{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:43:02Z","timestamp":1791999782269,"version":"4.4.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010287"],"award-info":[{"award-number":["2023A1515010287"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2021QN020751"],"award-info":[{"award-number":["2021QN020751"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2021QN02Y112"],"award-info":[{"award-number":["2021QN02Y112"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0303010002"],"award-info":[{"award-number":["2023B0303010002"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220818103206013"],"award-info":[{"award-number":["JCYJ20220818103206013"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["20231120133942002"],"award-info":[{"award-number":["20231120133942002"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515011636"],"award-info":[{"award-number":["2023A1515011636"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101297"],"award-info":[{"award-number":["82101297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173391"],"award-info":[{"award-number":["82173391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.celrep.2025.115559","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T16:49:36Z","timestamp":1744390176000},"page":"115559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission"],"prefix":"10.1016","volume":"44","author":[{"given":"Kangtai","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7473-0354","authenticated-orcid":false,"given":"Zilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115559_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2021.07.076","article-title":"Itch: Epidemiology, clinical presentation, and diagnostic workup","volume":"86","author":"Roh","year":"2022","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2025.115559_bib2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The Itch-Scratch Cycle: A Neuroimmune Perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.immuni.2019.03.013","article-title":"Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch","volume":"50","author":"Meixiong","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115559_bib4","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/all.13870","article-title":"Pruritus in ordinary scabies: IL-31 from macrophages induced by overexpression of thymic stromal lymphopoietin and periostin","volume":"74","author":"Hashimoto","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.115559_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni763","article-title":"Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation","volume":"3","author":"Fang","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2020.12.033","article-title":"A basophil-neuronal axis promotes itch","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115559_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1053\/j.gastro.2021.03.049","article-title":"Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine","volume":"161","author":"Chen","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2025.115559_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.jaci.2020.09.037","article-title":"Increased group 2 innate lymphoid cells in peripheral blood of adults with mastocytosis","volume":"147","author":"van der Ploeg","year":"2021","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib9","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaci.2022.11.009","article-title":"IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin","volume":"151","author":"Hashimoto","year":"2023","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.immuni.2020.04.008","article-title":"Itch: A Paradigm of Neuroimmune Crosstalk","volume":"52","author":"Wang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115559_bib11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1152\/physrev.00017.2019","article-title":"Physiology and Pathophysiology of Itch","volume":"100","author":"Cevikbas","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2025.115559_bib12","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cell.2009.11.034","article-title":"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus","volume":"139","author":"Liu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115559_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jaci.2021.09.014","article-title":"IL-33 signaling in sensory neurons promotes dry skin itch","volume":"149","author":"Trier","year":"2022","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115559_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2021.08.211","article-title":"Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis","volume":"98","author":"Xiao","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbi.2021.01.027","article-title":"Acupuncture ameliorates not only atopic dermatitis-like skin inflammation but also acute and chronic serotonergic itch possibly through blockade of 5-HT(2) and 5-HT(7) receptors in mice","volume":"93","author":"Park","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib17","doi-asserted-by":"crossref","first-page":"E7572","DOI":"10.1073\/pnas.1606608113","article-title":"IL-33\/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy","volume":"113","author":"Liu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115559_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","article-title":"IL-31: a new link between T\u00a0cells and pruritus in atopic skin inflammation","volume":"117","author":"Sonkoly","year":"2006","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/sj.bjp.0705754","article-title":"Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice","volume":"142","author":"Bell","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.115559_bib20","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature06029","article-title":"A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord","volume":"448","author":"Sun","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115559_bib21","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1174868","article-title":"Cellular basis of itch sensation","volume":"325","author":"Sun","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuron.2019.06.016","article-title":"Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch","volume":"103","author":"Pan","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115559_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.celrep.2019.06.033","article-title":"Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch","volume":"28","author":"Acton","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115559_bib24","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.jid.2018.05.008","article-title":"The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch","volume":"138","author":"Gao","year":"2018","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2025.115559_bib25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","article-title":"Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord","volume":"82","author":"Kardon","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115559_bib26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.aac8653","article-title":"Gate control of mechanical itch by a subpopulation of spinal cord interneurons","volume":"350","author":"Bourane","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2010.02.025","article-title":"Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice","volume":"65","author":"Ross","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115559_bib28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.3912","article-title":"STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch","volume":"21","author":"Shiratori-Hayashi","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115559_bib29","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/glia.23639","article-title":"Spinal IL-33\/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade","volume":"67","author":"Du","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2025.115559_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-019-0284-z","article-title":"Cannabinoids and the expanded endocannabinoid system in neurological disorders","volume":"16","author":"Cristino","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2025.115559_bib31","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/CIRCULATIONAHA.122.059304","article-title":"Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries","volume":"147","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2025.115559_bib32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbi.2023.02.001","article-title":"CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice","volume":"110","author":"Li","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/acs.chemrev.5b00411","article-title":"Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists","volume":"116","author":"Aghazadeh Tabrizi","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2025.115559_bib34","article-title":"Microglial Cannabinoid CB(2) Receptors in Pain Modulation","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.115559_bib35","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/glia.20871","article-title":"Microglia and neuropathic pain","volume":"57","author":"Inoue","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2025.115559_bib36","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.celrep.2016.06.018","article-title":"Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury","volume":"16","author":"Gu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115559_bib37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abl6773","article-title":"Microglia-mediated degradation of perineuronal nets promotes pain","volume":"377","author":"Tansley","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2020.11.030","article-title":"Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice","volume":"92","author":"Yi","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib39","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.4049\/jimmunol.179.9.5966","article-title":"Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia","volume":"179","author":"Qin","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib40","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.4049\/jimmunol.177.11.7761","article-title":"IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3","volume":"177","author":"Qin","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.stem.2022.02.004","article-title":"Decoding the temporal and regional specification of microglia in the developing human brain","volume":"29","author":"Li","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.115559_bib42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nri818","article-title":"Suppressors of cytokine signalling (SOCS) in the immune system","volume":"2","author":"Alexander","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib43","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib44","doi-asserted-by":"crossref","first-page":"13956","DOI":"10.1073\/pnas.96.24.13956","article-title":"Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway","volume":"96","author":"Kovarik","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115559_bib45","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1038\/s41467-020-16859-5","article-title":"Central circuit mechanisms of itch","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115559_bib46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.aaf4918","article-title":"A central neural circuit for itch sensation","volume":"357","author":"Mu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ijms22010019","article-title":"CB2 Receptor in Microglia: The Guardian of Self-Control","volume":"22","author":"Komorowska-Muller","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.115559_bib48","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neubiorev.2018.12.026","article-title":"Progress in brain cannabinoid CB(2) receptor research: From genes to behavior","volume":"98","author":"Jordan","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.celrep.2025.115559_bib49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12974-018-1174-9","article-title":"Cannabinoid CB(2) receptors in the mouse brain: relevance for Alzheimer's disease","volume":"15","author":"Lopez","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2025.115559_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abp8869","article-title":"Association of a common genetic variant with Parkinson's disease is mediated by microglia","volume":"14","author":"Langston","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115559_bib51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.abf6805","article-title":"A spinal microglia population involved in remitting and relapsing neuropathic pain","volume":"376","author":"Kohno","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115559_bib52","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1016\/j.celrep.2019.05.087","article-title":"Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain","volume":"27","author":"Zhou","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115559_bib53","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115559_bib54","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1111\/all.15699","article-title":"Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1beta-GRPR axis","volume":"78","author":"Liu","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.115559_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108739","article-title":"Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease","volume":"34","author":"Yang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115559_bib56","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115559_bib57","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz121","article-title":"IKAP-Identifying K mAjor cell Population groups in single-cell RNA-sequencing analysis","volume":"8","author":"Chen","year":"2019","journal-title":"GigaScience"},{"key":"10.1016\/j.celrep.2025.115559_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1093592","article-title":"The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice","volume":"14","author":"Hatcher","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.celrep.2025.115559_bib59","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12264-017-0124-3","article-title":"TNF-alpha\/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms","volume":"34","author":"Miao","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.celrep.2025.115559_bib60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2025.115559_bib61","first-page":"e67","article-title":"Real-life study of anti-itching effects of a cream containing menthoxypropanediol, a TRPM8 agonist, in atopic dermatitis patients","volume":"33","author":"Misery","year":"2019","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.celrep.2025.115559_bib62","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.4049\/jimmunol.179.6.3495","article-title":"Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages","volume":"179","author":"Schroder","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2025.115559_bib63","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1093\/emboj\/18.20.5601","article-title":"p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons","volume":"18","author":"Goh","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.115559_bib64","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41467-022-28473-8","article-title":"Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain","volume":"13","author":"Tansley","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115559_bib65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2015.06.002","article-title":"Endocannabinoids drive the acquisition of an alternative phenotype in microglia","volume":"49","author":"Mecha","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib66","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13045-022-01357-6","article-title":"CRISPR\/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality","volume":"15","author":"Sorrentino","year":"2022","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.celrep.2025.115559_bib67","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-079X.2011.00885.x","article-title":"Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats","volume":"51","author":"Tsai","year":"2011","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.celrep.2025.115559_bib68","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41419-022-05295-6","article-title":"Retraction Note to: Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression","volume":"13","author":"Choi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.115559_bib69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbi.2022.09.017","article-title":"Opening K(ATP) channels induces inflammatory tolerance and prevents chronic pain","volume":"107","author":"Qian","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib70","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-023-05607-4","article-title":"Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury","volume":"14","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.115559_bib71","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneuroim.2016.01.015","article-title":"Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism","volume":"292","author":"Boontanrart","year":"2016","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.celrep.2025.115559_bib72","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5240127","article-title":"Folic Acid Is Able to Polarize the Inflammatory Response in LPS Activated Microglia by Regulating Multiple Signaling Pathways","volume":"2016","author":"Cianciulli","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.celrep.2025.115559_bib73","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1007\/s00210-024-03070-2","article-title":"Mer activation ameliorates nerve injury-induced neuropathic pain by regulating microglial polarization and neuroinflammation via SOCS3 in male rats","volume":"397","author":"Wang","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.celrep.2025.115559_bib74","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1523\/JNEUROSCI.23-10-04017.2003","article-title":"p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain","volume":"23","author":"Jin","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2025.115559_bib75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/glia.10308","article-title":"Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury","volume":"45","author":"Tsuda","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2025.115559_bib76","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12974-017-0960-0","article-title":"Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y(12) and P2Y(13) receptors in neuropathic pain rats","volume":"14","author":"Niu","year":"2017","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2025.115559_bib77","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s10571-019-00703-6","article-title":"Lidocaine Potentiates SOCS3 to Attenuate Inflammation in Microglia and Suppress Neuropathic Pain","volume":"39","author":"Zheng","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2025.115559_bib78","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12264-017-0128-z","article-title":"Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice","volume":"34","author":"Jing","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.celrep.2025.115559_bib79","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1097\/j.pain.0000000000000208","article-title":"CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis","volume":"156","author":"Qu","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2025.115559_bib80","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.115559_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade7002","article-title":"Regulation of neuropathic pain by microglial Orai1 channels","volume":"9","author":"Tsujikawa","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2025.115559_bib82","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awaa430","article-title":"Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2025.115559_bib83","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbi.2024.01.002","article-title":"Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn","volume":"117","author":"Shan","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115559_bib84","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw6471","article-title":"Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates","volume":"12","author":"Wang","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115559_bib85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115559_bib86","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115559_bib87","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks461","article-title":"Camera: a competitive gene set test accounting for inter-gene correlation","volume":"40","author":"Wu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115559_bib88","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115559_bib89","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115559_bib90","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115559_bib91","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725003304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725003304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:09:02Z","timestamp":1778843342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725003304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2211124725003304"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115559","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115559","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115559"}}