{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:26:54Z","timestamp":1791685614737,"version":"4.3.4"},"reference-count":93,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RG060805"],"award-info":[{"award-number":["RG060805"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences Mental Health and Addiction","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.celrep.2024.115178","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T23:09:04Z","timestamp":1736204944000},"page":"115178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["G6PD deficiency triggers dopamine loss and the initiation of Parkinson\u2019s disease pathogenesis"],"prefix":"10.1016","volume":"44","author":[{"given":"Morgan G.","family":"Stykel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehani V.","family":"Siripala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Soubeyrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla L.","family":"Coackley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suelen","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharanya","family":"Thevasenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo Balderas","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaella W.L.","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachi","family":"Panchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet-Kalliopi","family":"Akrioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Haji-Ghassemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Era","family":"Taoufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq A.","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-4649","authenticated-orcid":false,"given":"Scott D.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.115178_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.expneurol.2012.01.011","article-title":"Axon degeneration in Parkinson's disease","volume":"246","author":"Burke","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.115178_bib2","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson's disease: substantia nigra regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.115178_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01249445","article-title":"Time course of nigrostriatal degeneration in parkinson's disease. A detailed study of influential factors in human brain amine analysis","volume":"38","author":"Riederer","year":"1976","journal-title":"J.\u00a0Neural. Transm."},{"key":"10.1016\/j.celrep.2024.115178_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ana.67","article-title":"Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation","volume":"49","author":"Spira","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.115178_bib5","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.neurobiolaging.2013.11.008","article-title":"Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant alpha-synuclein transgenic mice","volume":"35","author":"Martin","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2024.115178_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2005.09.028","article-title":"Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration","volume":"123","author":"Chandra","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115178_bib7","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2024.115178_bib8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115178_bib9","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1523\/JNEUROSCI.0074-22.2022","article-title":"Intracellular Accumulation of alpha-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines","volume":"42","author":"Hallam","year":"2022","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ana.10795","article-title":"The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia","volume":"55","author":"Zarranz","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.115178_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115178_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuron.2009.01.033","article-title":"Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons","volume":"62","author":"Mosharov","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115178_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35072550","article-title":"Experimental models of Parkinson's disease","volume":"2","author":"Beal","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM199403033300907","article-title":"Excitatory amino acids as a final common pathway for neurologic disorders","volume":"330","author":"Lipton","year":"1994","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.115178_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrd1958","article-title":"Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond","volume":"5","author":"Lipton","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2024.115178_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2024.119720","article-title":"Network analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease","volume":"1871","author":"Stykel","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.celrep.2024.115178_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41531-022-00370-3","article-title":"Nitrosative stress in Parkinson's disease","volume":"8","author":"Stykel","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.celrep.2024.115178_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/jnc.12226","article-title":"Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies","volume":"125","author":"Schildknecht","year":"2013","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115178_bib19","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1021\/ac901176t","article-title":"Preferentially increased nitration of \u03b1-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson\u2019s disease","volume":"81","author":"Danielson","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib20","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1523\/JNEUROSCI.21-20-08053.2001","article-title":"Induction of \u03b1-synuclein aggregation by intracellular nitrative insult","volume":"21","author":"Paxinou","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib21","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M000206200","article-title":"Dityrosine cross-linking promotes formation of stable \u03b1-synuclein polymers: implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies","volume":"275","author":"Souza","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","article-title":"Oxidative damage linked to neurodegeneration by selective \u03b1-synuclein nitration in synucleinopathy lesions","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115178_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2011.06.019","article-title":"Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations","volume":"146","author":"Soldner","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115178_bib24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cell.2013.11.009","article-title":"Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1\u03b1 transcription","volume":"155","author":"Ryan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115178_bib25","doi-asserted-by":"crossref","first-page":"14280","DOI":"10.1073\/pnas.1900576116","article-title":"Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus","volume":"116","author":"Czaniecki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115178_bib26","doi-asserted-by":"crossref","first-page":"E3679","DOI":"10.1073\/pnas.1617259114","article-title":"Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease","volume":"114","author":"Kouroupi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115178_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115178_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.expneurol.2012.11.020","article-title":"Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type histopathology in human brains","volume":"240","author":"Walker","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.115178_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ymeth.2016.11.016","article-title":"DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis","volume":"115","author":"Gilles","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2024.115178_bib30","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1084\/jem.20112457","article-title":"Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice","volume":"209","author":"Luk","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2024.115178_bib31","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.celrep.2014.05.033","article-title":"A-synuclein immunotherapy blocks uptake and templated propagation of misfolded alpha-synuclein and neurodegeneration","volume":"7","author":"Tran","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.115178_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41593-019-0541-x","article-title":"\u03b1-Synuclein strains target distinct brain regions and cell types","volume":"23","author":"Lau","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12104-021-10020-z","article-title":"Partial magic angle spinning NMR 1H, 13C, 15N resonance assignments of the flexible regions of a monomeric alpha-synuclein: conformation of C-terminus in the lipid-bound and amyloid fibril states","volume":"15","author":"Medeiros","year":"2021","journal-title":"Biomol. NMR Assign."},{"key":"10.1016\/j.celrep.2024.115178_bib34","article-title":"Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841\u00a0UK Biobank exomes","volume":"2","author":"Karczewski","year":"2022","journal-title":"Cell Genom."},{"key":"10.1016\/j.celrep.2024.115178_bib35","doi-asserted-by":"crossref","first-page":"D862","DOI":"10.1093\/nar\/gkv1222","article-title":"ClinVar: public archive of interpretations of clinically relevant variants","volume":"44","author":"Landrum","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.115178_bib36","doi-asserted-by":"crossref","first-page":"D835","DOI":"10.1093\/nar\/gkz972","article-title":"ClinVar: improvements to accessing data","volume":"48","author":"Landrum","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.115178_bib37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nmeth.1212","article-title":"Real-time imaging of the intracellular glutathione redox potential","volume":"5","author":"Gutscher","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.115178_bib38","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresbull.2022.05.008","article-title":"Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats","volume":"185","author":"Wang","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.celrep.2024.115178_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001339","article-title":"G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map","volume":"9","author":"Howes","year":"2012","journal-title":"PLoS Med."},{"key":"10.1016\/j.celrep.2024.115178_bib40","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1038\/s41467-018-06447-z","article-title":"Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator","volume":"9","author":"Hwang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115178_bib41","first-page":"390","article-title":"Glucose-6-phosphate dehydrogenase of leukocyte subpopulations in normal and enzyme deficient individuals","volume":"70","author":"Morellini","year":"1985","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2024.115178_bib42","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1073\/pnas.82.5.1465","article-title":"Tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3' end of the gene","volume":"82","author":"Battistuzzi","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115178_bib43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1","volume":"11","author":"Herrero-Mendez","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115178_bib44","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1523\/JNEUROSCI.16-19-06038.1996","article-title":"Glutathione is involved in the granular storage of dopamine in rat PC 12 pheochromocytoma cells: implications for the pathogenesis of Parkinson's disease","volume":"16","author":"Drukarch","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tins.2006.11.004","article-title":"Redox regulation of neuronal survival mediated by electrophilic compounds","volume":"30","author":"Satoh","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib46","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.0937239100","article-title":"NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"100","author":"Wu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115178_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jnc.13696","article-title":"Molecular changes in the postmortem parkinsonian brain","volume":"139","author":"Toulorge","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115178_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00702-023-02718-2","article-title":"Oxidation of dopamine and related catechols in dopaminergic brain regions in Parkinson\u2019s disease and during ageing in non-Parkinsonian subjects","volume":"131","author":"Fornstedt Wallin","year":"2024","journal-title":"J.\u00a0Neural. Transm."},{"key":"10.1016\/j.celrep.2024.115178_bib49","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cell.2012.12.029","article-title":"Vesicular glycolysis provides on-board energy for fast axonal transport","volume":"152","author":"Zala","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115178_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13233","article-title":"Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport","volume":"7","author":"Hinckelmann","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115178_bib51","first-page":"43","article-title":"Age-related changes in glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the subcellular fractions from the rat brain and the effect of dimethylaminoethanol","volume":"7","author":"Roy","year":"1983","journal-title":"Biochem. Int."},{"key":"10.1016\/j.celrep.2024.115178_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1471-4159.1974.tb06918.x","article-title":"Activation of hexose monophosphate pathway in brain by electrical stimulation in\u00a0vitro","volume":"23","author":"Kimura","year":"1974","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115178_bib53","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1471-4159.1977.tb10622.x","article-title":"Metabolites and enzymes of the pentose phosphate pathway in isolated nerve endings","volume":"28","author":"Kauffman","year":"1977","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115178_bib54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature16531","article-title":"Structural disorder of monomeric alpha-synuclein persists in mammalian cells","volume":"530","author":"Theillet","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115178_bib55","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0896-6273(95)90302-X","article-title":"The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system","volume":"14","author":"Iwai","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115178_bib56","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","article-title":"Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib57","doi-asserted-by":"crossref","first-page":"26292","DOI":"10.1074\/jbc.273.41.26292","article-title":"Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation","volume":"273","author":"Jensen","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib58","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1021\/bi036135+","article-title":"Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein","volume":"43","author":"Bussell","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2024.115178_bib59","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"Alpha-synuclein promotes SNARE-complex assembly in\u00a0vivo and in\u00a0vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115178_bib60","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000","article-title":"Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons","volume":"20","author":"Murphy","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115178_bib62","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1074\/jbc.275.1.390","article-title":"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein","volume":"275","author":"Okochi","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102810","article-title":"Rapid phosphorylation of glucose-6-phosphate dehydrogenase by casein kinase 2 sustains redox homeostasis under ionizing radiation","volume":"65","author":"Hao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2024.115178_bib64","article-title":"Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease","volume":"15","author":"Wu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.115178_bib65","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1523\/JNEUROSCI.0122-06.2006","article-title":"Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice","volume":"26","author":"Mej\u00edas","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib66","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1212\/WNL.0b013e318294b3c8","article-title":"Exposure to pesticides or solvents and risk of Parkinson disease","volume":"80","author":"Pezzoli","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2024.115178_bib67","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/cmdc.201900341","article-title":"Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface","volume":"14","author":"Raub","year":"2019","journal-title":"ChemMedChem"},{"key":"10.1016\/j.celrep.2024.115178_bib68","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.celrep.2017.02.048","article-title":"Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants","volume":"18","author":"Cunningham","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.115178_bib69","article-title":"Structural analysis of clinically relevant pathogenic G6PD variants reveals the importance of tetramerization for G6PD activity","volume":"2017","author":"Cunningham","year":"2017","journal-title":"Matters (Zur)"},{"key":"10.1016\/j.celrep.2024.115178_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101610","article-title":"Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants","volume":"298","author":"Garcia","year":"2022","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib71","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jnr.20107","article-title":"Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration","volume":"76","author":"Munoz","year":"2004","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.celrep.2024.115178_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012333","article-title":"Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice","volume":"5","author":"Clark","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.115178_bib73","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ana.22162","article-title":"N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-\/- mouse","volume":"69","author":"Berman","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.115178_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102070","article-title":"\u03b1-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism","volume":"202","author":"Ghosh","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2024.115178_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157602","article-title":"N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data","volume":"11","author":"Monti","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.115178_bib76","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/cpt.1548","article-title":"N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease","volume":"106","author":"Monti","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.celrep.2024.115178_bib77","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.chembiol.2023.06.018","article-title":"S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons","volume":"30","author":"Doulias","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2024.115178_bib78","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115178_bib79","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(02)00682-7","article-title":"Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein","volume":"34","author":"Giasson","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115178_bib80","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10930-013-9518-x","article-title":"Cloning, expression, purification and characterization of his-tagged human glucose-6-phosphate dehydrogenase: a simplified method for protein yield","volume":"32","author":"G\u00f3mez-Manzo","year":"2013","journal-title":"Protein J."},{"key":"10.1016\/j.celrep.2024.115178_bib81","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115178_bib82","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00726-020-02912-6","article-title":"Proteomic comparison of different synaptosome preparation procedures","volume":"52","author":"Guly\u00e1ssy","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.celrep.2024.115178_bib83","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41583-021-00455-7","article-title":"Spatial and temporal scales of dopamine transmission","volume":"22","author":"Liu","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2024.115178_bib84","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/ac902837x","article-title":"Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer","volume":"82","author":"Lu","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib85","doi-asserted-by":"crossref","first-page":"9818","DOI":"10.1021\/ac1021166","article-title":"Metabolomic analysis and visualization engine for LC-MS data","volume":"82","author":"Melamud","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib86","first-page":"Unit.14","article-title":"LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine","volume":"14","author":"Clasquin","year":"2012","journal-title":"Curr Protoc Bioinformatics."},{"key":"10.1016\/j.celrep.2024.115178_bib87","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jpba.2014.05.039","article-title":"A rapid and simple method for the determination of 3,4-dihydroxyphenylacetic acid, norepinephrine, dopamine, and serotonin in mouse brain homogenate by HPLC with fluorimetric detection","volume":"98","author":"De Benedetto","year":"2014","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.celrep.2024.115178_bib88","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","article-title":"Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease","volume":"357","author":"Burbulla","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115178_bib89","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1021\/acs.analchem.5b04420","article-title":"Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence","volume":"88","author":"Mazzulli","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2024.115178_bib90","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.115178_bib91","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115178_bib92","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2736(86)90302-0","article-title":"Vesicles of variable sizes produced by a rapid extrusion procedure","volume":"858","author":"Mayer","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2024.115178_bib93","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1080\/15548627.2016.1240856","article-title":"Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP","volume":"12","author":"Ant\u00f3n","year":"2016","journal-title":"Autophagy"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:22:44Z","timestamp":1781554964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724015298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2211124724015298"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115178","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"G6PD deficiency triggers dopamine loss and the initiation of Parkinson\u2019s disease pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115178"}}