{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:51:24Z","timestamp":1792612284286,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21NS123499"],"award-info":[{"award-number":["R21NS123499"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000297","name":"FRAXA Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.celrep.2025.115311","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:42:56Z","timestamp":1740048176000},"page":"115311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes"],"prefix":"10.1016","volume":"44","author":[{"given":"Stephanie A.","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Thomazeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.B.","family":"Finnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell J.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold J.","family":"Heynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noburu H.","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth G.N.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank S.","family":"Menniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Osterweil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9903-2541","authenticated-orcid":false,"given":"Mark F.","family":"Bear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115311_bib1","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1523\/JNEUROSCI.0827-16.2017","article-title":"A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density","volume":"37","author":"Liu","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib2","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.1227764","article-title":"Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders","volume":"338","author":"O'Roak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115311_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12264-017-0191-5","article-title":"Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy","volume":"34","author":"Xu","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.celrep.2025.115311_bib4","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0896-6273(00)80632-7","article-title":"NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus","volume":"21","author":"Lee","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib5","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.1523\/JNEUROSCI.18-23-09835.1998","article-title":"Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin","volume":"18","author":"Halpain","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib6","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/81823","article-title":"Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD","volume":"3","author":"Beattie","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib7","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1073\/pnas.89.10.4363","article-title":"Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade","volume":"89","author":"Dudek","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuron.2004.11.011","article-title":"Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses","volume":"44","author":"Zhou","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0896-6273(92)90248-C","article-title":"Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus","volume":"9","author":"Mulkey","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib10","doi-asserted-by":"crossref","first-page":"12303","DOI":"10.1523\/JNEUROSCI.4289-14.2015","article-title":"Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage","volume":"35","author":"Stein","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib11","doi-asserted-by":"crossref","first-page":"14705","DOI":"10.1073\/pnas.1520023112","article-title":"Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow","volume":"112","author":"Dore","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib12","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1523\/JNEUROSCI.0046-20.2020","article-title":"Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling in Dendritic Spine Shrinkage","volume":"40","author":"Stein","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108664","article-title":"Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines","volume":"34","author":"Stein","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115311_bib14","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1073\/pnas.1219454110","article-title":"Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression","volume":"110","author":"Nabavi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib15","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1523\/JNEUROSCI.5419-13.2014","article-title":"Ionotropic NMDA receptor signaling is required for the induction of long-term depression in the mouse hippocampal CA1 region","volume":"34","author":"Babiec","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.celrep.2014.01.005","article-title":"Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection","volume":"6","author":"Coultrap","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115311_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuron.2016.01.043","article-title":"NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca(2)(+)-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin","volume":"89","author":"Sanderson","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib18","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.neuron.2023.05.002","article-title":"NMDA receptor functions in health and disease: Old actor, new dimensions","volume":"111","author":"Dupuis","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib19","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1016\/j.neuron.2024.05.027","article-title":"APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors","volume":"112","author":"Dunot","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib20","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nn.4343","article-title":"Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction","volume":"19","author":"Carter","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib21","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1523\/JNEUROSCI.0394-18.2018","article-title":"Long-Term Depression Is Independent of GluN2 Subunit Composition","volume":"38","author":"Wong","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2020.02.020","article-title":"Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity","volume":"456","author":"Dore","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.115311_bib23","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0140-24.2024","article-title":"d-Serine Inhibits Non-ionotropic NMDA Receptor Signaling","volume":"44","author":"Barragan","year":"2024","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib24","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1038\/s41380-020-0821-6","article-title":"Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice","volume":"26","author":"Thomazeau","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2025.115311_bib25","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1073\/pnas.1219605110","article-title":"Metabotropic NMDA receptor function is required for beta-amyloid-induced synaptic depression","volume":"110","author":"Kessels","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainres.2006.02.044","article-title":"Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines","volume":"1084","author":"Grossman","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.115311_bib27","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1073\/pnas.122205699","article-title":"Altered synaptic plasticity in a mouse model of fragile X mental retardation","volume":"99","author":"Huber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib28","doi-asserted-by":"crossref","first-page":"15616","DOI":"10.1523\/JNEUROSCI.3888-10.2010","article-title":"Hypersensitivity to mGluR5 and ERK1\/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome","volume":"30","author":"Osterweil","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2017.03.018","article-title":"Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties","volume":"94","author":"Sun","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib30","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.neuron.2010.06.014","article-title":"Synapse-specific metaplasticity: to be silenced is not to silence 2B","volume":"66","author":"Philpot","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0092-8674(94)90108-2","article-title":"Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice","volume":"76","author":"Li","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115311_bib32","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/35021059","article-title":"Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex","volume":"406","author":"Iwasato","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115311_bib33","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.neuron.2011.08.007","article-title":"Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in\u00a0vivo","volume":"71","author":"Gray","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2202-9-6","article-title":"Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes","volume":"9","author":"Ryan","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148129","article-title":"MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit","volume":"11","author":"Volkmann","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115311_bib37","first-page":"614","article-title":"Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors","volume":"58","author":"Donevan","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2025.115311_bib38","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.neuron.2016.08.014","article-title":"Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors","volume":"91","author":"Yi","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2017.12.004","article-title":"Triheteromeric NMDA receptors: from structure to synaptic physiology","volume":"2","author":"Stroebel","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.celrep.2025.115311_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nn.3277","article-title":"Evolution of GluN2A\/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior","volume":"16","author":"Ryan","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10658","article-title":"Mutations causing syndromic autism define an axis of synaptic pathophysiology","volume":"480","author":"Auerbach","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115311_bib43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2017.07.013","article-title":"Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome","volume":"95","author":"Thomson","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib44","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.288.5469.1254","article-title":"Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression","volume":"288","author":"Huber","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115311_bib45","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1152\/jn.01316.2005","article-title":"Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome","volume":"95","author":"Nosyreva","year":"2006","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.celrep.2025.115311_bib46","doi-asserted-by":"crossref","first-page":"15073","DOI":"10.1523\/JNEUROSCI.1087-15.2015","article-title":"Convergence of hippocampal pathophysiology in Syngap+\/- and Fmr1-\/y mice","volume":"35","author":"Barnes","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/jn.2001.86.1.321","article-title":"Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1","volume":"86","author":"Huber","year":"2001","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.celrep.2025.115311_bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2012.03.009","article-title":"Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice","volume":"74","author":"Michalon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib49","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1152\/jn.1998.80.2.989","article-title":"Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges","volume":"80","author":"Merlin","year":"1998","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.celrep.2025.115311_bib50","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuron.2012.01.034","article-title":"Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome","volume":"77","author":"Osterweil","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib51","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of fragile X syndrome in mice","volume":"56","author":"Dolen","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/ijnp\/pyy101","article-title":"Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects","volume":"22","author":"Donello","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.celrep.2025.115311_bib53","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.neuropharm.2008.08.018","article-title":"A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus","volume":"55","author":"Zhang","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2025.115311_bib54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/13543784.2014.852536","article-title":"GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists","volume":"23","author":"Moskal","year":"2014","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.celrep.2025.115311_bib55","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.neubiorev.2011.06.006","article-title":"A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism","volume":"35","author":"Moskal","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.celrep.2025.115311_bib56","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.neurobiolaging.2009.04.012","article-title":"The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats","volume":"32","author":"Burgdorf","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2025.115311_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11264","article-title":"NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation","volume":"7","author":"Frank","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115311_bib58","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/88404","article-title":"A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux","volume":"4","author":"Vissel","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib59","article-title":"Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115311_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13041-020-0563-z","article-title":"Tripartite signalling by NMDA receptors","volume":"13","author":"Rajani","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.celrep.2025.115311_bib61","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1523\/JNEUROSCI.3652-04.2005","article-title":"Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression","volume":"25","author":"Nosyreva","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib62","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuropharm.2006.07.003","article-title":"Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex","volume":"52","author":"Chen","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2025.115311_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03581","article-title":"GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine","volume":"3","author":"Miller","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115311_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083941","article-title":"SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115311_bib65","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13229-020-00384-9","article-title":"Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP","volume":"11","author":"Hien","year":"2020","journal-title":"Mol. Autism."},{"key":"10.1016\/j.celrep.2025.115311_bib66","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1038\/s41467-022-30979-0","article-title":"Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome","volume":"13","author":"Seo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115311_bib67","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/jn.00449.2010","article-title":"Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis","volume":"104","author":"Auerbach","year":"2010","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.celrep.2025.115311_bib68","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1523\/JNEUROSCI.1777-05.2005","article-title":"Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model","volume":"25","author":"Chuang","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib69","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1523\/JNEUROSCI.1617-11.2011","article-title":"Loss of Tsc1 in\u00a0vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function","volume":"31","author":"Bateup","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib70","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1523\/JNEUROSCI.0672-16.2016","article-title":"Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome","volume":"36","author":"Tao","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nn.3911","article-title":"Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion","volume":"18","author":"Tian","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003501","article-title":"Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism","volume":"4","author":"Silverman","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115311_bib73","series-title":"Fragile X Syndrome: From Genetics to Targeted Treatment","first-page":"173","article-title":"The mGluR theory of fragile X: from mice to men","author":"Stoppel","year":"2017"},{"key":"10.1016\/j.celrep.2025.115311_bib74","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1126\/science.aas9963","article-title":"Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins","volume":"361","author":"Greenblatt","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115311_bib75","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.neuron.2022.11.012","article-title":"Excessive proteostasis contributes to pathology in fragile X syndrome","volume":"111","author":"Louros","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib76","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.neuropharm.2005.06.006","article-title":"GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator","volume":"49","author":"Moskal","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2025.115311_bib77","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam8572","article-title":"Selective inhibition of glycogen synthase kinase 3alpha corrects pathophysiology in a mouse model of fragile X syndrome","volume":"12","author":"McCamphill","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115311_bib78","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1570159X14666160321122703","article-title":"The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant","volume":"15","author":"Moskal","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.celrep.2025.115311_bib79","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.24073","article-title":"GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy","volume":"75","author":"Lemke","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2025.115311_bib80","article-title":"Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual\/Developmental Disabilities","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115311_bib81","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature12439","article-title":"De novo mutations in epileptic encephalopathies","volume":"501","author":"Epi4K Consortium","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115311_bib82","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib83","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/j.1471-4159.2006.03843.x","article-title":"Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of nitric oxide production","volume":"97","author":"Cossenza","year":"2006","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2025.115311_bib84","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2006.03.040","article-title":"Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis","volume":"125","author":"Sutton","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115311_bib85","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/35016089","article-title":"Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity","volume":"405","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115311_bib86","doi-asserted-by":"crossref","first-page":"E305","DOI":"10.1073\/pnas.1214705110","article-title":"Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening","volume":"110","author":"Oh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115311_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100996","article-title":"Induction of input-specific spine shrinkage on dendrites of rodent hippocampal CA1 neurons using two-photon glutamate uncaging","volume":"2","author":"Jang","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.115311_bib88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.eplepsyres.2003.12.011","article-title":"The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs","volume":"59","author":"Barton","year":"2004","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.celrep.2025.115311_bib89","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1523\/JNEUROSCI.0829-13.2013","article-title":"Triheteromeric NMDA receptors at hippocampal synapses","volume":"33","author":"Tovar","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115311_bib90","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"Feng","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115311_bib91","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1073\/pnas.0335786100","article-title":"Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice","volume":"100","author":"Townsend","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725000828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725000828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:07:19Z","timestamp":1776920839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725000828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":91,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2211124725000828"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115311","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115311"}}