{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:23:19Z","timestamp":1785396199697,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-02696"],"award-info":[{"award-number":["2020-02696"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["GS-2015-0006X"],"award-info":[{"award-number":["GS-2015-0006X"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U19NS104649"],"award-info":[{"award-number":["5U19NS104649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Brain Foundation","doi-asserted-by":"publisher","award":["FO2022-0293"],"award-info":[{"award-number":["FO2022-0293"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Government of Spain Ministry of Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","award":["ASAP-020551"],"award-info":[{"award-number":["ASAP-020551"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014069","name":"Funda\u00e7\u00e3o Champalimaud","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Spanish Scientific Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.celrep.2025.115988","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:19:36Z","timestamp":1752610776000},"page":"115988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering"],"prefix":"10.1016","volume":"44","author":[{"given":"Cristina","family":"Alcacer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Klaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara F.","family":"Abalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Cenci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-8374","authenticated-orcid":false,"given":"Rui M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.115988_bib1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/ana.25364","article-title":"Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts","volume":"84","author":"Espay","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2025.115988_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/mds.870070204","article-title":"Levodopa-induced dyskinesias in Parkinson\u2019s disease: Clinical and pharmacological classification","volume":"7","author":"Luquin","year":"1992","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2025.115988_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2023.102833","article-title":"Cells, pathways, and models in dyskinesia research","volume":"84","author":"Cenci","year":"2024","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2025.115988_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2018.01.017","article-title":"A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia","volume":"97","author":"Girasole","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115988_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41586-018-0090-6","article-title":"Diametric neural ensemble dynamics in parkinsonian and dyskinetic states","volume":"557","author":"Parker","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115988_bib6","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1016\/j.celrep.2018.05.059","article-title":"Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia","volume":"23","author":"Ryan","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115988_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature02033","article-title":"A gene expression atlas of the central nervous system based on bacterial artificial chromosomes","volume":"425","author":"Gong","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115988_bib8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.2147780","article-title":"D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons","volume":"250","author":"Gerfen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115988_bib9","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1172\/JCI90132","article-title":"Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson\u2019s disease therapy","volume":"127","author":"Alcacer","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.115988_bib10","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"Albin","year":"1989","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2025.115988_bib11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nature09159","article-title":"Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry","volume":"466","author":"Kravitz","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115988_bib12","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1038\/ncomms5315","article-title":"Balanced activity in basal ganglia projection pathways is critical for contraversive movements","volume":"5","author":"Tecuapetla","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115988_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cell.2018.04.019","article-title":"The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection","volume":"174","author":"Markowitz","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.115988_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11846","article-title":"Concurrent activation of striatal direct and indirect pathways during action initiation","volume":"494","author":"Cui","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115988_bib15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.neuron.2017.08.015","article-title":"The Spatiotemporal Organization of the Striatum Encodes Action Space","volume":"95","author":"Klaus","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115988_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106278","article-title":"D2 dopamine receptors and the striatopallidal pathway modulate L-DOPA-induced dyskinesia in the mouse","volume":"186","author":"S\u00e1ez","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115988_bib17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/mds.27337","article-title":"Animal models of l -dopa-induced dyskinesia in Parkinson\u2019s disease","volume":"33","author":"Cenci","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2025.115988_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/ejn.14173","article-title":"Viewpoint: Developing drugs for levodopa-induced dyskinesia in PD : Lessons learnt, what does the future hold?","volume":"49","author":"Fox","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115988_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2004.01.007","article-title":"A model of l-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function","volume":"16","author":"Lundblad","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115988_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2011.01.024","article-title":"Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson\u2019s disease","volume":"42","author":"Francardo","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115988_bib21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature25457","article-title":"Dopamine neuron activity before action initiation gates and invigorates future movements","volume":"554","author":"da Silva","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.115988_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105429","article-title":"Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism","volume":"157","author":"Andreoli","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.115988_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00227239","article-title":"Cortex, striatum and cerebellum: control of serial order in a grooming sequence","volume":"90","author":"Berridge","year":"1992","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.celrep.2025.115988_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2015.11.037","article-title":"Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data","volume":"89","author":"Pnevmatikakis","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115988_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28728","article-title":"Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data","volume":"7","author":"Zhou","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.115988_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12190","article-title":"Accurate spike estimation from noisy calcium signals for ultrafast three-dimensional imaging of large neuronal populations in vivo","volume":"7","author":"Deneux","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.115988_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68041","article-title":"Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum","volume":"10","author":"Maltese","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.115988_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.0953-816x.2001.01843.x","article-title":"Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson\u2019s disease","volume":"15","author":"Lundblad","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115988_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.expneurol.2003.09.001","article-title":"Ropinirole versus l-DOPA effects on striatal opioid peptide precursors in a rodent model of Parkinson\u2019s disease: implications for dyskinesia","volume":"185","author":"Ravenscroft","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2025.115988_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114483","article-title":"Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input","volume":"43","author":"Ryan","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.115988_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuron.2016.08.037","article-title":"Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information","volume":"92","author":"Barbera","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.115988_bib32","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1523\/JNEUROSCI.5493-07.2008","article-title":"Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson\u2019s Disease","volume":"28","author":"Taverna","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.115988_bib33","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.1136800","article-title":"Clustering by Passing Messages Between Data Points","volume":"315","author":"Frey","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.115988_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005423","article-title":"Fast online deconvolution of calcium imaging data","volume":"13","author":"Friedrich","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.celrep.2025.115988_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fninf.2015.00007","article-title":"Bonsai: an event-based framework for processing and controlling data streams","volume":"9","author":"Lopes","year":"2015","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.celrep.2025.115988_bib36","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.115988_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/A:1026543900054","article-title":"The Earth Mover\u2019s Distance as a Metric for Image Retrieval","volume":"40","author":"Rubner","year":"2000","journal-title":"Int. J. Comput. Vis."},{"key":"10.1016\/j.celrep.2025.115988_bib38","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"van der Maaten","year":"2008","journal-title":"J. Mach. Learn. Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:41:21Z","timestamp":1763991681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725007594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2211124725007594"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115988","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.06.611664","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.115988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115988"}}