{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:26:02Z","timestamp":1789165562220,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI170928"],"award-info":[{"award-number":["R01AI170928"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006224","name":"Argonne National Laboratory","doi-asserted-by":"publisher","award":["DE-AC02-06CH11357"],"award-info":[{"award-number":["DE-AC02-06CH11357"]}],"id":[{"id":"10.13039\/100006224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["CHAVD UM1 AI44462"],"award-info":[{"award-number":["CHAVD UM1 AI44462"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-004923"],"award-info":[{"award-number":["INV-004923"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006151","name":"Basic Energy Sciences","doi-asserted-by":"publisher","award":["DE-AC02\\u201376SF00515"],"award-info":[{"award-number":["DE-AC02\\u201376SF00515"]}],"id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P41GM103393"],"award-info":[{"award-number":["P41GM103393"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011664","name":"SLAC National Accelerator Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006206","name":"Biological and Environmental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.celrep.2025.115948","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:26:41Z","timestamp":1751876801000},"page":"115948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift"],"prefix":"10.1016","volume":"44","author":[{"given":"Ge","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tazio","family":"Capozzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan N.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-ting","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Musharrafieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dueker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Anzanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Avillion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Lina","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuduo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzamil","family":"Makhdoomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nemazee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Safonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Briney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5170-8071","authenticated-orcid":false,"given":"Raiees","family":"Andrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115948_bib1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-021-03324-6","article-title":"mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants","volume":"592","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi9915","article-title":"Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection","volume":"13","author":"Greaney","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib3","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-020-2852-1","article-title":"SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies","volume":"588","author":"Barnes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.cell.2020.06.025","article-title":"Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies","volume":"182","author":"Barnes","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115948_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.abc7520","article-title":"Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model","volume":"369","author":"Rogers","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.abd2321","article-title":"Structural basis of a shared antibody response to SARS-CoV-2","volume":"369","author":"Yuan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent antibody responses to SARS-CoV-2 in convalescent individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib8","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/s41591-020-0998-x","article-title":"Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein","volume":"26","author":"Zost","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.abc5902","article-title":"Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability","volume":"369","author":"Brouwer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.13084","article-title":"Protective neutralizing epitopes in SARS-CoV-2","volume":"310","author":"Liu","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.115948_bib11","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2108891","article-title":"Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant","volume":"385","author":"Lopez Bernal","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1056\/NEJMc2104974","article-title":"Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants","volume":"385","author":"Abu-Raddad","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib13","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cell.2022.12.018","article-title":"Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants","volume":"186","author":"Wang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115948_bib16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-022-05053-w","article-title":"Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5","volume":"608","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib17","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","article-title":"Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2","volume":"602","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-022-04594-4","article-title":"Antibody evasion properties of SARS-CoV-2 Omicron sublineages","volume":"604","author":"Iketani","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-022-04980-y","article-title":"BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection","volume":"608","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib20","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.chom.2022.09.018","article-title":"Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75","volume":"30","author":"Cao","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115948_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41586-022-05644-7","article-title":"Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution","volume":"614","author":"Cao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib22","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1056\/NEJMc2212117","article-title":"Neutralization escape by SARS-CoV-2 Omicron subvariant BA.4.6","volume":"387","author":"Hachmann","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib24","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/S1473-3099(22)00694-6","article-title":"Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation","volume":"22","author":"Wang","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.celrep.2025.115948_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110812","article-title":"LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants","volume":"39","author":"Westendorf","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib26","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.abh1139","article-title":"Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants","volume":"373","author":"Yuan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib27","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41586-021-03696-9","article-title":"Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection","volume":"595","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.abb7269","article-title":"A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV","volume":"368","author":"Yuan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205784119","article-title":"A broad and potent neutralization epitope in SARS-related coronaviruses","volume":"119","author":"Yuan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115948_bib30","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1016\/j.cell.2021.06.021","article-title":"In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies","volume":"184","author":"Li","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115948_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41586-021-03807-6","article-title":"SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape","volume":"597","author":"Starr","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-020-2349-y","article-title":"Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody","volume":"583","author":"Pinto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.abf4830","article-title":"Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody","volume":"371","author":"Rappazzo","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib34","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41590-022-01222-1","article-title":"Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses","volume":"23","author":"He","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.115948_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abl9605","article-title":"Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques","volume":"14","author":"He","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109760","article-title":"Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies","volume":"36","author":"Jette","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib37","article-title":"A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice","volume":"14","author":"Martinez","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691715","article-title":"Epitope classification and RBD binding properties of neutralizing antibodies against SARS-CoV-2 variants of concern","volume":"12","author":"Deshpande","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.115948_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41586-021-03817-4","article-title":"Broad sarbecovirus neutralization by a human monoclonal antibody","volume":"597","author":"Tortorici","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.abc7424","article-title":"Broad neutralization of SARS-related viruses by human monoclonal antibodies","volume":"369","author":"Wec","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib41","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/j.celrep.2019.04.082","article-title":"The chimpanzee SIV Envelope trimer: Structure and deployment as an HIV vaccine template","volume":"27","author":"Andrabi","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41564-020-0688-y","article-title":"Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses","volume":"5","author":"Letko","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.115948_bib43","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1073\/pnas.1517719113","article-title":"SARS-like WIV1-CoV poised for human emergence","volume":"113","author":"Menachery","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.115948_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl5842","article-title":"Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses","volume":"6","author":"Feldman","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.115948_bib45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1056\/NEJMc2213948","article-title":"Immunogenicity of BA.5 bivalent mRNA vaccine boosters","volume":"388","author":"Collier","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib46","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa2208343","article-title":"A bivalent Omicron-containing booster vaccine against Covid-19","volume":"387","author":"Chalkias","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib47","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.abf6840","article-title":"Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice","volume":"371","author":"Cohen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib48","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s42003-022-03700-6","article-title":"Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron","volume":"5","author":"Liu","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.115948_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn6859","article-title":"An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses","volume":"14","author":"Liu","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib50","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115948_bib51","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41586-021-03207-w","article-title":"Evolution of antibody immunity to SARS-CoV-2","volume":"591","author":"Gaebler","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41586-021-04060-7","article-title":"Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination","volume":"600","author":"Cho","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib53","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.cell.2021.02.032","article-title":"The antigenic anatomy of SARS-CoV-2 receptor binding domain","volume":"184","author":"Dejnirattisai","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115948_bib55","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.abm5835","article-title":"SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies","volume":"375","author":"Reincke","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib56","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2022.10.010","article-title":"Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses","volume":"31","author":"Dacon","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.115948_bib57","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2023.02.005","article-title":"Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease","volume":"56","author":"Zhou","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115948_bib54","doi-asserted-by":"crossref","first-page":"W34","DOI":"10.1093\/nar\/gkt382","article-title":"IgBLAST: an immunoglobulin variable domain sequence analysis tool","volume":"41","author":"Ye","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.115948_bib58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.coi.2018.04.025","article-title":"Strategies for a multi-stage neutralizing antibody-based HIV vaccine","volume":"53","author":"Andrabi","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2025.115948_bib59","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.immuni.2015.10.014","article-title":"Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design","volume":"43","author":"Andrabi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115948_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax4380","article-title":"A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses","volume":"366","author":"Steichen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib61","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.immuni.2022.09.001","article-title":"Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors","volume":"55","author":"Willis","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115948_bib62","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nsmb.3144","article-title":"Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design","volume":"23","author":"Gorman","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115948_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110318","article-title":"Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection","volume":"38","author":"Konrath","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib64","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.immuni.2018.07.005","article-title":"Glycan masking focuses immune responses to the HIV-1 CD4-binding site and enhances elicitation of VRC01-class precursor antibodies","volume":"49","author":"Duan","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115948_bib65","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00480-22","article-title":"Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes the omicron variant by disassembling the spike trimer","volume":"96","author":"Zhan","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.celrep.2025.115948_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110862","article-title":"Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron","volume":"39","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib67","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-021-03594-0","article-title":"Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses","volume":"594","author":"Saunders","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115948_bib68","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cell.2020.10.043","article-title":"Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2","volume":"183","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115948_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi5735","article-title":"A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates","volume":"14","author":"Joyce","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib70","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s42003-022-03262-7","article-title":"Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit","volume":"5","author":"Hurlburt","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2025.115948_bib71","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.abj3321","article-title":"Broad betacoronavirus neutralization by a stem helix-specific human antibody","volume":"373","author":"Pinto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi9215","article-title":"A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection","volume":"14","author":"Zhou","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.115948_bib73","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.abq3773","article-title":"Broadly neutralizing antibodies target the coronavirus fusion peptide","volume":"377","author":"Dacon","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib74","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41564-022-01155-3","article-title":"Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2","volume":"7","author":"Sun","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2025.115948_bib75","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.abq2679","article-title":"ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies","volume":"377","author":"Low","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib87","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115948_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107725","article-title":"Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections","volume":"31","author":"Lv","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115948_bib77","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.immuni.2020.10.023","article-title":"Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site Is mediated by avidity","volume":"53","author":"Liu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.115948_bib78","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1204839","article-title":"A highly conserved neutralizing epitope on group 2 influenza A viruses","volume":"333","author":"Ekiert","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115948_bib79","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jmb.2017.12.012","article-title":"Locking the elbow: improved antibody Fab fragments as chaperones for structure determination","volume":"430","author":"Bailey","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.115948_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232311","article-title":"Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing","volume":"15","author":"Lieu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.115948_bib81","first-page":"307","author":"Otwinowski","year":"1997","journal-title":"Processing of X-ray diffraction data collected in oscillation mode"},{"key":"10.1016\/j.celrep.2025.115948_bib82","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1107\/S0907444911007773","article-title":"Data processing and analysis with the autoPROC toolbox","volume":"67","author":"Vonrhein","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115948_bib83","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115948_bib84","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115948_bib85","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2025.115948_bib86","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jsb.2012.09.006","article-title":"RELION: implementation of a Bayesian approach to cryo-EM structure determination","volume":"180","author":"Scheres","year":"2012","journal-title":"J. Struct. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:32:57Z","timestamp":1786221177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725007193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":87,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2211124725007193"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115948","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.26.538488","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115948"}}