{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:05:40Z","timestamp":1792821940173,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.celrep.2024.114484","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:49:33Z","timestamp":1720604973000},"page":"114484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread"],"prefix":"10.1016","volume":"43","author":[{"given":"Deyang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans R.","family":"Widlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-2718","authenticated-orcid":false,"given":"Pere","family":"Puigserver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114484_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(23)00821-8","article-title":"Cutaneous melanoma","volume":"402","author":"Long","year":"2023","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.celrep.2024.114484_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102060","article-title":"Dedifferentiated melanomas: Morpho-phenotypic profile, genetic reprogramming and clinical implications","volume":"88","author":"Massi","year":"2020","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.celrep.2024.114484_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/labinvest.2017.9","article-title":"The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology","volume":"97","author":"Kawakami","year":"2017","journal-title":"Lab. Invest."},{"key":"10.1016\/j.celrep.2024.114484_bib4","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1101\/gad.324657.119","article-title":"MITF\u2014the first 25 years","volume":"33","author":"Goding","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.114484_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature03664","article-title":"Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma","volume":"436","author":"Garraway","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10630","article-title":"A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma","volume":"480","author":"Yokoyama","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature10539","article-title":"A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma","volume":"480","author":"Bertolotto","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib8","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1158\/0008-5472.CAN-07-2491","article-title":"In\u00a0vivo switching of human melanoma cells between proliferative and invasive states","volume":"68","author":"Hoek","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.114484_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2020.03.007","article-title":"Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance","volume":"37","author":"Marusyk","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib10","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1101\/gad.329771.119","article-title":"Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities","volume":"33","author":"Rambow","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.114484_bib11","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/jid.2011.218","article-title":"Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase","volume":"131","author":"Sensi","year":"2011","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2024.114484_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114484_bib14","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress","volume":"33","author":"Tsoi","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib16","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1101\/gad.314674.118","article-title":"Regulation of lipid peroxidation and ferroptosis in diverse species","volume":"32","author":"Conrad","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.114484_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114484_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cmet.2019.09.009","article-title":"Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation","volume":"30","author":"Zhu","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114484_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114484_bib20","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1016\/j.molcel.2023.08.032","article-title":"Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells","volume":"83","author":"He","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.tcb.2023.10.009","article-title":"Lysosomal cystine: an unexpected alarm bell for cysteine scarcity","volume":"33","author":"Hecht","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib22","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.bbrc.2018.07.078","article-title":"Ferroptosis is a lysosomal cell death process","volume":"503","author":"Gao","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.114484_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4203","article-title":"Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting","volume":"375","author":"Jouandin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114484_bib24","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.chembiol.2022.10.006","article-title":"Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein","volume":"29","author":"Armenta","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib25","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1016\/j.molcel.2023.08.004","article-title":"Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response","volume":"83","author":"Swanda","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ccr.2012.11.020","article-title":"PGC1\u03b1 expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress","volume":"23","author":"Vazquez","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ccr.2013.02.003","article-title":"Oncogenic BRAF regulates oxidative metabolism via PGC1\u03b1 and MITF","volume":"23","author":"Haq","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nature19347","article-title":"A PGC1\u03b1-mediated transcriptional axis suppresses melanoma metastasis","volume":"537","author":"Luo","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib29","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1038\/ncomms6712","article-title":"Low MITF\/AXL ratio predicts early resistance to multiple targeted drugs in melanoma","volume":"5","author":"M\u00fcller","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114484_bib30","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1038\/s41467-023-38968-7","article-title":"Epigenetic suppression of PGC1\u03b1 (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas","volume":"14","author":"Liang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114484_bib31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","article-title":"Quantitative Proteomics of the Cancer Cell Line Encyclopedia","volume":"180","author":"Nusinow","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib32","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114484_bib33","doi-asserted-by":"crossref","first-page":"E420","DOI":"10.1073\/pnas.1424576112","article-title":"MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells","volume":"112","author":"Ploper","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114484_bib34","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41598-018-37522-6","article-title":"MITF has a central role in regulating starvation-induced autophagy in melanoma","volume":"9","author":"M\u00f6ller","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114484_bib35","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting Ferroptosis to Iron Out Cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib36","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.aan6298","article-title":"Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes","volume":"358","author":"Abu-Remaileh","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114484_bib37","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2024.114484_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","author":"Dai","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41416-020-01156-1","article-title":"Cysteine metabolic circuitries: druggable targets in cancer","volume":"124","author":"Bonif\u00e1cio","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2024.114484_bib40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41586-022-04984-8","article-title":"PI3K drives the de novo synthesis of coenzyme A from vitamin B5","volume":"608","author":"Dibble","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib41","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/BST20170506","article-title":"Coenzyme A, protein CoAlation and redox regulation in mammalian cells","volume":"46","author":"Gout","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.celrep.2024.114484_bib42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2015.05.014","article-title":"Acetyl coenzyme A: a central metabolite and second messenger","volume":"21","author":"Pietrocola","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114484_bib43","doi-asserted-by":"crossref","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114484_bib44","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nchembio.1906","article-title":"Extracellular 4\u2019-phosphopantetheine is a source for intracellular coenzyme A synthesis","volume":"11","author":"Srinivasan","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.gde.2016.11.001","article-title":"H3K27 methylation: a promiscuous repressive chromatin mark","volume":"43","author":"Wiles","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2024.114484_bib46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nature24028","article-title":"Discovery of a selective catalytic p300\/CBP inhibitor that targets lineage-specific tumours","volume":"550","author":"Lasko","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib47","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1158\/2159-8290.CD-20-0751","article-title":"Targeting the p300\/CBP Axis in Lethal Prostate Cancer","volume":"11","author":"Welti","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2024.114484_bib48","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-020-2937-x","article-title":"MFSD12 mediates the import of cysteine into melanosomes and lysosomes","volume":"588","author":"Adelmann","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib49","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.celrep.2024.114484_bib50","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1073\/pnas.1821323116","article-title":"Cystine\/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance","volume":"116","author":"Lim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114484_bib51","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"Palmieri","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.114484_bib52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2024.114484_bib53","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1038\/jid.2014.272","article-title":"Primary melanoma tumors from CDKN2A mutation carriers do not belong to a distinct molecular subclass","volume":"134","author":"Staaf","year":"2014","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2024.114484_bib54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib55","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/jid.2014.65","article-title":"Melanocytes as instigators and victims of oxidative stress","volume":"134","author":"Denat","year":"2014","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2024.114484_bib56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/pcmr.12721","article-title":"Subcellular localization and stability of MITF are modulated by the bHLH-Zip domain","volume":"32","author":"Fock","year":"2019","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.celrep.2024.114484_bib57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature14587","article-title":"Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism","volume":"524","author":"Perera","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib58","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/s41467-020-16423-1","article-title":"Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death","volume":"11","author":"Balsa","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114484_bib59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature15726","article-title":"Oxidative stress inhibits distant metastasis by human melanoma cells","volume":"527","author":"Piskounova","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114484_bib61","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114484_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg3049","article-title":"Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer","volume":"15","author":"Li","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114484_bib63","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1158\/1078-0432.CCR-08-1144","article-title":"Imatinib targeting of KIT-mutant oncoprotein in melanoma","volume":"14","author":"Jiang","year":"2008","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.celrep.2024.114484_bib64","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201911036","article-title":"CDK4\/6 regulate lysosome biogenesis through TFEB\/TFE3","volume":"219","author":"Yin","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114484_bib65","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1038\/onc.2016.155","article-title":"FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma","volume":"35","author":"Li","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2024.114484_bib66","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114484_bib67","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114484_bib68","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724008131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724008131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:28:16Z","timestamp":1752578896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724008131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2211124724008131"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114484","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114484"}}