{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:07:53Z","timestamp":1791497273180,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221914\/Z\/20\/Z"],"award-info":[{"award-number":["221914\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.celrep.2025.115721","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:14:32Z","timestamp":1747286072000},"page":"115721","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection"],"prefix":"10.1016","volume":"44","author":[{"given":"Danielle J.","family":"Smyth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne H.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole W.P.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Colomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Di Carmine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Shek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Frangova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Campillo","family":"Poveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-7407","authenticated-orcid":false,"given":"Henry J.","family":"McSorley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115721_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","article-title":"Soil-transmitted helminth infections","volume":"391","author":"Jourdan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.115721_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.prevetmed.2020.105103","article-title":"Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe","volume":"182","author":"Charlier","year":"2020","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.celrep.2025.115721_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00436-023-08088-8","article-title":"Anthelmintic resistance in soil-transmitted helminths: One-Health considerations","volume":"123","author":"Ng'etich","year":"2023","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.celrep.2025.115721_bib4","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1017\/S003118201700227X","article-title":"Control of helminth ruminant infections by 2030","volume":"145","author":"Vercruysse","year":"2018","journal-title":"Parasitology"},{"key":"10.1016\/j.celrep.2025.115721_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004676","article-title":"Concerted activity of IgG1 antibodies and IL-4\/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection","volume":"11","author":"Hewitson","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.115721_bib6","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.4049\/jimmunol.1401645","article-title":"Antibody-mediated trapping of helminth larvae requires CD11b and Fcgamma receptor I","volume":"194","author":"Bieren","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2011.08.011","article-title":"Immune modulation and modulators in Heligmosomoides polygyrus infection","volume":"132","author":"Maizels","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.celrep.2025.115721_bib8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115721_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.molmed.2020.12.010","article-title":"Mining Helminths for Novel Therapeutics","volume":"27","author":"Lothstein","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2025.115721_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.immuni.2017.09.015","article-title":"HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33","volume":"47","author":"Osbourn","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115721_bib11","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1038\/s41467-024-49550-0","article-title":"Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2","volume":"15","author":"Jamwal","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115721_bib12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3389\/fimmu.2020.01363","article-title":"A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine","volume":"11","author":"Chauche","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.99000.3","article-title":"Heparan sulphate binding controls in vivo half-life of the HpARI protein family","volume":"13","author":"Colomb","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115721_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00395-23","article-title":"IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses","volume":"92","author":"Colomb","year":"2024","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2025.115721_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54017","article-title":"A helminth-derived suppressor of ST2 blocks allergic responses","volume":"9","author":"Vacca","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2025.115721_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13071-022-05211-z","article-title":"Transgenesis in parasitic helminths: a brief history and prospects for the future","volume":"15","author":"Quinzo","year":"2022","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.celrep.2025.115721_bib17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.115721_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101532","article-title":"IL-33: A central cytokine in helminth infections","volume":"53","author":"McSorley","year":"2021","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2012-05-434209","article-title":"Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent","volume":"121","author":"Enoksson","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.115721_bib20","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115721_bib21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature13577","article-title":"The alarmin IL-33 promotes regulatory T-cell function in the intestine","volume":"513","author":"Schiering","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115721_bib22","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1002\/eji.201141629","article-title":"IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells","volume":"41","author":"Yang","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib23","article-title":"Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products","volume":"98","author":"Johnston","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.celrep.2025.115721_bib24","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.1102832","article-title":"IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs","volume":"188","author":"Bartemes","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib25","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.4049\/jimmunol.1003020","article-title":"The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses","volume":"186","author":"Kouzaki","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib26","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/mi.2013.123","article-title":"Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy","volume":"7","author":"McSorley","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/mi.2016.93","article-title":"Eosinophils are required to suppress Th2 responses in Peyer's patches during intestinal infection by nematodes","volume":"10","author":"Strandmark","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13071-023-05785-2","article-title":"Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri","volume":"16","author":"Pollo","year":"2023","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.celrep.2025.115721_bib29","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02210-2022","article-title":"Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE\/EGFR signalling complex","volume":"62","author":"Strickson","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.celrep.2025.115721_bib30","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1038\/s41598-023-36642-y","article-title":"Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE\/EGFR to reduce inflammation and epithelial dysfunction","volume":"13","author":"England","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115721_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003492","article-title":"Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity","volume":"9","author":"Hewitson","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.115721_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41385-019-0231-8","article-title":"NK cell recruitment limits tissue damage during an enteric helminth infection","volume":"13","author":"Gentile","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.115721_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijpara.2020.07.011","article-title":"Characterisation of the secreted apyrase family of Heligmosomoides polygyrus","volume":"51","author":"Berkachy","year":"2021","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.celrep.2025.115721_bib34","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1038\/s41467-017-01886-6","article-title":"A structurally distinct TGF-beta mimic from an intestinal helminth parasite potently induces regulatory T cells","volume":"8","author":"Johnston","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115721_bib35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijpara.2017.12.004","article-title":"TGF-beta mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus","volume":"48","author":"Smyth","year":"2018","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.celrep.2025.115721_bib36","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/s41467-019-09996-z","article-title":"The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function","volume":"10","author":"Bancroft","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115721_bib37","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1016\/j.vaccine.2013.05.026","article-title":"Successful immunization against a parasitic nematode by vaccination with recombinant proteins","volume":"31","author":"Nisbet","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2025.115721_bib38","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115721_bib39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molbiopara.2016.11.005","article-title":"WormBase ParaSite - a comprehensive resource for helminth genomics","volume":"215","author":"Howe","year":"2017","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725004929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:16:38Z","timestamp":1776834998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725004929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2211124725004929"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115721","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.22.609138","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115721","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115721"}}