{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:12:10Z","timestamp":1793275930165,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.celrep.2024.114648","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T05:12:37Z","timestamp":1724130757000},"page":"114648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+\/NADH balance"],"prefix":"10.1016","volume":"43","author":[{"given":"Jingjing","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-3677","authenticated-orcid":false,"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114648_bib1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41564-022-01080-5","article-title":"Immunometabolic crosstalk during bacterial infection","volume":"7","author":"Rosenberg","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2024.114648_bib2","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1111\/febs.14446","article-title":"Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?","volume":"285","author":"Escoll","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2024.114648_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2017.07.020","article-title":"Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages","volume":"22","author":"Escoll","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114648_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/s41467-021-21186-4","article-title":"Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence","volume":"12","author":"Jiang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114648_bib5","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.cmet.2023.09.001","article-title":"Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection","volume":"35","author":"Tomlinson","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00125-19","article-title":"The HIF-1alpha\/LC3-II Axis Impacts Fungal Immunity in Human Macrophages","volume":"87","author":"Friedrich","year":"2019","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2024.114648_bib7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cmet.2018.03.019","article-title":"Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection","volume":"27","author":"Tucey","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011719","article-title":"Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection","volume":"19","author":"Carreno-Florez","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2024.114648_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114648_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41590-022-01185-3","article-title":"Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation","volume":"23","author":"Billingham","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","article-title":"Krebs Cycle Reborn in Macrophage Immunometabolism","volume":"38","author":"Ryan","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","article-title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","volume":"615","author":"Hooftman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-023-05770-w","article-title":"Fumarate induces vesicular release of mtDNA to drive innate immunity","volume":"615","author":"Zecchini","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","article-title":"Lactate limits CNS autoimmunity by stabilizing HIF-1alpha in dendritic cells","volume":"620","author":"Sanmarco","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s42255-020-0210-0","article-title":"Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages","volume":"2","author":"Swain","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.114648_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03632-21","article-title":"Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release","volume":"13","author":"Xu","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114648_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","article-title":"Type I interferon inhibits interleukin-1 production and inflammasome activation","volume":"34","author":"Guarda","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114648_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102280","article-title":"Type-1 interferon-dependent and -independent mechanisms in cyclic GMP-AMP synthase-stimulator of interferon genes-driven auto-inflammation","volume":"80","author":"Gao","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051134","article-title":"Crosstalk between Interleukin-1beta and Type I Interferons Signaling in Autoinflammatory Diseases","volume":"10","author":"Georgel","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2024.114648_bib24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2020.02.017","article-title":"Serine Catabolism Feeds NADH when Respiration Is Impaired","volume":"31","author":"Yang","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2024.114648_bib26","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmet.2020.03.012","article-title":"NADH Ties One-Carbon Metabolism to Cellular Respiration","volume":"31","author":"Maynard","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib27","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114648_bib28","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1089\/ars.2010.3713","article-title":"Lipopolysaccharide-induced mitochondrial DNA depletion","volume":"15","author":"Choumar","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.celrep.2024.114648_bib29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2016.08.010","article-title":"K(+) Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria","volume":"45","author":"Gro\u00df","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114648_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cmet.2014.07.011","article-title":"Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization","volume":"20","author":"Jin","year":"2014","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159498","article-title":"Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction","volume":"133","author":"Cai","year":"2023","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114648_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nature14020","article-title":"NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs","volume":"519","author":"Cahova","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2020.06.003","article-title":"NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction","volume":"32","author":"McElroy","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.it.2022.02.001","article-title":"NAD(+) in COVID-19 and viral infections","volume":"43","author":"Zheng","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s42003-020-01514-y","article-title":"NAD(+)\/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in\u00a0vitro","volume":"3","author":"Yuan","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2024.114648_bib38","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1016\/j.molcel.2022.10.026","article-title":"AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity","volume":"82","author":"Zhang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114648_bib39","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41564-024-01734-6","article-title":"Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice","volume":"9","author":"Yang","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2024.114648_bib40","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.4049\/jimmunol.1900820","article-title":"Enhanced Expression of Catalase in Mitochondria Modulates NF-kappaB-Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages","volume":"205","author":"Han","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib41","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD(+) repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114648_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.689337","article-title":"High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","article-title":"Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha\/Glycolysis-Dependent Axis","volume":"32","author":"Codo","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-023-06803-0","article-title":"Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes","volume":"624","author":"Nobs","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib45","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aar3318","article-title":"Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection","volume":"359","author":"Thaiss","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114648_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2024.114648_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cmet.2018.08.012","article-title":"Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114648_bib49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s42255-021-00507-3","article-title":"Viral infection as an NAD(+) battlefield","volume":"4","author":"Brenner","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.114648_bib50","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1172\/JCI138538","article-title":"Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure","volume":"130","author":"Zhou","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114648_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139828","article-title":"Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes","volume":"132","author":"Wu","year":"2022","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114648_bib52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1574-6968.2011.02287.x","article-title":"Overexpression and biochemical characterization of soluble pyridine nucleotide transhydrogenase from Escherichia coli","volume":"320","author":"Cao","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.celrep.2024.114648_bib53","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1038\/s41467-022-34850-0","article-title":"Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress","volume":"13","author":"Yang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114648_bib54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.aad4017","article-title":"Complementation of mitochondrial electron transport chain by manipulation of the NAD+\/NADH ratio","volume":"352","author":"Titov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114648_bib55","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/291381a0","article-title":"The evolution of metabolic cycles","volume":"291","author":"Baldwin","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib56","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.tibs.2018.04.012","article-title":"The Krebs Uric Acid Cycle: A Forgotten Krebs Cycle","volume":"43","author":"Salway","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2024.114648_bib57","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.1523\/JNEUROSCI.20-24-08972.2000","article-title":"Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress","volume":"20","author":"Tretter","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114648_bib58","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","article-title":"Itaconate: the poster child of metabolic reprogramming in macrophage function","volume":"19","author":"O'Neill","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.biochem.75.103004.142539","article-title":"Energy converting NADH:quinone oxidoreductase (complex I)","volume":"75","author":"Brandt","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2024.114648_bib60","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cmet.2013.07.002","article-title":"Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure","volume":"18","author":"Karamanlidis","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114648_bib61","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114648_bib62","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage Immunometabolism: Where Are We (Going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib63","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.molcel.2020.12.012","article-title":"Increased demand for NAD(+) relative to ATP drives aerobic glycolysis","volume":"81","author":"Luengo","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114648_bib64","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114648_bib65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib66","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114648_bib67","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1016\/j.molcel.2023.09.034","article-title":"Lactate activates the mitochondrial electron transport chain independently of its metabolism","volume":"83","author":"Cai","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114648_bib68","article-title":"Expression signature of the Leigh syndrome French-Canadian type","volume":"30","author":"Bchetnia","year":"2022","journal-title":"Mol. Genet. Metab. Rep."},{"key":"10.1016\/j.celrep.2024.114648_bib69","first-page":"420","article-title":"Metabolic reprograming in macrophage polarization","volume":"5","author":"Galvan-Pena","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib70","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.celrep.2024.114648_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74690","article-title":"Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses","volume":"11","author":"Lundahl","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114648_bib72","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.immuni.2017.02.011","article-title":"Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection","volume":"46","author":"Wang","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114648_bib73","doi-asserted-by":"crossref","first-page":"5.47.1","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.celrep.2024.114648_bib74","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103526118","article-title":"T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese","volume":"118","author":"Zhu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114648_bib75","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/s41467-021-25157-7","article-title":"NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114648_bib76","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s12035-022-02784-9","article-title":"Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model","volume":"59","author":"Li","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114648_bib77","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s11306-015-0809-4","article-title":"An integrated targeted metabolomic platform for high-throughput metabolite profiling and automated data processing","volume":"11","author":"Cai","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2024.114648_bib78","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.immuni.2022.07.017","article-title":"Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion","volume":"55","author":"Wang","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114648_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111976","article-title":"HIF-1\u03b1 accumulation in response to transient hypoglycemia may worsen diabetic eye disease","volume":"42","author":"Guo","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114648_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110304","article-title":"Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers","volume":"38","author":"Shen","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114648_bib81","article-title":"FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2024.114648_bib82","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.18632\/aging.203967","article-title":"Effects of caloric overload before caloric restriction in the murine heart","volume":"14","author":"Maldonado","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.celrep.2024.114648_bib83","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/cns.13435","article-title":"Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats","volume":"26","author":"Ding","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.celrep.2024.114648_bib84","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.actbio.2023.01.036","article-title":"Multifunctional gold nanorods in low-temperature photothermal interactions for combined tumor starvation and RNA interference therapy","volume":"159","author":"Fan","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.celrep.2024.114648_bib85","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3389\/fimmu.2020.01149","article-title":"Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome","volume":"11","author":"Hou","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114648_bib86","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.122.001283","article-title":"Activation of GPR183 by 7\u03b1,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor-\u03baB","volume":"383","author":"Braden","year":"2022","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.celrep.2024.114648_bib87","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1038\/s41467-022-33656-4","article-title":"Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes","volume":"13","author":"Yuan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114648_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123202","article-title":"Manganese potentiates lipopolysaccharide-induced innate immune responses and septic shock","volume":"230","author":"Gu","year":"2023","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724009999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T12:23:02Z","timestamp":1733833382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724009999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2211124724009999"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114648","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+\/NADH balance","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114648"}}