{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:52Z","timestamp":1792120432013,"version":"4.4.0"},"reference-count":180,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014055","name":"U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","award":["W81XWH-22-1-0721"],"award-info":[{"award-number":["W81XWH-22-1-0721"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01LM013617"],"award-info":[{"award-number":["R01LM013617"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG065854"],"award-info":[{"award-number":["R21AG065854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99AG075242"],"award-info":[{"award-number":["K99AG075242"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM142505"],"award-info":[{"award-number":["R35GM142505"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AG00255"],"award-info":[{"award-number":["T32AG00255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31AG060672"],"award-info":[{"award-number":["F31AG060672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32NS108598"],"award-info":[{"award-number":["F32NS108598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31NS087676"],"award-info":[{"award-number":["F31NS087676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM008275"],"award-info":[{"award-number":["T32GM008275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM099836"],"award-info":[{"award-number":["R01GM099836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001229","name":"G. Harold and Leila Y. Mathers Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001192","name":"Johnson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","award":["ALS IL-2023-C4-L2"],"award-info":[{"award-number":["ALS IL-2023-C4-L2"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["DISC0-13914"],"award-info":[{"award-number":["DISC0-13914"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013013","name":"Target ALS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.celrep.2024.115205","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T16:53:58Z","timestamp":1736873638000},"page":"115205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Opposing roles of p38\u03b1-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy"],"prefix":"10.1016","volume":"44","author":[{"given":"Mari","family":"Aikio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana M.","family":"Odeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike J.","family":"Wobst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Lim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dana","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn C.","family":"Mauna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korrie L.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Class","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Ollerhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice F.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Cupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Drake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Smalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ta","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Castello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashmita","family":"Baral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna N.","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd A.","family":"Najar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Gitler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Javaherian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Burslem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean G.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Finkbeiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Brandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-8533","authenticated-orcid":false,"given":"James","family":"Shorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.115205_bib1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/med.21661","article-title":"The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future","volume":"40","author":"Wobst","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.celrep.2024.115205_bib2","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","article-title":"Amyotrophic lateral sclerosis","volume":"344","author":"Rowland","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.115205_bib3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/01.wnl.0000296811.19811.db","article-title":"Genetics of familial amyotrophic lateral sclerosis","volume":"70","author":"Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2024.115205_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.tig.2018.03.001","article-title":"ALS Genes in the Genomic Era and their Implications for FTD","volume":"34","author":"Nguyen","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a024554","article-title":"Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies","volume":"7","author":"Guo","year":"2017","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.celrep.2024.115205_bib8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41586-023-06405-w","article-title":"TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP","volume":"620","author":"Arseni","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41586-021-04199-3","article-title":"Structure of pathological TDP-43 filaments from ALS with FTLD","volume":"601","author":"Arseni","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/d41586-021-03605-0","article-title":"Aggregates of TDP-43 protein spiral into view","volume":"601","author":"Odeh","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00401-024-02705-1","article-title":"RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS","volume":"147","author":"Spence","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.115205_bib12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41586-024-08024-5","article-title":"Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C","volume":"634","author":"Arseni","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tibs.2020.12.005","article-title":"FUS and TDP-43 Phases in Health and Disease","volume":"46","author":"Portz","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2024.115205_bib14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2013.12.018","article-title":"Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations","volume":"81","author":"Alami","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2741\/2727","article-title":"Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease","volume":"13","author":"Buratti","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.celrep.2024.115205_bib16","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1073\/pnas.1112427109","article-title":"TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes","volume":"109","author":"Kawahara","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115205_bib17","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1074\/jbc.M110.166587","article-title":"TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in\u00a0vivo","volume":"286","author":"Lalmansingh","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbapap.2017.10.001","article-title":"The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43","volume":"1866","author":"Li","year":"2018","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.celrep.2024.115205_bib19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/hmg\/ddr021","article-title":"TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1","volume":"20","author":"McDonald","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nn.2778","article-title":"Characterizing the RNA targets and position-dependent splicing regulation by TDP-43","volume":"14","author":"Tollervey","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.aab0983","article-title":"TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD","volume":"349","author":"Ling","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-022-04424-7","article-title":"TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A","volume":"603","author":"Ma","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","article-title":"TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A","volume":"603","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib24","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.abq5622","article-title":"Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies","volume":"379","author":"Baughn","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41593-018-0293-z","article-title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","volume":"22","author":"Melamed","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib26","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1242\/jcs.038950","article-title":"Structural determinants of the cellular localization and shuttling of TDP-43","volume":"121","author":"Ayala","year":"2008","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2024.115205_bib27","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail: an important region for the inhibition of\u00a0cystic fibrosis transmembrane conductance regulator exon 9 splicing","volume":"280","author":"Buratti","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbrc.2012.07.071","article-title":"The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity","volume":"425","author":"Chang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib29","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1021\/pr901076y","article-title":"Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery","volume":"9","author":"Freibaum","year":"2010","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2024.115205_bib30","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1038\/s41598-017-06263-3","article-title":"The N-terminal dimerization is required for TDP-43 splicing activity","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.115205_bib31","doi-asserted-by":"crossref","first-page":"20329","DOI":"10.1074\/jbc.M109.010264","article-title":"TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity","volume":"284","author":"Johnson","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib33","doi-asserted-by":"crossref","first-page":"13302","DOI":"10.1074\/jbc.M800342200","article-title":"Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation","volume":"283","author":"Winton","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnmol.2019.00025","article-title":"Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis","volume":"12","author":"Prasad","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib35","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1042\/BCJ20160499","article-title":"RNA-binding proteins with prion-like domains in health and disease","volume":"474","author":"Harrison","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2024.115205_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ana.21425","article-title":"Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"64","author":"Hasegawa","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2024.115205_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00401-008-0477-9","article-title":"Phosphorylation of S409\/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies","volume":"117","author":"Neumann","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.115205_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14728222.2018.1439923","article-title":"TDP-43 post-translational modifications in health and disease","volume":"22","author":"Buratti","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.celrep.2024.115205_bib39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41580-020-00322-w","article-title":"Diversity and versatility of p38 kinase signalling in health and disease","volume":"22","author":"Canovas","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2024.115205_bib41","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011254","article-title":"MAP kinase pathways","volume":"4","author":"Morrison","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149915","article-title":"p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets","volume":"6","author":"Brennan","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2024.115205_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2024.115205_bib44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/187152411794961040","article-title":"p38 MAP kinase inhibitors as potential therapeutic drugs for neural diseases","volume":"11","author":"Yasuda","year":"2011","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/emboj\/16.2.295","article-title":"Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK\/p38)","volume":"16","author":"Cuenda","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.115205_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2018.11.026","article-title":"Screening of a neuronal cell model of tau pathology for therapeutic compounds","volume":"76","author":"Pickhardt","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2024.115205_bib47","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.nbd.2006.12.023","article-title":"Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death","volume":"26","author":"Dewil","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41419-018-0624-8","article-title":"Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS","volume":"9","author":"Gibbs","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib49","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/hmg\/ddu493","article-title":"Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration","volume":"24","author":"Zhan","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jnen\/63.2.113","article-title":"Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice","volume":"63","author":"Bendotti","year":"2004","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.115205_bib51","article-title":"The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease","volume":"2012","author":"Correa","year":"2012","journal-title":"J.\u00a0Signal Transduct."},{"key":"10.1016\/j.celrep.2024.115205_bib52","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1044-7431(03)00022-8","article-title":"Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression","volume":"23","author":"Tortarolo","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib53","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnmol.2017.00046","article-title":"Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In\u00a0vitro","volume":"10","author":"Wobst","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1750-1326-6-73","article-title":"Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice","volume":"6","author":"Xu","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2024.115205_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76070-w","article-title":"Female sex mitigates motor and behavioural phenotypes in TDP-43(Q331K) knock-in mice","volume":"10","author":"Watkins","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.115205_bib56","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1073\/pnas.1222809110","article-title":"ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43","volume":"110","author":"Arnold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115205_bib57","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-009-0571-7","article-title":"TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy","volume":"118","author":"Gitcho","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.115205_bib58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neuron.2019.02.038","article-title":"Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death","volume":"102","author":"Gasset-Rosa","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib59","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43","volume":"14","author":"Polymenidou","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib60","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib61","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1523\/JNEUROSCI.4988-09.2010","article-title":"Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis","volume":"30","author":"Barmada","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib62","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1021\/ml2001455","article-title":"The Discovery of VX-745: A Novel and Selective p38alpha Kinase Inhibitor","volume":"2","author":"Duffy","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.celrep.2024.115205_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155485","article-title":"P38alpha MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease","volume":"21","author":"Germann","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2024.115205_bib64","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1038\/s41467-022-32944-3","article-title":"Preclinical and randomized clinical evaluation of the p38alpha kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib65","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13195-021-00843-2","article-title":"A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease","volume":"13","author":"Prins","year":"2021","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.celrep.2024.115205_bib66","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s11064-019-02832-2","article-title":"Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells","volume":"45","author":"Hicks","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.celrep.2024.115205_bib67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41593-018-0300-4","article-title":"ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair","volume":"22","author":"Klim","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib68","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1038\/s41467-022-32939-0","article-title":"Stress induced TDP-43 mobility loss independent of stress granules","volume":"13","author":"Streit","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib69","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1038\/s41467-021-25549-9","article-title":"Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration","volume":"12","author":"Linsley","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib70","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib71","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib72","doi-asserted-by":"crossref","first-page":"47040","DOI":"10.1074\/jbc.M404595200","article-title":"Active mutants of the human p38alpha mitogen-activated protein kinase","volume":"279","author":"Diskin","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb4309","article-title":"HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells","volume":"371","author":"Yu","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/srep23281","article-title":"Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains","volume":"6","author":"Kametani","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.115205_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2350-11-8","article-title":"Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosis","volume":"11","author":"Xiong","year":"2010","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib76","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.neurobiolaging.2012.03.014","article-title":"Screening of the TARDBP gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin","volume":"33","author":"Zou","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2024.115205_bib77","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.molcel.2013.05.021","article-title":"Defining the RGG\/RG motif","volume":"50","author":"Thandapani","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib78","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nchembio.422","article-title":"Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding","volume":"6","author":"Guo","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib79","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ncb2158","article-title":"Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation","volume":"13","author":"Hsu","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib80","article-title":"The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence","volume":"7","author":"Lu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2024.115205_bib81","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.molcel.2008.09.013","article-title":"Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt","volume":"32","author":"Yamagata","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib82","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf7329","article-title":"Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells","volume":"9","author":"Larsen","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2024.115205_bib83","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1038\/ncomms7758","article-title":"Comprehensive identification of arginine methylation in primary T\u00a0cells reveals regulatory roles in cell signalling","volume":"6","author":"Geoghegan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib84","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1074\/mcp.O113.032748","article-title":"Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest","volume":"13","author":"Sylvestersen","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2024.115205_bib85","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1074\/mcp.O113.027870","article-title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation","volume":"13","author":"Guo","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2024.115205_bib86","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41573-021-00159-8","article-title":"Protein arginine methylation: from enigmatic functions to therapeutic targeting","volume":"20","author":"Wu","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2024.115205_bib87","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1074\/jbc.275.11.7723","article-title":"PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells","volume":"275","author":"Tang","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib88","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/sj.emboj.7601389","article-title":"Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation","volume":"25","author":"Mostaqul Huq","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.115205_bib89","doi-asserted-by":"crossref","first-page":"27872","DOI":"10.1074\/jbc.M113.491092","article-title":"Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity","volume":"288","author":"Dillon","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib90","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1074\/jbc.M111.289496","article-title":"Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen","volume":"287","author":"Campbell","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib91","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.1008227107","article-title":"ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS\/TLS","volume":"107","author":"Ling","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115205_bib92","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.molcel.2018.07.002","article-title":"Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization","volume":"71","author":"McGurk","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib93","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuron.2019.01.048","article-title":"RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43","volume":"102","author":"Mann","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib94","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1016\/j.cell.2021.07.018","article-title":"TDP-43 condensation properties specify its RNA-binding and regulatory repertoire","volume":"184","author":"Hallegger","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib95","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb3774","article-title":"C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy","volume":"12","author":"Cook","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.115205_bib96","article-title":"Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains","author":"Guo","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2024.115205_bib97","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1471-4159.2010.07098.x","article-title":"Regulation of TDP-43 aggregation by phosphorylation and p62\/SQSTM1","volume":"116","author":"Brady","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115205_bib98","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbrc.2015.06.125","article-title":"A phosphomimetic mutant TDP-43 (S409\/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells","volume":"464","author":"Kim","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib99","doi-asserted-by":"crossref","first-page":"16208","DOI":"10.1523\/JNEUROSCI.2911-10.2010","article-title":"Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy","volume":"30","author":"Liachko","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.febslet.2008.12.031","article-title":"Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells","volume":"583","author":"Nonaka","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2024.115205_bib101","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1750-1326-5-33","article-title":"Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments","volume":"5","author":"Zhang","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2024.115205_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090452","article-title":"Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins","volume":"9","author":"Carlomagno","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2024.115205_bib103","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddt498","article-title":"TDP-43 Phosphorylation by casein kinase Iepsilon promotes oligomerization and enhances toxicity in\u00a0vivo","volume":"23","author":"Choksi","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib104","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1074\/jbc.M117.814111","article-title":"Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration","volume":"293","author":"Goh","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib105","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbrc.2009.03.038","article-title":"Identification of casein kinase-1 phosphorylation sites on TDP-43","volume":"382","author":"Kametani","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004803","article-title":"The tau tubulin kinases TTBK1\/2 promote accumulation of pathological TDP-43","volume":"10","author":"Liachko","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib107","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/hmg\/ddu497","article-title":"Activation of AMP-activated protein kinase alpha1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis","volume":"24","author":"Liu","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2024.115205_bib108","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1750-1326-6-57","article-title":"C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress","volume":"6","author":"Meyerowitz","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2024.115205_bib109","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1074\/jbc.M115.695379","article-title":"Phosphorylation of TAR DNA-binding Protein of 43\u00a0kDa (TDP-43) by Truncated Casein Kinase 1delta Triggers Mislocalization and Accumulation of TDP-43","volume":"291","author":"Nonaka","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106516","article-title":"CK1\u03b4\/\u03b5 kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation","volume":"196","author":"Ko","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105548","article-title":"Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology","volume":"161","author":"Tian","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib112","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s40478-024-01902-z","article-title":"CK1\u03b4\/\u03b5-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis","volume":"12","author":"Ko","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib113","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108443","article-title":"Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation","volume":"41","author":"Gruijs da Silva","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.115205_bib114","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1242\/jcs.051672","article-title":"Prion-like disorders: blurring the divide between transmissibility and infectivity","volume":"123","author":"Cushman","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2024.115205_bib115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.01.016","article-title":"The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease","volume":"1462","author":"King","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2024.115205_bib116","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2016.02.037","article-title":"Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease","volume":"1647","author":"March","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2024.115205_bib117","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.str.2016.07.007","article-title":"ALS Mutations Disrupt Phase Separation Mediated by alpha-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain","volume":"24","author":"Conicella","year":"2016","journal-title":"Structure"},{"key":"10.1016\/j.celrep.2024.115205_bib118","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl8809","article-title":"Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation","volume":"8","author":"Stefanoska","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2024.115205_bib119","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbrc.2010.12.076","article-title":"Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear\/cytoplasmic distribution","volume":"404","author":"Chang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib120","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/nar\/gky103","article-title":"Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization","volume":"46","author":"Huang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2024.115205_bib121","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jmb.2016.12.011","article-title":"Methylarginines within the RGG-Motif Region of hnRNP A1 Affect Its IRES Trans-Acting Factor Activity and Are Required for hnRNP A1 Stress Granule Localization and Formation","volume":"429","author":"Wall","year":"2017","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib122","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1080\/15384101.2015.1033595","article-title":"PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)","volume":"14","author":"Ratovitski","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2024.115205_bib123","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1523\/JNEUROSCI.3389-17.2018","article-title":"Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons","volume":"38","author":"Simandi","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib124","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuron.2020.01.020","article-title":"Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS\/FTD C9orf72 Toxicity","volume":"106","author":"Ortega","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib125","doi-asserted-by":"crossref","first-page":"e1868","DOI":"10.1212\/WNL.0000000000007311","article-title":"Increase of arginine dimethylation correlates with the progression and prognosis of ALS","volume":"92","author":"Ikenaka","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2024.115205_bib126","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1038\/emboj.2012.261","article-title":"Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS","volume":"31","author":"Dormann","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.115205_bib127","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cell.2018.03.004","article-title":"Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation","volume":"173","author":"Hofweber","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib128","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.cell.2018.03.056","article-title":"FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-pi Interactions","volume":"173","author":"Qamar","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib129","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00401-016-1544-2","article-title":"Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS","volume":"131","author":"Suarez-Calvet","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2024.115205_bib130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.expneurol.2015.05.003","article-title":"Serine phosphorylation and arginine methylation at the crossroads to neurodegeneration","volume":"271","author":"Basso","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.115205_bib131","article-title":"A stress-dependent TDP-43 SUMOylation program preserves neuronal function","author":"Suk","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2024.115205_bib132","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adl1030","article-title":"Poly-GR repeats associated with ALS\/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons","volume":"17","author":"Dong","year":"2024","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2024.115205_bib133","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/MCB.00695-12","article-title":"p38alpha mitogen-activated protein kinase depletion and repression of\u00a0signal transduction to translation machinery by miR-124 and -128 in neurons","volume":"33","author":"Lawson","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib134","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1096\/fj.201902731RR","article-title":"Neuronal deficiency of p38alpha-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models","volume":"34","author":"Schnoder","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2024.115205_bib135","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq6089","article-title":"Inhibition of p38alpha MAPK restores neuronal p38gamma MAPK and ameliorates synaptic degeneration in a mouse model of DLB\/PD","volume":"15","author":"Iba","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.115205_bib136","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13024-023-00663-y","article-title":"Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come","volume":"18","author":"Alam","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2024.115205_bib137","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3233\/JAD-150277","article-title":"Selective Brain-Targeted Antagonism of p38 MAPKalpha Reduces Hippocampal IL-1beta Levels and Improves Morris Water Maze Performance in Aged Rats","volume":"48","author":"Alam","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib138","doi-asserted-by":"crossref","first-page":"e1708","DOI":"10.1212\/WNL.0000000000207755","article-title":"Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies","volume":"101","author":"Alam","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2024.115205_bib139","doi-asserted-by":"crossref","first-page":"549","DOI":"10.14283\/jpad.2024.36","article-title":"Phase 2A Learnings Incorporated into RewinD-LB, a Phase 2B Clinical Trial of Neflamapimod in Dementia with Lewy Bodies","volume":"11","author":"Prins","year":"2024","journal-title":"J.\u00a0Prev. Alzheimers Dis."},{"key":"10.1016\/j.celrep.2024.115205_bib140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib141","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2024.115205_bib142","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","article-title":"Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis","volume":"79","author":"Ling","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2024.115205_bib143","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"van Es","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2024.115205_bib144","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2024.115205_bib145","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2024.115205_bib146","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/NEN.0b013e3181ee7d85","article-title":"TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy","volume":"69","author":"McKee","year":"2010","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2024.115205_bib147","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The neuropathology of chronic traumatic encephalopathy","volume":"25","author":"McKee","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.celrep.2024.115205_bib148","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature11922","article-title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS","volume":"495","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2024.115205_bib149","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1021\/acs.chemrev.4c00110","article-title":"Genetic Encoding of Phosphorylated Amino Acids into Proteins","volume":"124","author":"Allen","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2024.115205_bib150","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2011.08.052","article-title":"A mechanism for the evolution of phosphorylation sites","volume":"147","author":"Pearlman","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib151","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202211164","article-title":"Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions","volume":"19","author":"Kliche","year":"2023","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib152","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1098\/rstb.2012.0013","article-title":"Why nature chose phosphate to modify proteins","volume":"367","author":"Hunter","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2024.115205_bib153","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nchembio.1823","article-title":"Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog","volume":"11","author":"Rogerson","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2024.115205_bib154","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1021\/acs.chemrev.3c00850","article-title":"Orthogonal Translation for Site-Specific Installation of Post-translational Modifications","volume":"124","author":"Gan","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2024.115205_bib155","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1021\/ja3108214","article-title":"Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding","volume":"135","author":"Le","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2024.115205_bib156","doi-asserted-by":"crossref","DOI":"10.1126\/science.aag1465","article-title":"Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity","volume":"354","author":"Wright","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115205_bib157","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbrc.2011.09.137","article-title":"Site-specific incorporation of arginine analogs into proteins using arginyl-tRNA synthetase","volume":"414","author":"Akahoshi","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib158","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3858","article-title":"Expression and Purification of Recombinant Skd3 (Human ClpB) Protein and Tobacco Etch Virus (TEV) Protease from Escherichia coli","volume":"10","author":"Cupo","year":"2020","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.celrep.2024.115205_bib159","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.cell.2018.03.025","article-title":"Stress Granule Assembly Disrupts Nucleocytoplasmic Transport","volume":"173","author":"Zhang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2024.115205_bib161","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1073\/pnas.0409777102","article-title":"Automated microscope system for determining factors that predict neuronal fate","volume":"102","author":"Arrasate","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2024.115205_bib162","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/bioinformatics\/btr645","article-title":"MSnbase-an R\/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation","volume":"28","author":"Gatto","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.115205_bib163","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.jproteome.0c00313","article-title":"MSnbase, Efficient and Elegant R-Based Processing and Visualization of Raw Mass Spectrometry Data","volume":"20","author":"Gatto","year":"2021","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2024.115205_bib164","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41593-021-01006-0","article-title":"Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines","volume":"25","author":"Baxi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib165","article-title":"An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients","volume":"24","author":"Li","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2024.115205_bib166","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.stem.2018.02.012","article-title":"Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology","volume":"22","author":"Ziller","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2024.115205_bib167","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1093\/emboj\/18.18.4969","article-title":"The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism","volume":"18","author":"Winzen","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2024.115205_bib168","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1021\/jm101423y","volume":"54","author":"Goldstein","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib169","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1038\/s41467-021-25549-9","article-title":"Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration","volume":"12","author":"Linsley","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib170","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41593-021-01006-0","article-title":"Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines","volume":"25","author":"Baxi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib171","first-page":"370","article-title":"Generalized linear models","volume":"135","author":"Nelder","year":"1972","journal-title":"Soc. Anim."},{"key":"10.1016\/j.celrep.2024.115205_bib172","unstructured":"R Core Team (2012). R: A language and environment for statistical computing."},{"key":"10.1016\/j.celrep.2024.115205_bib173","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2024.115205_bib174","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/jms.229","article-title":"Proteomics: the move to mixtures","volume":"36","author":"Peng","year":"2001","journal-title":"J.\u00a0Mass Spectrom."},{"key":"10.1016\/j.celrep.2024.115205_bib175","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database","volume":"5","author":"Eng","year":"1994","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.celrep.2024.115205_bib176","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nbt1240","article-title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization","volume":"24","author":"Beausoleil","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2024.115205_bib177","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1017404","article-title":"Analyzing the mechanisms that facilitate the subtype-specific assembly of gamma-aminobutyric acid type A receptors","volume":"15","author":"Choi","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2020.563091","article-title":"Isolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes","volume":"13","author":"Smalley","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.celrep.2024.115205_bib179","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1038\/ncomms6277","article-title":"MS-GF+ makes progress towards a universal database search tool for proteomics","volume":"5","author":"Kim","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115205_bib180","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201797452","article-title":"A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing","volume":"37","author":"Wang","year":"2018","journal-title":"EMBO J."}],"updated-by":[{"DOI":"10.1016\/j.celrep.2025.115386","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000}}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:31:58Z","timestamp":1781555518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724015560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":180,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2211124724015560"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115205","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.04.455154","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opposing roles of p38\u03b1-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115205"}}