{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:59:00Z","timestamp":1792641540209,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP200254"],"award-info":[{"award-number":["RP200254"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["SCR_021756"],"award-info":[{"award-number":["SCR_021756"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011730","name":"Ataxia-Telangiectasia Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008163","name":"A-T Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS126747"],"award-info":[{"award-number":["R01NS126747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.celrep.2024.113896","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T07:37:08Z","timestamp":1709537828000},"page":"113896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase"],"prefix":"10.1016","volume":"43","author":[{"given":"Phillip R.","family":"Woolley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette A.","family":"Ender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-651X","authenticated-orcid":false,"given":"Tanya T.","family":"Paull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.113896_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13023-016-0543-7","article-title":"Ataxia telangiectasia: a review","volume":"11","author":"Rothblum-Oviatt","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.celrep.2024.113896_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib3","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41580-021-00394-2","article-title":"Cellular functions of the protein kinase ATM and their relevance to human disease","volume":"22","author":"Lee","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.113896_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.celrep.2024.113896_bib6","doi-asserted-by":"crossref","first-page":"eadi8291","DOI":"10.1126\/sciadv.adi8291","article-title":"Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress","volume":"9","author":"Howes","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.113896_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5598","article-title":"ATM directs DNA damage responses and proteostasis via genetically separable pathways","volume":"11","author":"Lee","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2024.113896_bib8","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajmg.1320420524","article-title":"Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity","volume":"42","author":"Chessa","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1086\/301755","article-title":"Genotype-phenotype relationships in ataxia-telangiectasia and variants","volume":"62","author":"Gilad","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<141::AID-AJMG4>3.0.CO;2-W","article-title":"Ataxia-telangiectasia without immunodeficiency: novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain","volume":"75","author":"Toyoshima","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib11","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.molcel.2021.01.019","article-title":"Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency","volume":"81","author":"Lee","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.113896_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-0-444-64189-2.00007-X","article-title":"Nonsyndromic cerebellar ataxias associated with disorders of DNA single-strand break repair","volume":"155","author":"Yoon","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.celrep.2024.113896_bib13","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1101\/gad.301325.117","article-title":"Genome integrity and disease prevention in the nervous system","volume":"31","author":"McKinnon","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.113896_bib14","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/j.jmb.2016.10.021","article-title":"Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration","volume":"429","author":"Groh","year":"2017","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41582-018-0051-6","article-title":"Spinocerebellar ataxias: prospects and challenges for therapy development","volume":"14","author":"Ashizawa","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2024.113896_bib16","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.1212\/NXG.0000000000000357","article-title":"A family with spinocerebellar ataxia and retinitis pigmentosa attributed to an ELOVL4 mutation","volume":"5","author":"Xiao","year":"2019","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng1758","article-title":"Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes","volume":"38","author":"Waters","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib18","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/archneur.60.12.1749","article-title":"Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma","volume":"60","author":"Yabe","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.celrep.2024.113896_bib19","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1371\/journal.pgen.0030108","article-title":"Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans","volume":"3","author":"van de Leemput","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000487","article-title":"CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait","volume":"5","author":"T\u00fcrkmen","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng1728","article-title":"Spectrin mutations cause spinocerebellar ataxia type 5","volume":"38","author":"Ikeda","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151429","article-title":"ATP1A3 Mutation in Adult Rapid-Onset Ataxia","volume":"11","author":"Sweadner","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.113896_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s004390050722","article-title":"Three novel KCNA1 mutations in episodic ataxia type I families","volume":"102","author":"Scheffer","year":"1998","journal-title":"Hum. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib24","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.1073\/pnas.1207488109","article-title":"Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis","volume":"109","author":"Zanni","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.113896_bib25","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/brain\/awu202","article-title":"TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment","volume":"137","author":"Delplanque","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.113896_bib26","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/brain\/awx251","article-title":"Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia","volume":"140","author":"Nibbeling","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.113896_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104656","article-title":"A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder","volume":"299","author":"Magrino","year":"2023","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.113896_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature20790","article-title":"XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia","volume":"541","author":"Hoch","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.113896_bib29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ng1927","article-title":"Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia","volume":"39","author":"Gros-Louis","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12311-014-0557-4","article-title":"Radiological Imaging in Ataxia Telangiectasia: a Review","volume":"13","author":"Sahama","year":"2014","journal-title":"Cerebellum"},{"key":"10.1016\/j.celrep.2024.113896_bib31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3233\/JAD-2010-091363","article-title":"An in\u00a0vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons","volume":"20","author":"Agholme","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.celrep.2024.113896_bib32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.113896_bib33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41586-021-03468-5","article-title":"Neuronal enhancers are hotspots for DNA single-strand break repair","volume":"593","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.113896_bib34","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1021\/acs.biochem.7b00670","article-title":"Generation and Characterization of Recombinant Antibody-like ADP-Ribose Binding Proteins","volume":"56","author":"Gibson","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2024.113896_bib35","doi-asserted-by":"crossref","first-page":"eaat1719","DOI":"10.1126\/sciadv.aat1719","article-title":"The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models","volume":"4","author":"Durant","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.113896_bib36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1158\/2159-8290.CD-17-0993","article-title":"MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification","volume":"8","author":"Zimmerman","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2024.113896_bib38","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/ng.3921","article-title":"Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries","volume":"49","author":"Boeva","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.113896_bib37","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1158\/0008-5472.CAN-15-2507","article-title":"Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas","volume":"76","author":"Henrich","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.113896_bib39","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1093\/nar\/gkw250","article-title":"Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality","volume":"44","author":"Pundhir","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.113896_bib40","doi-asserted-by":"crossref","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib41","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2017.10.008","article-title":"R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters","volume":"68","author":"Chen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.113896_bib42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.113896_bib43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1101\/gad.291518.116","article-title":"PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes","volume":"31","author":"Gupte","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.113896_bib44","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrm.2017.53","article-title":"The multifaceted roles of PARP1 in DNA repair and chromatin remodelling","volume":"18","author":"Ray Chaudhuri","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.745922","article-title":"The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response","volume":"9","author":"Sch\u00fctzenhofer","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abb9032","article-title":"Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons","volume":"372","author":"Reid","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.113896_bib47","doi-asserted-by":"crossref","first-page":"eabg6363","DOI":"10.1126\/sciadv.abg6363","article-title":"Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration","volume":"7","author":"Kwak","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.113896_bib48","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0092-8674(03)00433-1","article-title":"PARP goes transcription","volume":"113","author":"Kraus","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.113896_bib49","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.3390\/cancers14174162","article-title":"PARP1: Liaison of Chromatin Remodeling and Transcription","volume":"14","author":"Zong","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.celrep.2024.113896_bib50","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.molcel.2021.04.028","article-title":"Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease","volume":"81","author":"Prokhorova","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.113896_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103182","article-title":"Defining R-loop classes and their contributions to genome instability","volume":"106","author":"Castillo-Guzman","year":"2021","journal-title":"DNA Repair"},{"key":"10.1016\/j.celrep.2024.113896_bib52","article-title":"Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor","volume":"7","author":"Wang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.113896_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108166","article-title":"BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation","volume":"32","author":"Edwards","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.113896_bib54","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.molcel.2017.12.029","article-title":"The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations","volume":"69","author":"Chen","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.113896_bib55","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1038\/s41467-018-06586-3","article-title":"ROS-induced R loops trigger a transcription-coupled but BRCA1\/2-independent homologous recombination pathway through CSB","volume":"9","author":"Teng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.113896_bib56","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.21873\/anticanres.12831","article-title":"Inhibition of Human Neuroblastoma Cell Proliferation by N-acetyl-L-cysteine as a Result of Increased Sulfane Sulfur Level","volume":"38","author":"Jurkowska","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.celrep.2024.113896_bib57","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1096\/fj.11-199869","article-title":"Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity","volume":"26","author":"Zhang","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2024.113896_bib58","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3390\/ijms18102098","article-title":"Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents","volume":"18","author":"P\u00e9rez-Torres","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2024.113896_bib59","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1101\/gr.158436.113","article-title":"GC skew at the 5\u2032 and 3\u2032 ends of human genes links R-loop formation to epigenetic regulation and transcription termination","volume":"23","author":"Ginno","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2024.113896_bib60","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1440-1789.2011.01263.x","article-title":"Neuropathology in classical and variant ataxia-telangiectasia","volume":"32","author":"Verhagen","year":"2012","journal-title":"Neuropathology"},{"key":"10.1016\/j.celrep.2024.113896_bib61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2021.08.014","article-title":"Brain region specificity in reactive oxygen species production and maintenance of redox balance","volume":"174","author":"Vinokurov","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2024.113896_bib62","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/nar\/gkaa140","article-title":"Atm deficiency in the DNA polymerase \u03b2 null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation","volume":"48","author":"Kim","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.113896_bib63","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1093\/nar\/gkac104","article-title":"Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction","volume":"50","author":"Bourseguin","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.113896_bib64","article-title":"Single-nucleus transcriptomic analyses reveal microglial activation underlying cerebellar degeneration in Ataxia Telangiectasia","author":"Lai","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2024.113896_bib65","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1523\/JNEUROSCI.0774-19.2019","article-title":"Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences","volume":"39","author":"Song","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.113896_bib66","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nprot.2017.128","article-title":"Live-cell measurements of kinase activity in single cells using translocation reporters","volume":"13","author":"Kudo","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.113896_bib67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.redox.2013.12.020","article-title":"OpenComet: An automated tool for comet assay image analysis","volume":"2","author":"Gyori","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib68","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2016","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2024.113896_bib69","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.113896_bib70","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.113896_bib71","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1016\/j.jmb.2019.04.045","article-title":"refTSS: A Reference Data Set for Human and Mouse Transcription Start Sites","volume":"431","author":"Abugessaisa","year":"2019","journal-title":"J.\u00a0Mol. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724002249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724002249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:59:15Z","timestamp":1778842755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724002249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S2211124724002249"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.113896","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.12.06.570417","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.113896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"113896"}}