{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:30:11Z","timestamp":1770557411568,"version":"3.49.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFHZ0080"],"award-info":[{"award-number":["2024YFHZ0080"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20335"],"award-info":[{"award-number":["U23A20335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.celrep.2025.115857","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T07:48:23Z","timestamp":1749714503000},"page":"115857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal vitamin D regulates the metabolic rearrangement of offspring CD4+ T cells in response to intestinal inflammation"],"prefix":"10.1016","volume":"44","author":[{"given":"Binjun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runmin","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115857_bib1","first-page":"45","article-title":"Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation","volume":"379","author":"Hata","year":"2023","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib2","doi-asserted-by":"crossref","first-page":"12776","DOI":"10.1073\/pnas.1202556109","article-title":"Modeling an autism risk factor in mice leads to permanent immune dysregulation","volume":"109","author":"Hsiao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115857_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116514","article-title":"A prospective population-based study of gestational vitamin D status and brain morphology in preadolescents","volume":"209","author":"Zou","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.celrep.2025.115857_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yfrne.2012.07.001","article-title":"Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease","volume":"34","author":"Eyles","year":"2013","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.celrep.2025.115857_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/mp.2016.213","article-title":"Gestational vitamin D deficiency and autism-related traits: the Generation R Study","volume":"23","author":"Vinkhuyzen","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.celrep.2025.115857_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0140-6736(13)61647-5","article-title":"Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis","volume":"383","author":"Reid","year":"2014","journal-title":"Lancet (N. Am. Ed.)"},{"key":"10.1016\/j.celrep.2025.115857_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.beem.2011.05.009","article-title":"Vitamin D and the brain","volume":"25","author":"Harms","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.celrep.2025.115857_bib8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbr.2015.03.008","article-title":"Maternal vitamin D deficiency alters fetal brain development in the BALB\/c mouse","volume":"286","author":"Hawes","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.celrep.2025.115857_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40168-016-0225-7","article-title":"Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study","volume":"5","author":"Kang","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2025.115857_bib10","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2019.10.027","article-title":"Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways","volume":"179","author":"Huang","year":"2019","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib11","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/s41591-022-01845-9","article-title":"Parental inflammatory bowel disease and autism in children","volume":"28","author":"Sadik","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115857_bib12","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s10803-017-3409-5","article-title":"Association of Autism Spectrum Disorders and Inflammatory Bowel Disease","volume":"48","author":"Lee","year":"2018","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.celrep.2025.115857_bib13","first-page":"2281","article-title":"Prevalence of Inflammatory Bowel Disease Among Patients with Autism Spectrum Disorders","volume":"21","author":"Doshi-Velez","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.celrep.2025.115857_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbi.2023.06.014","article-title":"MIA mice exhibit enteric nerve defects and are more susceptible to dextran sulfate sodium-induced colitis","volume":"112","author":"Li","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2025.115857_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2021.11.005","article-title":"Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells","volume":"55","author":"Kim","year":"2022","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tem.2019.04.005","article-title":"Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity","volume":"30","author":"Cantorna","year":"2019","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.celrep.2025.115857_bib17","doi-asserted-by":"crossref","first-page":"E1678","DOI":"10.1073\/pnas.1615783114","article-title":"Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis","volume":"114","author":"Zeitelhofer","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115857_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41590-021-01080-3","article-title":"Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells","volume":"23","author":"Chauss","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2311566120","article-title":"Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets","volume":"120","author":"Ramanan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115857_bib20","first-page":"481","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115857_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2023.01.014","article-title":"Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation","volume":"56","author":"Krausgruber","year":"2023","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib23","first-page":"933","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib24","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nm1749","article-title":"CD3-specific antibody\u2013induced immune tolerance involves transforming growth factor-\u03b2 from phagocytes digesting apoptotic T cells","volume":"14","author":"Perruche","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115857_bib25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature10228","article-title":"Control of TH17 cells occurs in the small intestine","volume":"475","author":"Esplugues","year":"2011","journal-title":"Nature (London)"},{"key":"10.1016\/j.celrep.2025.115857_bib26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/ibd\/izad160","article-title":"Exploring Colitis through Dynamic T Cell Adoptive Transfer Models","volume":"29","author":"Yang","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.celrep.2025.115857_bib27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.immuni.2017.02.010","article-title":"Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation","volume":"46","author":"Tan","year":"2017","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib28","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.cmet.2017.05.007","article-title":"Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation","volume":"25","author":"Tarasenko","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.115857_bib29","article-title":"mTOR- and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib30","first-page":"1255","article-title":"mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence","volume":"367","author":"Hwang","year":"2020","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08114","article-title":"The AP-1 transcription factor Batf controls TH17 differentiation","volume":"460","author":"Schraml","year":"2009","journal-title":"Nature (London)"},{"key":"10.1016\/j.celrep.2025.115857_bib32","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ni.2037","article-title":"The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells","volume":"12","author":"Ise","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib33","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20182009","article-title":"AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation","volume":"217","author":"Yukawa","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.115857_bib34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.immuni.2024.04.007","article-title":"A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification","volume":"57","author":"Liu","year":"2024","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13059-024-03175-0","article-title":"BORIS\/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites","volume":"25","author":"Pugacheva","year":"2024","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115857_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025647118","article-title":"Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer","volume":"118","author":"Miyata","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115857_bib37","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.immuni.2023.05.004","article-title":"Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation","volume":"56","author":"Chandra","year":"2023","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2320938121","article-title":"The Myc-associated zinc finger protein epigenetically controls expression of interferon-\u03b3-stimulated genes by recruiting STAT1 to chromatin","volume":"121","author":"Xiao","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115857_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00386-18","article-title":"Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling","volume":"38","author":"Triner","year":"2018","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115857_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/intimm\/dxr045","article-title":"Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling","volume":"23","author":"Bruce","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib41","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/mi.2014.94","article-title":"Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells","volume":"8","author":"Chen","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib42","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ajg.2016.53","article-title":"Association of Vitamin D Level With Clinical Status in Inflammatory Bowel Disease: A 5-Year Longitudinal Study","volume":"111","author":"Kabbani","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.115857_bib43","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.immuni.2020.09.003","article-title":"T Cell Receptor Is Required for Differentiation, but Not Maintenance, of Intestinal CD4+ Intraepithelial Lymphocytes","volume":"53","author":"Bilate","year":"2020","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nri1600","article-title":"Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?","volume":"5","author":"Eberl","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume":"3","author":"Mowat","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib46","article-title":"Trained immunity: A program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib47","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2020.04.030","article-title":"An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint","volume":"181","author":"Ramanan","year":"2020","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib48","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.immuni.2018.08.011","article-title":"IgA Responses to Microbiota","volume":"49","author":"Bunker","year":"2018","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib49","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.immuni.2015.08.007","article-title":"Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A","volume":"43","author":"Bunker","year":"2015","journal-title":"Immunity (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115857_bib50","article-title":"Natural polyreactive IgA antibodies coat the intestinal microbiota","volume":"358","author":"Bunker","year":"2017","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20041069","article-title":"CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate","volume":"200","author":"Wilson","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.115857_bib52","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1084\/jem.146.5.1311","article-title":"Origin of IgA-secreting plasma cells in the mammary gland","volume":"146","author":"Roux","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.115857_bib53","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00394-015-0966-2","article-title":"Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract","volume":"55","author":"Bashir","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.celrep.2025.115857_bib54","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/15548627.2015.1072670","article-title":"VDR\/vitamin D receptor regulates autophagic activity through ATG16L1","volume":"12","author":"Sun","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2025.115857_bib55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/MOG.0000000000000449","article-title":"Vitamin D in inflammatory bowel disease: more than just a supplement","volume":"34","author":"Gubatan","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.celrep.2025.115857_bib56","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13046-019-1499-y","article-title":"Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle","volume":"38","author":"Huang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.115857_bib57","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.autrev.2011.05.002","article-title":"Effects of vitamin D on the peripheral adaptive immune system: a review","volume":"10","author":"Peelen","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.celrep.2025.115857_bib58","first-page":"428","article-title":"Vitamin D regulates microbiome-dependent cancer immunity","volume":"384","author":"Giampazolias","year":"2024","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115857_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cell.2020.05.043","article-title":"Integrative Proteomic Characterization of Human Lung Adenocarcinoma","volume":"182","author":"Xu","year":"2020","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib60","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.115857_bib61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cell.2006.06.021","article-title":"Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling","volume":"126","author":"Cipolat","year":"2006","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm8182","article-title":"OXPHOS promotes apoptotic resistance and cellular persistence in TH 17 cells in the periphery and tumor microenvironment","volume":"7","author":"Hong","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib63","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","article-title":"Metabolic Regulation of T Lymphocytes","volume":"31","author":"MacIver","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.115857_bib64","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.cmet.2021.11.004","article-title":"Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis","volume":"33","author":"Hinrichsen","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2025.115857_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.107","article-title":"Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp","volume":"2","author":"Chen","year":"2023","journal-title":"iMeta"},{"key":"10.1016\/j.celrep.2025.115857_bib66","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/bioinformatics\/bty648","article-title":"Scaling read aligners to hundreds of threads on general-purpose processors","volume":"35","author":"Langmead","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115857_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.celrep.2025.115857_bib68","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.115857_bib69","doi-asserted-by":"crossref","first-page":"W187","DOI":"10.1093\/nar\/gku365","article-title":"deepTools: a flexible platform for exploring deep-sequencing data","volume":"42","author":"Ram\u00edrez","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115857_bib70","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based Analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115857_bib71","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature (London)"},{"key":"10.1016\/j.celrep.2025.115857_bib72","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.115857_bib73","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.cell.2016.04.038","article-title":"Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape","volume":"165","author":"O\u2019Malley","year":"2016","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13059-019-1642-2","article-title":"Identification of transcription factor binding sites using ATAC-seq","volume":"20","author":"Li","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.115857_bib75","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cell.2022.12.030","article-title":"Opioid-induced fragile-like regulatory T cells contribute to withdrawal","volume":"186","author":"Zhu","year":"2023","journal-title":"Cell (Cambridge, MA, U. S.)"},{"key":"10.1016\/j.celrep.2025.115857_bib76","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nprot.2007.41","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.115857_bib77","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20021345","article-title":"CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms","volume":"197","author":"Maloy","year":"2003","journal-title":"J. Exp. Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500628X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500628X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:06:47Z","timestamp":1762603607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472500628X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S221112472500628X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115857","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal vitamin D regulates the metabolic rearrangement of offspring CD4+ T cells in response to intestinal inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115857"}}