{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:43:32Z","timestamp":1789037012236,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32-CA254805"],"award-info":[{"award-number":["F32-CA254805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR045203"],"award-info":[{"award-number":["R01AR045203"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012644","name":"Friends of FSH Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012644","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.celrep.2023.113114","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:58:50Z","timestamp":1694167130000},"page":"113114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["DUX4 expression in cancer induces a metastable early embryonic totipotent program"],"prefix":"10.1016","volume":"42","author":[{"given":"Andrew A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee","family":"Nip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle C.","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.L.F.","family":"Lemmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"van der Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Setty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silv\u00e8re M.","family":"van der Maarel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-0968","authenticated-orcid":false,"given":"Stephen J.","family":"Tapscott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.113114_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature12624","article-title":"Tumour heterogeneity and cancer cell plasticity","volume":"501","author":"Meacham","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113114_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.celrep.2023.113114_bib3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2023.113114_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12943-017-0600-4","article-title":"Intra-tumor heterogeneity from a cancer stem cell perspective","volume":"16","author":"Prasetyanti","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2023.113114_bib5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","article-title":"An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors","volume":"40","author":"Ben-Porath","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib6","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.devcel.2019.06.011","article-title":"DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade","volume":"50","author":"Chew","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ng.3844","article-title":"Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL\/HERVL retrotransposons","volume":"49","author":"Hendrickson","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ng.3846","article-title":"Conservation and innovation in the DUX4-family gene network","volume":"49","author":"Whiddon","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/ng.3858","article-title":"DUX-family transcription factors regulate zygotic genome activation in placental mammals","volume":"49","author":"De Iaco","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.stem.2022.01.014","article-title":"8C-like cells capture the human zygotic genome activation program in\u00a0vitro","volume":"29","author":"Taubenschmid-Stowers","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib11","article-title":"DUX: One Transcription Factor Controls 2-Cell-like Fate","volume":"23","author":"Ren","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2023.113114_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.celrep.2016.08.087","article-title":"MERVL\/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs","volume":"17","author":"Eckersley-Maslin","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.113114_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/dnares\/dsv013","article-title":"Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells","volume":"22","author":"Akiyama","year":"2015","journal-title":"DNA Res."},{"key":"10.1016\/j.celrep.2023.113114_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay5181","article-title":"A transcriptional roadmap for 2C-like-to-pluripotent state transition","volume":"6","author":"Fu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2023.113114_bib15","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1189044","article-title":"A unifying genetic model for facioscapulohumeral muscular dystrophy","volume":"329","author":"Lemmers","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.113114_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001181","article-title":"Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene","volume":"6","author":"Snider","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2044-5040-4-12","article-title":"Facioscapulohumeral dystrophy: the path to consensus on pathophysiology","volume":"4","author":"Tawil","year":"2014","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.celrep.2023.113114_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(99)00267-X","article-title":"Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element","volume":"236","author":"Gabri\u00ebls","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2023.113114_bib19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.gde.2015.08.007","article-title":"Genetic and epigenetic contributors to FSHD","volume":"33","author":"Daxinger","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2023.113114_bib20","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/CON.0000000000000399","article-title":"Facioscapulohumeral Muscular Dystrophy","volume":"22","author":"Statland","year":"2016","journal-title":"Continuum"},{"key":"10.1016\/j.celrep.2023.113114_bib21","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1093\/hmg\/ddv315","article-title":"Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways","volume":"24","author":"Rickard","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113114_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.devcel.2011.11.013","article-title":"DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy","volume":"22","author":"Geng","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib24","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1093\/nar\/gkw141","article-title":"DUX4 recruits p300\/CBP through its C-terminus and induces global H3K27 acetylation changes","volume":"44","author":"Choi","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.113114_bib25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ng.3535","article-title":"Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults","volume":"48","author":"Yasuda","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.113114_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/biolre\/ioaa179","article-title":"Dux facilitates post-implantation development, but is not essential for zygotic genome activationdagger","volume":"104","author":"Bosnakovski","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2023.113114_bib28","first-page":"4419","article-title":"Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells","volume":"25","author":"Jagannathan","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-generation characterization of the Cancer Cell Line Encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113114_bib30","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2023.113114_bib31","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1038\/sj.onc.1207396","article-title":"Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes","volume":"23","author":"Willis","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2023.113114_bib32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1126\/science.aax3649","article-title":"A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies","volume":"365","author":"Boettcher","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.113114_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31023","article-title":"NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins","volume":"7","author":"Campbell","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2023.113114_bib34","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ajpath.2012.07.007","article-title":"Generation of isogenic D4Z4 contracted and noncontracted immortal muscle cell clones from a mosaic patient: a cellular model for FSHD","volume":"181","author":"Krom","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2023.113114_bib35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/hmg\/ddu486","article-title":"Inter-individual differences in CpG methylation at D4Z4 correlate with clinical variability in FSHD1 and FSHD2","volume":"24","author":"Lemmers","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib36","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-021-00893-0","article-title":"p53 convergently activates Dux\/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models","volume":"53","author":"Grow","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ng1262","article-title":"Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy","volume":"35","author":"van Overveld","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003947","article-title":"DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis","volume":"9","author":"Young","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib39","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41588-019-0418-7","article-title":"Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development","volume":"51","author":"Chen","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib40","doi-asserted-by":"crossref","DOI":"10.1242\/dev.177725","article-title":"DUX Is a Non-essential Synchronizer of Zygotic Genome Activation","volume":"147","author":"De Iaco","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.113114_bib41","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.stemcr.2022.06.002","article-title":"Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2","volume":"17","author":"Yoshihara","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.celrep.2023.113114_bib42","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1101\/gad.321174.118","article-title":"Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program","volume":"33","author":"Eckersley-Maslin","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2023.113114_bib43","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1093\/nar\/gkz005","article-title":"SMCHD1 is involved in de novo methylation of the DUX4-encoding D4Z4 macrosatellite","volume":"47","author":"Dion","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.113114_bib44","doi-asserted-by":"crossref","first-page":"C655","DOI":"10.1152\/ajpcell.00116.2019","article-title":"SMCHD1 terminates the first embryonic genome activation event in mouse two-cell embryos and contributes to a transcriptionally repressive state","volume":"317","author":"Ruebel","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2023.113114_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb9149","article-title":"The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins","volume":"7","author":"Huang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2023.113114_bib46","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1093\/hmg\/ddy162","article-title":"Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscle","volume":"27","author":"Campbell","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113114_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41582-022-00762-2","article-title":"Facioscapulohumeral muscular dystrophy: the road to targeted therapies","volume":"19","author":"Tihaya","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2023.113114_bib48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/jpet.119.259663","article-title":"Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy","volume":"370","author":"Oliva","year":"2019","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2023.113114_bib49","doi-asserted-by":"crossref","first-page":"11837","DOI":"10.1074\/jbc.RA118.002633","article-title":"Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy","volume":"293","author":"Cruz","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.113114_bib50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/270515a0","article-title":"Isolation of a human teratoma cell line which expresses F9 antigen","volume":"270","author":"Hogan","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113114_bib51","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a Cancer Dependency Map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib52","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.ymthe.2018.04.019","article-title":"Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy","volume":"26","author":"Himeda","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2023.113114_bib53","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113114_bib56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis","volume":"162","author":"Levine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib57","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113114_bib58","series-title":"SeuratDisk: Interfaces for HDF5-Based Single Cell File Formats","author":"P","year":"2022"},{"key":"10.1016\/j.celrep.2023.113114_bib59","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2023.113114_bib60","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.113114_bib61","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.celrep.2023.113114_bib62","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkac947","article-title":"CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data","volume":"51","author":"Hu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2023.113114_bib63","series-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2023.113114_bib64","series-title":"Resample: Resampling Functions","author":"Hesterberg","year":"2022"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723011257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723011257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:39:53Z","timestamp":1769038793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723011257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2211124723011257"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113114","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DUX4 expression in cancer induces a metastable early embryonic totipotent program","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"113114"}}