{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:01:07Z","timestamp":1790456467514,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007923","name":"University of Wisconsin Carbone Cancer Center","doi-asserted-by":"publisher","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}],"id":[{"id":"10.13039\/100007923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01CA250972"],"award-info":[{"award-number":["P01CA250972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP5DO024576"],"award-info":[{"award-number":["1DP5DO024576"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA233102"],"award-info":[{"award-number":["U01CA233102"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR002375"],"award-info":[{"award-number":["TL1TR002375"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA278595"],"award-info":[{"award-number":["P50 CA278595"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30CA250263"],"award-info":[{"award-number":["F30CA250263"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM140935"],"award-info":[{"award-number":["T32GM140935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 DE026787"],"award-info":[{"award-number":["P50 DE026787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.celrep.2023.113556","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T13:05:25Z","timestamp":1702472725000},"page":"113556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["NK cells propagate T\u00a0cell immunity following in situ tumor vaccination"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-9735","authenticated-orcid":false,"given":"Won Jong","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Jagodinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Zuleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Erbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Tetreault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Rakhmilevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyungMann","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Sondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.113556_bib1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20112738","article-title":"Cancer immunoediting by the innate immune system in the absence of adaptive immunity","volume":"209","author":"O'Sullivan","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature10755","article-title":"Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting","volume":"482","author":"Matsushita","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.113556_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","article-title":"Approaches to treat immune hot, altered and cold tumours with combination immunotherapies","volume":"18","author":"Galon","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2023.113556_bib4","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S1470-2045(18)30700-9","article-title":"Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial","volume":"19","author":"Hodi","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S1470-2045(14)70189-5","article-title":"Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial","volume":"15","author":"Kwon","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrc820","article-title":"Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses","volume":"2","author":"Yee","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2023.113556_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib8","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1158\/1078-0432.CCR-13-2116","article-title":"Intratumoral immunization: a new paradigm for cancer therapy","volume":"20","author":"Marabelle","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2023.113556_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15618","article-title":"DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity","volume":"8","author":"Vanpouille-Box","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2023.113556_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1200\/JCO.20.00290","article-title":"Randomized Phase II Trial of Nivolumab With Stereotactic Body Radiotherapy Versus Nivolumab Alone in Metastatic Head and Neck Squamous Cell Carcinoma","volume":"39","author":"McBride","year":"2021","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib11","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1001\/jamaoncol.2019.1478","article-title":"Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial","volume":"5","author":"Theelen","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib12","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.4049\/jimmunol.167.10.5565","article-title":"Role of CD28-B7 interactions in generation and maintenance of CD8 T\u00a0cell memory","volume":"167","author":"Suresh","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/imm.12896","article-title":"Adaptive immune education by gut microbiota antigens","volume":"154","author":"Zhao","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2023.113556_bib14","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1182\/blood-2010-05-283770","article-title":"CTLs respond with activation and granule secretion when serving as targets for T-cell recognition","volume":"117","author":"Milstein","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.113556_bib15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2023.113556_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","article-title":"Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy","volume":"38","author":"Liao","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.113556_bib18","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1158\/0008-5472.CAN-15-2644","article-title":"In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments","volume":"76","author":"Morris","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.113556_bib19","first-page":"5234","article-title":"Augmentation of antibody dependent cell mediated cytotoxicity following in\u00a0vivo therapy with recombinant interleukin 2","volume":"50","author":"Hank","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2023.113556_bib20","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1073\/pnas.89.4.1428","article-title":"Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells","volume":"89","author":"Gillies","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113556_bib21","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1200\/JCO.21.00675","article-title":"Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma","volume":"39","author":"Diab","year":"2021","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.591139","article-title":"Tumor-Specific Antibody, Cetuximab, Enhances the In Situ Vaccine Effect of Radiation in Immunologically Cold Head and Neck Squamous Cell Carcinoma","volume":"11","author":"Jin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1084\/jem.20041463","article-title":"Interferon-gamma acts directly on CD8+ T\u00a0cells to increase their abundance during virus infection","volume":"201","author":"Whitmire","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib24","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.1103474","article-title":"NK cells regulate CD8+ T\u00a0cell priming and dendritic cell migration during influenza A infection by IFN-\u03b3 and perforin-dependent mechanisms","volume":"189","author":"Ge","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib25","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.4049\/jimmunol.179.4.2115","article-title":"Role of direct effects of IFN-gamma on T\u00a0cells in the regulation of CD8 T\u00a0cell homeostasis","volume":"179","author":"Tewari","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib26","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1158\/2326-6066.CIR-18-0940","article-title":"Systemic Interferon-\u03b3 Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial","volume":"7","author":"Zhang","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2023.113556_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/19420862.2017.1323159","article-title":"Affinity of human IgG subclasses to mouse Fc gamma receptors","volume":"9","author":"Dekkers","year":"2017","journal-title":"mAbs"},{"key":"10.1016\/j.celrep.2023.113556_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/leu.2017.293","article-title":"A new mouse expressing human Fc\u03b3 receptors to better predict therapeutic efficacy of human anti-cancer antibodies","volume":"32","author":"Casey","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2023.113556_bib29","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3389\/fimmu.2020.01393","article-title":"Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation","volume":"11","author":"Junker","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.celrep.2017.10.024","article-title":"A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present","volume":"21","author":"Sheng","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2023.113556_bib31","first-page":"1","article-title":"Dendritic cell subsets and locations","volume":"348","author":"Balan","year":"2019","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2023.113556_bib32","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41590-019-0420-3","article-title":"Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage","volume":"20","author":"Dress","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/ard.61.6.522","article-title":"Neutrophil CD64 expression: distinguishing acute inflammatory autoimmune disease from systemic infections","volume":"61","author":"Allen","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2023.113556_bib34","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","author":"Van Gassen","year":"2015","journal-title":"Cytometry A."},{"key":"10.1016\/j.celrep.2023.113556_bib35","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T\u00a0cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2023.113556_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T\u00a0cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib37","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41422-020-0343-4","article-title":"Immune checkpoint signaling and cancer immunotherapy","volume":"30","author":"He","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2023.113556_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.0105-2896.2010.00899.x","article-title":"Plasticity in programming of effector and memory CD8 T-cell formation","volume":"235","author":"Arens","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2023.113556_bib39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.192.2.295","article-title":"Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation","volume":"192","author":"Read","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12943-019-0956-8","article-title":"Natural killer group 2D receptor and its ligands in cancer immune escape","volume":"18","author":"Duan","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2023.113556_bib41","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1182\/blood-2010-06-291898","article-title":"Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells","volume":"117","author":"Kanada","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.113556_bib42","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.4049\/jimmunol.163.12.6386","article-title":"T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC","volume":"163","author":"Li","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib43","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1084\/jem.183.6.2533","article-title":"CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T\u00a0cells","volume":"183","author":"Krummel","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib44","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.4049\/jimmunol.156.8.2700","article-title":"Interactions of CD80 and CD86 with CD28 and CTLA4","volume":"156","author":"Ellis","year":"1996","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib45","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/s41591-018-0232-2","article-title":"Radiotherapy induces responses of lung cancer to CTLA-4 blockade","volume":"24","author":"Formenti","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib46","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1200\/JCO.1999.17.7.2105","article-title":"High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993","volume":"17","author":"Atkins","year":"1999","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2023.113556_bib47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0162-3109(97)00041-6","article-title":"Vascular leak syndrome: a side effect of immunotherapy","volume":"37","author":"Baluna","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.celrep.2023.113556_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nri3823","article-title":"The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases","volume":"15","author":"Klatzmann","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib49","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2217\/imt.11.100","article-title":"Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions","volume":"3","author":"Nolz","year":"2011","journal-title":"Immunotherapy"},{"key":"10.1016\/j.celrep.2023.113556_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg9433","article-title":"Virtual memory T\u00a0cells orchestrate extralymphoid responses conducive to resident memory","volume":"6","author":"Hou","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/imm.12074","article-title":"T-cell memory differentiation: insights from transcriptional signatures and epigenetics","volume":"139","author":"Youngblood","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2023.113556_bib52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103730118","article-title":"Critical role of the CD44(low)CD62L(low) CD8(+) T\u00a0cell subset in restoring antitumor immunity in aged mice","volume":"118","author":"Nakajima","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113556_bib53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.imlet.2017.02.012","article-title":"Understanding memory CD8(+) T\u00a0cells","volume":"185","author":"Samji","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.celrep.2023.113556_bib54","first-page":"84","article-title":"Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma","volume":"9","author":"Propper","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2023.113556_bib55","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fimmu.2016.00235","article-title":"Natural Regulators\": NK Cells as Modulators of T Cell Immunity","volume":"7","author":"Schuster","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib56","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S1074-7613(03)00264-4","article-title":"Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T\u00a0cell responses","volume":"19","author":"Mocikat","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.113556_bib57","doi-asserted-by":"crossref","first-page":"18360","DOI":"10.1073\/pnas.1110584108","article-title":"Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T\u00a0cells","volume":"108","author":"Nakayama","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.113556_bib58","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20082387","article-title":"Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T\u00a0cell regulation during viral infection","volume":"206","author":"Lee","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib59","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1182\/blood-2009-01-201467","article-title":"NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses","volume":"113","author":"Krebs","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2023.113556_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031959","article-title":"Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T\u00a0cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94\/NKG2A","volume":"7","author":"Nielsen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.113556_bib61","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20020190","article-title":"Interleukin 2 signaling is required for CD4(+) regulatory T\u00a0cell function","volume":"196","author":"Furtado","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib62","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T\u00a0cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib63","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/emm.2006.56","article-title":"Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation","volume":"38","author":"Kim","year":"2006","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2023.113556_bib64","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.4049\/jimmunol.1200934","article-title":"Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention","volume":"189","author":"Yang","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.113556_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1115641","article-title":"First oncolytic virus approved for melanoma immunotherapy","volume":"5","author":"Pol","year":"2016","journal-title":"OncoImmunology"},{"key":"10.1016\/j.celrep.2023.113556_bib66","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00262-012-1372-8","article-title":"Enhancement of the anti-melanoma response of Hu14.18K322A by alphaCD40\u00a0+ CpG","volume":"62","author":"Alderson","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.celrep.2023.113556_bib67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-0716-2926-0_18","article-title":"A Guide on Analyzing Flow Cytometry Data Using Clustering Methods and Nonlinear Dimensionality Reduction (tSNE or UMAP)","volume":"2616","author":"Ujas","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2023.113556_bib68","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s43587-021-00148-x","article-title":"Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice","volume":"2","author":"Krishnarajah","year":"2022","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2023.113556_bib69","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2023.113556_bib70","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2105-15-182","article-title":"Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads","volume":"15","author":"Jiang","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2023.113556_bib71","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2023.113556_bib72","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2023.113556_bib73","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2023.113556_bib74","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.celrep.2023.113556_bib75","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723015681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723015681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:42:06Z","timestamp":1790455326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723015681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":75,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2211124723015681"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113556","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NK cells propagate T\u00a0cell immunity following in situ tumor vaccination","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.113556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"113556"}}