{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:08:56Z","timestamp":1784740136457,"version":"3.55.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["1F31 CA261046-01"],"award-info":[{"award-number":["1F31 CA261046-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.celrep.2025.115356","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:03:22Z","timestamp":1740751402000},"page":"115356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis"],"prefix":"10.1016","volume":"44","author":[{"given":"Samantha M.","family":"Golomb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Guldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Aleksandrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaneann R.","family":"Fross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karena","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-3666","authenticated-orcid":false,"given":"Siyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115356_bib1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ccell.2017.02.009","article-title":"The Microenvironmental Landscape of Brain Tumors","volume":"31","author":"Quail","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1158\/0008-5472.CAN-18-1805","article-title":"A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis","volume":"79","author":"Doron","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.115356_bib3","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1038\/s41467-023-38252-8","article-title":"Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment","volume":"14","author":"Ma","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115356_bib4","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41591-018-0044-4","article-title":"STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis","volume":"24","author":"Priego","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115356_bib5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cell.2020.09.064","article-title":"CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10","volume":"183","author":"Guldner","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ccell.2023.12.018","article-title":"Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms","volume":"42","author":"Bejarano","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib7","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1016\/j.cell.2023.08.043","article-title":"The local microenvironment drives activation of neutrophils in human brain tumors","volume":"186","author":"Maas","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib8","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1158\/1078-0432.CCR-21-1549","article-title":"Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis","volume":"27","author":"Wu","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.115356_bib9","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","article-title":"A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment","volume":"22","author":"Van Hove","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115356_bib10","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated with Restricting Development of Alzheimer\u2019s Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.immuni.2018.01.011","article-title":"High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease","volume":"48","author":"Mrdjen","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115356_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat7554","article-title":"Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation","volume":"363","author":"Jord\u00e3o","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115356_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20180794","article-title":"Microbiome\u2013microglia connections via the gut\u2013brain axis","volume":"216","author":"Abdel-Haq","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2025.115356_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chom.2015.04.011","article-title":"Control of Brain Development, Function, and Behavior by the Microbiome","volume":"17","author":"Sampson","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115356_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-019-1434-3","article-title":"Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis","volume":"16","author":"Ma","year":"2019","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2025.115356_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115356_bib17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115356_bib18","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","article-title":"Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease","volume":"33","author":"Erny","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.115356_bib19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T\u00a0cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115356_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115356_bib22","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature15367","article-title":"Neutrophil ageing is regulated by the microbiome","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib23","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1158\/0008-5472.CAN-18-3464","article-title":"Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer","volume":"79","author":"Buchta Rosean","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.115356_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017996","article-title":"Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression","volume":"6","author":"Reikvam","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115356_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2019.06.002","article-title":"Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells","volume":"51","author":"Bachem","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115356_bib27","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1038\/s41598-022-27086-x","article-title":"Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids","volume":"13","author":"Caetano-Silva","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115356_bib28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115356_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jnutbio.2018.03.007","article-title":"Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development","volume":"57","author":"Tian","year":"2018","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.celrep.2025.115356_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mi.2014.44","article-title":"Short-chain fatty acids induce both effector and regulatory T\u00a0cells by suppression of histone deacetylases and regulation of the mTOR\u2013S6K pathway","volume":"8","author":"Park","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib31","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2018.04.022","article-title":"Dietary Fiber Confers Protection against Flu by Shaping Ly6c\u2212 Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism","volume":"48","author":"Trompette","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115356_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.01995","article-title":"Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection","volume":"9","author":"Bhaskaran","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.115356_bib33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.cell.2017.11.042","article-title":"Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner","volume":"172","author":"Thion","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100537","article-title":"Isolation of mouse brain-infiltrating leukocytes for single cell profiling of epitopes and transcriptomes","volume":"2","author":"Guldner","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.115356_bib35","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115356_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108438","article-title":"Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis","volume":"33","author":"Golomb","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115356_bib38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib39","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115356_bib40","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41592-024-02303-9","article-title":"CellRank 2: unified fate mapping in multiview single-cell data","volume":"21","author":"Weiler","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115356_bib41","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.cell.2021.04.004","article-title":"A single-embryo, single-cell time-resolved model for mouse gastrulation","volume":"184","author":"Mittnenzweig","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib42","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2016.07.043","article-title":"The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome","volume":"166","author":"Gury-BenAri","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115356_bib44","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.immuni.2022.09.005","article-title":"Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation","volume":"55","author":"Vlaminck","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115356_bib45","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/s41556-023-01273-y","article-title":"Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis","volume":"25","author":"Evans","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115356_bib46","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1242\/jcs.064097","article-title":"Chromatin interaction of TATA-binding protein is dynamically regulated in human cells","volume":"123","author":"de Graaf","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2025.115356_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0968-0004(00)89005-2","article-title":"D-type cyclins","volume":"20","author":"Sherr","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2025.115356_bib48","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.3390\/ijms18122614","article-title":"The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease","volume":"18","author":"Fries","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.115356_bib49","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ceb.2009.09.002","article-title":"Growth control and ribosome biogenesis","volume":"21","author":"Lempi\u00e4inen","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115356_bib50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40168-017-0263-9","article-title":"Microbiota-activated CD103\u00a0+ DCs stemming from microbiota adaptation specifically drive \u03b3\u03b4T17 proliferation and activation","volume":"5","author":"Fleming","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2025.115356_bib51","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41467-018-05901-2","article-title":"Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis","volume":"9","author":"Sun","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115356_bib52","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.chom.2021.07.013","article-title":"A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1","volume":"29","author":"Li","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115356_bib53","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41590-020-0776-4","article-title":"Meningeal \u03b3\u03b4 T\u00a0cells regulate anxiety-like behavior via IL-17a signaling in neurons","volume":"21","author":"Alves de Lima","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib54","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1084\/jem.20100269","article-title":"Contribution of IL-17\u2013producing \u03b3\u03b4 T\u00a0cells to the efficacy of anticancer chemotherapy","volume":"208","author":"Ma","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2025.115356_bib55","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T\u00a0cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib56","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.cell.2018.12.040","article-title":"Commensal Microbiota Promote Lung Cancer Development via \u03b3\u03b4 T Cells","volume":"176","author":"Jin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib57","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/eji.200838741","article-title":"In\u00a0vivo application of mAb directed against the \u03b3\u03b4 TCR does not deplete but generates \u201cinvisible\u201d \u03b3\u03b4 T\u00a0cells","volume":"39","author":"Koenecke","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib58","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nri.2015.1","article-title":"Regulatory T\u00a0cell memory","volume":"16","author":"Rosenblum","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau8380","article-title":"Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T\u00a0cell entry to initiate neuroinflammation","volume":"4","author":"Mundt","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100211","article-title":"Protocol for brain-wide or region-specific microglia depletion and repopulation in adult mice","volume":"1","author":"Willis","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.115356_bib61","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1084\/jem.190.12.1801","article-title":"Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors Cd94\/Nkg2c and Cd94\/Nkg2e on Mouse Natural Killer Cells","volume":"190","author":"Vance","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2025.115356_bib62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/intimm\/13.3.321","article-title":"The non-classical MHC class I molecule Qa-1b inhibits classical MHC class I-restricted cytotoxicity of cytotoxic T lymphocytes","volume":"13","author":"Lohwasser","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib63","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.4049\/jimmunol.176.3.1703","article-title":"Qa-1b and CD94-NKG2a Interaction Regulate Cytolytic Activity of Herpes Simplex Virus-Specific Memory CD8+ T Cells in the Latently Infected Trigeminal Ganglia1","volume":"176","author":"Suvas","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2025.115356_bib64","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.cell.2018.10.014","article-title":"Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells","volume":"175","author":"Andr\u00e9","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib65","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1053\/j.seminoncol.2011.01.016","article-title":"Nilotinib: a Novel, Selective Tyrosine Kinase Inhibitor","volume":"38","author":"Blay","year":"2011","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.celrep.2025.115356_bib66","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib67","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2019.03.036","article-title":"A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology","volume":"177","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib68","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T\u00a0cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115356_bib69","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.abb5920","article-title":"Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients","volume":"371","author":"Baruch","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115356_bib70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.115356_bib71","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.ccell.2021.08.006","article-title":"Microbiome and cancer","volume":"39","author":"Cullin","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.115356_bib72","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115356_bib73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"R: A Language for Data Analysis and Graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J.\u00a0Comput. Graph Stat."},{"key":"10.1016\/j.celrep.2025.115356_bib74","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115356_bib75","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.115356_bib76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115356_bib77","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725001275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725001275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:56:24Z","timestamp":1776920184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725001275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2211124725001275"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115356","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115356"}}