{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:05:30Z","timestamp":1793221530326,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009750","name":"University of Rochester Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG072298"],"award-info":[{"award-number":["R01AG072298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.celrep.2025.115762","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:03:09Z","timestamp":1749560589000},"page":"115762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human glial progenitors transplanted into Huntington disease mice normalize neuronal gene expression, dendritic structure, and behavior"],"prefix":"10.1016","volume":"44","author":[{"given":"Carlos Benitez","family":"Villanueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen P.T.","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Sysh\u00f8j","family":"Lorenzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Chandler-Militello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Benraiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-4303","authenticated-orcid":false,"given":"Steven A.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115762_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.410310412","article-title":"Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease","volume":"31","author":"Albin","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2025.115762_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1602\/neurorx.1.2.255","article-title":"Huntington's disease genetics","volume":"1","author":"Myers","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.celrep.2025.115762_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2025.115762_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1474-4422(22)00121-1","article-title":"Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2025.115762_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/stem.3300","article-title":"Cell therapy in Huntington's disease: Taking stock of past studies to move the field forward","volume":"39","author":"Bachoud-Levi","year":"2021","journal-title":"Stem Cell."},{"key":"10.1016\/j.celrep.2025.115762_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/bs.pbr.2017.02.009","article-title":"Pluripotent stem cell-derived neurons for transplantation in Huntington's disease","volume":"230","author":"Li","year":"2017","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.celrep.2025.115762_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1474-4422(22)00189-2","article-title":"Huntington's disease: disappointments and new beginnings","volume":"21","author":"Saft","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.celrep.2025.115762_bib8","doi-asserted-by":"crossref","first-page":"22480","DOI":"10.1073\/pnas.0911503106","article-title":"Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms","volume":"106","author":"Bradford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115762_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","article-title":"Astrocytes: a central element in neurological diseases","volume":"131","author":"Pekny","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2025.115762_bib10","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","article-title":"Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity","volume":"171","author":"Shin","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115762_bib11","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11758","article-title":"Human glia can both induce and rescue aspects of disease phenotype in Huntington disease","volume":"7","author":"Benraiss","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115762_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2018.03.003","article-title":"An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales","volume":"98","author":"Octeau","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115762_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.stem.2018.11.010","article-title":"Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation","volume":"24","author":"Osipovitch","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib15","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1007\/s12035-021-02451-5","article-title":"Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice","volume":"58","author":"Jing","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2025.115762_bib16","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.1523\/JNEUROSCI.1510-14.2014","article-title":"A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia","volume":"34","author":"Windrem","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib17","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.1523\/JNEUROSCI.1510-14.2014","article-title":"A Competitive Advantage by Neonatally Engrafted Human Glial Progenitors Yields Mice Whose Brains Are Chimeric for Human Glia","volume":"34","author":"Windrem","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41587-023-01798-5","article-title":"Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain","volume":"42","author":"Vieira","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115762_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ajhg.2011.07.002","article-title":"Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease","volume":"89","author":"Weedon","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2025.115762_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/jmedgenet-2011-100542","article-title":"Mutations in DYNC1H1 cause severe intellectual disability with neuronal migration defects","volume":"49","author":"Willemsen","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.celrep.2025.115762_bib21","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1073\/pnas.0610628104","article-title":"Huntingtin facilitates dynein\/dynactin-mediated vesicle transport","volume":"104","author":"Caviston","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115762_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fncel.2019.00005","article-title":"Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation","volume":"13","author":"Sayas","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib23","doi-asserted-by":"crossref","first-page":"D877","DOI":"10.1093\/nar\/gkw1012","article-title":"MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search","volume":"45","author":"Rappaport","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115762_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuron.2019.05.002","article-title":"SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse","volume":"103","author":"Koopmans","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115762_bib25","first-page":"139","article-title":"Relative importance for linear regression in R: The package relaimpo","volume":"17","author":"Groemping","year":"2007","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.celrep.2025.115762_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-022-01078-9","article-title":"The role of histone modifications: from neurodevelopment to neurodiseases","volume":"7","author":"Park","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2025.115762_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib28","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington's disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.celrep.2025.115762_bib29","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115762_bib30","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1523\/JNEUROSCI.2137-12.2013","article-title":"Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models","volume":"33","author":"Cepeda","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib31","doi-asserted-by":"crossref","DOI":"10.1042\/AN20090058","article-title":"Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms","volume":"2","author":"Cepeda","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.celrep.2025.115762_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200626","article-title":"Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+\/- mouse model of Huntington's Disease","volume":"13","author":"Goodliffe","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115762_bib33","series-title":"Handbook of Basal Ganglia Structure and Function","first-page":"99","article-title":"The Striatal Skeleton: Medium Spiny Projection Neurons and their Lateral Connections","author":"Dietmar Plenz","year":"2010"},{"key":"10.1016\/j.celrep.2025.115762_bib34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2007.03.008","article-title":"D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons","volume":"30","author":"Surmeier","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s13311-012-0112-2","article-title":"Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease","volume":"9","author":"Ehrlich","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.celrep.2025.115762_bib36","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1523\/JNEUROSCI.21-23-09112.2001","article-title":"Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease","volume":"21","author":"Laforet","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib37","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.115762_bib38","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/77528","article-title":"Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115762_bib39","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1523\/JNEUROSCI.22-05-01592.2002","article-title":"Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease","volume":"22","author":"Ferrante","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","article-title":"The role of dopamine in motor symptoms in the R6\/2 transgenic mouse model of Huntington's disease","volume":"81","author":"Hickey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.celrep.2025.115762_bib41","article-title":"Prevention of Huntington's Disease-Like Behavioral Deficits in R6\/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.celrep.2025.115762_bib42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(98)00736-7","article-title":"Striking changes in anxiety in Huntington's disease transgenic mice","volume":"805","author":"File","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.115762_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2005.01.024","article-title":"Early behavioral deficits in R6\/2 mice suitable for use in preclinical drug testing","volume":"20","author":"Hickey","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115762_bib44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.nbd.2011.04.009","article-title":"Reduced expression of conditioned fear in the R6\/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex","volume":"43","author":"Walker","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115762_bib45","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nn.3080","article-title":"An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin","volume":"15","author":"Lo Sardo","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib46","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"Liot","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104637","article-title":"Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the htt(Q140\/Q140) mouse model of Huntington's disease","volume":"134","author":"McAdam","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115762_bib48","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/hmg\/ddab047","article-title":"ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease","volume":"30","author":"Cozzolino","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2025.115762_bib49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuroscience.2021.10.007","article-title":"Estrogen-related Receptor Alpha (ERRalpha) is Required for PGC-1alpha-dependent Gene Expression in the Mouse Brain","volume":"479","author":"McMeekin","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2025.115762_bib50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41420-024-01953-0","article-title":"PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration","volume":"10","author":"You","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.celrep.2025.115762_bib51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.neuron.2010.04.038","article-title":"Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex","volume":"66","author":"Cubelos","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115762_bib53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnins.2020.00082","article-title":"Cortical and Striatal Circuits in Huntington's Disease","volume":"14","author":"Blumenstock","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib54","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1176\/jnp.2010.22.2.196","article-title":"Frontal\" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness","volume":"22","author":"Duff","year":"2010","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib55","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.3693-15.2016","article-title":"Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice","volume":"36","author":"Jiang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jnnp.2006.098368","article-title":"Functional connectivity of the prefrontal cortex in Huntington's disease","volume":"78","author":"Thiruvady","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2025.115762_bib57","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.stem.2008.03.020","article-title":"Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse","volume":"2","author":"Windrem","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib58","doi-asserted-by":"crossref","first-page":"14635","DOI":"10.1523\/JNEUROSCI.1729-10.2010","article-title":"Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting","volume":"30","author":"Wang","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115762_bib59","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nbt0901-843","article-title":"High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain","volume":"19","author":"Keyoung","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115762_bib60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2004.08.018","article-title":"CD44 expression identifies astrocyte-restricted precursor cells","volume":"276","author":"Liu","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2025.115762_bib61","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib62","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.stem.2013.04.014","article-title":"Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease","volume":"12","author":"Benraiss","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib63","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory","volume":"1","author":"Bevins","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.115762_bib64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115762_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115762_bib66","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2025.115762_bib67","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41587-021-01206-w","article-title":"A Python library for probabilistic analysis of single-cell omics data","volume":"40","author":"Gayoso","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115762_bib68","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.115762_bib69","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115762_bib70","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2025.115762_bib71","article-title":"org.Mm.eg.db: Genome wide annotation for Mouse","volume":"3.8.2","author":"Carlson","year":"2019","journal-title":"R package version"},{"key":"10.1016\/j.celrep.2025.115762_bib72","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115762_bib73","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi G","year":"2006","journal-title":"InterJournal, Complex Systems"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725005339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725005339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:00:54Z","timestamp":1762603254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725005339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2211124725005339"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115762","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human glial progenitors transplanted into Huntington disease mice normalize neuronal gene expression, dendritic structure, and behavior","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115762"}}