{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:24:48Z","timestamp":1789431888784,"version":"build-2803163510"},"reference-count":111,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM147414"],"award-info":[{"award-number":["R35 GM147414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DP1AI158186"],"award-info":[{"award-number":["DP1AI158186"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93022C00036"],"award-info":[{"award-number":["75N93022C00036"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010319","name":"Shurl and Kay Curci Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.celrep.2025.115696","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T11:48:21Z","timestamp":1747050501000},"page":"115696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals"],"prefix":"10.1016","volume":"44","author":[{"given":"Risako","family":"Gen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Addetia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Asarnow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Quispe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody G.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Lapointe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-8675","authenticated-orcid":false,"given":"David","family":"Veesler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115696_bib1","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2020-0355","article-title":"Zoonotic spillover: Understanding basic aspects for better prevention","volume":"44","author":"Ellwanger","year":"2021","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41586-020-03128-0","article-title":"Lessons from the host defences of bats, a unique viral reservoir","volume":"589","author":"Irving","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib3","article-title":"A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special?","volume":"280","author":"Luis","year":"2013","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.celrep.2025.115696_bib4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature22975","article-title":"Host and viral traits predict zoonotic spillover from mammals","volume":"546","author":"Olival","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100958","article-title":"Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection","volume":"23","author":"Banerjee","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2025.115696_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/v11020152","article-title":"Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat","volume":"11","author":"Banerjee","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2025.115696_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fimmu.2020.00026","article-title":"Novel Insights Into Immune Systems of Bats","volume":"11","author":"Banerjee","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.115696_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib9","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1073\/pnas.1518240113","article-title":"Contraction of the type I IFN locus and unusual constitutive expression of IFN-\u03b1 in bats","volume":"113","author":"Zhou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115696_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chom.2018.01.006","article-title":"Dampened STING-Dependent Interferon Activation in Bats","volume":"23","author":"Xie","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115696_bib11","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cell.2018.03.070","article-title":"The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity","volume":"173","author":"Pavlovich","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00608-22","article-title":"Species-specific molecular barriers to SARS-CoV-2 replication in bat cells","volume":"96","author":"Aicher","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41564-019-0371-3","article-title":"Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host","volume":"4","author":"Ahn","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.115696_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108345","article-title":"Interferon regulatory factors IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection","volume":"33","author":"Irving","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115696_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41579-020-0394-z","article-title":"Bat-borne virus diversity, spillover and emergence","volume":"18","author":"Letko","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2025.115696_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.virusres.2018.02.013","article-title":"Tools to study pathogen-host interactions in bats","volume":"248","author":"Banerjee","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.celrep.2025.115696_bib17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3389\/fimmu.2017.01098","article-title":"Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans","volume":"8","author":"Schountz","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.115696_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1863-2378.2012.01528.x","article-title":"Antiviral immune responses of bats: a review","volume":"60","author":"Baker","year":"2013","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.celrep.2025.115696_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41577-021-00523-0","article-title":"Decoding bat immunity: the need for a coordinated research approach","volume":"21","author":"Wang","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115696_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-animal-022516-022811","article-title":"Bat biology, genomes, and the Bat1K project: To generate chromosome-level genomes for all living bat species","volume":"6","author":"Teeling","year":"2018","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.celrep.2025.115696_bib21","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.immuni.2022.10.008","article-title":"Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea","volume":"55","author":"Gamage","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115696_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib23","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115696_bib24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115696_bib25","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","article-title":"Identification of a novel coronavirus in patients with severe acute respiratory syndrome","volume":"348","author":"Drosten","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115696_bib26","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","article-title":"A novel coronavirus associated with severe acute respiratory syndrome","volume":"348","author":"Ksiazek","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115696_bib27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.115696_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-022-00884-5","article-title":"Structural biology of SARS-CoV-2: open the door for novel therapies","volume":"7","author":"Yan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2025.115696_bib29","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1126\/science.abc8665","article-title":"Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2","volume":"369","author":"Thoms","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00266-21","article-title":"SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors","volume":"95","author":"Kumar","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib31","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1128\/JVI.01700-12","article-title":"Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA","volume":"86","author":"Tanaka","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib32","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.molcel.2020.10.034","article-title":"Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA","volume":"80","author":"Yuan","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41594-020-0511-8","article-title":"SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation","volume":"27","author":"Schubert","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109841","article-title":"The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression","volume":"37","author":"Mendez","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115696_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1261\/rna.078121.120","article-title":"The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation","volume":"27","author":"Tidu","year":"2020","journal-title":"RNA"},{"key":"10.1016\/j.celrep.2025.115696_bib36","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1128\/JVI.02485-08","article-title":"Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses","volume":"83","author":"Tohya","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib37","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1128\/JVI.01352-15","article-title":"Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin","volume":"89","author":"Lokugamage","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib38","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0603144103","article-title":"Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation","volume":"103","author":"Kamitani","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115696_bib39","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1016\/j.molcel.2023.09.002","article-title":"Universal features of Nsp1-mediated translational shutdown by coronaviruses","volume":"83","author":"Schubert","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113156","article-title":"Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses","volume":"42","author":"Devarkar","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115696_bib41","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1111\/tbed.14713","article-title":"SARS-CoV-2 infection in dogs and cats is associated with contact to COVID-19-positive household members","volume":"69","author":"Kannekens-Jager","year":"2022","journal-title":"Transboundary and emerging diseases"},{"key":"10.1016\/j.celrep.2025.115696_bib42","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.23.2001005","article-title":"SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020","volume":"25","author":"Oreshkova","year":"2020","journal-title":"Euro Surveill."},{"key":"10.1016\/j.celrep.2025.115696_bib43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41586-021-04353-x","article-title":"SARS-CoV-2 infection in free-ranging white-tailed deer","volume":"602","author":"Hale","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib44","unstructured":"Food and Agricultural Organization of the United Nations. SARS-CoV-2 in animals situation update. https:\/\/www.fao.org\/animal-health\/situation-updates\/sars-cov-2-in-animals\/en. (2024)."},{"key":"10.1016\/j.celrep.2025.115696_bib45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41421-020-00210-9","article-title":"Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2","volume":"6","author":"Wu","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.celrep.2025.115696_bib46","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1080\/22221751.2020.1831405","article-title":"Susceptibility of swine cells and domestic pigs to SARS-CoV-2","volume":"9","author":"Meekins","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.celrep.2025.115696_bib47","article-title":"Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2","volume":"118","author":"Liu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115696_bib48","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/tbed.13861","article-title":"Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies","volume":"68","author":"Vergara-Alert","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.celrep.2025.115696_bib49","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1016\/j.cell.2021.06.008","article-title":"Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses","volume":"184","author":"Zhou","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib50","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41467-021-21240-1","article-title":"Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia","volume":"12","author":"Wacharapluesadee","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115696_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00449-22","article-title":"A Look inside the Replication Dynamics of SARS-CoV-2 in Blyth\u2019s Horseshoe Bat Kidney Cells","volume":"10","author":"Auerswald","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2025.115696_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.immuni.2005.06.008","article-title":"Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA","volume":"23","author":"Karik\u00f3","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115696_bib53","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nsmb.1680","article-title":"A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein","volume":"16","author":"Kamitani","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/srep27726","article-title":"Phylogenomic analyses of bat subordinal relationships based on transcriptome data","volume":"6","author":"Lei","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115696_bib55","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/molbev\/msi180","article-title":"A nuclear DNA phylogenetic perspective on the evolution of echolocation and historical biogeography of extant bats (chiroptera)","volume":"22","author":"Eick","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.celrep.2025.115696_bib56","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.aaa3872","article-title":"Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome","volume":"348","author":"Greber","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature13895","article-title":"The complete structure of the large subunit of the mammalian mitochondrial ribosome","volume":"515","author":"Greber","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib58","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1126\/science.289.5481.905","article-title":"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution","volume":"289","author":"Ban","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib59","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.289.5481.920","article-title":"The structural basis of ribosome activity in peptide bond synthesis","volume":"289","author":"Nissen","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/35030006","article-title":"Structure of the 30S ribosomal subunit","volume":"407","author":"Wimberly","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib61","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35030019","article-title":"Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics","volume":"407","author":"Carter","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib62","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)00084-2","article-title":"Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution","volume":"102","author":"Schluenzen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03080","article-title":"Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine","volume":"3","author":"Wong","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115696_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017715118","article-title":"Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation","volume":"118","author":"Lapointe","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115696_bib65","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1128\/JVI.78.11.5633-5641.2004","article-title":"Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively","volume":"78","author":"Shaw","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib66","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3390\/v14050936","article-title":"Henipavirus immune evasion and pathogenesis mechanisms: Lessons learnt from natural infection and animal models","volume":"14","author":"Lawrence","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2025.115696_bib67","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1128\/JVI.79.10.6078-6088.2005","article-title":"Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways","volume":"79","author":"Shaw","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib68","doi-asserted-by":"crossref","first-page":"11476","DOI":"10.1128\/JVI.76.22.11476-11483.2002","article-title":"Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation","volume":"76","author":"Rodriguez","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012709","article-title":"The nonstructural proteins of Nipah virus play a key role in pathogenicity in experimentally infected animals","volume":"5","author":"Yoneda","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115696_bib70","doi-asserted-by":"crossref","first-page":"11842","DOI":"10.1128\/JVI.77.21.11842-11845.2003","article-title":"Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation","volume":"77","author":"Rodriguez","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib71","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/v11030291","article-title":"Differential innate immune responses elicited by Nipah virus and Cedar virus correlate with disparate in vivo pathogenesis in hamsters","volume":"11","author":"Schountz","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2025.115696_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002836","article-title":"Cedar virus: a novel Henipavirus isolated from Australian bats","volume":"8","author":"Marsh","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.115696_bib73","article-title":"Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2025.115696_bib74","doi-asserted-by":"crossref","first-page":"8677","DOI":"10.1093\/nar\/gkad627","article-title":"SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome","volume":"51","author":"Tardivat","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115696_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111892","article-title":"SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D","volume":"41","author":"Lee","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115696_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030109","article-title":"Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines","volume":"3","author":"Z\u00fcst","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.115696_bib77","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1128\/JVI.00702-07","article-title":"Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain","volume":"81","author":"Wathelet","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib78","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/JVI.03535-14","article-title":"The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU","volume":"89","author":"Zhang","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.752214","article-title":"Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition","volume":"12","author":"Yuan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.115696_bib80","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s42003-022-03427-4","article-title":"SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication","volume":"5","author":"Miyamoto","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib81","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.02191-21","article-title":"ICP22 of herpes simplex virus 1 decreases RNA polymerase processivity","volume":"96","author":"Birkenheuer","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib82","first-page":"1232","article-title":"Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro","volume":"13","author":"Clark","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib83","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(04)00132-1","article-title":"TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus","volume":"116","author":"Le May","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib84","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/jvi.68.4.2425-2432.1994","article-title":"The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)","volume":"68","author":"Qiu","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib85","doi-asserted-by":"crossref","first-page":"9527","DOI":"10.1128\/JVI.01230-12","article-title":"A common strategy for host RNA degradation by divergent viruses","volume":"86","author":"Gaglia","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib86","doi-asserted-by":"crossref","first-page":"11089","DOI":"10.1073\/pnas.95.19.11089","article-title":"Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection","volume":"95","author":"Gradi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115696_bib87","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1128\/JVI.02201-08","article-title":"Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation","volume":"83","author":"Blakqori","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115696_bib88","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2022.10.012","article-title":"Translation-A tug of war during viral infection","volume":"83","author":"Rozman","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib89","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.meegid.2010.05.014","article-title":"Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities","volume":"10","author":"Wang","year":"2010","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.celrep.2025.115696_bib90","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40486","article-title":"Structures of translationally inactive mammalian ribosomes","volume":"7","author":"Brown","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115696_bib91","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1038\/s41467-024-50672-8","article-title":"Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit","volume":"15","author":"Brito Querido","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115696_bib92","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41586-023-06487-6","article-title":"Neutralization, effector function and immune imprinting of Omicron variants","volume":"621","author":"Addetia","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib93","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1126\/science.adc9127","article-title":"Imprinted antibody responses against SARS-CoV-2 Omicron sublineages","volume":"378","author":"Park","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib94","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.abq0203","article-title":"Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines","volume":"377","author":"Bowen","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib95","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cell.2022.01.011","article-title":"SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses","volume":"185","author":"Walls","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib96","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/s41586-021-04386-2","article-title":"Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift","volume":"602","author":"Cameroni","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib97","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1038\/s41467-023-39782-x","article-title":"Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115696_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.587317","article-title":"SARS-CoV-2 nsp1: Bioinformatics, potential structural and functional features, and implications for drug\/vaccine designs","volume":"11","author":"Min","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2025.115696_bib99","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.abn8652","article-title":"Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement","volume":"375","author":"McCallum","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115696_bib100","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.molcel.2007.05.019","article-title":"eIF3j is located in the decoding center of the human 40S ribosomal subunit","volume":"26","author":"Fraser","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.115696_bib101","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","article-title":"Automated electron microscope tomography using robust prediction of specimen movements","volume":"152","author":"Mastronarde","year":"2005","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib102","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1017\/S1431927620021194","article-title":"Algorithmic Advances in Single Particle Cryo-EM Data Processing Using CryoSPARC","volume":"26","author":"Punjani","year":"2020","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.celrep.2025.115696_bib103","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115696_bib104","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: Meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2025.115696_bib105","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-024-07215-4","article-title":"Automated model building and protein identification in cryo-EM maps","volume":"628","author":"Jamali","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115696_bib106","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115696_bib107","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib108","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1107\/S2059798318002425","article-title":"ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps","volume":"74","author":"Croll","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.celrep.2025.115696_bib109","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17219","article-title":"Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta","volume":"5","author":"Wang","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115696_bib110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.celrep.2025.115696_bib111","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41594-024-01274-x","article-title":"The structure of the human 80S ribosome at 1.9 \u00c5 resolution reveals the molecular role of chemical modifications and ions in RNA","volume":"31","author":"Holvec","year":"2024","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500467X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500467X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:30:14Z","timestamp":1776835814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472500467X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":111,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S221112472500467X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115696","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.14.633005","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115696"}}