{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:21:54Z","timestamp":1790378514652,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020963","name":"Japan Science and Technology Agency Moonshot Research and Development Program","doi-asserted-by":"publisher","award":["JPMJMS2023"],"award-info":[{"award-number":["JPMJMS2023"]}],"id":[{"id":"10.13039\/501100020963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23gm1510011"],"award-info":[{"award-number":["JP23gm1510011"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.celrep.2025.115433","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T09:26:25Z","timestamp":1741857985000},"page":"115433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal progesterone and adipose mPR\u03b5 in pregnancy regulate the embryonic nutritional state"],"prefix":"10.1016","volume":"44","author":[{"given":"Keita","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Ohue-Kitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Masujima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Inuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Osakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junken","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-145X","authenticated-orcid":false,"given":"Ikuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115433_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41569-023-00869-z","article-title":"Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course","volume":"20","author":"Gaillard","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.celrep.2025.115433_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s42255-022-00570-4","article-title":"Sex differences in the intergenerational inheritance of metabolic traits","volume":"4","author":"Sandovici","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41574-020-0370-8","article-title":"Unravelling the role of epigenetics in reproductive adaptations to early-life environment","volume":"16","author":"Bar-Sadeh","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.115433_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw8429","article-title":"Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice","volume":"367","author":"Kimura","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115433_bib5","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.cmet.2023.06.007","article-title":"Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene","volume":"35","author":"Lopez-Tello","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ncpendmet0965","article-title":"Gestational diabetes mellitus: postpartum opportunities for the diagnosis and prevention of type 2 diabetes mellitus","volume":"4","author":"Bentley-Lewis","year":"2008","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0029-1237424","article-title":"Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms","volume":"27","author":"Wadhwa","year":"2009","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.celrep.2025.115433_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbadis.2013.07.007","article-title":"Maternal nutrition and risk of obesity in offspring: the Trojan horse of developmental plasticity","volume":"1842","author":"Parlee","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2025.115433_bib9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM199709253371301","article-title":"Predicting obesity in young adulthood from childhood and parental obesity","volume":"337","author":"Whitaker","year":"1997","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115433_bib10","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1542\/peds.82.6.828","article-title":"Birth weight and childhood growth","volume":"82","author":"Binkin","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.celrep.2025.115433_bib11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/aje\/kwk071","article-title":"Birth weight and subsequent risk of type 2 diabetes: a meta-analysis","volume":"165","author":"Harder","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.celrep.2025.115433_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.6065\/apem.2018.23.1.9","article-title":"Small for gestational age and obesity: epidemiology and general risks","volume":"23","author":"Nam","year":"2018","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.183.4125.610","article-title":"Female steroid hormones and target cell nuclei","volume":"183","author":"O'Malley","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115433_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1152\/physrev.00041.2022","article-title":"Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms","volume":"104","author":"Drury","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.115433_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/physrev.1968.48.3.601","article-title":"Effects of sex steroids and related compounds on pregnancy and on development of the young","volume":"48","author":"Saunders","year":"1968","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.115433_bib16","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1210\/en.2008-0084","article-title":"Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice","volume":"149","author":"L\u00f3pez-Garc\u00eda","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2025.115433_bib17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/physrev.00003.2003","article-title":"Nongenomic steroid action: controversies, questions, and answers","volume":"83","author":"Losel","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.115433_bib18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tem.2017.05.006","article-title":"Progesterone-Mediated Non-Classical Signaling","volume":"28","author":"Garg","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrendo.2011.122","article-title":"The G-protein-coupled estrogen receptor GPER in health and disease","volume":"7","author":"Prossnitz","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.115433_bib20","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yfrne.2008.01.001","article-title":"Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions","volume":"29","author":"Thomas","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.celrep.2025.115433_bib21","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1038\/s41598-017-05423-9","article-title":"Membrane progesterone receptor beta (mPR\u03b2\/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling","volume":"7","author":"Kasubuchi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115433_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1471-2180-12-194","article-title":"Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii","volume":"12","author":"Gonzalez-Velazquez","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.celrep.2025.115433_bib23","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1073\/pnas.0306324101","article-title":"Metalloregulation of yeast membrane steroid receptor homologs","volume":"101","author":"Lyons","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115433_bib24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00239-004-0375-2","article-title":"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif","volume":"61","author":"Tang","year":"2005","journal-title":"J.\u00a0Mol. Evol."},{"key":"10.1016\/j.celrep.2025.115433_bib25","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.0436133100","article-title":"Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor","volume":"100","author":"Zhu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115433_bib26","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.steroids.2008.05.003","article-title":"Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors","volume":"73","author":"Smith","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.celrep.2025.115433_bib27","article-title":"Progesterone induces meiosis through two obligate co-receptors with PLA2 activity","volume":"13","author":"Nader","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115433_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101331","article-title":"PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPAR\u03b1","volume":"53","author":"Lin","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.115433_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.112032","article-title":"PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in \u03b2 cells in\u00a0vitro under stress conditions","volume":"575","author":"Li","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.celrep.2025.115433_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/biolreprod\/8.2.203","article-title":"Corpus luteum function in guinea pigs, hamsters, rats, mice and rabbits","volume":"8","author":"Hilliad","year":"1973","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2025.115433_bib31","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115433_bib32","first-page":"20","article-title":"Extreme insulin resistance during pregnancy: a therapeutic challenge","volume":"2021","author":"Kampmann","year":"2021","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"10.1016\/j.celrep.2025.115433_bib33","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202088","article-title":"Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism","volume":"150","author":"Kramer","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.celrep.2025.115433_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving lipid mediators and mechanisms in the resolution of acute inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115433_bib35","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1096\/fj.201500127","article-title":"Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance","volume":"30","author":"Chan","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2025.115433_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012748","article-title":"TRPV1 in brain is involved in acetaminophen-induced antinociception","volume":"5","author":"Mallet","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115433_bib37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1210\/en.2006-0974","article-title":"Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins","volume":"148","author":"Thomas","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2025.115433_bib38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115433_bib39","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/nar\/gkp1137","article-title":"The Sanger FASTQ file format for sequences with quality scores, and the Solexa\/Illumina FASTQ variants","volume":"38","author":"Cock","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115433_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115433_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.115433_bib42","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1038\/s41467-021-22431-6","article-title":"Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115433_bib43","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"BLIGH","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.celrep.2025.115433_bib44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00018-023-04813-9","article-title":"Cell density-dependent membrane distribution of ganglioside GM3 in melanoma cells","volume":"80","author":"Murate","year":"2023","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725002049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725002049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:06:35Z","timestamp":1776920795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725002049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2211124725002049"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115433","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.26.609823","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal progesterone and adipose mPR\u03b5 in pregnancy regulate the embryonic nutritional state","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115433"}}