{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:41:11Z","timestamp":1791848471130,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304102"],"award-info":[{"award-number":["2022YFC2304102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["YD9100002040"],"award-info":[{"award-number":["YD9100002040"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.celrep.2024.114269","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:30:10Z","timestamp":1716478210000},"page":"114269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus"],"prefix":"10.1016","volume":"43","author":[{"given":"Tianxi","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinge","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Entao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114269_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010141","article-title":"The changing epidemiology of human monkeypox-A potential threat? A systematic review","volume":"16","author":"Bunge","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.celrep.2024.114269_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101710","article-title":"Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis","volume":"54","author":"DeWitt","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.celrep.2024.114269_bib3","series-title":"2022 Global Map\u00a0& Case Count","year":"2023"},{"key":"10.1016\/j.celrep.2024.114269_bib4","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1080\/22221751.2022.2095309","article-title":"Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters","volume":"11","author":"Xiang","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.celrep.2024.114269_bib5","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1099\/vir.0.81215-0","article-title":"A tale of two clades: monkeypox viruses","volume":"86","author":"Likos","year":"2005","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.add4153","article-title":"Multiple lineages of monkeypox virus detected in the United States, 2021-2022","volume":"378","author":"Gigante","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114269_bib7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/ije\/17.3.643","article-title":"The transmission potential of monkeypox virus in human populations","volume":"17","author":"Fine","year":"1988","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.celrep.2024.114269_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/DDDT.S3687","article-title":"ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile","volume":"4","author":"Nalca","year":"2010","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.celrep.2024.114269_bib9","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1016\/j.vaccine.2020.01.058","article-title":"A randomized phase II trial to compare safety and immunogenicity of the MVA-BN smallpox vaccine at various doses in adults with a history of AIDS","volume":"38","author":"Overton","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2024.114269_bib10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40265-022-01742-y","article-title":"Prevention and Treatment of Monkeypox","volume":"82","author":"Rizk","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.celrep.2024.114269_bib11","doi-asserted-by":"crossref","first-page":"7805","DOI":"10.1128\/JVI.03481-12","article-title":"Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques","volume":"87","author":"Hatch","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib12","series-title":"FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox","year":"2019"},{"key":"10.1016\/j.celrep.2024.114269_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/v14091960","article-title":"Vaccinia-Virus-Based Vaccines Are Expected to Elicit Highly Cross-Reactive Immunity to the 2022 Monkeypox Virus","volume":"14","author":"Ahmed","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2024.114269_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ttbdis.2022.102019","article-title":"The life cycle of Hyalomma scupense (Acari: Ixodidae) under laboratory conditions","volume":"13","author":"Yang","year":"2022","journal-title":"Ticks and tick-borne diseases"},{"key":"10.1016\/j.celrep.2024.114269_bib15","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMc2211944","article-title":"Breakthrough Infections after Postexposure Vaccination against Mpox","volume":"387","author":"Thy","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.114269_bib16","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.3201\/eid2811.221215","article-title":"Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak","volume":"28","author":"Turner","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114269_bib17","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1016\/S1473-3099(22)00574-6","article-title":"Prevention of monkeypox with vaccines: a rapid review","volume":"22","author":"Poland","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114269_bib18","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1016\/S1470-2045(22)00372-2","article-title":"Clinical advances and ongoing trials on mRNA vaccines for cancer treatment","volume":"23","author":"Lorentzen","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2024.114269_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s12274-022-4627-5","article-title":"mRNA-based modalities for infectious disease management","volume":"16","author":"Zhang","year":"2023","journal-title":"Nano Res."},{"key":"10.1016\/j.celrep.2024.114269_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9040390","article-title":"mRNA-Based Vaccines","volume":"9","author":"Kowalzik","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.celrep.2024.114269_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines - a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2024.114269_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/v15051120","article-title":"Development of a Multi-Epitope Universal mRNA Vaccine Candidate for Monkeypox, Smallpox, and Vaccinia Viruses: Design and In Silico Analyses","volume":"15","author":"Rcheulishvili","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2024.114269_bib23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41392-023-01432-5","article-title":"Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus","volume":"8","author":"Sang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2024.114269_bib24","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2204151","article-title":"Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge","volume":"12","author":"Zeng","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.celrep.2024.114269_bib25","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2192815","article-title":"Rational development of multicomponent mRNA vaccine candidates against mpox","volume":"12","author":"Zhang","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.celrep.2024.114269_bib26","first-page":"86","article-title":"Differences between extracellular and intracellular forms of poxvirus and their implications","volume":"16","author":"Boulter","year":"1973","journal-title":"Prog. Med. Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-065X.2010.00975.x","article-title":"Smallpox vaccines: targets of protective immunity","volume":"239","author":"Moss","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2024.114269_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003850","article-title":"BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-\/-) Mice from Monkeypoxvirus Lethal Challenge","volume":"9","author":"Franceschi","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.celrep.2024.114269_bib29","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.177.4.2552","article-title":"Subunit recombinant vaccine protects against monkeypox","volume":"177","author":"Heraud","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114269_bib30","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/JVI.78.9.4433-4443.2004","article-title":"Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox","volume":"78","author":"Hooper","year":"2004","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/viro.1999.0096","article-title":"DNA vaccination with vaccinia virus L1R and A33R genes protects mice against a lethal poxvirus challenge","volume":"266","author":"Hooper","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2024.114269_bib32","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.chom.2022.11.003","article-title":"Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T\u00a0cell responses in humans","volume":"30","author":"Grifoni","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114269_bib33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41422-023-00792-5","article-title":"Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens","volume":"33","author":"Fang","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114269_bib34","doi-asserted-by":"crossref","first-page":"eadg3540","DOI":"10.1126\/scitranslmed.adg3540","article-title":"An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge","volume":"15","author":"Freyn","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114269_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105668","article-title":"Mpox virus mRNA-lipid nanoparticle vaccine candidates evoke antibody responses and drive protection against the Vaccinia virus challenge in mice","volume":"216","author":"Xia","year":"2023","journal-title":"Antiviral Res."},{"key":"10.1016\/j.celrep.2024.114269_bib36","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1038\/s41467-023-41628-5","article-title":"mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge","volume":"14","author":"Hou","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114269_bib37","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s11427-023-2378-x","article-title":"Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity. Science China","volume":"66","author":"Zhang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.celrep.2024.114269_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29140","article-title":"Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice","volume":"95","author":"Yang","year":"2023","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib39","doi-asserted-by":"crossref","DOI":"10.4110\/in.2023.23.e33","article-title":"SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents","volume":"23","author":"Choi","year":"2023","journal-title":"Immune Netw."},{"key":"10.1016\/j.celrep.2024.114269_bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(21)01642-1","article-title":"Spike-antibody waning after second dose of BNT162b2 or ChAdOx1","volume":"398","author":"Shrotri","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2024.114269_bib41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1099\/vir.0.19565-0","article-title":"Poxvirus genomes: a phylogenetic analysis","volume":"85","author":"Gubser","year":"2004","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2024.114269_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41392-022-01215-4","article-title":"Monkeypox: epidemiology, pathogenesis, treatment and prevention","volume":"7","author":"Huang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2024.114269_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/v13112160","article-title":"2A and 2A-like Sequences: Distribution in Different Virus Species and Applications in Biotechnology","volume":"13","author":"de Lima","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2024.114269_bib44","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.ymthe.2024.02.011","article-title":"A potential bivalent mRNA vaccine candidate protects against both RSV and SARS-CoV-2 infections","volume":"32","author":"Wu","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2024.114269_bib45","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41392-023-01574-6","article-title":"Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2024.114269_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.antiviral.2018.11.002","article-title":"HBV antigen and DNA loss from mouse serum is associated with novel vaccine-induced HBV surface antigen-specific cell-mediated immunity and cytokine production","volume":"161","author":"Chuai","year":"2019","journal-title":"Antiviral Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724005977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724005977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:39:45Z","timestamp":1779453585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724005977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2211124724005977"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114269","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114269"}}