{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:52:56Z","timestamp":1790434376604,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI141436"],"award-info":[{"award-number":["R01 AI141436"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI153209"],"award-info":[{"award-number":["R01 AI153209"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI142790"],"award-info":[{"award-number":["U19 AI142790"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93022C00035"],"award-info":[{"award-number":["75N93022C00035"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007172"],"award-info":[{"award-number":["T32 AI007172"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI163019"],"award-info":[{"award-number":["R01 AI163019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 CA009547"],"award-info":[{"award-number":["T32 CA009547"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI201800001"],"award-info":[{"award-number":["AI201800001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","award":["MCDC2103-01"],"award-info":[{"award-number":["MCDC2103-01"]}],"id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","award":["EQ1090_2023"],"award-info":[{"award-number":["EQ1090_2023"]}],"id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.celrep.2024.114809","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T06:25:45Z","timestamp":1728109545000},"page":"114809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses"],"prefix":"10.1016","volume":"43","author":[{"given":"Sathvik","family":"Palakurty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sariol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlu","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan","family":"Wagoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daved H.","family":"Fremont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.J.","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Klimstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114809_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.virol.2007.05.041","article-title":"Alpha-beta T\u00a0cells provide protection against lethal encephalitis in the murine model of VEEV infection","volume":"367","author":"Paessler","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2024.114809_bib2","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1128\/JVI.80.6.2784-2796.2006","article-title":"Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN\/VEE viruses","volume":"80","author":"Paessler","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3181\/00379727-97-23862","article-title":"Chronic latent infections of birds with Western equine encephalomyelitis virus","volume":"97","author":"Reeves","year":"1958","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.celrep.2024.114809_bib4","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1056\/NEJM199706263362604","article-title":"Clinical and Neuroradiographic Manifestations of Eastern Equine Encephalitis","volume":"336","author":"Deresiewicz","year":"1997","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.114809_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrmicro1006","article-title":"Transmission cycles, host range, evolution and emergence of arboviral disease","volume":"2","author":"Weaver","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2024.114809_bib6","article-title":"Molecular epidemiology of Western equine encephalitis virus in Brazil, 2023-2024","author":"Campos","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.celrep.2024.114809_bib7","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S1473-3099(22)00052-4","article-title":"Safety and immunogenicity of a trivalent virus-like particle vaccine against western, eastern, and Venezuelan equine encephalitis viruses: a phase 1, open-label, dose-escalation, randomised clinical trial","volume":"22","author":"Coates","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114809_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41586-018-0121-3","article-title":"Mxra8 is a receptor for multiple arthritogenic alphaviruses","volume":"557","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114809_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41586-020-2915-3","article-title":"LDLRAD3 is a receptor for Venezuelan equine encephalitis virus","volume":"588","author":"Ma","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114809_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-021-04326-0","article-title":"VLDLR and ApoER2 are receptors for multiple alphaviruses","volume":"602","author":"Clark","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114809_bib11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41467-024-44872-5","article-title":"LDLR is used as a cell entry receptor by multiple alphaviruses","volume":"15","author":"Zhai","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114809_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41467-023-44624-x","article-title":"The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses","volume":"15","author":"Ma","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114809_bib13","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1016\/j.cell.2023.09.007","article-title":"Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8","volume":"186","author":"Zimmerman","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114809_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.cell.2023.11.031","article-title":"Structural and functional basis of\u00a0VLDLR usage by Eastern equine encephalitis virus","volume":"187","author":"Adams","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114809_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112946","article-title":"Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice","volume":"42","author":"Kafai","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114809_bib16","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.1128\/JVI.72.9.7349-7356.1998","article-title":"Binding of Sindbis virus to cell surface heparan sulfate","volume":"72","author":"Byrnes","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.virol.2004.11.043","article-title":"Heparin binding sites on Ross River virus revealed by electron cryo-microscopy","volume":"332","author":"Zhang","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2024.114809_bib18","doi-asserted-by":"crossref","first-page":"8890","DOI":"10.1073\/pnas.1910670117","article-title":"Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues","volume":"117","author":"Chen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114809_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00432-17","article-title":"Genome-wide screening uncovers the significance of N-sulfation of heparan sulfate as a host cell factor for Chikungunya virus infection","volume":"91","author":"Tanaka","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib20","doi-asserted-by":"crossref","first-page":"8582","DOI":"10.1128\/JVI.00937-13","article-title":"Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice","volume":"87","author":"Gardner","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41586-024-07740-2","article-title":"Shifts in receptors during submergence of an encephalitic arbovirus","volume":"632","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114809_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02731-19","article-title":"Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry","volume":"11","author":"Salimi","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114809_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.78.1.1-8.2004","article-title":"Generation and characterization of closely related epizootic and enzootic infectious cDNA clones for studying interferon sensitivity and emergence mechanisms of Venezuelan equine encephalitis virus","volume":"78","author":"Anishchenko","year":"2004","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/v15010005","article-title":"In\u00a0vitro and in\u00a0vivo phenotypes of Venezuelan, eastern and western equine encephalitis viruses derived from cDNA clones of human isolates","volume":"15","author":"Gardner","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2024.114809_bib25","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1128\/JVI.02990-13","article-title":"Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease","volume":"88","author":"Sun","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0042-6822(91)90584-X","article-title":"Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus","volume":"182","author":"Kuhn","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2024.114809_bib27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/JVI.80.2.737-749.2006","article-title":"Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis","volume":"80","author":"Morrison","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114809_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.celrep.2024.114809_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/2041-210X.12628","article-title":"Ggtree: An r package for visualization and annotation of phylogenetic trees with their covariates and other associated data","volume":"8","author":"Yu","year":"2017","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.celrep.2024.114809_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001805","article-title":"LRRC15 inhibits SARS-CoV-2 cellular entry in trans","volume":"20","author":"Song","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2024.114809_bib31","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41467-018-07901-8","article-title":"Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities","volume":"9","author":"Sanson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114809_bib32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114809_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s13059-015-0843-6","article-title":"Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR","volume":"16","author":"Li","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114809_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav3113","article-title":"A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates","volume":"11","author":"Ko","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114809_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade8273","article-title":"A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans","volume":"15","author":"Raju","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114809_bib36","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212532","article-title":"Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge","volume":"219","author":"Kafai","year":"2022","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.114809_bib37","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2015.10.050","article-title":"Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress","volume":"163","author":"Fox","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114809_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008061","article-title":"Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins","volume":"15","author":"Quiroz","year":"2019","journal-title":"PLoS Pathog."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724011604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724011604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T14:32:15Z","timestamp":1746109935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724011604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2211124724011604"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114809","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114809"}}