{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:11:12Z","timestamp":1776838272160,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["CPRIT RR170008"],"award-info":[{"award-number":["CPRIT RR170008"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.celrep.2025.115674","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T14:49:24Z","timestamp":1746715764000},"page":"115674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-7485","authenticated-orcid":false,"given":"Wei-Hsin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloukick Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Blagdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep Kumar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einav","family":"Shoshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Bachar-Lustig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Reisner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115674_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.seminhematol.2019.03.003","article-title":"Veto cells for safer nonmyeloablative haploidentical HSCT and CAR T cell therapy","volume":"56","author":"Reisner","year":"2019","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.celrep.2025.115674_bib2","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1182\/blood-2003-03-0759","article-title":"Anti\u2013third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose","volume":"102","author":"Bachar-Lustig","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib3","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.jtct.2023.10.016","article-title":"Generation of Non-Alloreactive Antiviral Central Memory CD8 Human Veto T Cells for Cell Therapy","volume":"30","author":"Bachar-Lustig","year":"2024","journal-title":"Transplant. Cell. Ther."},{"key":"10.1016\/j.celrep.2025.115674_bib4","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood-2009-10-248716","article-title":"Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo\u2013induced central memory CD8 T cells","volume":"115","author":"Ophir","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib5","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1182\/blood-2012-07-441493","article-title":"Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells","volume":"121","author":"Ophir","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib6","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1038\/s41409-021-01237-6","article-title":"Correction of murine sickle cell disease by allogeneic haematopoietic cell transplantation with anti-3rd party veto cells","volume":"56","author":"Singh","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.celrep.2025.115674_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/stcltm\/szad021","article-title":"Correction of T-Cell Repertoire and Autoimmune Diabetes in NOD Mice by Non-myeloablative T-Cell Depleted Allogeneic HSCT","volume":"12","author":"Sidlik Muskatel","year":"2023","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.celrep.2025.115674_bib8","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1038\/s41375-019-0501-1","article-title":"Next-generation CD8 memory veto T cells directed against memory antigens","volume":"33","author":"Or-Geva","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.115674_bib9","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1182\/blood-2022-159183","article-title":"First in Human Study of Anti-Viral Veto Cells Enabling Successful Engraftment without Severe Gvhd in Non-Myeloablative T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)","volume":"140","author":"Champlin","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib46","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/leu.2017.332","article-title":"Towards \u2018off-the-shelf\u2019 genetically modified T cells: prolonging functional engraftment in mice by CD8 veto T cells","volume":"32","author":"Or-Geva","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.115674_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1074-7613(00)00050-9","article-title":"Anti-Third Party CD8+CTLs as Potent Veto Cells: Coexpression of CD8 and FasL Is a Prerequisite","volume":"13","author":"Reich-Zeliger","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115674_bib11","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.4049\/jimmunol.173.11.6660","article-title":"Tolerance Induction by Veto CTLs in the TCR Transgenic 2C Mouse Model. II. Deletion of Effector Cells by Fas-Fas Ligand Apoptosis1","volume":"173","author":"Reich-Zeliger","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/TP.0b013e3181e86b28","article-title":"Deletion of Alloreactive T Cells by Veto Cytotoxic T Lymphocytes Is Mediated Through Extracellular Signal-Regulated Kinase Phosphorylation","volume":"90","author":"Reich-Zeliger","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.celrep.2025.115674_bib13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood-2009-10-248716","article-title":"Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells","volume":"115","author":"Ophir","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib14","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1084\/jem.165.4.1212","article-title":"Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection","volume":"165","author":"Murphy","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.115674_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbmt.2003.09.002","article-title":"The immunobiology of natural killer cells and bone marrow allograft rejection","volume":"9","author":"Barao","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.celrep.2025.115674_bib16","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.133.5.2390","article-title":"Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen","volume":"133","author":"Rammensee","year":"1984","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.175.3.863","article-title":"Clonal deletion of postthymic T cells: veto cells kill precursor cytotoxic T lymphocytes","volume":"175","author":"Hiruma","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.115674_bib18","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/intimm\/8.12.1833","article-title":"Ly-49 G2+ NK cells are responsible for mediating the rejection of H-2b bone marrow allografts in mice","volume":"8","author":"Raziuddin","year":"1996","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-065X.1997.tb00938.x","article-title":"Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors","volume":"155","author":"Raulet","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.115674_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100262","article-title":"Flow cytometry-based ex vivo murine NK cell cytotoxicity assay","volume":"2","author":"Wong","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.115674_bib21","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.1182\/blood-2012-03-415364","article-title":"Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells","volume":"119","author":"Gill","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.732511","article-title":"T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells","volume":"12","author":"Kiekens","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib24","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.immuni.2020.09.010","article-title":"CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8(+) T Cells","volume":"53","author":"Braun","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115674_bib25","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1158\/1078-0432.CCR-20-0575","article-title":"IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma","volume":"26","author":"Chauvin","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.115674_bib26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1034\/j.1600-0854.2003.t01-1-00109.x","article-title":"Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation","volume":"4","author":"Jiang","year":"2003","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2025.115674_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2010.02.004","article-title":"Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase","volume":"32","author":"Kim","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115674_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/19420889.2016.1216739","article-title":"Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity","volume":"9","author":"Matalon","year":"2016","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.celrep.2025.115674_bib29","doi-asserted-by":"crossref","first-page":"28950","DOI":"10.1074\/jbc.M304474200","article-title":"Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis","volume":"278","author":"Duan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.115674_bib30","doi-asserted-by":"crossref","first-page":"37153","DOI":"10.1074\/jbc.M403210200","article-title":"c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes","volume":"279","author":"Ravid","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.115674_bib31","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.4049\/jimmunol.0901226","article-title":"Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells1","volume":"183","author":"Carlsten","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15184616","article-title":"Dysregulation of DNAM-1-Mediated NK Cell Anti-Cancer Responses in the Tumor Microenvironment","volume":"15","author":"Paolini","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.115674_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054406","article-title":"Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells","volume":"8","author":"Kamran","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115674_bib34","doi-asserted-by":"crossref","first-page":"E2973","DOI":"10.1073\/pnas.1524924113","article-title":"Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation","volume":"113","author":"Gross","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115674_bib35","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1182\/blood-2009-08-238584","article-title":"Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance","volume":"115","author":"Adeegbe","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/frtra.2023.1217065","article-title":"Tregs in transplantation tolerance: role and therapeutic potential","volume":"2","author":"Cassano","year":"2023","journal-title":"Front. Transplant."},{"key":"10.1016\/j.celrep.2025.115674_bib37","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1158\/1078-0432.CCR-16-1300","article-title":"Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition","volume":"23","author":"Ren","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.115674_bib38","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1182\/blood.2020005185","article-title":"Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR\/Cas9-mediated TCR knockout CAR","volume":"136","author":"Stenger","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib39","doi-asserted-by":"crossref","first-page":"e833","DOI":"10.1016\/S2352-3026(22)00245-9","article-title":"UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial","volume":"9","author":"Benjamin","year":"2022","journal-title":"Lancet. Haematol."},{"key":"10.1016\/j.celrep.2025.115674_bib40","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1182\/blood-2013-03-478255","article-title":"Toward eliminating HLA class I expression to generate universal cells from allogeneic donors","volume":"122","author":"Torikai","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115674_bib41","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1158\/2326-6066.CIR-18-0508","article-title":"Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy","volume":"8","author":"Kagoya","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2025.115674_bib42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u2018missing self\u2019: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1016\/j.celrep.2025.115674_bib43","first-page":"295","article-title":"MHC gene control of the natural killer system at the level of the target and the host","volume":"2","author":"K\u00e4rre","year":"1991","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.celrep.2025.115674_bib44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.smim.2006.03.003","article-title":"Missing self recognition and self tolerance of natural killer (NK) cells","volume":"18","author":"Raulet","year":"2006","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2025.115674_bib45","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1182\/blood-2023-175033","article-title":"Allogeneic Veto-CAR CD8 T Cells Enabling Prolonged Graft Survival, Anti-Tumor Specificity, and Low Risk of Graft Versus Host Disease","volume":"142","author":"Liu","year":"2023","journal-title":"Blood"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:25:49Z","timestamp":1776835549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725004450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2211124725004450"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115674","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115674"}}