{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:45:04Z","timestamp":1790052304572,"version":"4.0.1"},"reference-count":96,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01 NS041280"],"award-info":[{"award-number":["R01 NS041280"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01 NS121174"],"award-info":[{"award-number":["R01 NS121174"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation Los Angeles","doi-asserted-by":"publisher","award":["A-5071"],"award-info":[{"award-number":["A-5071"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","award":["ASAP-020600"],"award-info":[{"award-number":["ASAP-020600"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.celrep.2024.114495","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T20:37:47Z","timestamp":1722026267000},"page":"114495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Movement-related increases in subthalamic activity optimize locomotion"],"prefix":"10.1016","volume":"43","author":[{"given":"Joshua W.","family":"Callahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy F.","family":"Atherton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena","family":"Kostic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-0163","authenticated-orcid":false,"given":"Mark D.","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114495_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-neuro-072116-031033","article-title":"What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation","volume":"42","author":"Klaus","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41583-021-00485-1","article-title":"Towards real-world generalizability of a circuit for action-stopping","volume":"22","author":"Hannah","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib4","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0959-4388(93)90167-W","article-title":"Basal ganglia intrinsic circuits and their role in behavior","volume":"3","author":"Mink","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114495_bib5","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1523\/JNEUROSCI.15-10-06531.1995","article-title":"In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time but induce a dramatic premature responding deficit","volume":"15","author":"Baunez","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nn.3456","article-title":"Canceling actions involves a race between basal ganglia pathways","volume":"16","author":"Schmidt","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27689","article-title":"Causal role for the subthalamic nucleus in interrupting behavior","volume":"6","author":"Fife","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114495_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31627","article-title":"A selective role for ventromedial subthalamic nucleus in inhibitory control","volume":"6","author":"Pasquereau","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114495_bib9","doi-asserted-by":"crossref","first-page":"17278","DOI":"10.1073\/pnas.2000523117","article-title":"Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114495_bib10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuron.2020.12.025","article-title":"Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation","volume":"109","author":"Mosher","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111139","article-title":"Dynamic control of visually guided locomotion through corticosubthalamic projections","volume":"40","author":"Adam","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114495_bib12","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1523\/JNEUROSCI.0487-08.2008","article-title":"Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement","volume":"28","author":"Isoda","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib13","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/s41467-022-29750-2","article-title":"Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia","volume":"13","author":"Hasegawa","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114495_bib14","article-title":"Subthalamic Activity for Motor Execution and Cancelation in Monkeys","volume":"44","author":"Polyakova","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib15","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/mds.22547","article-title":"Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys","volume":"24","author":"Karachi","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2024.114495_bib16","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1523\/JNEUROSCI.22-02-00592.2002","article-title":"Effects of transient focal inactivation of the basal ganglia in parkinsonian primates","volume":"22","author":"Baron","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147226","article-title":"Experimental investigation into the role of the subthalamic nucleus (STN) in motor control using optogenetics in mice","volume":"1755","author":"Guillaumin","year":"2021","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2024.114495_bib18","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1152\/jn.1992.68.5.1850","article-title":"Excitotoxic acid lesions of the primate subthalamic nucleus result in transient dyskinesias of the contralateral limbs","volume":"68","author":"Hamada","year":"1992","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2024.114495_bib19","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1038\/s41380-021-01162-6","article-title":"Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson\u2019s disease and OCD-like behaviors in mice","volume":"26","author":"Parolari","year":"2021","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.celrep.2024.114495_bib20","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1523\/JNEUROSCI.0734-23.2023","article-title":"Selective Activation of Subthalamic Nucleus Output Quantitatively Scales Movements","volume":"43","author":"Friedman","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13917","article-title":"Subthalamic neurons interact with nigral dopaminergic neurons to regulate movement in mice","volume":"237","author":"Fan","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.celrep.2024.114495_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75253","article-title":"Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice","volume":"11","author":"Schor","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114495_bib23","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/ejn.13738","article-title":"Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys","volume":"46","author":"Iwamuro","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib24","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1152\/jn.1994.72.2.494","article-title":"The primate subthalamic nucleus. I. Functional properties in intact animals","volume":"72","author":"Wichmann","year":"1994","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2024.114495_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16443","article-title":"Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys","volume":"5","author":"Deffains","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114495_bib26","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1523\/JNEUROSCI.03-08-01586.1983","article-title":"Relations between parameters of step-tracking movements and single cell discharge in the globus pallidus and subthalamic nucleus of the behaving monkey","volume":"3","author":"Georgopoulos","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0166-2236(90)90110-V","article-title":"Primate models of movement disorders of basal ganglia origin","volume":"13","author":"DeLong","year":"1990","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib28","doi-asserted-by":"crossref","first-page":"8964","DOI":"10.1523\/JNEUROSCI.1767-20.2020","article-title":"Entraining Stepping Movements of Parkinson\u2019s Patients to Alternating Subthalamic Nucleus Deep Brain Stimulation","volume":"40","author":"Fischer","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib29","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1093\/brain\/awad006","article-title":"Subthalamic and nigral neurons are differentially modulated during parkinsonian gait","volume":"146","author":"Gulberti","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.114495_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo1800","article-title":"Principles of gait encoding in the subthalamic nucleus of people with Parkinson\u2019s disease","volume":"14","author":"Thenaisie","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114495_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnana.2011.00026","article-title":"Somatotopic organization of the primate Basal Ganglia","volume":"5","author":"Nambu","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.celrep.2024.114495_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110439","article-title":"Topographic connectivity and cellular profiling reveal detailed input pathways and functionally distinct cell types in the subthalamic nucleus","volume":"38","author":"Jeon","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114495_bib33","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1002\/cne.23655","article-title":"Rat subthalamic nucleus and zona incerta share extensively overlapped representations of cortical functional territories","volume":"522","author":"Kita","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib34","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1152\/jn.1985.53.2.530","article-title":"Primate globus pallidus and subthalamic nucleus: functional organization","volume":"53","author":"DeLong","year":"1985","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2024.114495_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/cne.902360103","article-title":"Topographical projections of the cerebral cortex to the subthalamic nucleus","volume":"236","author":"Afsharpour","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib36","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1523\/JNEUROSCI.4674-12.2013","article-title":"The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for Basal Ganglia models and deep brain stimulation","volume":"33","author":"Haynes","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/mds.28862","article-title":"Functional Topography of the Human Subthalamic Nucleus: Relevance for Subthalamotomy in Parkinson\u2019s Disease","volume":"37","author":"Rodriguez-Rojas","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2024.114495_bib38","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1523\/JNEUROSCI.21-15-05764.2001","article-title":"Segregation and Convergence of Information Flow through the Cortico-Subthalamic Pathways","volume":"21","author":"Kolomiets","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib39","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.1523\/JNEUROSCI.18-22-09539.1998","article-title":"Relationships between the prefrontal cortex and the basal ganglia in the rat: physiology of the corticosubthalamic circuits","volume":"18","author":"Maurice","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0306-4522(92)90353-4","article-title":"Mapping of the motor pathways in rats: c-fos induction by intracortical microstimulation of the motor cortex correlated with efferent connectivity of the site of cortical stimulation","volume":"49","author":"Wan","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2024.114495_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-021-03970-w","article-title":"Cellular anatomy of the mouse primary motor cortex","volume":"598","author":"Mu\u00f1oz-Casta\u00f1eda","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuron.2016.12.013","article-title":"On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition","volume":"93","author":"Wessel","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1523\/JNEUROSCI.17-01-00308.1997","article-title":"Synaptic integration of functionally diverse pallidal information in the entopeduncular nucleus and subthalamic nucleus in the rat","volume":"17","author":"Bevan","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s42003-020-1028-8","article-title":"Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures","volume":"3","author":"Wall\u00e9n-Mackenzie","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2024.114495_bib45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0168-0102(96)01065-6","article-title":"Calcium-binding proteins in primate basal ganglia","volume":"25","author":"Parent","year":"1996","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.celrep.2024.114495_bib46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41586-022-04806-x","article-title":"Targeting thalamic circuits rescues motor and mood deficits in PD mice","volume":"607","author":"Zhang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib47","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11065-015-9308-7","article-title":"High Frequency Deep Brain Stimulation and Neural Rhythms in Parkinson\u2019s Disease","volume":"25","author":"Blumenfeld","year":"2015","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.celrep.2024.114495_bib48","first-page":"S131","article-title":"Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesia","volume":"47","author":"Vitek","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tins.2007.05.004","article-title":"Pathological synchronization in Parkinson\u2019s disease: networks, models and treatments","volume":"30","author":"Hammond","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib50","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1523\/JNEUROSCI.0782-21.2022","article-title":"Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington\u2019s Disease Mice","volume":"42","author":"Callahan","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib51","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.neuron.2016.10.064","article-title":"Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington\u2019s Disease Models","volume":"92","author":"Beaumont","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21616","article-title":"Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington\u2019s disease","volume":"5","author":"Atherton","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114495_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1010253","article-title":"Lead location as a determinant of motor benefit in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease","volume":"16","author":"Vitek","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib54","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/brain\/awq144","article-title":"Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson\u2019s disease","volume":"133","author":"Zaidel","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.114495_bib55","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1136\/jnnp-2020-323421","article-title":"Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort","volume":"91","author":"Chabardes","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2024.114495_bib56","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fneur.2018.00341","article-title":"Anatomical Correlates of Uncontrollable Laughter With Unilateral Subthalamic Deep Brain Stimulation in Parkinson\u2019s Disease","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib57","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/brain\/aww182","article-title":"Brain networks modulated by subthalamic nucleus deep brain stimulation","volume":"139","author":"Accolla","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.114495_bib58","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/mds.29168","article-title":"Early Changes in Striatal Activity and Motor Kinematics in a Huntington\u2019s Disease Mouse Model","volume":"37","author":"Koch","year":"2022","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2024.114495_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243052","article-title":"Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington\u2019s disease","volume":"15","author":"Heikkinen","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114495_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington\u2019s disease: zQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114495_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington\u2019s disease","volume":"7","author":"Heikkinen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114495_bib62","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0022-510X(76)90114-3","article-title":"Morphometric studies of the neuropathological changes in choreatic diseases","volume":"28","author":"Lange","year":"1976","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.celrep.2024.114495_bib63","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/s41596-019-0176-0","article-title":"Using DeepLabCut for 3D markerless pose estimation across species and behaviors","volume":"14","author":"Nath","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114495_bib64","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib65","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1523\/JNEUROSCI.0450-05.2005","article-title":"Globus Pallidus Neurons Dynamically Regulate the Activity Pattern of Subthalamic Nucleus Neurons through the Frequency-Dependent Activation of Postsynaptic GABA A and GABA B Receptors","volume":"25","author":"Hallworth","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib66","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1152\/jn.00582.2001","article-title":"Regulation of the Timing and Pattern of Action Potential Generation in Rat Subthalamic Neurons In Vitro by GABA-A IPSPs","volume":"87","author":"Bevan","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2024.114495_bib67","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/s41593-019-0502-4","article-title":"Single-trial neural dynamics are dominated by richly varied movements","volume":"22","author":"Musall","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib68","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1523\/JNEUROSCI.15-11-07105.1995","article-title":"Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat","volume":"15","author":"Bevan","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib69","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/cne.903610312","article-title":"The glutamate-enriched cortical and thalamic input to neurons in the subthalamic nucleus of the rat: convergence with GABA-positive terminals","volume":"361","author":"Bevan","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib70","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1152\/jn.00253.2020","article-title":"Contribution of the ventrolateral thalamus to the locomotion-related activity of motor cortex","volume":"124","author":"Beloozerova","year":"2020","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2024.114495_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe9192","article-title":"Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms","volume":"7","author":"Watson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114495_bib72","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1113\/JP279232","article-title":"Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation","volume":"598","author":"Kovaleski","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2024.114495_bib73","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuron.2015.03.007","article-title":"Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus","volume":"86","author":"Dodson","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib74","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cub.2020.11.019","article-title":"A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition","volume":"31","author":"Aristieta","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2024.114495_bib75","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.neuron.2020.11.006","article-title":"Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo","volume":"109","author":"Ketzef","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib76","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/j.cell.2022.06.031","article-title":"What is a cell type and how to define it?","volume":"185","author":"Zeng","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114495_bib77","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2016.06.032","article-title":"Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution","volume":"166","author":"Tecuapetla","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114495_bib78","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41586-018-0090-6","article-title":"Diametric neural ensemble dynamics in parkinsonian and dyskinetic states","volume":"557","author":"Parker","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib79","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11846","article-title":"Concurrent activation of striatal direct and indirect pathways during action initiation","volume":"494","author":"Cui","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib80","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cell.2018.04.019","article-title":"The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection","volume":"174","author":"Markowitz","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114495_bib81","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nature09159","article-title":"Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry","volume":"466","author":"Kravitz","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib82","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cell.2015.12.037","article-title":"Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia","volume":"164","author":"Roseberry","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114495_bib83","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/s41593-023-01431-3","article-title":"Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences","volume":"26","author":"Mizes","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib84","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1038\/s41593-023-01401-9","article-title":"Unique functional responses differentially map onto genetic subtypes of dopamine neurons","volume":"26","author":"Azcorra","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib85","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature18942","article-title":"Rapid signalling in distinct dopaminergic axons during locomotion and reward","volume":"535","author":"Howe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib86","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2020.01.028","article-title":"Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons","volume":"106","author":"Lahiri","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114495_bib87","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41586-022-05611-2","article-title":"Spontaneous behaviour is structured by reinforcement without explicit reward","volume":"614","author":"Markowitz","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib88","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature25457","article-title":"Dopamine neuron activity before action initiation gates and invigorates future movements","volume":"554","author":"da Silva","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114495_bib89","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41593-018-0245-7","article-title":"The timing of action determines reward prediction signals in identified midbrain dopamine neurons","volume":"21","author":"Coddington","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114495_bib90","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41582-020-0389-4","article-title":"Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities","volume":"16","author":"Tabrizi","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2024.114495_bib91","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gaitpost.2016.11.039","article-title":"Subthalamic nucleus stimulation and gait in Parkinson\u2019s Disease: a not always fruitful relationship","volume":"52","author":"Cossu","year":"2017","journal-title":"Gait Posture"},{"key":"10.1016\/j.celrep.2024.114495_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/fninf.2023.1185723","article-title":"Effect of subthalamic coordinated reset deep brain stimulation on Parkinsonian gait","volume":"17","author":"Bosley","year":"2023","journal-title":"Front. Neuroinf."},{"key":"10.1016\/j.celrep.2024.114495_bib94","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cell.2010.02.037","article-title":"Molecular and cellular approaches for diversifying and extending optogenetics","volume":"141","author":"Gradinaru","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114495_bib95","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114495_bib96","first-page":"328","article-title":"[\u2019\u2019R\"--project for statistical computing]","volume":"170","author":"Dessau","year":"2008","journal-title":"Ugeskr. Laeger"},{"key":"10.1016\/j.celrep.2024.114495_bib93","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/01621459.1987.10478478","article-title":"Sample size determination for some common nonparametric tests. Journal of the American Statistical Association","volume":"82","author":"Noether","year":"1987","journal-title":"J. Am. Stat. Assoc."}],"updated-by":[{"DOI":"10.1016\/j.celrep.2025.116894","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000}}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724008246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724008246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:50:48Z","timestamp":1775307048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724008246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":96,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2211124724008246"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114495","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.12.07.570617","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Movement-related increases in subthalamic activity optimize locomotion","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114495"}}