{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:21:16Z","timestamp":1790302876711,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93019C00051"],"award-info":[{"award-number":["75N93019C00051"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI168178"],"award-info":[{"award-number":["R01AI168178"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93021C00014"],"award-info":[{"award-number":["75N93021C00014"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["G20AI174733"],"award-info":[{"award-number":["G20AI174733"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["75N91021F00001"],"award-info":[{"award-number":["75N91021F00001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["SF349247"],"award-info":[{"award-number":["SF349247"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["U24 GM129539"],"award-info":[{"award-number":["U24 GM129539"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020105","name":"VIVA Foundation for Children with Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["S10OD026880"],"award-info":[{"award-number":["S10OD026880"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["S10OD030463"],"award-info":[{"award-number":["S10OD030463"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/05661-1"],"award-info":[{"award-number":["2021\/05661-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/08943-5"],"award-info":[{"award-number":["2020\/08943-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/02345-7"],"award-info":[{"award-number":["2023\/02345-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.celrep.2024.114922","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T09:14:12Z","timestamp":1730798052000},"page":"114922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination"],"prefix":"10.1016","volume":"43","author":[{"given":"Jordan J.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Hoxie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Adelsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iden A.","family":"Sapse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Andreata-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Amanat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnstone","family":"Tcheou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gonz\u00e1lez-Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Bournazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Carre\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Ellebedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Bajic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-776X","authenticated-orcid":false,"given":"Florian","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114922_bib1","series-title":"The pandemic\u2019s true death toll","year":"2023"},{"key":"10.1016\/j.celrep.2024.114922_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00281-023-00996-2","article-title":"The role of vaccines in the COVID-19 pandemic: what have we learned?","volume":"45","author":"Krammer","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.celrep.2024.114922_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41564-020-0688-y","article-title":"Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses","volume":"5","author":"Letko","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2024.114922_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-020-2349-y","article-title":"Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody","volume":"583","author":"Pinto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.abe3354","article-title":"Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms","volume":"370","author":"Tortorici","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib7","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.cell.2021.03.028","article-title":"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2","volume":"184","author":"McCallum","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41586-021-03817-4","article-title":"Broad sarbecovirus neutralization by a human monoclonal antibody","volume":"597","author":"Tortorici","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.abq2679","article-title":"ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies","volume":"377","author":"Low","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib10","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.cell.2021.06.005","article-title":"SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2","volume":"184","author":"Amanat","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.abm3425","article-title":"Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial","volume":"375","author":"Gilbert","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41591-021-01377-8","article-title":"Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection","volume":"27","author":"Khoury","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib13","series-title":"Correlates of Protection Against SARS CoV-2 Infection and Covid 19 Disease","author":"Goldblatt","year":"2022"},{"key":"10.1016\/j.celrep.2024.114922_bib14","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1016\/j.vaccine.2021.05.063","article-title":"Evidence for antibody as a protective correlate for COVID-19 vaccines","volume":"39","author":"Earle","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2024.114922_bib15","article-title":"The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD","author":"Amanat","year":"2021","journal-title":"MedRxiv"},{"key":"10.1016\/j.celrep.2024.114922_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-076892","article-title":"Protection of the third-dose and fourth-dose mRNA vaccines against SARS-CoV-2 Omicron subvariant: a systematic review and meta-analysis","volume":"13","author":"Rahman","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.celrep.2024.114922_bib17","article-title":"Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study","volume":"30","author":"Vikstr\u00f6m","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"10.1016\/j.celrep.2024.114922_bib18","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1182\/blood-2012-01-380121","article-title":"Properties of mouse and human IgG receptors and their contribution to disease models","volume":"119","author":"Bruhns","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2024.114922_bib19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molimm.2004.07.034","article-title":"Activation of NK cell cytotoxicity","volume":"42","author":"Smyth","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fimmu.2019.00332","article-title":"Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses","volume":"10","author":"Tay","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib21","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ni.3858","article-title":"Novel mechanisms and functions of complement","volume":"18","author":"Hajishengallis","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or Adaptive Immunity? The Example of Natural Killer Cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep34310","article-title":"CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes","volume":"6","author":"Yeap","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114922_bib24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.immuni.2020.07.020","article-title":"Distinct Early Serological Signatures Track with SARS-CoV-2 Survival","volume":"53","author":"Atyeo","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2024.114922_bib25","doi-asserted-by":"crossref","DOI":"10.1101\/2021.10.14.464464","article-title":"Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2","volume":"12","author":"Bahnan","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5629","article-title":"Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality","volume":"7","author":"Brunet-Ratnasingham","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114922_bib27","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201993","article-title":"Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in\u00a0vivo","volume":"218","author":"Sch\u00e4fer","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib28","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.cell.2021.02.026","article-title":"Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection","volume":"184","author":"Winkler","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib29","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.cell.2020.10.052","article-title":"Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality","volume":"183","author":"Zohar","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03580-21","article-title":"Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain","volume":"13","author":"Altomare","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114922_bib31","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.cell.2020.09.050","article-title":"A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice","volume":"183","author":"Leist","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ade0958","article-title":"Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein","volume":"8","author":"Bianchini","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/vaccines8040771","article-title":"A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine","volume":"8","author":"Sun","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.celrep.2024.114922_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260954","article-title":"Fc-engineered antibodies with immune effector functions completely abolished","volume":"16","author":"Wilkinson","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114922_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01296","article-title":"Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life","volume":"10","author":"Saunders","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib36","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S2213-2600(21)00220-4","article-title":"BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: a prospective, single-centre, longitudinal cohort study in health-care workers","volume":"9","author":"Lustig","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2020.12.015","article-title":"COVID-19-neutralizing antibodies predict disease severity and survival","volume":"184","author":"Garcia-Beltran","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.02107-20","article-title":"Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate","volume":"58","author":"Addetia","year":"2020","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.celrep.2024.114922_bib39","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1038\/s41596-020-0394-5","article-title":"Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay","volume":"15","author":"Nie","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114922_bib40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2018.07.009","article-title":"A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus","volume":"24","author":"Gunn","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114922_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abm3151","article-title":"Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection","volume":"14","author":"Dias","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib42","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41590-018-0233-9","article-title":"Antibody-mediated protection against Ebola virus","volume":"19","author":"Saphire","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib43","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.chom.2016.05.014","article-title":"Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection","volume":"19","author":"Henry Dunand","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2024.114922_bib44","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2014.08.023","article-title":"Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In\u00a0Vivo Activity","volume":"158","author":"Bournazos","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib45","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1172\/JCI84428","article-title":"Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in\u00a0vivo protection","volume":"126","author":"DiLillo","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114922_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92750","article-title":"Fc functional antibodies in humans with severe H7N9 and seasonal influenza","volume":"2","author":"Vanderven","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2024.114922_bib47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature06106","article-title":"Fc receptor but not complement binding is important in antibody protection against HIV","volume":"449","author":"Hessell","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib48","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1222908","article-title":"Highly Conserved Protective Epitopes on Influenza B Viruses","volume":"337","author":"Dreyfus","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01603-17","article-title":"In\u00a0Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice","volume":"91","author":"Sutton","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2024.114922_bib50","doi-asserted-by":"crossref","first-page":"eabj6824","DOI":"10.1126\/scitranslmed.abj6824","article-title":"Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T\u00a0cell immunity","volume":"14","author":"Riou","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03617-21","article-title":"Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8+ T-Cell Epitopes Identified in COVID-19 Convalescent Individuals","volume":"13","author":"Redd","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114922_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abj1750","article-title":"SARS-CoV-2 variants of concern partially escape humoral but not T\u00a0cell responses in COVID-19 convalescent donors and vaccine recipients","volume":"6","author":"Geers","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib53","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41423-022-00838-5","article-title":"T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant","volume":"19","author":"Choi","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib54","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41586-022-04460-3","article-title":"T cell responses to SARS-CoV-2 spike cross-recognize Omicron","volume":"603","author":"Keeton","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib55","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1016\/S0021-9258(17)37050-3","article-title":"Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells","volume":"269","author":"Ghazizadeh","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114922_bib56","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.180.3.1165","article-title":"Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn","volume":"180","author":"Wang","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib57","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1126\/science.1837175","article-title":"Regulation of Phagocytosis and [Ca2+]i Flux by Distinct Regions of an Fc Receptor","volume":"254","author":"Odin","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4049\/jimmunol.150.2.605","article-title":"Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45","volume":"150","author":"Rankin","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2024.114922_bib60","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nri2620","article-title":"Complement regulators and inhibitory proteins","volume":"9","author":"Zipfel","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1615\/CritRevImmunol.v30.i1.30","article-title":"Role of Complement in Innate Immunity and Infections","volume":"30","author":"Daha","year":"2010","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib62","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.4049\/jimmunol.147.8.2657","article-title":"Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG","volume":"147","author":"Lund","year":"1991","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib63","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1074\/jbc.M116.767749","article-title":"Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice","volume":"292","author":"Lo","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114922_bib64","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/s12276-022-00870-5","article-title":"An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies","volume":"54","author":"Ko","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13550-023-01030-0","article-title":"Fc-engineered monoclonal antibodies to reduce off-target liver uptake","volume":"13","author":"Mangeat","year":"2023","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.celrep.2024.114922_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282147","article-title":"LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity","volume":"18","author":"Mausser","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.114922_bib67","doi-asserted-by":"crossref","first-page":"20054","DOI":"10.1073\/pnas.1911842116","article-title":"Differential requirements for Fc\u03b3R engagement by protective antibodies against Ebola virus","volume":"116","author":"Bournazos","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114922_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15092","article-title":"Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains","volume":"8","author":"Yuan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114922_bib69","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02250-23","article-title":"The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera","volume":"15","author":"Singh","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114922_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19993-w","article-title":"Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells","volume":"12","author":"Shimizu","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.114922_bib71","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1038\/s41467-020-19568-1","article-title":"Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114922_bib72","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1016\/j.cell.2021.06.021","article-title":"In\u00a0vitro and in\u00a0vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies","volume":"184","author":"Li","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib73","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1016\/j.cell.2021.05.032","article-title":"An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies","volume":"184","author":"Liu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib74","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/19420862.2017.1323159","article-title":"Affinity of human IgG subclasses to mouse Fc gamma receptors","volume":"9","author":"Dekkers","year":"2017","journal-title":"mAbs"},{"key":"10.1016\/j.celrep.2024.114922_bib75","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-021-04017-w","article-title":"Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy","volume":"599","author":"Yamin","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib76","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.4049\/jimmunol.177.6.3848","article-title":"IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions","volume":"177","author":"Rogers","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib77","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.1203954109","article-title":"Mouse model recapitulating human Fc\u03b3 receptor structural and functional diversity","volume":"109","author":"Smith","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114922_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad354","article-title":"Intramuscular vs Intravenous SARS-CoV-2 Neutralizing Antibody Sotrovimab for Treatment of COVID-19 (COMET-TAIL): A Randomized Noninferiority Clinical Trial","volume":"10","author":"Shapiro","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.celrep.2024.114922_bib79","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1056\/NEJMoa2109682","article-title":"Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19","volume":"385","author":"O\u2019Brien","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib80","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2102685","article-title":"Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19","volume":"385","author":"Michael","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105638","article-title":"Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model","volume":"215","author":"Driouich","year":"2023","journal-title":"Antivir. Res."},{"key":"10.1016\/j.celrep.2024.114922_bib82","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1016\/j.cell.2021.06.002","article-title":"The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies","volume":"184","author":"Copin","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114922_bib83","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00350-21","article-title":"Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study","volume":"65","author":"Wu","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.celrep.2024.114922_bib84","doi-asserted-by":"crossref","first-page":"e569","DOI":"10.1016\/S2666-5247(23)00118-0","article-title":"Bivalent COVID-19 booster vaccines and the absence of BA.5-specific antibodies","volume":"4","author":"Carre\u00f1o","year":"2023","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.celrep.2024.114922_bib85","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ni.3684","article-title":"Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins","volume":"18","author":"Nachbagauer","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2024.114922_bib86","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1002\/cpmc.100","article-title":"SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup","volume":"57","author":"Stadlbauer","year":"2020","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.celrep.2024.114922_bib87","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41591-020-0913-5","article-title":"A serological assay to detect SARS-CoV-2 seroconversion in humans","volume":"26","author":"Amanat","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2024.114922_bib88","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-022-04399-5","article-title":"Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron","volume":"602","author":"Carre\u00f1o","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114922_bib89","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01908-21","article-title":"Safety and Immunogenicity of a Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate, AVX\/COVID-12-HEXAPRO (Patria), in Pigs","volume":"12","author":"Lara-Puente","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2024.114922_bib90","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","article-title":"Structure-based design of prefusion-stabilized SARS-CoV-2 spikes","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114922_bib91","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.114922_bib92","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.celrep.2024.114922_bib100","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s42003-021-02399-1","article-title":"DeepEMhancer: a deep learning solution for cryo-EM volume post-processing","volume":"4","author":"Sanchez-Garcia","year":"2021","journal-title":"Communications biology"},{"key":"10.1016\/j.celrep.2024.114922_bib93","doi-asserted-by":"crossref","first-page":"W474","DOI":"10.1093\/nar\/gkw361","article-title":"SAbPred: a structure-based antibody prediction server","volume":"44","author":"Dunbar","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.114922_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: Tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2024.114922_bib95","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2024.114922_bib96","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nsmb.3115","article-title":"Privateer: software for the conformational validation of carbohydrate structures","volume":"22","author":"Agirre","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2024.114922_bib97","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.celrep.2024.114922_bib98","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2024.114922_bib99","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01456","article-title":"Collaboration gets the most out of software","volume":"2","author":"Morin","year":"2013","journal-title":"Elife"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012737?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724012737?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:03:56Z","timestamp":1778843036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724012737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":100,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2211124724012737"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114922","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.28.582613","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114922"}}