{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:09:55Z","timestamp":1792537795430,"version":"4.5.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["KL 3612\/1-1"],"award-info":[{"award-number":["KL 3612\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R37CA237421"],"award-info":[{"award-number":["R37CA237421"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI157384"],"award-info":[{"award-number":["R01AI157384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM145470"],"award-info":[{"award-number":["GM145470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071384"],"award-info":[{"award-number":["R01AR071384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01s"],"award-info":[{"award-number":["R01s"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","award":["AI007413"],"award-info":[{"award-number":["AI007413"]}],"id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002651","name":"Barth Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["23PRE1019408"],"award-info":[{"award-number":["23PRE1019408"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017065","name":"Rogel Cancer Center, University of Michigan","doi-asserted-by":"publisher","award":["P30CA046592"],"award-info":[{"award-number":["P30CA046592"]}],"id":[{"id":"10.13039\/100017065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005565","name":"Johnson & Johnson Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.celrep.2024.114607","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T06:10:47Z","timestamp":1723183847000},"page":"114607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection"],"prefix":"10.1016","volume":"43","author":[{"given":"Mack B.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McFadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah K.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton C","family":"Michmerhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R.","family":"O\u2019Meara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Z.","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas A.","family":"Lyssiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michelle","family":"Kahlenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary X.","family":"O\u2019Riordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114607_bib1","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.4049\/jimmunol.2100829","article-title":"Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and Opportunities","volume":"207","author":"Tandon","year":"2021","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrrheum.2017.37","article-title":"Metabolic regulation of inflammation","volume":"13","author":"Gaber","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2024.114607_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41422-020-0291-z","article-title":"Targeting immunometabolism as an anti-inflammatory strategy","volume":"30","author":"P\u00e5lsson-McDermott","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114607_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-020-00251-y","article-title":"Metabolic reprogramming in macrophage responses","volume":"9","author":"Liu","year":"2021","journal-title":"Biomark. Res."},{"key":"10.1016\/j.celrep.2024.114607_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The Metabolic Signature of Macrophage Responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","article-title":"Krebs Cycle Reborn in Macrophage Immunometabolism","volume":"38","author":"Ryan","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010005","article-title":"Metabolic Reprogramming in Mitochondria of Myeloid Cells","volume":"9","author":"Zuo","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2024.114607_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s41232-022-00198-7","article-title":"Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome","volume":"42","author":"Hachiya","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.celrep.2024.114607_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imr.12858","article-title":"Immunometabolism: From basic mechanisms to translation","volume":"295","author":"Makowski","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2024.114607_bib10","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.119.315939","article-title":"Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis","volume":"126","author":"Tabas","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2024.114607_bib11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fendo.2020.00062","article-title":"Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity","volume":"11","author":"Orliaguet","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.celrep.2024.114607_bib12","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/lifemedi\/lnac035","article-title":"The Yin-Yang functions of macrophages in metabolic disorders","volume":"1","author":"Bai","year":"2022","journal-title":"life. Med"},{"key":"10.1016\/j.celrep.2024.114607_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcb.2020.01.006","article-title":"Mitochondrial Functions in Infection and Immunity","volume":"30","author":"Tiku","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2024.114607_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109195","article-title":"Type I interferon decreases macrophage energy metabolism during mycobacterial infection","volume":"35","author":"Olson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib16","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s42255-022-00605-w","article-title":"TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages","volume":"4","author":"Schuster","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.114607_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41467-021-21718-y","article-title":"Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation","volume":"12","author":"Tomlinson","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114607_bib18","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.celrep.2018.02.027","article-title":"S.\u00a0aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking","volume":"22","author":"Cohen","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cmet.2022.03.009","article-title":"Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection","volume":"34","author":"Wong Fok Lung","year":"2022","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114607_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.chom.2018.10.005","article-title":"Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus","volume":"24","author":"Abuaita","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114607_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.copbio.2021.01.020","article-title":"Complexity of macrophage metabolism in infection","volume":"68","author":"He","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.celrep.2024.114607_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fimmu.2018.00270","article-title":"Metabolic Modulation in Macrophage Effector Function","volume":"9","author":"Diskin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fimmu.2015.00164","article-title":"Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway","volume":"6","author":"Nagy","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.114607_bib28","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.chom.2016.05.016","article-title":"The Roles of Type I Interferon in Bacterial Infection","volume":"19","author":"Boxx","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114607_bib29","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3389\/fimmu.2016.00652","article-title":"Type I Interferons in Bacterial Infections: A Balancing Act","volume":"7","author":"Kovarik","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib30","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/rheumatology\/ken196","article-title":"Long-term outcome and short-term survival of patients with systemic lupus erythematosus after bacteraemia episodes: 6-yr follow-up","volume":"47","author":"Chen","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2024.114607_bib31","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jid.2019.11.016","article-title":"Staphylococcus aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by IFN-Mediated Barrier Disruption","volume":"140","author":"Sirobhushanam","year":"2020","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2024.114607_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13075-016-1079-x","article-title":"Association between Staphylococcus aureus nasal carriage and disease phenotype in patients affected by systemic lupus erythematosus","volume":"18","author":"Conti","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.celrep.2024.114607_bib33","series-title":"Infection and Autoimmune Diseases","author":"Arango","year":"2013"},{"key":"10.1016\/j.celrep.2024.114607_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro732","article-title":"The damage-response framework of microbial pathogenesis","volume":"1","author":"Casadevall","year":"2003","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.925746","article-title":"Anti-Inflammatory Metabolites in the Pathogenesis of Bacterial Infection","volume":"12","author":"Urso","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112064","article-title":"Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst","volume":"42","author":"Tomlinson","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri3010","article-title":"Immunity against Staphylococcus aureus cutaneous infections","volume":"11","author":"Miller","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00281-011-0291-7","article-title":"Immunopathogenesis of Staphylococcus aureus pulmonary infection","volume":"34","author":"Parker","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.celrep.2024.114607_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg3517","article-title":"Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection","volume":"8","author":"Forde","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/v13091725","article-title":"Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons","volume":"13","author":"Oliva","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2024.114607_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc5569","article-title":"Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence","volume":"6","author":"Thurlow","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114607_bib42","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s10096-020-03984-8","article-title":"Virulence factors and clonal diversity of Staphylococcus aureus in colonization and wound infection with emphasis on diabetic foot infection","volume":"39","author":"Shettigar","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114607_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006669","article-title":"Pathogen manipulation of host metabolism: A common strategy for immune evasion","volume":"13","author":"Freyberg","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2024.114607_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tim.2011.04.003","article-title":"Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis","volume":"19","author":"Rohmer","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcimb.2013.00024","article-title":"Metabolic host responses to infection by intracellular bacterial pathogens","volume":"3","author":"Eisenreich","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib46","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.bbabio.2014.04.008","article-title":"Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V","volume":"1837","author":"Forkink","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2024.114607_bib47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jointm.2022.01.001","article-title":"Mitochondrial ACOD1\/IRG1 in infection and sterile inflammation","volume":"2","author":"Wu","year":"2022","journal-title":"J.\u00a0Intensive Med."},{"key":"10.1016\/j.celrep.2024.114607_bib48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","article-title":"Inducible nitric oxide synthase: Regulation, structure, and inhibition","volume":"40","author":"Cinelli","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.celrep.2024.114607_bib49","doi-asserted-by":"crossref","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","article-title":"Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels","volume":"291","author":"Cordes","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114607_bib50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in\u00a0vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114607_bib51","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41467-020-14433-7","article-title":"Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase","volume":"11","author":"Palmieri","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114607_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade8701","article-title":"Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation","volume":"9","author":"Reynolds","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114607_bib53","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.celrep.2019.06.018","article-title":"Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation","volume":"28","author":"Bailey","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib54","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41577-021-00633-9","article-title":"The type I interferonopathies: 10 years on","volume":"22","author":"Crow","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib55","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3201\/eid1206.051141","article-title":"Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season","volume":"12","author":"Hageman","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114607_bib56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib57","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10753-022-01637-w","article-title":"Lactylation: a Passing Fad or the Future of Posttranslational Modification","volume":"45","author":"Xin","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.celrep.2024.114607_bib58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114607_bib59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jid.2021.05.029","article-title":"IFN-\u03ba Is a Rheostat for Development of Psoriasiform Inflammation","volume":"142","author":"Gharaee-Kermani","year":"2022","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2024.114607_bib60","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152765","article-title":"IFN-\u03ba is critical for normal wound repair and is decreased in diabetic wounds","volume":"7","author":"Wolf","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2024.114607_bib61","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.4049\/jimmunol.1002794","article-title":"Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in\u00a0vivo","volume":"186","author":"Thurlow","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib62","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1128\/IAI.01304-12","article-title":"Epicutaneous model of community-acquired Staphylococcus aureus skin infections","volume":"81","author":"Prabhakara","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2024.114607_bib63","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0304-4165(01)00223-9","article-title":"Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I","volume":"1568","author":"Walker","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2024.114607_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003047","article-title":"Neutrophil-derived IL-1\u03b2 is sufficient for abscess formation in immunity against Staphylococcus aureus in mice","volume":"8","author":"Cho","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2024.114607_bib65","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.179.10.6933","article-title":"Inflammasome-Mediated Production of IL-1\u03b2 Is Required for Neutrophil Recruitment against Staphylococcus aureus In\u00a0Vivo","volume":"179","author":"Miller","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib66","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/eji.201847556","article-title":"IL-1\u03b2 activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms","volume":"48","author":"Pires","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib67","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/CMR.18.3.521-540.2005","article-title":"Recognition of Staphylococcus aureus by the innate immune system","volume":"18","author":"Fournier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.celrep.2024.114607_bib68","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/femsre\/fuy025","article-title":"Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors","volume":"42","author":"Askarian","year":"2018","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.celrep.2024.114607_bib69","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling","volume":"13","author":"Kawai","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2024.114607_bib70","article-title":"The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib71","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1128\/IAI.00447-16","article-title":"Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response","volume":"84","author":"Gries","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2024.114607_bib72","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114607_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2024.114607_bib74","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41590-022-01185-3","article-title":"Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation","volume":"23","author":"Billingham","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib75","article-title":"The Role of Macrophages in Staphylococcus aureus Infection","volume":"11","author":"Pidwill","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib76","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.3390\/ijms21228790","article-title":"The Immune Functions of Keratinocytes in Skin Wound Healing","volume":"21","author":"Piipponen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2024.114607_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14070464","article-title":"Exploring the Role of Staphylococcus aureus in Inflammatory Diseases","volume":"14","author":"Chen","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.celrep.2024.114607_bib78","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau2125","article-title":"The probacterial effect of type I interferon signaling requires its own negative regulator USP18","volume":"3","author":"Shaabani","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003951","article-title":"Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains","volume":"10","author":"Parker","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2024.114607_bib80","article-title":"STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/cmi.2016.25","article-title":"Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses","volume":"14","author":"Mayer-Barber","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib82","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114607_bib83","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-023-05770-w","article-title":"Fumarate induces vesicular release of mtDNA to drive innate immunity","volume":"615","author":"Zecchini","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114607_bib84","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","article-title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","volume":"615","author":"Hooftman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114607_bib85","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome","volume":"183","author":"Mu\u00f1oz-Planillo","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007446","article-title":"Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells","volume":"4","author":"Craven","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114607_bib87","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.immuni.2017.02.011","article-title":"Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection","volume":"46","author":"Wang","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114607_bib88","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.4049\/jimmunol.1700515","article-title":"Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1\u03b1 and Repression of NF-\u03baB","volume":"199","author":"Braverman","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib89","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2024.114607_bib90","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41564-020-0756-3","article-title":"Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection","volume":"5","author":"Heim","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2024.114607_bib91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114607_bib92","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1016\/j.molcel.2023.09.034","article-title":"Lactate activates the mitochondrial electron transport chain independently of its metabolism","volume":"83","author":"Cai","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114607_bib93","article-title":"Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2024.114607_bib94","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202254685","article-title":"Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells","volume":"23","author":"Lopez Krol","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib95","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/10985549.2023.2253131","article-title":"Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation","volume":"43","author":"Susser","year":"2023","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114607_bib96","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02253-23","article-title":"Lactate promotes Salmonella intracellular replication and systemic infection via driving macrophage M2 polarization","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2024.114607_bib97","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0002-9610(02)00815-2","article-title":"Role of nitric oxide in wound repair","volume":"183","author":"Witte","year":"2002","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.celrep.2024.114607_bib98","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1745-7254.2005.00058.x","article-title":"Nitric oxide: a newly discovered function on wound healing","volume":"26","author":"Luo","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.celrep.2024.114607_bib99","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1182\/blood-2007-05-089086","article-title":"Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis","volume":"110","author":"Denny","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2024.114607_bib100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4049\/jimmunol.1502190","article-title":"Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease","volume":"197","author":"Delaney","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib101","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1089\/jir.2011.0045","article-title":"Type I interferon and systemic lupus erythematosus","volume":"31","author":"Elkon","year":"2011","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.celrep.2024.114607_bib102","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fimmu.2014.00479","article-title":"\u201cOf mice and men\u201d: arginine metabolism in macrophages","volume":"5","author":"Thomas","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib103","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00537-12","article-title":"A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes","volume":"4","author":"Fey","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114607_bib104","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52982-0","article-title":"Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in\u00a0vivo imaging of experimental bacteremia and mixed infections","volume":"9","author":"Miller","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114607_bib105","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2024.114607_bib106","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114607_bib107","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/acs.jproteome.9b00640","article-title":"Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics","volume":"19","author":"Adams","year":"2020","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2024.114607_bib108","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cmet.2019.02.001","article-title":"Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer","volume":"29","author":"Halbrook","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114607_bib109","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11306-019-1564-8","article-title":"A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics","volume":"15","author":"Lee","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2024.114607_bib110","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.4049\/jimmunol.1301758","article-title":"Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses","volume":"192","author":"Gross","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114607_bib111","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. j."},{"key":"10.1016\/j.celrep.2024.114607_bib112","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114607_bib113","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:03:01Z","timestamp":1778842981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724009574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":113,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2211124724009574"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114607","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114607"}}