{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:41:01Z","timestamp":1791488461642,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Center for Cardiovascular Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123-B10"],"award-info":[{"award-number":["SFB1123-B10"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP2306 BA4925\/2-1"],"award-info":[{"award-number":["SPP2306 BA4925\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031584","name":"Deutsches Zentrum f\u00fcr Diabetesforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["949017"],"award-info":[{"award-number":["949017"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.celrep.2024.115225","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T11:52:52Z","timestamp":1737201172000},"page":"115225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Chronic intermittent fasting impairs \u03b2 cell maturation and function in adolescent mice"],"prefix":"10.1016","volume":"44","author":[{"given":"Leonardo","family":"Matta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suheda","family":"Erener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Walth-Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Hass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"B\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Klepac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Szendroedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sterr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Lickert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-3991","authenticated-orcid":false,"given":"Alexander","family":"Bartelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2024.115225_bib1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2023.02.003","article-title":"The global burden of metabolic disease: Data from 2000 to 2019","volume":"35","author":"Chew","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.115225_bib2","first-page":"117","article-title":"Intermittent fasting and weight loss: Systematic review","volume":"66","author":"Welton","year":"2020","journal-title":"Can. Fam. Physician"},{"key":"10.1016\/j.celrep.2024.115225_bib3","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1056\/NEJMra1905136","article-title":"Effects of Intermittent Fasting on Health, Aging, and Disease","volume":"381","author":"de Cabo","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2024.115225_bib4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cmet.2020.06.018","article-title":"Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity","volume":"32","author":"Cienfuegos","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.115225_bib5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/ajcn\/nqy196","article-title":"Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial","volume":"108","author":"Sch\u00fcbel","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.celrep.2024.115225_bib6","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/jamainternmed.2017.0936","article-title":"Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial","volume":"177","author":"Trepanowski","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.celrep.2024.115225_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41467-017-00178-3","article-title":"Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice","volume":"8","author":"Xie","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2024.115225_bib8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cmet.2017.08.019","article-title":"Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota","volume":"26","author":"Li","year":"2017","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.115225_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: molecular mechanisms and clinical applications","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.115225_bib10","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s42255-021-00469-6","article-title":"Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan","volume":"3","author":"Mishra","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.115225_bib11","doi-asserted-by":"crossref","first-page":"eabc4203","DOI":"10.1126\/science.abc4203","article-title":"Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting","volume":"375","author":"Jouandin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115225_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2022.02.021","article-title":"The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function","volume":"182","author":"Zhao","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2024.115225_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/oby.22065","article-title":"Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting","volume":"26","author":"Anton","year":"2018","journal-title":"Obesity"},{"key":"10.1016\/j.celrep.2024.115225_bib14","article-title":"\u03b2-cell dynamics in type 2 diabetes and in dietary and exercise interventions","volume":"14","author":"Lv","year":"2022","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2024.115225_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108804","article-title":"Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms","volume":"34","author":"Harney","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.115225_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10081184","article-title":"Oxidized LDLs as Signaling\u00a0Molecules","volume":"10","author":"Zingg","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.celrep.2024.115225_bib18","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1016\/j.celrep.2020.02.051","article-title":"Multi-omics Analysis of the Intermittent Fasting Response in Mice Identifies an Unexpected Role for HNF4\u03b1","volume":"30","author":"Hatchwell","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.115225_bib17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/jdi.14147","article-title":"Oxidative stress suppresses PHB2-mediated mitophagy in \u03b2-cells via the Nrf2\/PHB2 pathway","volume":"15","author":"Liu","year":"2024","journal-title":"J.\u00a0Diabetes Investig."},{"key":"10.1016\/j.celrep.2024.115225_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4239\/wjd.v14.i3.130","article-title":"Pancreatic \u03b2-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress","volume":"14","author":"Dludla","year":"2023","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.celrep.2024.115225_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006534","article-title":"Restoration of the unfolded protein response in pancreatic \u03b2 cells protects mice against type 1 diabetes","volume":"5","author":"Engin","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2024.115225_bib21","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijms22041509","article-title":"The Role of Oxidative Stress in Pancreatic \u03b2 Cell Dysfunction in Diabetes","volume":"22","author":"Eguchi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2024.115225_bib22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2024.115225_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155813","article-title":"Intermittent fasting protects \u03b2-cell identity and function in a type-2 diabetes model","volume":"153","author":"Patel","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.celrep.2024.115225_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00359","article-title":"Intermittent Fasting Exacerbates the Acute Immune and Behavioral Sickness Response to the Viral Mimic Poly(I:C) in Mice","volume":"13","author":"Zenz","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2024.115225_bib27","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s42255-023-00876-x","article-title":"Delineating mouse \u03b2-cell identity during lifetime and in diabetes with a single cell atlas","volume":"5","author":"Hrovatin","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2024.115225_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112559","article-title":"Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions","volume":"42","author":"Harney","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2024.115225_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu15163525","article-title":"Efficacy of Fasting in Type 1 and Type 2 Diabetes Mellitus: A Narrative Review","volume":"15","author":"Herz","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2024.115225_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0047-6374(90)90107-Q","article-title":"Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age","volume":"55","author":"Goodrick","year":"1990","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2024.115225_bib29","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.39558","article-title":"Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials","volume":"4","author":"Patikorn","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.celrep.2024.115225_bib30","doi-asserted-by":"crossref","first-page":"e22831","DOI":"10.1096\/fj.202201907R","article-title":"Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling","volume":"37","author":"Yin","year":"2023","journal-title":"Faseb. J."},{"key":"10.1016\/j.celrep.2024.115225_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111182","article-title":"Middle age as a turning point in mouse cerebral cortex energy and redox metabolism: Modulation by every-other-day fasting","volume":"145","author":"Bayliak","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.celrep.2024.115225_bib32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1471-4159.2011.07184.x","article-title":"Alternate day fasting impacts the brain insulin-signaling pathway of young adult male C57BL\/6 mice","volume":"117","author":"Lu","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2024.115225_bib33","doi-asserted-by":"crossref","first-page":"e075681","DOI":"10.1136\/bmj-2023-075681","article-title":"New advances in type 1 diabetes","volume":"384","author":"Subramanian","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.celrep.2024.115225_bib34","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1210\/jc.2014-1425","article-title":"\u03b2-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment","volume":"99","author":"Halban","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2024.115225_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0002-9343(88)90392-0","article-title":"Islet dysfunction in non-insulin-dependent diabetes mellitus","volume":"85","author":"Kahn","year":"1988","journal-title":"Am. J. Med."},{"key":"10.1016\/j.celrep.2024.115225_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/bios13030382","article-title":"Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells","volume":"13","author":"Jeyarajan","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.celrep.2024.115225_bib37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1101\/gad.294389.116","article-title":"All mixed up: defining roles for \u03b2-cell subtypes in mature islets","volume":"31","author":"Liu","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2024.115225_bib38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cmet.2017.11.004","article-title":"mTORC1 Signaling: A Double-Edged Sword in Diabetic \u03b2 Cells","volume":"27","author":"Ardestani","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2024.115225_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s43587-020-00013-3","article-title":"Intermittent and periodic fasting, longevity and disease","volume":"1","author":"Longo","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.celrep.2024.115225_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu12041029","article-title":"Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats","volume":"12","author":"Munhoz","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2024.115225_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e25708","article-title":"Comparison of three methods of intermittent fasting in high-fat-diet-induced obese mice","volume":"10","author":"Habiby","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.celrep.2024.115225_bib42","article-title":"A protocol for studying glucose homeostasis and islet function in mice","volume":"3","author":"Al Rijjal","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2024.115225_bib43","doi-asserted-by":"crossref","DOI":"10.3791\/50374-v","article-title":"A method for mouse pancreatic islet isolation and intracellular cAMP determination","author":"Neuman","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2024.115225_bib44","article-title":"Protocol for in\u00a0vivo and ex\u00a0vivo assessments of glucose-stimulated insulin secretion in mouse islet \u03b2 cells","volume":"2","author":"Zhu","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2024.115225_bib45","doi-asserted-by":"crossref","first-page":"27664","DOI":"10.1074\/jbc.M109.041616","article-title":"Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation","volume":"284","author":"Fujimoto","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2024.115225_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-1-0716-0385-7_21","article-title":"Determining Beta Cell Mass, Apoptosis, Proliferation, and Individual Beta Cell in Pancreatic Sections","volume":"2128","author":"T\u00e9llez","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2024.115225_bib47","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btw777","article-title":"Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R","volume":"33","author":"McCarthy","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2024.115225_bib48","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2024.115225_bib49","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2024.115225_bib50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2024.115225_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.115225_bib52","doi-asserted-by":"crossref","DOI":"10.1140\/epjb\/e2013-40829-0","article-title":"A smart local moving algorithm for large-scale modularity-based community detection","volume":"86","author":"Waltman","year":"2013","journal-title":"Eur. Phys. J. B"},{"key":"10.1016\/j.celrep.2024.115225_bib53","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2024.115225_bib54","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2024.115225_bib55","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2024.115225_bib56","series-title":"Visualization of Functional Enrichment Result","author":"Guangchuang","year":"2023"},{"key":"10.1016\/j.celrep.2024.115225_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2024.115225_bib58","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2024.115225_bib59","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124724015766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:02:33Z","timestamp":1762603353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124724015766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2211124724015766"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115225","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.18.590140","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic intermittent fasting impairs \u03b2 cell maturation and function in adolescent mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2024.115225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115225"}}