{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:13:24Z","timestamp":1793798004084,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP120459"],"award-info":[{"award-number":["RP120459"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP120348"],"award-info":[{"award-number":["RP120348"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA270025"],"award-info":[{"award-number":["R01CA270025"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA31534"],"award-info":[{"award-number":["R01CA31534"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008275","name":"University of Florida Health","doi-asserted-by":"publisher","award":["381.915"],"award-info":[{"award-number":["381.915"]}],"id":[{"id":"10.13039\/100008275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR079220"],"award-info":[{"award-number":["R01AR079220"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR060209"],"award-info":[{"award-number":["R01AR060209"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR081648"],"award-info":[{"award-number":["R01AR081648"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.celrep.2025.115689","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T02:57:01Z","timestamp":1746845821000},"page":"115689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-8721","authenticated-orcid":false,"given":"Jeremy B.","family":"Ducharme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Neyroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Schonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Gutierrez-Monreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley O.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn A.","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115689_bib1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: A new definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.celrep.2025.115689_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2025.115689_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2025.115689_bib4","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1172\/JCI68523","article-title":"NF-\u03baB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia","volume":"123","author":"He","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.115689_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087776","article-title":"C26 Cancer-Induced Muscle Wasting Is IKK\u03b2-Dependent and NF-kappaB-Independent","volume":"9","author":"Cornwell","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115689_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022538","article-title":"STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia","volume":"6","author":"Bonetto","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115689_bib7","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/emboj.2011.292","article-title":"C\/EBP\u03b2 mediates tumour-induced ubiquitin ligase atrogin1\/MAFbx upregulation and muscle wasting","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.115689_bib8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1096\/fj.11-189977","article-title":"Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy","volume":"26","author":"Reed","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2025.115689_bib9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/sj.cgt.7701091","article-title":"Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice","volume":"14","author":"Liu","year":"2007","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.celrep.2025.115689_bib10","doi-asserted-by":"crossref","first-page":"C1258","DOI":"10.1152\/ajpcell.00105.2009","article-title":"Myostatin reduces Akt\/TORC1\/p70S6K signaling, inhibiting myoblast differentiation and myotube size","volume":"296","author":"Trendelenburg","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2025.115689_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/1471-2407-12-265","article-title":"Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia","volume":"12","author":"Skorokhod","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2025.115689_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jcsm.12666","article-title":"FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness","volume":"12","author":"Neyroud","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2025.115689_bib13","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00701.2024","article-title":"Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting","volume":"328","author":"Schonk","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2025.115689_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s42003-023-04902-2","article-title":"Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth","volume":"6","author":"Neyroud","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.115689_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13668","article-title":"Local Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer","volume":"16","author":"Neyroud","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2025.115689_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115689_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13395-015-0039-5","article-title":"The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle","volume":"5","author":"Hodge","year":"2015","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.celrep.2025.115689_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molmet.2013.10.005","article-title":"Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock","volume":"3","author":"Dyar","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2025.115689_bib19","first-page":"2213","article-title":"Brain and muscle Arnt-like 1 is a key regulator of myogenesis","volume":"126","author":"Chatterjee","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2025.115689_bib20","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1113\/JP271436","article-title":"Intrinsic muscle clock is necessary for musculoskeletal health","volume":"593","author":"Schroder","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2025.115689_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13395-016-0082-x","article-title":"Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis","volume":"6","author":"Harfmann","year":"2016","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.celrep.2025.115689_bib22","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2016.04.039","article-title":"Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis","volume":"165","author":"Masri","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115689_bib23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0748730417728663","article-title":"Guidelines for Genome-Scale Analysis of Biological Rhythms","volume":"32","author":"Hughes","year":"2017","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.celrep.2025.115689_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab224","article-title":"Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications","volume":"22","author":"Ding","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.celrep.2025.115689_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111982","article-title":"Defining the age-dependent and tissue-specific circadian transcriptome in male mice","volume":"42","author":"Wolff","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115689_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/jncics\/pky043","article-title":"Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival","volume":"2","author":"Judge","year":"2018","journal-title":"JNCI Cancer Spectr."},{"key":"10.1016\/j.celrep.2025.115689_bib27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/jcsm.12550","article-title":"Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle","volume":"11","author":"Nosacka","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2025.115689_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2020.04.017","article-title":"Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia","volume":"484","author":"Shukla","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2025.115689_bib29","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1158\/0008-5472.CAN-19-1558","article-title":"MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients","volume":"80","author":"Judge","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.115689_bib30","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.celrep.2025.115689_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-3-642-25950-0_6","article-title":"Circadian clocks and metabolism","author":"Marcheva","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.celrep.2025.115689_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semcdb.2015.11.005","article-title":"The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting","volume":"54","author":"Carson","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.115689_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi9654","article-title":"Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle","volume":"7","author":"Gabriel","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2025.115689_bib34","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115689_bib35","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.tips.2018.07.003","article-title":"Training the circadian clock, clocking the drugs and drugging the clock to prevent, manage and treat chronic diseases","volume":"39","author":"Sulli","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.celrep.2025.115689_bib36","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1249\/MSS.0b013e318255cf4c","article-title":"Scheduled exercise phase shifts the circadian clock in skeletal muscle","volume":"44","author":"Wolff","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.celrep.2025.115689_bib37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41574-023-00805-8","article-title":"Metabolism and exercise: the skeletal muscle clock takes centre stage","volume":"19","author":"Martin","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2025.115689_bib38","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s11914-020-00628-w","article-title":"Sex Differences in Cancer Cachexia","volume":"18","author":"Zhong","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.celrep.2025.115689_bib39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1182\/blood-2009-07-232694","article-title":"Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development","volume":"115","author":"Feng","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115689_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.115689_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.115689_bib42","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.115689_bib43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115689_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115689_bib45","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/bioinformatics\/btac166","article-title":"Analysing high-throughput sequencing data in Python with HTSeq 2.0","volume":"38","author":"Putri","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115689_bib46","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1172\/JCI123540","article-title":"Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer","volume":"129","author":"Sivaram","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.115689_bib47","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni.2890","article-title":"The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells","volume":"15","author":"Wang","year":"2014","journal-title":"Nat. Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:11:19Z","timestamp":1778843479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725004607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2211124725004607"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115689","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115689"}}