{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:02:40Z","timestamp":1774623760010,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0107700"],"award-info":[{"award-number":["2023YFE0107700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.celrep.2024.113677","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T22:06:23Z","timestamp":1705529183000},"page":"113677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-1203","authenticated-orcid":false,"given":"Shanming","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules A.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.113677_bib1","article-title":"A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses","volume":"118","author":"Chen","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.113677_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/311223a0","article-title":"Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA","volume":"311","author":"Anderson","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.113677_bib3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(85)90275-2","article-title":"Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product","volume":"42","author":"Anderson","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ni747","article-title":"Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections","volume":"3","author":"Tauszig-Delamasure","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.113677_bib6","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.4049\/jimmunol.168.4.1542","article-title":"Cutting edge: the toll pathway is required for resistance to gram-positive bacterial infections in Drosophila","volume":"168","author":"Rutschmann","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.113677_bib7","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1242\/dev.02482","article-title":"Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila","volume":"133","author":"Cela","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2024.113677_bib8","doi-asserted-by":"crossref","first-page":"12654","DOI":"10.1073\/pnas.231471798","article-title":"Drosophila MyD88 is an adaptor in the Toll signaling pathway","volume":"98","author":"Horng","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.113677_bib9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1534\/genetics.117.300167","article-title":"Development and Function of the Drosophila Tracheal System","volume":"209","author":"Hayashi","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2024.113677_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2022.876673","article-title":"Airway remodeling: The Drosophila model permits a purely epithelial perspective","volume":"3","author":"Ehrhardt","year":"2022","journal-title":"Front. Allergy"},{"key":"10.1016\/j.celrep.2024.113677_bib11","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/j.1460-2075.1994.tb06426.x","article-title":"The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway","volume":"13","author":"Biggs","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.113677_bib12","doi-asserted-by":"crossref","first-page":"108956","DOI":"10.1016\/j.celrep.2021.108956","article-title":"Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways","volume":"35","author":"Wagner","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.113677_bib13","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.devcel.2021.04.012","article-title":"Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity","volume":"56","author":"Tamada","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib14","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.devcel.2021.03.030","article-title":"Formation of polarized contractile interfaces by self-organized Toll-8\/Cirl GPCR asymmetry","volume":"56","author":"Lavalou","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature13953","article-title":"A positional Toll receptor code directs convergent extension in Drosophila","volume":"515","author":"Par\u00e9","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.113677_bib16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.neuron.2015.02.003","article-title":"Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit","volume":"85","author":"Ward","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.113677_bib17","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nn.3474","article-title":"Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS","volume":"16","author":"McIlroy","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.113677_bib18","article-title":"A Toll-receptor map underlies structural brain plasticity","volume":"9","author":"Li","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.113677_bib19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.immuni.2012.03.003","article-title":"Virus recognition by Toll-7 activates antiviral autophagy in Drosophila","volume":"36","author":"Nakamoto","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.113677_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110817","article-title":"Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila","volume":"39","author":"Shields","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.113677_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258236","article-title":"An ancient defense system eliminates unfit cells from developing tissues during cell competition","volume":"346","author":"Meyer","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.113677_bib22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.devcel.2018.08.001","article-title":"Spatially Restricted Regulation of Spatzle\/Toll Signaling during Cell Competition","volume":"46","author":"Alpar","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tig.2021.09.006","article-title":"The Toll gene in Drosophila pattern formation","volume":"38","author":"N\u00fcsslein-Volhard","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.celrep.2024.113677_bib24","first-page":"63","article-title":"Toll receptors in Drosophila: a family of molecules regulating development and immunity","volume":"270","author":"Imler","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.celrep.2024.113677_bib25","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1101\/gad.6.8.1518","article-title":"dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo","volume":"6","author":"Ip","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.113677_bib26","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1101\/gad.5.10.1881","article-title":"The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos","volume":"5","author":"Jiang","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.113677_bib27","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/jcb.22956","article-title":"Hypoxia-mediated biological control","volume":"112","author":"Cassavaugh","year":"2011","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.celrep.2024.113677_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-022-01080-1","article-title":"Hypoxia signaling in human health and diseases: implications and prospects for therapeutics","volume":"7","author":"Luo","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2024.113677_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(94)90200-3","article-title":"Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma","volume":"79","author":"O'Reilly","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.113677_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000142","article-title":"Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes","volume":"4","author":"Simcox","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2024.113677_bib31","article-title":"A Feedback Regulatory Loop Involving dTrbd\/dTak1 in Controlling IMD Signaling in Drosophila Melanogaster","volume":"13","author":"Hua","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.113677_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2022.11.005","article-title":"E3 ligase Cul2 mediates Drosophila early germ cell differentiation through targeting Bam","volume":"493","author":"Cai","year":"2023","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2024.113677_bib33","article-title":"Endoplasmic reticulum-associated protein degradation contributes to Toll innate immune defense in Drosophila melanogaster","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.113677_bib34","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.14336\/AD.2020.1008","article-title":"Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd","volume":"12","author":"Zhu","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.celrep.2024.113677_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111795","article-title":"A Toll-dependent Bre1\/Rad6-cact feedback loop in controlling host innate immune response","volume":"41","author":"Cai","year":"2022","journal-title":"Cell Rep."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724000056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724000056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T12:14:09Z","timestamp":1727871249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724000056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2211124724000056"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.113677","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.113677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"113677"}}