{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:05:33Z","timestamp":1786986333867,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023ZYD0057"],"award-info":[{"award-number":["2023ZYD0057"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023NSFSC1904"],"award-info":[{"award-number":["2023NSFSC1904"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732434"],"award-info":[{"award-number":["2023M732434"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732457"],"award-info":[{"award-number":["2023M732457"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011501","name":"Qinghai Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023-ZJ-791"],"award-info":[{"award-number":["2023-ZJ-791"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303317"],"award-info":[{"award-number":["82303317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170171"],"award-info":[{"award-number":["82170171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2221004"],"award-info":[{"award-number":["T2221004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472783"],"award-info":[{"award-number":["82472783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130007"],"award-info":[{"award-number":["82130007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000514"],"award-info":[{"award-number":["82000514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330087"],"award-info":[{"award-number":["82330087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170675"],"award-info":[{"award-number":["82170675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21011"],"award-info":[{"award-number":["ZYJC21011"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD22012"],"award-info":[{"award-number":["ZYGD22012"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21003"],"award-info":[{"award-number":["ZYJC21003"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.celrep.2024.114952","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T04:57:17Z","timestamp":1731214637000},"page":"114952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis"],"prefix":"10.1016","volume":"43","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runda","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongkai","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6787-0495","authenticated-orcid":false,"given":"Chong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.114952_bib1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1053\/j.gastro.2016.01.035","article-title":"Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population","volume":"150","author":"Sawada","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(12)60643-6","article-title":"Oesophageal carcinoma","volume":"381","author":"Pennathur","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2024.114952_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ng.3076","article-title":"Genetic landscape of esophageal squamous cell carcinoma","volume":"46","author":"Gao","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114952_bib5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ajhg.2015.12.013","article-title":"Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma","volume":"98","author":"Cheng","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib6","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41422-020-0333-6","article-title":"Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma","volume":"30","author":"Cui","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.114952_bib7","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1158\/2159-8290.CD-12-0189","article-title":"Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma","volume":"2","author":"Agrawal","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2024.114952_bib8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ng.2935","article-title":"Genomic and molecular characterization of esophageal squamous cell carcinoma","volume":"46","author":"Lin","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1126\/science.aau3879","article-title":"Somatic mutant clones colonize the human esophagus with age","volume":"362","author":"Martincorena","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114952_bib10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41588-020-0624-3","article-title":"Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium","volume":"52","author":"Colom","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib11","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/s41467-020-16245-1","article-title":"Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties","volume":"11","author":"Nakayama","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114952_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41588-022-01280-z","article-title":"Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth","volume":"55","author":"Abby","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112757","article-title":"Genetically engineered mouse models of esophageal cancer","volume":"406","author":"Mahmoudian","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2024.114952_bib14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI0215324","article-title":"A mouse model of human oral-esophageal cancer","volume":"110","author":"Opitz","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.celrep.2024.114952_bib15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s43018-022-00361-6","article-title":"KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming","volume":"3","author":"Na","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2024.114952_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111482","article-title":"Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice","volume":"41","author":"Lu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.114952_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature14415","article-title":"Sequential cancer mutations in cultured human intestinal stem cells","volume":"521","author":"Drost","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114952_bib18","article-title":"A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2024.114952_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/1319-3767.203366","article-title":"Early squamous neoplasia of the esophagus: The endoscopic approach to diagnosis and management","volume":"23","author":"Kandiah","year":"2017","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.celrep.2024.114952_bib20","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1053\/j.gastro.2015.08.054","article-title":"Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma","volume":"149","author":"Ohashi","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib21","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","article-title":"Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm","volume":"134","author":"Que","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2024.114952_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ccell.2018.03.007","article-title":"Genomic and Functional Approaches to Understanding Cancer Aneuploidy","volume":"33","author":"Taylor","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114952_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2024.114952_bib24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGFbeta signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114952_bib25","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1038\/s41596-020-0379-4","article-title":"Establishment of patient-derived cancer organoids for drug-screening applications","volume":"15","author":"Driehuis","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.114952_bib26","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1158\/2159-8290.CD-20-1109","article-title":"A CRISPR\/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation","volume":"11","author":"Lo","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2024.114952_bib27","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ccell.2022.08.010","article-title":"Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer","volume":"40","author":"Wang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114952_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq6146","article-title":"Generation and multiomic profiling of a TP53\/CDKN2A double-knockout gastroesophageal junction organoid model","volume":"14","author":"Zhao","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.114952_bib29","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/j.gastro.2023.05.030","article-title":"Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion","volume":"165","author":"Ko","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41588-021-00859-2","article-title":"Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence","volume":"53","author":"Wu","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2024.114952_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2011.12.004","article-title":"Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia","volume":"21","author":"Quante","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114952_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1158\/1078-0432.CCR-0999-3","article-title":"Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice","volume":"10","author":"Tang","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2024.114952_bib33","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1053\/j.gastro.2010.08.048","article-title":"Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice","volume":"139","author":"Tetreault","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/j.gastro.2010.03.048","article-title":"Esophageal squamous cell dysplasia and delayed differentiation with deletion of kruppel-like factor 4 in murine esophagus","volume":"139","author":"Tetreault","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib35","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3892\/ijo.2012.1669","article-title":"Function and cancer genomics of FAT family genes (review)","volume":"41","author":"Katoh","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.celrep.2024.114952_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ccell.2022.11.015","article-title":"KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition","volume":"41","author":"Pan","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.114952_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4618","article-title":"KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer","volume":"8","author":"Kim","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.114952_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2024.114952_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-pathol-052016-100127","article-title":"The Varied Roles of Notch in Cancer","volume":"12","author":"Aster","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.celrep.2024.114952_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrc.2016.145","article-title":"Notch as a tumour suppressor","volume":"17","author":"Nowell","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2024.114952_bib41","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2022.02.015","article-title":"Spatial CRISPR genomics identifies regulators of the tumor microenvironment","volume":"185","author":"Dhainaut","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.114952_bib42","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1158\/0008-5472.CAN-19-0161","article-title":"Dysregulated Tgfbr2\/ERK-Smad4\/SOX2 Signaling Promotes Lung Squamous Cell Carcinoma Formation","volume":"79","author":"Wang","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.114952_bib43","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1158\/0008-5472.CAN-17-3303","article-title":"Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer","volume":"78","author":"Sakai","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.114952_bib44","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature25459","article-title":"Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes","volume":"554","author":"Mueller","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.114952_bib45","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1038\/onc.2014.258","article-title":"TGF-beta signaling alters the pattern of liver tumorigenesis induced by Pten inactivation","volume":"34","author":"Morris","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2024.114952_bib46","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1158\/0008-5472.CAN-07-5597","article-title":"Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment","volume":"68","author":"Bierie","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2024.114952_bib47","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1090922","article-title":"TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia","volume":"303","author":"Bhowmick","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.114952_bib48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41580-018-0007-0","article-title":"Contextual determinants of TGFbeta action in development, immunity and cancer","volume":"19","author":"David","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.114952_bib49","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.13.7.804","article-title":"A mechanism of repression of TGFbeta\/Smad signaling by oncogenic Ras","volume":"13","author":"Kretzschmar","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.114952_bib50","doi-asserted-by":"crossref","first-page":"37413","DOI":"10.1074\/jbc.274.52.37413","article-title":"Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription","volume":"274","author":"Engel","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2024.114952_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14677","article-title":"Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development","volume":"8","author":"Tang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.114952_bib52","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1053\/j.gastro.2019.01.263","article-title":"Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-beta and JNK Signaling Pathways in Esophageal Cancer","volume":"156","author":"Blum","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.114952_bib53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/hep.24653","article-title":"Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss","volume":"55","author":"Morris","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2024.114952_bib54","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cmet.2021.03.009","article-title":"Creatine promotes cancer metastasis through activation of Smad2\/3","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2024.114952_bib55","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/sj.onc.1207218","article-title":"Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray","volume":"23","author":"Luo","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2024.114952_bib56","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.114952_bib57","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.114952_bib58","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"}],"updated-by":[{"DOI":"10.1016\/j.celrep.2025.115756","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000}}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724013032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724013032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:35:09Z","timestamp":1773236109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724013032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2211124724013032"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114952","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.114952","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114952"}}