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(2022). cluster: Cluster Analysis Basics and Extensions. https:\/\/cran.r-project.org\/package=cluster."},{"key":"10.1016\/j.celrep.2025.115734_bib62","first-page":"2847","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics (Oxford, England)"},{"key":"10.1016\/j.celrep.2025.115734_bib63","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2025.115734_bib64","doi-asserted-by":"crossref","unstructured":"Ogan Mancarci, L.F. (2019). Quick Access to Homologene and Gene Annotation Updates. https:\/\/doi.org\/10.32614\/CRAN.package.homologene.","DOI":"10.32614\/CRAN.package.homologene"},{"key":"10.1016\/j.celrep.2025.115734_bib65","unstructured":"P.L. 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