{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T08:03:33Z","timestamp":1782633813000,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGY0069"],"award-info":[{"award-number":["RGY0069"]}],"id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS089521"],"award-info":[{"award-number":["R01NS089521"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["DP1MH125776"],"award-info":[{"award-number":["DP1MH125776"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["F32MH118698"],"award-info":[{"award-number":["F32MH118698"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.celrep.2025.115862","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:46:35Z","timestamp":1752626795000},"page":"115862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation"],"prefix":"10.1016","volume":"44","author":[{"given":"Ethan","family":"Sorrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Rule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Forni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"O\u2019Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115862_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nature03721","article-title":"Microstructure of a spatial map in the entorhinal cortex","volume":"436","author":"Hafting","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1523\/JNEUROSCI.10-02-00420.1990","article-title":"Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis","volume":"10","author":"Taube","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(71)90358-1","article-title":"The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat","volume":"34","author":"O'Keefe","year":"1971","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2025.115862_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110504","article-title":"Adaptive integration of self-motion and goals in posterior parietal cortex","volume":"38","author":"Alexander","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115862_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature10918","article-title":"Choice-specific sequences in parietal cortex during a virtual-navigation decision task","volume":"484","author":"Harvey","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/cercor\/4.1.27","article-title":"Cortical representation of motion during unrestrained spatial navigation in the rat","volume":"4","author":"McNaughton","year":"1994","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2025.115862_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nlm.2008.08.007","article-title":"Parietal cortex, navigation, and the construction of arbitrary reference frames for spatial information","volume":"91","author":"Nitz","year":"2009","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.celrep.2025.115862_bib8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2006.01.037","article-title":"Tracking route progression in the posterior parietal cortex","volume":"49","author":"Nitz","year":"2006","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib9","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nn.3213","article-title":"Spaces within spaces: rat parietal cortex neurons register position across three reference frames","volume":"15","author":"Nitz","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2011.12.028","article-title":"Functional split between parietal and entorhinal cortices in the rat","volume":"73","author":"Whitlock","year":"2012","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib11","doi-asserted-by":"crossref","first-page":"14755","DOI":"10.1073\/pnas.0804216105","article-title":"Navigating from hippocampus to parietal cortex","volume":"105","author":"Whitlock","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115862_bib12","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1523\/JNEUROSCI.0511-14.2014","article-title":"Interaction of egocentric and world-centered reference frames in the rat posterior parietal cortex","volume":"34","author":"Wilber","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib13","doi-asserted-by":"crossref","first-page":"12913","DOI":"10.1523\/JNEUROSCI.1463-08.2008","article-title":"Decoding trajectories from posterior parietal cortex ensembles","volume":"28","author":"Mulliken","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76051","article-title":"Cognitive experience alters cortical involvement in goal-directed navigation","volume":"11","author":"Arlt","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.115862_bib15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2017.07.021","article-title":"Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex","volume":"170","author":"Driscoll","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115862_bib16","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1523\/JNEUROSCI.0105-17.2017","article-title":"Posterior Parietal Cortex Guides Visual Decisions in Rats","volume":"37","author":"Licata","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-023-06357-1","article-title":"A cell-type-specific error-correction signal in the posterior parietal cortex","volume":"620","author":"Green","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib18","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/nn.3865","article-title":"A category-free neural population supports evolving demands during decision-making","volume":"17","author":"Raposo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2021.10.020","article-title":"Sequential and efficient neural-population coding of complex task information","volume":"110","author":"Koay","year":"2022","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51121","article-title":"Stable task information from an unstable neural population","volume":"9","author":"Rule","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.115862_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2017.06.040","article-title":"Partially Mixed Selectivity in Human Posterior Parietal Association Cortex","volume":"95","author":"Zhang","year":"2017","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42583","article-title":"Decision and navigation in mouse parietal cortex","volume":"7","author":"Krumin","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.115862_bib23","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1038\/s41467-018-05012-y","article-title":"Task-dependent representations of stimulus and choice in mouse parietal cortex","volume":"9","author":"Pho","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115862_bib24","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.neuron.2019.08.025","article-title":"Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions","volume":"104","author":"Pinto","year":"2019","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuron.2019.01.029","article-title":"The Spatial Structure of Neural Encoding in Mouse Posterior Cortex during Navigation","volume":"102","author":"Minderer","year":"2019","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib26","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/j.neuron.2022.05.012","article-title":"Shared and specialized coding across posterior cortical areas for dynamic navigation decisions","volume":"110","author":"Tseng","year":"2022","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature13186","article-title":"A mesoscale connectome of the mouse brain","volume":"508","author":"Oh","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/cercor\/bhaa230","article-title":"Comprehensive Analysis of Long-Range Connectivity from and to the Posterior Parietal Cortex of the Mouse","volume":"31","author":"Oh","year":"2021","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2025.115862_bib29","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.neuron.2019.09.028","article-title":"Corticostriatal Flow of Action Selection Bias","volume":"104","author":"Hwang","year":"2019","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0000042","article-title":"Learning to control a brain-machine interface for reaching and grasping by primates","volume":"1","author":"Carmena","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2025.115862_bib31","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nn.3712","article-title":"Volitional modulation of optically recorded calcium signals during neuroprosthetic learning","volume":"17","author":"Clancy","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuron.2020.12.001","article-title":"The sensory representation of causally controlled objects","volume":"109","author":"Clancy","year":"2021","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature13665","article-title":"Neural constraints on learning","volume":"512","author":"Sadtler","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature04968","article-title":"A high-performance brain-computer interface","volume":"442","author":"Santhanam","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature16442","article-title":"Acute off-target effects of neural circuit manipulations","volume":"528","author":"Otchy","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.conb.2018.01.004","article-title":"The promise and perils of causal circuit manipulations","volume":"49","author":"Wolff","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2025.115862_bib37","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.115862_bib38","article-title":"Suite2p: beyond 10,000 neurons with standard two-photon microscopy","author":"Pachitariu","year":"2017","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.115862_bib39","article-title":"Behavioral clusters revealed by end-to-end decoding from microendoscopic imaging","author":"Chang","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.115862_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-925X-2-13","article-title":"ScanImage: flexible software for operating laser scanning microscopes","volume":"2","author":"Pologruto","year":"2003","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.celrep.2025.115862_bib41","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1038\/s41598-019-44166-7","article-title":"Principled BCI Decoder Design and Parameter Selection Using a Feedback Control Model","volume":"9","author":"Willett","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.115862_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature23020","article-title":"Distinct timescales of population coding across cortex","volume":"548","author":"Runyan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115862_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102609","article-title":"Representational drift: Emerging theories for continual learning and experimental future directions","volume":"76","author":"Driscoll","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2025.115862_bib44","first-page":"906","article-title":"Neurophysiology. Decoding motor imagery from the posterior parietal cortex of a tetraplegic human","volume":"348","author":"Aflalo","year":"2015","journal-title":"Sci. Technol. Humanit."},{"key":"10.1016\/j.celrep.2025.115862_bib45","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1523\/JNEUROSCI.07-07-01951.1987","article-title":"The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells","volume":"7","author":"Muller","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115862_bib46","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.neuron.2022.07.017","article-title":"Task specificity in mouse parietal cortex","volume":"110","author":"Lee","year":"2022","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib47","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuron.2014.08.042","article-title":"Engagement of neural circuits underlying 2D spatial navigation in a rodent virtual reality system","volume":"84","author":"Aronov","year":"2014","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.celrep.2025.115862_bib48","first-page":"1","article-title":"Application of the hierarchical bootstrap to multi-level data in neuroscience","volume":"3","author":"Saravanan","year":"2020","journal-title":"Neuron. Behav. Data Anal. Theory"},{"key":"10.1016\/j.celrep.2025.115862_bib49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/sim.4780090710","article-title":"More powerful procedures for multiple significance testing","volume":"9","author":"Hochberg","year":"1990","journal-title":"Stat. Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725006333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725006333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:44:21Z","timestamp":1763991861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725006333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2211124725006333"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115862","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.29.626034","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115862"}}