{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:11:58Z","timestamp":1789150318521,"version":"build-2803163510"},"reference-count":79,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007259","name":"Stony Brook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1ZIANS009424"],"award-info":[{"award-number":["1ZIANS009424"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1ZIANS009422"],"award-info":[{"award-number":["1ZIANS009422"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["2RF1NS023945-28"],"award-info":[{"award-number":["2RF1NS023945-28"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS022061"],"award-info":[{"award-number":["NS022061"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1ZIANS009416"],"award-info":[{"award-number":["1ZIANS009416"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010473","name":"Alzheimer's Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019236","name":"Department of Radiology, Weill Cornell Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.celrep.2025.115249","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T19:24:43Z","timestamp":1738265083000},"page":"115249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-2350","authenticated-orcid":false,"given":"Mala R.","family":"Ananth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Gardus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Palekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Slifstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Zaborszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin V.","family":"Parsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Talmage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"DeLorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna W.","family":"Role","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115249_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41583-023-00677-x","article-title":"Basal forebrain cholinergic signalling: development, connectivity and roles in cognition","volume":"24","author":"Ananth","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.celrep.2017.01.060","article-title":"The Input-Output Relationship of the Cholinergic Basal Forebrain","volume":"18","author":"Gielow","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115249_bib3","series-title":"The Rat Nervous System","first-page":"491","article-title":"Chapter 19 - Organization of the Basal Forebrain Cholinergic Projection System: Specific or Diffuse?","author":"Zaborszky","year":"2015"},{"key":"10.1016\/j.celrep.2025.115249_bib4","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1523\/JNEUROSCI.1676-18.2018","article-title":"Specific Basal Forebrain-Cortical Cholinergic Circuits Coordinate Cognitive Operations","volume":"38","author":"Z\u00e1borszky","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib5","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/jnc.15471","article-title":"Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance","volume":"158","author":"Geula","year":"2021","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2025.115249_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cercor\/6.2.165","article-title":"Systematic Regional Variations in the Loss of Cortical Cholinergic Fibers in Alzheimer's Disease","volume":"6","author":"Geula","year":"1996","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.celrep.2025.115249_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0306-4522(89)90399-0","article-title":"Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study","volume":"33","author":"Geula","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.115249_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/NEN.0b013e31816a1df3","article-title":"Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease","volume":"67","author":"Geula","year":"2008","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2025.115249_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tins.2022.11.006","article-title":"Entorhinal cortex dysfunction in Alzheimer's disease","volume":"46","author":"Igarashi","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib10","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021733","article-title":"The Corticohippocampal Circuit, Synaptic Plasticity, and Memory","volume":"7","author":"Basu","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2025.115249_bib11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nn.3304","article-title":"Memory, navigation and theta rhythm in the hippocampal-entorhinal system","volume":"16","author":"Buzs\u00e1ki","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2025.115249_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49132","article-title":"Cortical tau deposition follows patterns of entorhinal functional connectivity in aging","volume":"8","author":"Adams","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115249_bib14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1212\/01.wnl.0000256697.20968.d7","article-title":"Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease","volume":"68","author":"Devanand","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2025.115249_bib15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease","volume":"17","author":"Khan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib16","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3389\/fnins.2020.00804","article-title":"Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease","volume":"14","author":"Kulason","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib17","article-title":"Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer's disease","volume":"12","author":"Holbrook","year":"2020","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.celrep.2025.115249_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","article-title":"Tau seeding activity begins in the transentorhinal\/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART","volume":"136","author":"Kaufman","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2025.115249_bib19","doi-asserted-by":"crossref","first-page":"E4264","DOI":"10.1073\/pnas.1411250111","article-title":"Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans","volume":"111","author":"Reagh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115249_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2021.12.008","article-title":"Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment","volume":"112","author":"Tran","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2025.115249_bib21","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1162\/jocn_a_01385","article-title":"Object-in-place Memory Predicted by Anterolateral Entorhinal Cortex and Parahippocampal Cortex Volume in Older Adults","volume":"31","author":"Yeung","year":"2019","journal-title":"J.\u00a0Cognit. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2012.00032","article-title":"Effects of acetylcholine on neuronal properties in entorhinal cortex","volume":"6","author":"Heys","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.celrep.2025.115249_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1037\/neu0000093","article-title":"Psychometric properties of the Penn Computerized Neurocognitive Battery","volume":"29","author":"Moore","year":"2015","journal-title":"Neuropsychology"},{"key":"10.1016\/j.celrep.2025.115249_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.996089","article-title":"Cholinergic regulation of object recognition memory","volume":"16","author":"Okada","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/cercor\/bhs033","article-title":"Distinct roles of medial and lateral entorhinal cortex in spatial cognition","volume":"23","author":"Van Cauter","year":"2013","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.celrep.2025.115249_bib27","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1016\/j.bmc.2015.05.058","article-title":"Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter","volume":"23","author":"Tu","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.celrep.2025.115249_bib28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/jnc.14291","article-title":"Kinetic modeling of [18F] V AT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain","volume":"144","author":"Jin","year":"2018","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2025.115249_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13550-015-0149-4","article-title":"Radiation dosimetry of [(18)F]VAT in nonhuman primates","volume":"5","author":"Karimi","year":"2015","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.celrep.2025.115249_bib79","doi-asserted-by":"crossref","first-page":"956","DOI":"10.2967\/jnumed.123.266860","article-title":"PET Quantification of [18F] VAT in Human Brain and Its Test\u2013Retest Reproducibility and Age Dependence","volume":"65","author":"O\u2019Donnell","year":"2024","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.celrep.2025.115249_bib30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hipo.22553","article-title":"Cholinergic neuronal lesions in the medial septum and vertical limb of the diagonal bands of Broca induce contextual fear memory generalization and impair acquisition of fear extinction","volume":"26","author":"Knox","year":"2016","journal-title":"Hippocampus"},{"key":"10.1016\/j.celrep.2025.115249_bib31","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/cne.23967","article-title":"Topographic organization of the basal forebrain projections to the perirhinal, postrhinal, and entorhinal cortex in rats","volume":"524","author":"Kondo","year":"2016","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.115249_bib32","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuroimage.2008.05.055","article-title":"Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain","volume":"42","author":"Zaborszky","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2025.115249_bib33","doi-asserted-by":"crossref","first-page":"12867","DOI":"10.1073\/pnas.0601075103","article-title":"NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease","volume":"103","author":"Colton","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115249_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2008-15405","article-title":"The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP","volume":"15","author":"Colton","year":"2008","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.celrep.2025.115249_bib35","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1523\/JNEUROSCI.5066-07.2008","article-title":"Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2","volume":"28","author":"Wilcock","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib36","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1460-9568.2011.07671.x","article-title":"A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons","volume":"33","author":"Grybko","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cub.2013.01.036","article-title":"Traces of experience in the lateral entorhinal cortex","volume":"23","author":"Tsao","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.115249_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2017.00081","article-title":"Disentangling the Role of the MEC and LEC in the Processing of Spatial and Non-Spatial Information: Contribution of Lesion Studies","volume":"11","author":"Save","year":"2017","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2006.02.006","article-title":"Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study","volume":"170","author":"Parron","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.celrep.2025.115249_bib40","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1002\/cne.23415","article-title":"Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease","volume":"521","author":"Mesulam","year":"2013","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.115249_bib41","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cne.902140206","article-title":"Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey","volume":"214","author":"Mesulam","year":"1983","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.115249_bib42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2025.115249_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104784","article-title":"APOE-amyloid interaction: Therapeutic targets","volume":"138","author":"Wisniewski","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115249_bib44","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1093\/hmg\/ddp406","article-title":"Genome-wide association studies in Alzheimer's disease","volume":"18","author":"Bertram","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2025.115249_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.119908","article-title":"Distribution of cholinergic nerve terminals in the aged human brain measured with [18F]FEOBV PET and its correlation with histological data","volume":"269","author":"Okkels","year":"2023","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2025.115249_bib46","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.celrep.2018.06.001","article-title":"Longitudinal Alzheimer's Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections","volume":"24","author":"Schmitz","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115249_bib47","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.neurobiolaging.2010.05.019","article-title":"A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease","volume":"32","author":"Sexton","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2025.115249_bib48","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbadis.2011.08.003","article-title":"Diffusion tensor imaging of cerebral white matter integrity in cognitive aging","volume":"1822","author":"Madden","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.115249_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0306-4522(01)00302-5","article-title":"Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex","volume":"107","author":"Manns","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.115249_bib50","doi-asserted-by":"crossref","first-page":"E2644","DOI":"10.1073\/pnas.1716531115","article-title":"Target selectivity of septal cholinergic neurons in the medial and lateral entorhinal cortex","volume":"115","author":"Desikan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115249_bib51","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/cercor\/bhz016","article-title":"Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease","volume":"29","author":"Petrache","year":"2019","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.celrep.2025.115249_bib52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41398-022-02024-7","article-title":"Neuronal hyperexcitability in Alzheimer\u2019s disease: what are the drivers behind this aberrant phenotype?","volume":"12","author":"Targa Dias Anastacio","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.celrep.2025.115249_bib53","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115249_bib54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tins.2008.03.008","article-title":"Cholinergic control of GABA release: emerging parallels between neocortex and hippocampus","volume":"31","author":"Lawrence","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.115249_bib55","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2967\/jnumed.113.124792","article-title":"In\u00a0Vivo Imaging of Human Cholinergic Nerve Terminals with (\u2013)-5-18F-Fluoroethoxybenzovesamicol: Biodistribution, Dosimetry, and Tracer Kinetic Analyses","volume":"55","author":"Petrou","year":"2014","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.celrep.2025.115249_bib56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1098-2396(199811)30:3<263::AID-SYN4>3.0.CO;2-9","article-title":"[18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses","volume":"30","author":"Mulholland","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.celrep.2025.115249_bib57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.nucmedbio.2009.02.007","article-title":"Positron emission tomography imaging of (2R,3R)-5-[(18)F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter","volume":"36","author":"Kilbourn","year":"2009","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.celrep.2025.115249_bib58","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/mp.2017.183","article-title":"Quantification of brain cholinergic denervation in Alzheimer\u2019s disease using PET imaging with [18F]-FEOBV","volume":"22","author":"Aghourian","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.celrep.2025.115249_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.102992","article-title":"Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment","volume":"34","author":"Xia","year":"2022","journal-title":"Neuroimage. Clin."},{"key":"10.1016\/j.celrep.2025.115249_bib60","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41380-018-0130-5","article-title":"Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV","volume":"24","author":"Nejad-Davarani","year":"2019","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.celrep.2025.115249_bib61","article-title":"Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli","volume":"2023","author":"Kim","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.115249_bib62","article-title":"Basal forebrain cholinergic neurons are part of the threat memory engram","volume":"2021","author":"Rajebhosale","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.115249_bib63","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aan2475","article-title":"Chemogenetics revealed: DREADD occupancy and activation via converted clozapine","volume":"357","author":"Gomez","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115249_bib64","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.neuroimage.2016.12.010","article-title":"A multi-centre evaluation of eleven clinically feasible brain PET\/MRI attenuation correction techniques using a large cohort of patients","volume":"147","author":"Ladefoged","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2025.115249_bib65","first-page":"962","article-title":"A new method for assessing PET-MRI coregistration","volume":"7259","author":"DeLorenzo","year":"2009"},{"key":"10.1016\/j.celrep.2025.115249_bib66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12021-011-9109-y","article-title":"An open source multivariate framework for n-tissue segmentation with evaluation on public data","volume":"9","author":"Avants","year":"2011","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.celrep.2025.115249_bib67","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2025.115249_bib68","series-title":"The Human Brain: Surface, Three-Dimensional Sectional Anatomy with MRI, and Blood Supply","author":"Duvernoy","year":"1999"},{"key":"10.1016\/j.celrep.2025.115249_bib69","unstructured":"Talairach, P.J. (1988). Co-planar stereotaxic atlas of the human brain."},{"key":"10.1016\/j.celrep.2025.115249_bib70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0925-4927(97)00019-X","article-title":"Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome","volume":"75","author":"Kates","year":"1997","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.celrep.2025.115249_bib71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1097-0193(1997)5:5<355::AID-HBM4>3.0.CO;2-2","article-title":"An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes","volume":"5","author":"Killiany","year":"1997","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.celrep.2025.115249_bib72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.jcbfm.9600329","article-title":"In\u00a0vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations","volume":"27","author":"Ogden","year":"2007","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.celrep.2025.115249_bib73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneumeth.2004.07.014","article-title":"Quantitative comparison of algorithms for inter-subject registration of 3D volumetric brain MRI scans","volume":"142","author":"Ardekani","year":"2005","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2025.115249_bib74","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1088\/0031-9155\/57\/21\/R119","article-title":"A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology","volume":"57","author":"Erlandsson","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.celrep.2025.115249_bib75","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1109\/23.552745","article-title":"Investigation of partial volume correction methods for brain FDG PET studies","volume":"43","author":"Yang","year":"1996","journal-title":"IEEE Trans. Nucl. Sci."},{"key":"10.1016\/j.celrep.2025.115249_bib76","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1088\/0031-9155\/61\/22\/7975","article-title":"PETPVC: a toolbox for performing partial volume correction techniques in positron emission tomography","volume":"61","author":"Thomas","year":"2016","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.celrep.2025.115249_bib77","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","article-title":"Consensus Nomenclature for in\u00a0vivo Imaging of Reversibly Binding Radioligands","volume":"27","author":"Innis","year":"2007","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.celrep.2025.115249_bib78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-0270(95)00085-2","article-title":"Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex","volume":"63","author":"Gray","year":"1995","journal-title":"J.\u00a0Neurosci. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725000208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725000208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:57:28Z","timestamp":1762603048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725000208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2211124725000208"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115249","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115249"}}