{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:37:23Z","timestamp":1790714243327,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220530141013030"],"award-info":[{"award-number":["JCYJ20220530141013030"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804400"],"award-info":[{"award-number":["2020YFA0804400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["2020SDUCRCC021"],"award-info":[{"award-number":["2020SDUCRCC021"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170790"],"award-info":[{"award-number":["82170790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071854"],"award-info":[{"award-number":["82071854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370767"],"award-info":[{"award-number":["82370767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470791"],"award-info":[{"award-number":["82470791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82321002"],"award-info":[{"award-number":["82321002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200866"],"award-info":[{"award-number":["82200866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.celrep.2024.114859","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T23:42:16Z","timestamp":1729035736000},"page":"114859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["ILC2-derived CGRP triggers acute inflammation and nociceptive responses in bacterial cystitis"],"prefix":"10.1016","volume":"43","author":[{"given":"Zizhuo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinrui","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benkang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-3037","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114859_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Flores-Mireles","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2024.114859_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41579-020-0324-0","article-title":"Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies","volume":"18","author":"Klein","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2024.114859_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev-immunol-101220-032117","article-title":"Tissue Immunity in the Bladder","volume":"40","author":"Bowyer","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.it.2023.07.001","article-title":"Immune defenses in the urinary tract","volume":"44","author":"Kuhn","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nri3887","article-title":"The nature of immune responses to urinary tract infections","volume":"15","author":"Abraham","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib6","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate Lymphoid Cells: 10 Years On","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114859_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"Klose","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/304129a0","article-title":"Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing","volume":"304","author":"Rosenfeld","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114859_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2024.114859_bib10","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2024.114859_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2020.102697","article-title":"Morphological and neurochemical characterisation of anterogradely labelled spinal sensory and autonomic nerve endings in the mouse bladder","volume":"227","author":"Sharma","year":"2020","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.celrep.2024.114859_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ar.23937","article-title":"Innervation of the Epithelium and Lamina Propria of the Urethra of the Female Rat","volume":"302","author":"Eggermont","year":"2019","journal-title":"Anat. Rec."},{"key":"10.1016\/j.celrep.2024.114859_bib13","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/cne.24362","article-title":"Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice","volume":"526","author":"Spencer","year":"2018","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2024.114859_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1006903507321","article-title":"Distribution of afferent axons in the bladder of rats","volume":"27","author":"Gabella","year":"1998","journal-title":"J.\u00a0Neurocytol."},{"key":"10.1016\/j.celrep.2024.114859_bib15","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2147\/JIR.S356960","article-title":"Nociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections","volume":"15","author":"Gao","year":"2022","journal-title":"J.\u00a0Inflamm. Res."},{"key":"10.1016\/j.celrep.2024.114859_bib16","doi-asserted-by":"crossref","first-page":"F779","DOI":"10.1152\/ajprenal.00217.2023","article-title":"Antinociceptive effect of the calcitonin gene-related peptide receptor antagonist BIBN4096BS in mice with bacterial cystitis","volume":"325","author":"Montalbetti","year":"2023","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.celrep.2024.114859_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00383-002-0937-6","article-title":"Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction","volume":"19","author":"Chertin","year":"2003","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.celrep.2024.114859_bib18","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114859_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-023-05753-x","article-title":"Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion","volume":"615","author":"Pinho-Ribeiro","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114859_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/physrev.00030.2012","article-title":"Urothelial signaling","volume":"93","author":"Birder","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2024.114859_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114859_bib22","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114859_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain","volume":"2","author":"Cao","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib24","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1038\/s41467-023-40993-5","article-title":"A tissue-intrinsic IL-33\/EGF circuit promotes epithelial regeneration after intestinal injury","volume":"14","author":"Calafiore","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114859_bib25","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1038\/s41467-022-33171-6","article-title":"Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis","volume":"13","author":"Fujimoto","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114859_bib26","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1681\/ASN.2019040335","article-title":"Single-Cell Transcriptomic Map of the Human and Mouse Bladders","volume":"30","author":"Yu","year":"2019","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2024.114859_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cellimm.2018.01.018","article-title":"Bladder resident macrophages: Mucosal sentinels","volume":"330","author":"Lacerda Mariano","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib28","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.4049\/jimmunol.181.8.5579","article-title":"CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection","volume":"181","author":"Engel","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib29","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1086\/315006","article-title":"Neutrophil recruitment and resistance to urinary tract infection","volume":"180","author":"Haraoka","year":"1999","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114859_bib30","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/j.1462-5822.2008.01230.x","article-title":"G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity","volume":"10","author":"Ingersoll","year":"2008","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.celrep.2024.114859_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005044","article-title":"Macrophages Subvert Adaptive Immunity to Urinary Tract Infection","volume":"11","author":"Mora-Bau","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2024.114859_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc5739","article-title":"Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder","volume":"6","author":"Lacerda Mariano","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114859_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coph.2008.12.007","article-title":"CGRP receptors in the control of pain and inflammation","volume":"9","author":"Benemei","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.celrep.2024.114859_bib34","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/01.CCM.0000134404.63292.71","article-title":"Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes","volume":"32","author":"Linscheid","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.celrep.2024.114859_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-5728(02)00221-7","article-title":"Production and secretion of calcitonin gene-related peptide from human lymphocytes","volume":"130","author":"Wang","year":"2002","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.celrep.2024.114859_bib36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2310\/6650.2001.33628","article-title":"Calcitonin gene-related peptide expression in sepsis: postulation of microbial infection-specific response elements within the calcitonin I gene promoter","volume":"49","author":"Domenech","year":"2001","journal-title":"J.\u00a0Investig. Med."},{"key":"10.1016\/j.celrep.2024.114859_bib37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.immuni.2018.06.002","article-title":"Why Innate Lymphoid Cells?","volume":"48","author":"Kotas","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib38","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ni.3481","article-title":"Development of innate lymphoid cells","volume":"17","author":"Zook","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103303","article-title":"Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder","volume":"9","author":"Huang","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2024.114859_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104660","article-title":"Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence","volume":"25","author":"Riding","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2024.114859_bib41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.it.2022.09.006","article-title":"Neuro-epithelial-ILC2 crosstalk in barrier tissues","volume":"43","author":"Yin","year":"2022","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867351","article-title":"Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology","volume":"13","author":"Sunaga","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib43","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.immuni.2015.06.006","article-title":"Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation","volume":"42","author":"Molofsky","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib44","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1128\/IAI.00315-16","article-title":"Lipopolysaccharide Domains Modulate Urovirulence","volume":"84","author":"Aguiniga","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2024.114859_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnins.2014.00023","article-title":"Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis","volume":"8","author":"Assas","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.114859_bib46","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2018.04.006","article-title":"Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection","volume":"173","author":"Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114859_bib47","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.immuni.2019.06.009","article-title":"Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation","volume":"51","author":"Nagashima","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib48","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.immuni.2019.09.005","article-title":"Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses","volume":"51","author":"Wallrapp","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib49","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.immuni.2019.09.004","article-title":"Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide \u03b1-CGRP Modulates Group 2 Innate Lymphoid Cell Responses","volume":"51","author":"Xu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbi.2022.09.008","article-title":"Dorsal root ganglia CX3CR1 expressing monocytes\/macrophages contribute to arthritis pain","volume":"106","author":"Oggero","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2024.114859_bib51","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/JLB.4CE0917-382R","article-title":"Trans-mission control in the urinary tract: Local cytokine regulation of monocyte proliferation to combat infection","volume":"103","author":"Ligon","year":"2018","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2024.114859_bib52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ebiom.2014.10.011","article-title":"Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis","volume":"1","author":"Hannan","year":"2014","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2024.114859_bib53","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2014.01.006","article-title":"Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium","volume":"156","author":"Schiwon","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114859_bib54","first-page":"1287","article-title":"Role of PTHrP and Sensory Nerve Peptides in Regulating Contractility of Muscularis Mucosae and Detrusor Smooth Muscle in the Guinea Pig Bladder","volume":"196","author":"Lee","year":"2016","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.celrep.2024.114859_bib55","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/0306-4522(94)90361-1","article-title":"Intraspinal release of immunoreactive calcitonin gene-related peptide during development of inflammation in the joint in\u00a0vivo--a study with antibody microprobes in cat and rat","volume":"62","author":"Schaible","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2024.114859_bib56","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0306-4522(89)90443-0","article-title":"Release of sensory neuropeptides in the spinal cord: studies with calcitonin gene-related peptide and\u00a0galanin","volume":"31","author":"Morton","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2024.114859_bib57","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies - successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2024.114859_bib58","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0140-6736(19)32504-8","article-title":"Targeting calcitonin gene-related peptide: a new era in migraine therapy","volume":"394","author":"Charles","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2024.114859_bib59","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/nprot.2009.116","article-title":"A murine model of urinary tract infection","volume":"4","author":"Hung","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114859_bib60","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41590-020-0688-3","article-title":"A highly polarized T(H)2 bladder response to infection promotes epithelial repair at the expense of preventing new infections","volume":"21","author":"Wu","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib61","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abn4332","article-title":"Tissue-resident memory T\u00a0cells mediate mucosal immunity to recurrent urinary tract infection","volume":"8","author":"Rousseau","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2012.10.019","article-title":"Mast cell interleukin-10 drives localized tolerance in chronic bladder infection","volume":"38","author":"Chan","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114859_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adi5578","article-title":"Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity","volume":"9","author":"Hayes","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114859_bib64","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1590\/S1677-5538.IBJU.2014.0046","article-title":"Reliability and Validity of a Chinese Version of Urinary Tract Infection Symptom Assessment Questionnaire","volume":"41","author":"Chang","year":"2015","journal-title":"Int. Braz J. Urol."},{"key":"10.1016\/j.celrep.2024.114859_bib65","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1464-410X.2005.05630.x","article-title":"Validation of a patient-administered questionnaire to measure the severity and bothersomeness of lower urinary tract symptoms in uncomplicated urinary tract infection (UTI): the UTI Symptom Assessment questionnaire","volume":"96","author":"Clayson","year":"2005","journal-title":"BJU Int."},{"key":"10.1016\/j.celrep.2024.114859_bib66","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0304-3959(97)00134-6","article-title":"Sex, time-of-day and estrous variations in behavioral and bladder histological consequences of cyclophosphamide-induced cystitis in rats","volume":"73","author":"Bon","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2024.114859_bib67","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/nau.24205","article-title":"Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy","volume":"39","author":"Liu","year":"2020","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.celrep.2024.114859_bib68","first-page":"2440","article-title":"Nicotinic signaling ameliorates acute bladder inflammation induced by protamine sulfate or cyclophosphamide","volume":"179","author":"Starkman","year":"2008","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.celrep.2024.114859_bib69","doi-asserted-by":"crossref","first-page":"F1077","DOI":"10.1152\/ajprenal.00526.2017","article-title":"Endogenous H(2)S sensitizes PAR4-induced bladder pain","volume":"314","author":"Wang","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:47:29Z","timestamp":1762602449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724012105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2211124724012105"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114859","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ILC2-derived CGRP triggers acute inflammation and nociceptive responses in bacterial cystitis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114859"}}