{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:23:48Z","timestamp":1790915028180,"version":"4.1.0"},"reference-count":112,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004727","name":"VIB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.celrep.2024.114719","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T06:34:37Z","timestamp":1725863677000},"page":"114719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting EGLN2\/PHD1 protects motor neurons and normalizes the astrocytic interferon response"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4586-7962","authenticated-orcid":false,"given":"Christine","family":"Germeys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijs","family":"Vandoorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer","family":"Davie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Poovathingal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Heeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Vermeire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FatemehArefeh","family":"Nami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Moisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Quaegebeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annerieke","family":"Sierksma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ru\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e0","family":"Sicart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Eykens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenja","family":"De Cock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Strooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"De Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludo","family":"Van Den Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114719_bib1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.114719_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ccr.2005.06.017","article-title":"HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability","volume":"8","author":"Isaacs","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm1366","article-title":"Oxygen sensing by HIF hydroxylases","volume":"5","author":"Schofield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114719_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tibs.2012.10.004","article-title":"Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes","volume":"38","author":"Wong","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2024.114719_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C.\u00a0elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"Bruick","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.molcel.2017.06.002","article-title":"The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks","volume":"66","author":"Ivan","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.2007.62","article-title":"Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism","volume":"40","author":"Aragon\u00e9s","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114719_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1053\/j.gastro.2009.09.057","article-title":"Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia\/reperfusion injury","volume":"138","author":"Schneider","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114719_bib11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2015.12.007","article-title":"Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism","volume":"23","author":"Quaegebeur","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114719_bib12","doi-asserted-by":"crossref","first-page":"18154","DOI":"10.1073\/pnas.0602235103","article-title":"Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity","volume":"103","author":"Cummins","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114719_bib13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/path.4861","article-title":"Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis","volume":"241","author":"Van Welden","year":"2017","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2024.114719_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ana.410380424","article-title":"Oxidative damage to protein in sporadic motor neuron disease spinal cord","volume":"38","author":"Shaw","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.114719_bib16","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1046\/j.1471-4159.1997.69052064.x","article-title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","volume":"69","author":"Ferrante","year":"1997","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.114719_bib17","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tips.2016.06.007","article-title":"Targeting Oxidative Stress in Central Nervous System Disorders","volume":"37","author":"Patel","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.celrep.2024.114719_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00401-018-1835-x","article-title":"Energy metabolism in ALS: an underappreciated opportunity?","volume":"135","author":"Vandoorne","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/genes10121011","article-title":"Existing and Emerging Metabolomic Tools for ALS Research","volume":"10","author":"Germeys","year":"2019","journal-title":"Genes"},{"key":"10.1016\/j.celrep.2024.114719_bib20","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1096\/fj.09-130047","article-title":"Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis","volume":"23","author":"Kupershmidt","year":"2009","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2024.114719_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuroscience.2019.06.025","article-title":"Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model","volume":"415","author":"Nomura","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2024.114719_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/88842","article-title":"Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration","volume":"28","author":"Oosthuyse","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114719_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nn1360","article-title":"Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS","volume":"8","author":"Storkebaum","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nbd.2004.06.004","article-title":"Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration","volume":"17","author":"Van Den Bosch","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2024.114719_bib25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3389\/fimmu.2017.01005","article-title":"Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114719_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mcn.2005.10.016","article-title":"The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS","volume":"31","author":"Henkel","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-016-0698-0","article-title":"Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients","volume":"13","author":"Mishra","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2024.114719_bib28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1468-1331.2009.02560.x","article-title":"Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis","volume":"16","author":"Kuhle","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.celrep.2024.114719_bib29","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1038\/s41598-020-62756-8","article-title":"Peripheral proinflammatory Th1\/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis","volume":"10","author":"Jin","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114719_bib30","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuron.2014.01.013","article-title":"Microglia induce motor neuron death via the classical NF-\u03baB pathway in amyotrophic lateral sclerosis","volume":"81","author":"Frakes","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114719_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017187","article-title":"Astroglial inhibition of NF-\u03baB does not ameliorate disease onset and progression in a mouse model for amyotrophic lateral sclerosis (ALS)","volume":"6","author":"Crosio","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114719_bib32","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/hmg\/ddm193","article-title":"Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish","volume":"16","author":"Lemmens","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.114719_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.2007.62","article-title":"Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism","volume":"40","author":"Aragones","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114719_bib34","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib35","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.celrep.2018.02.003","article-title":"Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior","volume":"22","author":"Sathyamurthy","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114719_bib36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1126\/science.aam8999","article-title":"Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding","volume":"360","author":"Rosenberg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib37","doi-asserted-by":"crossref","DOI":"10.1242\/dev.173807","article-title":"Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord","volume":"146","author":"Delile","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.celrep.2024.114719_bib38","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular Architecture of the Mouse Nervous System","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib39","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.celrep.2017.11.050","article-title":"A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche","volume":"21","author":"Artegiani","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114719_bib40","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41593-020-00795-0","article-title":"Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons","volume":"24","author":"Blum","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib42","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41467-021-22691-2","article-title":"Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord","volume":"12","author":"Alkaslasi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib43","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1038\/s41467-021-25125-1","article-title":"A harmonized atlas of mouse spinal cord cell types and their spatial organization","volume":"12","author":"Russ","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41593-018-0293-z","article-title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","volume":"22","author":"Melamed","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41593-018-0300-4","article-title":"ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair","volume":"22","author":"Klim","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib46","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s12035-017-0393-x","article-title":"Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach","volume":"55","author":"Morello","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114719_bib47","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/15548627.2019.1686729","article-title":"PTK2\/FAK regulates UPS impairment via SQSTM1\/p62 phosphorylation in TARDBP\/TDP-43 proteinopathies","volume":"16","author":"Lee","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2024.114719_bib48","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s13311-019-00811-7","article-title":"Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis","volume":"17","author":"M\u00f2dol-Caballero","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.celrep.2024.114719_bib49","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nn.2778","article-title":"Characterizing the RNA targets and position-dependent splicing regulation by TDP-43","volume":"14","author":"Tollervey","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00401-019-02093-x","article-title":"Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis","volume":"139","author":"Oeckl","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2016.05.021","article-title":"Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis","volume":"91","author":"Lee","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114719_bib52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5483\/BMBRep.2020.53.1.273","article-title":"Translocator protein (TSPO): the new story of the old protein in neuroinflammation","volume":"53","author":"Lee","year":"2020","journal-title":"BMB Rep."},{"key":"10.1016\/j.celrep.2024.114719_bib53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fneur.2019.00135","article-title":"Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis","volume":"10","author":"Chew","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.celrep.2024.114719_bib54","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-020-2625-x","article-title":"C9orf72 in myeloid cells suppresses STING-induced inflammation","volume":"585","author":"McCauley","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114719_bib86","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tins.2020.10.008","article-title":"Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging","volume":"44","author":"Paul","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib55","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.stem.2014.03.004","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","volume":"14","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.expneurol.2010.11.019","article-title":"Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse","volume":"227","author":"Yang","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.114719_bib57","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.neuron.2020.05.014","article-title":"CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes","volume":"107","author":"Barbar","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114719_bib58","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114719_bib59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1101\/gr.275939.121","article-title":"Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states","volume":"32","author":"Ziff","year":"2022","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2024.114719_bib60","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41467-017-01283-z","article-title":"A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models","volume":"8","author":"Tyzack","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-022-00591-3","article-title":"FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms","volume":"18","author":"Stoklund Dittlau","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2024.114719_bib62","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s12015-021-10179-x","article-title":"SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System","volume":"17","author":"Neyrinck","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.celrep.2024.114719_bib63","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ebiom.2019.11.026","article-title":"Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity","volume":"50","author":"Birger","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2024.114719_bib64","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3389\/fnins.2017.00671","article-title":"Current Advances and Limitations in Modeling ALS\/FTD in a Dish Using Induced Pluripotent Stem Cells","volume":"11","author":"Guo","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boill\u00e9e","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114719_bib66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41582-021-00487-8","article-title":"Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers","volume":"17","author":"Vahsen","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2024.114719_bib67","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.tins.2021.04.008","article-title":"Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis","volume":"44","author":"Van Harten","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104877","article-title":"Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis","volume":"141","author":"Liu","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2024.114719_bib69","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s42003-022-03128-y","article-title":"Neuronal-glial communication perturbations in murine SOD1","volume":"5","author":"MacLean","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2024.114719_bib70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.aav9776","article-title":"Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis","volume":"364","author":"Maniatis","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib71","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1038\/s41467-023-41033-y","article-title":"Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib72","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/glia.21167","article-title":"Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model","volume":"59","author":"Wang","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2024.114719_bib74","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz4699","article-title":"Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss","volume":"13","author":"Rodriguez","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114719_bib75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00401-020-02176-0","article-title":"Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS","volume":"140","author":"LaClair","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib76","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib77","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2020.03.005","article-title":"The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice","volume":"106","author":"Gerbino","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.114719_bib78","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00401-024-02688-z","article-title":"Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"147","author":"Marques","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib79","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3389\/fnins.2020.00824","article-title":"Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease","volume":"14","author":"Izrael","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.114719_bib80","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1038\/s41467-020-17514-9","article-title":"Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model","volume":"11","author":"Guttenplan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib81","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-024-00416-x","article-title":"Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications","volume":"13","author":"Huang","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.celrep.2024.114719_bib82","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1074\/jbc.M109.078600","article-title":"Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway","volume":"285","author":"Fu","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114719_bib83","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","article-title":"Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity","volume":"138","author":"Xue","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114719_bib84","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1158\/0008-5472.CAN-10-3838","article-title":"Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGF\u03b2","volume":"71","author":"Klotzsche-von Ameln","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.114719_bib85","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbrainres.2004.07.002","article-title":"Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS","volume":"130","author":"Alexander","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.celrep.2024.114719_bib87","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00401-017-1796-5","article-title":"A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism","volume":"135","author":"Swinnen","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib88","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114719_bib89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114719_bib90","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2024.114719_bib91","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.cell.2018.05.057","article-title":"A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain","volume":"174","author":"Davie","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114719_bib92","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114719_bib93","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"Mi","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.114719_bib94","doi-asserted-by":"crossref","first-page":"W415","DOI":"10.1093\/nar\/gkae456","article-title":"WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics","volume":"52","author":"Elizarraras","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.114719_bib95","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt Removes Adapter Sequences From High-Throughput Sequencing Reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. j."},{"key":"10.1016\/j.celrep.2024.114719_bib96","series-title":"ShortRead: Base Classes and Methods for High-Throughput Short-Read Sequencing Data","author":"Morgan","year":"2009"},{"key":"10.1016\/j.celrep.2024.114719_bib97","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114719_bib98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114719_bib99","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114719_bib100","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114719_bib101","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/1471-2105-12-480","article-title":"GC-content normalization for RNA-Seq data","volume":"12","author":"Risso","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2024.114719_bib102","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1093\/bioinformatics\/btm453","article-title":"Moderated statistical tests for assessing differences in tag abundance","volume":"23","author":"Robinson","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.114719_bib103","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00401-022-02471-y","article-title":"HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS","volume":"144","author":"Braems","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.114719_bib104","article-title":"Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies","volume":"14","author":"Dittlau","year":"2024","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.celrep.2024.114719_bib105","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1126\/science.1256800","article-title":"C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins","volume":"345","author":"Mizielinska","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib106","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2024.114719_bib107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nbt.3055","article-title":"In\u00a0vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9","volume":"33","author":"Swiech","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2024.114719_bib108","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of region-specific astrocyte subtypes at single cell resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib109","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.conb.2017.10.005","article-title":"Single-cell transcriptomic analysis of oligodendrocyte lineage cells","volume":"47","author":"van Bruggen","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2024.114719_bib110","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.aaf6463","article-title":"Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system","volume":"352","author":"Marques","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114719_bib111","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s40478-019-0759-6","article-title":"Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis","volume":"7","author":"Ru\u00e9","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2024.114719_bib112","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0Roy. Stat. Soc. B"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724010702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724010702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T17:57:15Z","timestamp":1733853435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724010702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":112,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2211124724010702"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114719","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting EGLN2\/PHD1 protects motor neurons and normalizes the astrocytic interferon response","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114719"}}