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2023.113012_bib35","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1016\/S0021-9258(18)66662-1","article-title":"Actin polymerization. The mechanism of action of cytochalasin D","volume":"261","author":"Goddette","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.113012_bib36","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1074\/jbc.M112.411728","article-title":"Depletion of the ubiquitin-binding adaptor molecule SQSTM1\/p62 from macrophages harboring cftr DeltaF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery","volume":"288","author":"Abdulrahman","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.113012_bib37","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113012_bib38","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.4049\/jimmunol.175.4.2630","article-title":"IL-converting enzyme\/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients","volume":"175","author":"Stack","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.coi.2015.01.010","article-title":"The NAIP\/NLRC4 inflammasomes","volume":"32","author":"Vance","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib40","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0913087107","article-title":"Innate immune detection of the type\u00a0III secretion apparatus through the NLRC4 inflammasome","volume":"107","author":"Miao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113012_bib41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.4049\/jimmunol.2000382","article-title":"Salmonella flagellin activates NAIP\/NLRC4 and canonical NLRP3 inflammasomes in human macrophages","volume":"206","author":"Gram","year":"2021","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib42","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/eji.201545523","article-title":"Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells","volume":"45","author":"Schmid-Burgk","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib43","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1073\/pnas.1402911111","article-title":"Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex","volume":"111","author":"Man","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113012_bib44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1084\/jem.20132234","article-title":"NLRP3 recruitment by NLRC4 during Salmonella infection","volume":"213","author":"Qu","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113012_bib45","doi-asserted-by":"crossref","first-page":"e0066321","DOI":"10.1128\/iai.00663-21","article-title":"Salmonella enterica serovar Typhimurium induces NAIP\/NLRC4- and NLRP3\/ASC-independent, caspase-4-dependent inflammasome activation in human intestinal epithelial cells","volume":"90","author":"Naseer","year":"2022","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.113012_bib46","doi-asserted-by":"crossref","first-page":"ftab006","DOI":"10.1093\/femspd\/ftab006","article-title":"Microbiology's next top model: Galleria in the molecular age","volume":"79","author":"Dinh","year":"2021","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.celrep.2023.113012_bib47","doi-asserted-by":"crossref","first-page":"e0003723","DOI":"10.1128\/iai.00037-23","article-title":"Identification of virulence factors involved in a murine model of severe Achromobacter xylosoxidans Infection","volume":"91","author":"Wills","year":"2023","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.113012_bib48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.plrev.2021.05.007","article-title":"An elegant nano-injection machinery for sabotaging the host: Role of Type III secretion system in virulence of different human and animal pathogenic bacteria","volume":"38","author":"Hajra","year":"2021","journal-title":"Phys. Life Rev."},{"key":"10.1016\/j.celrep.2023.113012_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1348-0421.1971.tb00607.x","article-title":"Achromobacter xylosoxidans n. sp. from human ear discharge","volume":"15","author":"Yabuuchi","year":"1971","journal-title":"Jpn. J. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib50","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1462-2920.2008.01576.x","article-title":"A system for the construction of targeted unmarked gene deletions in the genus Burkholderia","volume":"10","author":"Flannagan","year":"2008","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib51","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2010.04.009","article-title":"A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system","volume":"7","author":"Brodsky","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2023.113012_bib52","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1152\/physrev.00002.2021","article-title":"The evolution of regulated cell death pathways in animals and their evasion by pathogens","volume":"102","author":"Tummers","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2023.113012_bib53","doi-asserted-by":"crossref","first-page":"930882","DOI":"10.3389\/fimmu.2022.930882","article-title":"Bacterial subversion of NLR-mediated immune responses","volume":"13","author":"Kienes","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.113012_bib54","doi-asserted-by":"crossref","first-page":"13242","DOI":"10.1073\/pnas.1710433114","article-title":"Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP\/NLRC4 inflammasome","volume":"114","author":"Reyes Ruiz","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113012_bib55","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113012_bib56","doi-asserted-by":"crossref","first-page":"100924","DOI":"10.1016\/j.mam.2020.100924","article-title":"An overview of the non-canonical inflammasome","volume":"76","author":"Downs","year":"2020","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.celrep.2023.113012_bib57","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1462-5822.2003.00260.x","article-title":"Bordetella type III secretion induces caspase 1-independent necrosis","volume":"5","author":"Stockbauer","year":"2003","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib58","doi-asserted-by":"crossref","first-page":"e1009927","DOI":"10.1371\/journal.ppat.1009927","article-title":"Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology","volume":"17","author":"Bagayoko","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2023.113012_bib59","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of Pseudomonas aeruginosa mediated by the IPAF\/NLRC4 inflammasome","volume":"204","author":"Sutterwala","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113012_bib60","doi-asserted-by":"crossref","first-page":"167333","DOI":"10.1016\/j.jmb.2021.167333","article-title":"Proto-pyroptosis: An ancestral origin for mammalian inflammatory cell death mechanism in Drosophila melanogaster","volume":"434","author":"Dziedziech","year":"2022","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2023.113012_bib61","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/1744-7917.12325","article-title":"Immunity of the greater wax moth Galleria mellonella","volume":"24","author":"Wojda","year":"2017","journal-title":"Insect Sci."},{"key":"10.1016\/j.celrep.2023.113012_bib62","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00011-022-01641-8","article-title":"CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans","volume":"71","author":"Elias-Oliveira","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.celrep.2023.113012_bib63","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/AEM.03024-09","article-title":"Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay","volume":"76","author":"Hamad","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib64","doi-asserted-by":"crossref","first-page":"e0372922","DOI":"10.1128\/spectrum.03729-22","article-title":"Polymyxin resistance and heteroresistance are common in clinical isolates of Achromobacter species and correlate with modifications of the lipid A moiety of lipopolysaccharide","volume":"11","author":"MacDonald","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2023.113012_bib65","doi-asserted-by":"crossref","first-page":"35988","DOI":"10.1074\/jbc.M110.120402","article-title":"BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB","volume":"285","author":"Aubert","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.113012_bib66","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/AEM.01669-09","article-title":"Versatile dual-technology system for markerless allele replacement in Burkholderia pseudomallei","volume":"75","author":"L\u00f3pez","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib67","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/jb.170.6.2575-2583.1988","article-title":"A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR","volume":"170","author":"Miller","year":"1988","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.celrep.2023.113012_bib68","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/IAI.01338-07","article-title":"A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia","volume":"76","author":"Aubert","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.113012_bib69","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1128\/IAI.00743-09","article-title":"Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection","volume":"78","author":"Vergunst","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.113012_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.MP.0000043519.29370.C2","article-title":"Morphological quantification of emphysema in small human lung specimens: comparison of methods and relation with clinical data","volume":"16","author":"Robbesom","year":"2003","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.celrep.2023.113012_bib71","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2023.113012_bib72","first-page":"e50964","article-title":"Use of Galleria mellonella as a model organism to study Legionella pneumophila infection","author":"Harding","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2023.113012_bib73","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1365-2958.1992.tb01351.x","article-title":"Isolation and molecular characterization of a novel broad-host-range plasmid from Bordetella bronchiseptica with sequence similarities to plasmids from gram-positive organisms","volume":"6","author":"Antoine","year":"1992","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2023.113012_bib74","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2023.113012_bib75","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/cyto.990120612","article-title":"Membrane cell permeabilization with saponin and multiparametric analysis by flow cytometry","volume":"12","author":"Jacob","year":"1991","journal-title":"Cytometry"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723010239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723010239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:20:13Z","timestamp":1759958413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723010239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2211124723010239"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113012","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.06.535904","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"113012"}}