{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:50:34Z","timestamp":1792025434686,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08703"],"award-info":[{"award-number":["19K08703"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPMJCR2123"],"award-info":[{"award-number":["JPMJCR2123"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005683","name":"Kyoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21zf0127001"],"award-info":[{"award-number":["JP21zf0127001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22bm0104001"],"award-info":[{"award-number":["JP22bm0104001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22bm0804013"],"award-info":[{"award-number":["JP22bm0804013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm0704072"],"award-info":[{"award-number":["JP23bm0704072"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1123002"],"award-info":[{"award-number":["JP23bm1123002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015146","name":"Canadian Internet Registration Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.celrep.2023.113431","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T10:29:26Z","timestamp":1701340166000},"page":"113431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD"],"prefix":"10.1016","volume":"42","author":[{"given":"Shin-Ichi","family":"Mae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Hattanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Teranaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Kudoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Matsuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ryosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Soga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-2763","authenticated-orcid":false,"given":"Kenji","family":"Osafune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.113431_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2023.113431_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","article-title":"Polycystic kidney disease","volume":"4","author":"Bergmann","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2023.113431_bib3","first-page":"F169","article-title":"Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease","volume":"271","author":"Devuyst","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.celrep.2023.113431_bib4","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1038\/ncomms9715","article-title":"Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids","volume":"6","author":"Freedman","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib5","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nmat4994","article-title":"Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease","volume":"16","author":"Cruz","year":"2017","journal-title":"Nat. Mater."},{"key":"10.1016\/j.celrep.2023.113431_bib6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.stem.2018.04.022","article-title":"High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping","volume":"22","author":"Czerniecki","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.stem.2022.06.005","article-title":"A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery","volume":"29","author":"Tran","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib8","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbrc.2020.06.141","article-title":"A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs","volume":"529","author":"Shimizu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib9","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1681\/ASN.2020030378","article-title":"PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud\/Collecting Duct Organoids","volume":"31","author":"Kuraoka","year":"2020","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107963","article-title":"Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential","volume":"32","author":"Mae","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.113431_bib11","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1038\/s41467-021-23911-5","article-title":"Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors","volume":"12","author":"Zeng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41587-022-01429-5","article-title":"Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types","volume":"41","author":"Shi","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2023.113431_bib13","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ydbio.2005.04.008","article-title":"The role of GDNF in patterning the excretory system","volume":"283","author":"Shakya","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.113431_bib15","first-page":"1722","article-title":"Multi-institutional Study of All-Trans-Retinoic Acid as a Differentiation Therapy of Refractory Acute Promyelocytic Leukemia","volume":"7","author":"Ohno","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2023.113431_bib16","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1038\/srep03594","article-title":"A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells","volume":"4","author":"Nakagawa","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.113431_bib17","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.128.7.1045","article-title":"TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis","volume":"128","author":"Plisov","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.113431_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ydbio.2003.10.023","article-title":"TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud","volume":"266","author":"Bush","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.113431_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/gtc.12163","article-title":"Identification and characterization of retinoic acid-responsive genes in mouse kidney development","volume":"19","author":"Takayama","year":"2014","journal-title":"Gene Cell."},{"key":"10.1016\/j.celrep.2023.113431_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068508","article-title":"Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development","volume":"8","author":"Toyoda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.113431_bib21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ydbio.2006.07.026","article-title":"c-kit delineates a distinct domain of progenitors in the developing kidney","volume":"299","author":"Schmidt-Ott","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.113431_bib22","first-page":"3177","article-title":"Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development","volume":"144","author":"Rutledge","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.celrep.2023.113431_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ydbio.2020.11.002","article-title":"Molecular detection of maturation stages in the developing kidney","volume":"470","author":"Naganuma","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2023.113431_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72449","article-title":"The right time for senescence","volume":"10","author":"Paramos-de-Carvalho","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2023.113431_bib25","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib26","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1038\/s41467-019-10861-2","article-title":"A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys","volume":"10","author":"Lake","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib27","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.stem.2022.10.008","article-title":"Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib28","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41467-021-21301-5","article-title":"Renal metabolism and hypertension","volume":"12","author":"Tian","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng1097-179","article-title":"Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation","volume":"17","author":"Lu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2023.113431_bib30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","article-title":"An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells","volume":"31","author":"Okita","year":"2013","journal-title":"Stem Cell."},{"key":"10.1016\/j.celrep.2023.113431_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41598-017-18568-4","article-title":"Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells","volume":"8","author":"Ishida","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.113431_bib32","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1091\/mbc.e03-05-0296","article-title":"A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells","volume":"15","author":"Roitbak","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40169-019-0254-5","article-title":"Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)","volume":"9","author":"Rahimmanesh","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.celrep.2023.113431_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/hmg\/ddi421","article-title":"Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors","volume":"15","author":"Allen","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113431_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.046","article-title":"Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles","volume":"51","author":"Malas","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2023.113431_bib36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJM198807073190105","article-title":"HMG-CoA reductase inhibitors for treatment of hypercholesterolemia","volume":"319","author":"Grundy","year":"1988","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2023.113431_bib37","doi-asserted-by":"crossref","first-page":"F854","DOI":"10.1152\/ajprenal.00059.2007","article-title":"Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model","volume":"293","author":"Zafar","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2023.113431_bib38","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2215\/CJN.08350813","article-title":"Effect of pravastatin on total kidney volume, left ventricular mass index, and microalbuminuria in pediatric autosomal dominant polycystic kidney disease","volume":"9","author":"Cadnapaphornchai","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib39","doi-asserted-by":"crossref","first-page":"F1135","DOI":"10.1152\/ajprenal.00366.2020","article-title":"Overexpression of TGF-beta1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease","volume":"319","author":"Zhang","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2023.113431_bib40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2023.113431_bib41","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.V1171179","article-title":"cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells","volume":"11","author":"Hanaoka","year":"2000","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000013552","article-title":"Elevation of serum levels of metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and type IV collagen, and plasma levels of metalloproteinase-9 in polycystic kidney disease","volume":"20","author":"Nakamura","year":"2000","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/srep30013","article-title":"Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models","volume":"6","author":"Ameku","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.113431_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2369-8-12","article-title":"p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels","volume":"8","author":"Park","year":"2007","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib45","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/hmg\/ddn039","article-title":"Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1","volume":"17","author":"Shibazaki","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2023.113431_bib46","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/sj.emboj.7600160","article-title":"A transcriptional network in polycystic kidney disease","volume":"23","author":"Gresh","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2023.113431_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203623","article-title":"Branching morphogenesis of the urinary collecting system in the human embryonic metanephros","volume":"13","author":"Ishiyama","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.113431_bib48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13073-022-01023-z","article-title":"DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets","volume":"14","author":"Wilson","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2023.113431_bib49","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1038\/s41598-021-84609-8","article-title":"Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease","volume":"11","author":"Baliga","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.113431_bib50","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2215\/CJN.00550110","article-title":"Evidence of extraordinary growth in the progressive enlargement of renal cysts","volume":"5","author":"Grantham","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib51","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1038\/s41467-019-13398-6","article-title":"Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease","volume":"10","author":"Tsukiyama","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113431_bib52","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2215\/CJN.13291019","article-title":"Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential","volume":"15","author":"Nowak","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2023.113431_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1242916","article-title":"Synergistic Antiproliferative Effects of All-Trans Retinoic Acid and Paclitaxel on Autosomal Dominant Polycystic Kidney Disease Epithelial Cells","volume":"2021","author":"Nguyen","year":"2021","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.celrep.2023.113431_bib54","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1111\/febs.16162","article-title":"Current status and future directions of clinical applications using iPS cells-focus on Japan","volume":"289","author":"Tsujimoto","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2023.113431_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/7651_2015_251","article-title":"Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons","volume":"1357","author":"Kim","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.celrep.2023.113431_bib59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.celrep.2023.113431_bib58","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11306-009-0178-y","article-title":"Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles","volume":"6","author":"Sugimoto","year":"2010","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2023.113431_bib61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with Census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods."},{"key":"10.1016\/j.celrep.2023.113431_bib62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113431_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101484","article-title":"Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids","volume":"3","author":"Ryosaka","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2023.113431_bib56","doi-asserted-by":"crossref","first-page":"16768","DOI":"10.1074\/jbc.M601876200","article-title":"Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption","volume":"281","author":"Soga","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2023.113431_bib57","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1021\/ac900675k","article-title":"Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry","volume":"81","author":"Soga","year":"2009","journal-title":"Anal. Chem."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723014432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723014432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:29:17Z","timestamp":1790454557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723014432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2211124723014432"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113431","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"113431"}}