{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:33:20Z","timestamp":1791470000138,"version":"4.3.4"},"reference-count":136,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.celrep.2024.114637","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T20:22:05Z","timestamp":1723839725000},"page":"114637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes"],"prefix":"10.1016","volume":"43","author":[{"given":"Platon","family":"Megagiannis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Eckersberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Todd","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuwook","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Uyen","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Catoire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rochefort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Krishnaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Cloutier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Stifani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Petrecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene W.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Ideker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville E.","family":"Sanjana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114637_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","article-title":"Astrocyte roles in traumatic brain injury","volume":"275","author":"Burda","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.114637_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.20041918","article-title":"Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury","volume":"202","author":"Brambilla","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.114637_bib7","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1523\/JNEUROSCI.2121-13.2013","article-title":"Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury","volume":"33","author":"Wanner","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.stem.2013.01.019","article-title":"Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog","volume":"12","author":"Sirko","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41422-022-00673-3","article-title":"Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response","volume":"32","author":"Li","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114637_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-022-04739-5","article-title":"Divergent transcriptional regulation of astrocyte reactivity across disorders","volume":"606","author":"Burda","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib11","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41593-022-01180-9","article-title":"CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states","volume":"25","author":"Leng","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mcn.2017.11.010","article-title":"Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair","volume":"87","author":"Koreman","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib13","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.neuron.2023.05.006","article-title":"An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology","volume":"111","author":"Sheehan","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib14","doi-asserted-by":"crossref","first-page":"109048","DOI":"10.1016\/j.celrep.2021.109048","article-title":"Reactive astrocytes facilitate vascular repair and remodeling after stroke","volume":"35","author":"Williamson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114637_bib16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.1227764","article-title":"Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders","volume":"338","author":"O'Roak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2014.06.017","article-title":"Disruptive CHD8 mutations define a subtype of autism early in development","volume":"158","author":"Bernier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib18","doi-asserted-by":"crossref","first-page":"e1500447","DOI":"10.1126\/sciadv.1500447","article-title":"Mammalian SWI\/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics","volume":"1","author":"Kadoch","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114637_bib19","doi-asserted-by":"crossref","first-page":"12809","DOI":"10.1093\/nar\/gkac1134","article-title":"CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing","volume":"50","author":"Kerschbamer","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.114637_bib20","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1126\/science.1145339","article-title":"CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in\u00a0vivo","volume":"317","author":"Konev","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1089\/scd.2014.0544","article-title":"Chromodomain helicase DNA-binding proteins in stem cells and human developmental diseases","volume":"24","author":"Micucci","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.celrep.2024.114637_bib22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/cr.2011.32","article-title":"ATP-dependent chromatin remodeling: genetics, genomics and mechanisms","volume":"21","author":"Hargreaves","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114637_bib23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.molcel.2006.08.008","article-title":"CTCF-dependent chromatin insulator is linked to epigenetic remodeling","volume":"23","author":"Ishihara","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib24","doi-asserted-by":"crossref","first-page":"22331","DOI":"10.1073\/pnas.1921963117","article-title":"CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation","volume":"117","author":"Sood","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114637_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.devcel.2018.05.022","article-title":"Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair","volume":"45","author":"Zhao","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib26","doi-asserted-by":"crossref","first-page":"eabe2626","DOI":"10.1126\/sciadv.abe2626","article-title":"The CHD8\/CHD7\/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects","volume":"7","author":"Coll-Tane","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114637_bib27","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nn.4592","article-title":"Germline Chd8 haploinsufficiency alters brain development in mouse","volume":"20","author":"Gompers","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nature19357","article-title":"CHD8 haploinsufficiency results in autistic-like phenotypes in mice","volume":"537","author":"Katayama","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib29","doi-asserted-by":"crossref","first-page":"110615","DOI":"10.1016\/j.celrep.2022.110615","article-title":"CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories","volume":"39","author":"Villa","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib30","doi-asserted-by":"crossref","first-page":"108932","DOI":"10.1016\/j.celrep.2021.108932","article-title":"The autism-associated protein CHD8 is required for cerebellar development and motor function","volume":"35","author":"Atsuki Kawamura","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib31","doi-asserted-by":"crossref","first-page":"108780","DOI":"10.1016\/j.celrep.2021.108780","article-title":"Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors","volume":"34","author":"Kweon","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.celrep.2017.03.052","article-title":"Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits","volume":"19","author":"Platt","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/gene.10021","article-title":"A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action","volume":"32","author":"Guo","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2024.114637_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature16971","article-title":"Adult restoration of Shank3 expression rescues selective autistic-like phenotypes","volume":"530","author":"Mei","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib35","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1073\/pnas.0709002105","article-title":"Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain","volume":"105","author":"Buffo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114637_bib36","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1523\/JNEUROSCI.2696-11.2011","article-title":"Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in\u00a0vitro and in\u00a0vivo","volume":"31","author":"Robel","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1602\/neurorx.2.3.410","article-title":"Animal models of head trauma","volume":"2","author":"Cernak","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.celrep.2024.114637_bib38","doi-asserted-by":"crossref","first-page":"e47311","DOI":"10.1371\/journal.pone.0047311","article-title":"Role of gap junction protein connexin43 in astrogliosis induced by brain injury","volume":"7","author":"Theodoric","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114637_bib39","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.neuroscience.2011.06.035","article-title":"Vascular endothelial growth factor and platelet derived growth factor modulates the glial response to a cortical stab injury","volume":"192","author":"Norazit","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2024.114637_bib40","doi-asserted-by":"crossref","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114637_bib41","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nn.2535","article-title":"Selective induction of astrocytic gliosis generates deficits in neuronal inhibition","volume":"13","author":"Ortinski","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2024.114637_bib43","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.neuron.2016.11.030","article-title":"New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In\u00a0Vivo","volume":"92","author":"Srinivasan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-020-1999-0","article-title":"MAFG-driven astrocytes promote CNS inflammation","volume":"578","author":"Wheeler","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib45","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41586-020-03060-3","article-title":"Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis","volume":"590","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib46","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.neuron.2021.03.024","article-title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nature24638","article-title":"Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis","volume":"551","author":"Stogsdill","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114637_bib49","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1038\/s41598-023-32903-y","article-title":"Stereology neuron counts correlate with deep learning estimates in the human hippocampal subregions","volume":"13","author":"Oltmer","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib50","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.nurt.2010.07.002","article-title":"Role of microglia in neurotrauma","volume":"7","author":"Loane","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.celrep.2024.114637_bib51","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0448-18.2019","article-title":"Tmem119-EGFP and Tmem119-CreERT2 Transgenic Mice for Labeling and Manipulating Microglia","volume":"6","author":"Kaiser","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2024.114637_bib52","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","article-title":"A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis","volume":"597","author":"Absinta","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abl6773","article-title":"Microglia-mediated degradation of perineuronal nets promotes pain","volume":"377","author":"Tansley","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib54","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nn.3371","article-title":"Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation","volume":"16","author":"Bardehle","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib55","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0266-18.2018","article-title":"3DMorph Automatic Analysis of Microglial Morphology in Three Dimensions from Ex\u00a0Vivo and In\u00a0Vivo Imaging","volume":"5","author":"York","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2024.114637_bib56","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s41467-020-15267-z","article-title":"Microglial metabolic flexibility supports immune surveillance of the brain parenchyma","volume":"11","author":"Bernier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114637_bib57","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib58","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2024.114637_bib59","doi-asserted-by":"crossref","first-page":"e69123","DOI":"10.1371\/journal.pone.0069123","article-title":"A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1beta, [corrected] TNF-alpha and IL-6 challenges in C57BL\/6 mice","volume":"8","author":"Skelly","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114637_bib60","doi-asserted-by":"crossref","first-page":"109508","DOI":"10.1016\/j.celrep.2021.109508","article-title":"Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation","volume":"36","author":"Diaz-Castro","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib61","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","article-title":"Astrocytes and Microglia: In Sickness and in Health","volume":"43","author":"Vainchtein","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib62","doi-asserted-by":"crossref","first-page":"e0201375","DOI":"10.1371\/journal.pone.0201375","article-title":"Recovery from an acute systemic and central LPS-inflammation challenge is affected by mouse sex and genetic background","volume":"13","author":"Meneses","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114637_bib63","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.22930","article-title":"Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge","volume":"64","author":"Norden","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2024.114637_bib64","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1038\/s41598-018-22020-6","article-title":"Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry","volume":"8","author":"Mei","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib65","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib66","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1007\/s11064-019-02721-8","article-title":"Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk","volume":"44","author":"Clark","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.celrep.2024.114637_bib67","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib68","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib69","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular Architecture of the Mouse Nervous System","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib70","doi-asserted-by":"crossref","first-page":"eaar2124","DOI":"10.1126\/scisignal.aar2124","article-title":"Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation","volume":"12","author":"Kano","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2024.114637_bib71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib72","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-021-00905-6","article-title":"Neuroinflammatory astrocyte subtypes in the mouse brain","volume":"24","author":"Hasel","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib73","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of region-specific astrocyte subtypes at single cell resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114637_bib74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-008-0008-y","article-title":"The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response","volume":"326","author":"Golovko","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.celrep.2024.114637_bib75","doi-asserted-by":"crossref","first-page":"100830","DOI":"10.1016\/j.jbc.2021.100830","article-title":"The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis","volume":"297","author":"White","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114637_bib76","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41593-022-01205-3","article-title":"Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes","volume":"26","author":"Humphrey","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib77","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12916-021-01903-y","article-title":"Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases","volume":"19","author":"Li","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.celrep.2024.114637_bib78","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/s41380-020-0698-4","article-title":"Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder","volume":"26","author":"Liu","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2024.114637_bib79","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12035-022-03091-z","article-title":"Meloxicam Inhibits Apoptosis in Neurons by Deactivating Tumor Necrosis Factor Receptor Superfamily Member 25, Leading to the Decreased Cleavage of DNA Fragmentation Factor Subunit alpha in Alzheimer's Disease","volume":"60","author":"Guan","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114637_bib80","doi-asserted-by":"crossref","first-page":"159123","DOI":"10.1016\/j.bbalip.2022.159123","article-title":"Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders","volume":"1867","author":"Turri","year":"2022","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.celrep.2024.114637_bib81","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02591418","article-title":"Lecithin cholesterol acyltransferase in human cerebrospinal fluid: reduced level in patients with multiple sclerosis and evidence of direct synthesis in the brain","volume":"22","author":"Albers","year":"1992","journal-title":"Int. J. Clin. Lab. Res."},{"key":"10.1016\/j.celrep.2024.114637_bib82","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2018.02.041","article-title":"The level of 24-hydroxycholesteryl esters decreases in plasma of patients with Parkinson's disease","volume":"672","author":"Di Natale","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2024.114637_bib83","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41593-023-01288-6","article-title":"Lipid-accumulated reactive astrocytes promote disease progression in epilepsy","volume":"26","author":"Chen","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib84","doi-asserted-by":"crossref","first-page":"eadc9020","DOI":"10.1126\/science.adc9020","article-title":"Molecular basis of astrocyte diversity and morphology across the CNS in health and disease","volume":"378","author":"Endo","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib85","doi-asserted-by":"crossref","first-page":"eabk1051","DOI":"10.1126\/scitranslmed.abk1051","article-title":"Widespread cell stress and mitochondrial dysfunction occur\u00a0in patients with early Alzheimer's disease","volume":"14","author":"Venkataraman","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114637_bib86","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.ajhg.2023.09.004","article-title":"Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction","volume":"110","author":"Shi","year":"2023","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2024.114637_bib87","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","article-title":"Astrocyte roles in traumatic brain injury","volume":"275","author":"Burda","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.114637_bib88","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/s41593-020-00735-y","article-title":"Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H(2)O(2)(-) production","volume":"23","author":"Chun","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib89","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41467-021-27702-w","article-title":"Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Ass pathology","volume":"13","author":"Jiwaji","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114637_bib90","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41582-019-0240-y","article-title":"Chronic inflammation in multiple sclerosis - seeing what was always there","volume":"15","author":"Matthews","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2024.114637_bib91","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature14299","article-title":"In\u00a0vivo genome editing using Staphylococcus aureus Cas9","volume":"520","author":"Ran","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib92","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/glia.20622","article-title":"GFAP promoter elements required for region-specific and astrocyte-specific expression","volume":"56","author":"Lee","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2024.114637_bib93","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.cell.2019.03.019","article-title":"Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue","volume":"177","author":"Nagai","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib94","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.neuron.2020.09.021","article-title":"Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable","volume":"108","author":"Yu","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114637_bib95","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.abq4822","article-title":"Droplet-based forward genetic screening of astrocyte-microglia cross-talk","volume":"379","author":"Wheeler","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib96","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.addr.2020.04.009","article-title":"Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods","volume":"159","author":"van Kruining","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.celrep.2024.114637_bib97","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.conb.2015.10.004","article-title":"Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease","volume":"36","author":"Villegas-Llerena","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114637_bib98","doi-asserted-by":"crossref","first-page":"eaaz4564","DOI":"10.1126\/scitranslmed.aaz4564","article-title":"APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia","volume":"13","author":"Sienski","year":"2021","journal-title":"Sci.\u00a0Transl. Med."},{"key":"10.1016\/j.celrep.2024.114637_bib99","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s42255-023-00756-4","article-title":"Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration","volume":"5","author":"Mi","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.114637_bib100","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-kappaB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2024.114637_bib101","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fnins.2015.00477","article-title":"Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology","volume":"9","author":"Barnard","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib102","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.biopsych.2019.07.020","article-title":"Clinical Phenotypes of Carriers of Mutations in CHD8 or Its Conserved Target Genes","volume":"87","author":"Beighley","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2024.114637_bib103","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ajhg.2020.04.004","article-title":"Insufficient Evidence for \"Autism-Specific\" Genes","volume":"106","author":"Myers","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2024.114637_bib104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.114637_bib105","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.biopsych.2015.08.007","article-title":"Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder","volume":"81","author":"Krakowiak","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2024.114637_bib106","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1742-2094-11-113","article-title":"Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study","volume":"11","author":"Zerbo","year":"2014","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2024.114637_bib107","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1517\/14728222.9.5.887","article-title":"Neuroinflammation: a potential therapeutic target","volume":"9","author":"Craft","year":"2005","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.celrep.2024.114637_bib108","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/CIA.S357558","article-title":"Neuroinflammation as a Potential Therapeutic Target in Alzheimer's Disease","volume":"17","author":"Liu","year":"2022","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.celrep.2024.114637_bib109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40035-015-0042-0","article-title":"Neuroinflammation in Parkinson's disease and its potential as therapeutic target","volume":"4","author":"Wang","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.celrep.2024.114637_bib110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib111","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41577-019-0262-0","article-title":"Neuroinflammation and neurodegeneration in human brain at single-cell resolution","volume":"20","author":"Colonna","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114637_bib112","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.abj8894","article-title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","volume":"379","author":"Hata","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib113","doi-asserted-by":"crossref","first-page":"e18339","DOI":"10.1016\/j.heliyon.2023.e18339","article-title":"Time-resolved single-cell RNAseq profiling identifies a novel Fabp5(+) subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury","volume":"9","author":"Hamel","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.celrep.2024.114637_bib114","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41583-020-0264-8","article-title":"Improved tools to study astrocytes","volume":"21","author":"Yu","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.114637_bib115","doi-asserted-by":"crossref","first-page":"108721","DOI":"10.1016\/j.celrep.2021.108721","article-title":"Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis","volume":"34","author":"Wei","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib116","doi-asserted-by":"crossref","first-page":"107776","DOI":"10.1016\/j.celrep.2020.107776","article-title":"Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury","volume":"31","author":"Guttenplan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114637_bib117","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41586-023-05927-7","article-title":"Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms","volume":"616","author":"Soto","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114637_bib118","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13918","article-title":"A robust activity marking system for exploring active neuronal ensembles","volume":"5","author":"Sorensen","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114637_bib119","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cell.2020.02.055","article-title":"Functionally Distinct Neuronal Ensembles within the Memory Engram","volume":"181","author":"Sun","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114637_bib120","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114637_bib121","first-page":"3769","article-title":"The tail suspension test","author":"Can","year":"2012","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2024.114637_bib122","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1038\/s41380-021-01052-x","article-title":"Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling","volume":"26","author":"Amar","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2024.114637_bib123","doi-asserted-by":"crossref","first-page":"eaat8127","DOI":"10.1126\/science.aat8127","article-title":"Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder","volume":"362","author":"Gandal","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114637_bib124","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. j."},{"key":"10.1016\/j.celrep.2024.114637_bib125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114637_bib126","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114637_bib127","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2024.114637_bib128","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114637_bib129","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114637_bib130","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114637_bib131","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.celrep.2024.114637_bib132","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114637_bib133","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114637_bib134","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114637_bib135","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114637_bib136","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T23:23:03Z","timestamp":1760224983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724009872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":136,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2211124724009872"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114637","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114637"}}