{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:11:58Z","timestamp":1791587518538,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC2-DK118620"],"award-info":[{"award-number":["RC2-DK118620"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01-AG051459"],"award-info":[{"award-number":["P01-AG051459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["855170"],"award-info":[{"award-number":["855170"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","award":["R01-DK136619"],"award-info":[{"award-number":["R01-DK136619"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","award":["R01-DK136532"],"award-info":[{"award-number":["R01-DK136532"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","award":["HF-GRO-23-1199262-27"],"award-info":[{"award-number":["HF-GRO-23-1199262-27"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","award":["R01-DK138035"],"award-info":[{"award-number":["R01-DK138035"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK138035"],"award-info":[{"award-number":["R01-DK138035"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK136619"],"award-info":[{"award-number":["R01-DK136619"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK136532"],"award-info":[{"award-number":["R01-DK136532"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK131537"],"award-info":[{"award-number":["R01-DK131537"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK55758"],"award-info":[{"award-number":["R01-DK55758"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK127274"],"award-info":[{"award-number":["R01-DK127274"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK099110"],"award-info":[{"award-number":["R01-DK099110"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.celrep.2024.115165","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T07:51:52Z","timestamp":1736409112000},"page":"115165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["The adiponectin-PPAR\u03b3 axis in hepatic stellate cells regulates liver fibrosis"],"prefix":"10.1016","volume":"44","author":[{"given":"Shangang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Hsin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Bernd","family":"Funcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Nan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mbolle","family":"Ekane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Kusminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Terry D.","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-3392","authenticated-orcid":false,"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.115165_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2024.115165_bib2","article-title":"Liver fibrosis: Pathophysiology and clinical implications","volume":"13","author":"Berumen","year":"2021","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.celrep.2024.115165_bib3","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115165_bib4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2024.115165_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCRESAHA.120.314458","article-title":"Adiponectin, Leptin and Cardiovascular Disorders","volume":"128","author":"Zhao","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2024.115165_bib6","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1053\/j.gastro.2003.08.029","article-title":"Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin","volume":"125","author":"Kamada","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2024.115165_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1210\/en.2003-1068","article-title":"A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity","volume":"145","author":"Combs","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2024.115165_bib8","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.ajpath.2011.02.035","article-title":"Adiponectin regulation of stellate cell activation via PPARgamma-dependent and -independent mechanisms","volume":"178","author":"Shafiei","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2024.115165_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110405","article-title":"Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice","volume":"9","author":"Kumar","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.115165_bib10","article-title":"Adiponectin preserves metabolic fitness during aging","volume":"10","author":"Li","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2024.115165_bib11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00109-015-1313-z","article-title":"Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells","volume":"93","author":"Dong","year":"2015","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.celrep.2024.115165_bib12","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1074\/jbc.M114.598011","article-title":"Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion","volume":"290","author":"Ramezani-Moghadam","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115165_bib13","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1016\/j.febslet.2005.07.098","article-title":"Adiponectin is synthesized and secreted by human and murine cardiomyocytes","volume":"579","author":"Pineiro","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2024.115165_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/ndt\/gfl552","article-title":"Up-regulation of adiponectin, its isoforms and receptors in end-stage kidney disease","volume":"22","author":"Shen","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.celrep.2024.115165_bib15","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1111\/j.1530-0277.2007.00529.x","article-title":"Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis","volume":"31","author":"Potter","year":"2007","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.celrep.2024.115165_bib16","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1038\/s41467-023-42188-4","article-title":"Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization","volume":"14","author":"Onodera","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115165_bib17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm1262","article-title":"Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy","volume":"11","author":"Pajvani","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2024.115165_bib18","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.2337\/db07-1631","article-title":"PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation","volume":"57","author":"Wang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2024.115165_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1681\/ASN.2012040414","article-title":"Adiponectin promotes functional recovery after podocyte ablation","volume":"24","author":"Rutkowski","year":"2013","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2024.115165_bib20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gut.2005.071118","article-title":"Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice","volume":"55","author":"Tomita","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2024.115165_bib21","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm.4346","article-title":"Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling","volume":"23","author":"Giles","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2024.115165_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1095132","article-title":"Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease","volume":"14","author":"Oates","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2024.115165_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2018.10.012","article-title":"Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?","volume":"29","author":"Febbraio","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2024.115165_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2024.115165_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1463-1326.2012.01626.x","article-title":"Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARgamma-dependent and PPARgamma-independent mechanisms","volume":"14","author":"Rao","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.celrep.2024.115165_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106157","article-title":"Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl(4) in mice","volume":"79","author":"Sha","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2024.115165_bib27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2337\/diacare.25.2.376","article-title":"Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients","volume":"25","author":"Yang","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.celrep.2024.115165_bib28","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1210\/jc.2002-020635","article-title":"Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone","volume":"87","author":"Motoshima","year":"2002","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2024.115165_bib29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.kint.2016.09.016","article-title":"Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression","volume":"91","author":"Rutkowski","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2024.115165_bib31","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41467-018-03196-x","article-title":"De novo adipocyte differentiation from Pdgfrbeta(+) preadipocytes protects against pathologic visceral adipose expansion in obesity","volume":"9","author":"Shao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115165_bib30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1007\/s00125-017-4516-8","article-title":"Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice","volume":"61","author":"Xia","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.celrep.2024.115165_bib32","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cmet.2014.04.003","article-title":"alpha\/beta-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion","volume":"19","author":"Zhao","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2024.115165_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152242","article-title":"Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD","volume":"131","author":"Wang","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2024.115165_bib34","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.2337\/db17-0323","article-title":"Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression","volume":"66","author":"Zhu","year":"2017","journal-title":"Diabetes"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472401516X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472401516X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:23:46Z","timestamp":1781555026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472401516X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S221112472401516X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115165","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The adiponectin-PPAR\u03b3 axis in hepatic stellate cells regulates liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115165"}}