{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:49:19Z","timestamp":1783694959024,"version":"3.55.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91857000"],"award-info":[{"award-number":["91857000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22327901"],"award-info":[{"award-number":["22327901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32021003"],"award-info":[{"award-number":["32021003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92354301"],"award-info":[{"award-number":["92354301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2019YFA0802701"],"award-info":[{"award-number":["2019YFA0802701"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2023ZD0508800"],"award-info":[{"award-number":["2023ZD0508800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.celrep.2024.114912","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T12:40:03Z","timestamp":1730119203000},"page":"114912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols"],"prefix":"10.1016","volume":"43","author":[{"given":"Mei-Yan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhuo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Liang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1535-3880","authenticated-orcid":false,"given":"Xiaolu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114912_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2019.06.008","article-title":"The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling","volume":"61","author":"Hu","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.molcel.2017.02.015","article-title":"Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling","volume":"66","author":"Xiao","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.114912_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41422-022-00622-0","article-title":"Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate","volume":"32","author":"Hu","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114912_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib6","doi-asserted-by":"crossref","first-page":"11029","DOI":"10.1002\/anie.201302886","article-title":"The concerted nature of the cyclization of squalene oxide to the protosterol cation","volume":"52","author":"Hess","year":"2013","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.celrep.2024.114912_bib7","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1021\/cr200021m","article-title":"Biosynthesis of cholesterol and other sterols","volume":"111","author":"Nes","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2024.114912_bib8","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1006\/bbrc.2001.2008","article-title":"Membrane-bound enzymes of cholesterol synthesis from lanosterol","volume":"292","author":"Gaylor","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.114912_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1194\/jlr.R009548","article-title":"Malformation syndromes caused by disorders of cholesterol synthesis","volume":"52","author":"Porter","year":"2011","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2024.114912_bib10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/cr.2008.61","article-title":"Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase","volume":"18","author":"DeBose-Boyd","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114912_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-biochem-062917-011852","article-title":"Retrospective on Cholesterol Homeostasis: The Central Role of Scap","volume":"87","author":"Brown","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2024.114912_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmet.2005.01.001","article-title":"Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol","volume":"1","author":"Song","year":"2005","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114912_bib13","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1194\/jlr.RA119000201","article-title":"Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing","volume":"60","author":"Chen","year":"2019","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2024.114912_bib14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2011.01.015","article-title":"Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase","volume":"13","author":"Gill","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.114912_bib15","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.M115.699546","article-title":"Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis","volume":"291","author":"Prabhu","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1097-010X(19991015)285:3<237::AID-JEZ6>3.0.CO;2-S","article-title":"Meiosis activating sterols (MAS) and fertility in mammals and man","volume":"285","author":"Byskov","year":"1999","journal-title":"J.\u00a0Exp. Zool."},{"key":"10.1016\/j.celrep.2024.114912_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0303-7207(01)00693-1","article-title":"Lanosterol 14alpha-demethylase and MAS sterols in mammalian gametogenesis","volume":"187","author":"Rozman","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.celrep.2024.114912_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41586-018-0360-3","article-title":"Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination","volume":"560","author":"Hubler","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41589-022-01115-2","article-title":"The landscape of targets and lead molecules for remyelination","volume":"18","author":"Caprariello","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1039\/D1CB00145K","article-title":"Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation","volume":"3","author":"Pleshinger","year":"2022","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-023-06878-9","article-title":"7-Dehydrocholesterol is an endogenous suppressor of ferroptosis","volume":"626","author":"Freitas","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41586-023-06983-9","article-title":"7-Dehydrocholesterol dictates ferroptosis sensitivity","volume":"626","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib23","doi-asserted-by":"crossref","first-page":"16927","DOI":"10.1074\/jbc.271.28.16927","article-title":"Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue","volume":"271","author":"Li","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24030451","article-title":"Metabolism and Biological Activities of\u00a04-Methyl-Sterols","volume":"24","author":"Darnet","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.celrep.2024.114912_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100362","article-title":"Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6","volume":"64","author":"Qian","year":"2023","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2024.114912_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1073\/pnas.93.1.186","article-title":"Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase","volume":"93","author":"Bard","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114912_bib27","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1016\/S0021-9258(18)91979-4","article-title":"Investigation of the component reactions of oxidative sterol demethylation. Evidence against participation of cytochrome P-450","volume":"243","author":"Gaylor","year":"1968","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib28","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1016\/S0021-9258(18)62764-4","article-title":"Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4 alpha-methyl sterol to a 4 alpha-carboxylic acid during cholesterol biosynthesis","volume":"245","author":"Miller","year":"1970","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2013.10.009","article-title":"The role of sterol-C4-methyl oxidase in epidermal biology","volume":"1841","author":"He","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2024.114912_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ymgme.2017.06.013","article-title":"A rare case of sterol-C4-methyl oxidase deficiency in a young Italian male: Biochemical and molecular characterization","volume":"121","author":"Frisso","year":"2017","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.celrep.2024.114912_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/MCD.0000000000000461","article-title":"MSMO1 deficiency: a potentially partially treatable, ultrarare neurodevelopmental disorder with psoriasiform dermatitis, alopecia and polydactyly","volume":"32","author":"Tkemaladze","year":"2023","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.celrep.2024.114912_bib32","doi-asserted-by":"crossref","first-page":"31385","DOI":"10.1074\/jbc.M803496200","article-title":"Defining the in\u00a0Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5","volume":"283","author":"Finn","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1124\/mol.110.064246","article-title":"Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism","volume":"78","author":"McLaughlin","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2024.114912_bib34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature14549","article-title":"X-ray structure of a mammalian stearoyl-CoA desaturase","volume":"524","author":"Bai","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jsbmb.2014.11.024","article-title":"Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms","volume":"151","author":"Storbeck","year":"2015","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib36","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1016\/S0021-9258(19)69327-0","article-title":"Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase","volume":"256","author":"Fukushima","year":"1981","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11248-010-9426-1","article-title":"Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis","volume":"20","author":"Finn","year":"2011","journal-title":"Transgenic Res."},{"key":"10.1016\/j.celrep.2024.114912_bib38","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s11745-015-4065-1","article-title":"Electron Transfer Pathways in Cholesterol Synthesis","volume":"50","author":"Porter","year":"2015","journal-title":"Lipids"},{"key":"10.1016\/j.celrep.2024.114912_bib39","doi-asserted-by":"crossref","first-page":"21204","DOI":"10.1074\/jbc.M301698200","article-title":"Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells","volume":"278","author":"Ogishima","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib40","doi-asserted-by":"crossref","first-page":"20228","DOI":"10.1074\/jbc.M113.474916","article-title":"The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells","volume":"288","author":"Plitzko","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ab.2011.11.015","article-title":"A micropreparation of mitochondria from cells using magnetic beads with immunoaffinity","volume":"421","author":"Ru","year":"2012","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.celrep.2024.114912_bib42","doi-asserted-by":"crossref","first-page":"31097","DOI":"10.1074\/jbc.273.47.31097","article-title":"Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5","volume":"273","author":"Kuroda","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/bbrc.2001.5375","article-title":"Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis","volume":"286","author":"Sakakura","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.114912_bib44","doi-asserted-by":"crossref","first-page":"18707","DOI":"10.1074\/jbc.R113.479808","article-title":"Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)","volume":"288","author":"Sharpe","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0163-7827(01)00010-8","article-title":"Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes","volume":"40","author":"Shimano","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.celrep.2024.114912_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4939-9136-5_11","article-title":"Intracellular and Plasma Membrane Cholesterol Labeling and Quantification Using Filipin and GFP-D4","volume":"1949","author":"Wilhelm","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib47","doi-asserted-by":"crossref","first-page":"43668","DOI":"10.1074\/jbc.M111.313643","article-title":"Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism","volume":"286","author":"Thomas","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.cellbio.16.1.459","article-title":"The role of orphan nuclear receptors in the regulation of cholesterol homeostasis","volume":"16","author":"Repa","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2024.114912_bib49","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1073\/pnas.95.11.5987","article-title":"Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice","volume":"95","author":"Horton","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114912_bib50","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41586-020-2928-y","article-title":"Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib51","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1021\/bi2004729","article-title":"Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between beta-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5","volume":"50","author":"Parthasarathy","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2024.114912_bib52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1159\/000511126","article-title":"New Homozygous Missense MSMO1 Mutation in Two Siblings with SC4MOL Deficiency Presenting with Psoriasiform Dermatitis","volume":"160","author":"Kalay Yildizhan","year":"2020","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.celrep.2024.114912_bib53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0022-2275(20)30190-5","article-title":"Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS)","volume":"43","author":"Tacer","year":"2002","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.celrep.2024.114912_bib54","first-page":"1","article-title":"Sterols from the Post-Lanosterol Part of Cholesterol Synthesis: Novel Signaling Players","author":"Skubic","year":"2020","journal-title":"Mammalian Sterols"},{"key":"10.1016\/j.celrep.2024.114912_bib55","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1016\/S0021-9258(18)61979-9","article-title":"Investigation of the component reactions of oxidative demethylation of sterols. Metabolism of 4 -hydroxymethyl steroids","volume":"246","author":"Miller","year":"1971","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/ed079p377","article-title":"Cholesterol Biosynthesis: Lanosterol to Cholesterol","volume":"79","author":"Risley","year":"2002","journal-title":"J.\u00a0Chem. Educ."},{"key":"10.1016\/j.celrep.2024.114912_bib57","article-title":"Generation and validation of a conditional knockout mouse model for desmosterolosis","volume":"62","author":"Kanuri","year":"2021","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2024.114912_bib58","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07999","article-title":"Flux analysis of cholesterol biosynthesis in\u00a0vivo reveals multiple tissue and cell-type specific pathways","volume":"4","author":"Mitsche","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.114912_bib59","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/374559a0","article-title":"Chemical structure of sterols that activate oocyte meiosis","volume":"374","author":"Byskov","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114912_bib60","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1016\/S0021-9258(18)47983-5","article-title":"Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver","volume":"262","author":"Reinhart","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114912_bib61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbrc.2011.12.022","article-title":"The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria","volume":"417","author":"Fujimoto","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.114912_bib62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.livres.2018.12.001","article-title":"Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2","volume":"2","author":"Lee","year":"2018","journal-title":"Liver Res."},{"key":"10.1016\/j.celrep.2024.114912_bib63","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/09168451.2018.1559719","article-title":"RNA-Seq analysis reveals a negative role of MSMO1 with a synergized NSDHL expression during adipogenesis of 3T3-L1","volume":"83","author":"Xin","year":"2019","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.celrep.2024.114912_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.103059","article-title":"Selective PPAR\u03b3 modulator diosmin improves insulin sensitivity and promotes browning of white fat","volume":"299","author":"Yu","year":"2023","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:06:56Z","timestamp":1778843216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724012634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2211124724012634"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114912","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114912"}}