{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:08:29Z","timestamp":1791374909354,"version":"4.3.1"},"reference-count":82,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["U54 CA209891"],"award-info":[{"award-number":["U54 CA209891"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["NIH - T32 GM007752"],"award-info":[{"award-number":["NIH - T32 GM007752"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["DD2204"],"award-info":[{"award-number":["DD2204"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["R01GM129523"],"award-info":[{"award-number":["R01GM129523"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["K01OD030513"],"award-info":[{"award-number":["K01OD030513"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["U54 CA274502"],"award-info":[{"award-number":["U54 CA274502"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","award":["K00 CA274649"],"award-info":[{"award-number":["K00 CA274649"]}],"id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"Tobacco-Related Disease Research Program","doi-asserted-by":"publisher","award":["T32IR4672"],"award-info":[{"award-number":["T32IR4672"]}],"id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"National Institutes of Health Office of the Director","doi-asserted-by":"publisher","award":["R35-CA220512"],"award-info":[{"award-number":["R35-CA220512"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["CA220512-S1"],"award-info":[{"award-number":["CA220512-S1"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-2038238"],"award-info":[{"award-number":["DGE-2038238"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["EDUC4-12804"],"award-info":[{"award-number":["EDUC4-12804"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.celrep.2025.116010","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T14:48:51Z","timestamp":1753195731000},"page":"116010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["A STAT3\/integrin axis accelerates pancreatic cancer initiation and progression"],"prefix":"10.1016","volume":"44","author":[{"given":"Alejandro D.","family":"Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Heumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arin","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Cable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Kouhmareh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Klemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Ideker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"De Arruda Saldanha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami","family":"Von Schalscha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi I.","family":"Wettersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-8595","authenticated-orcid":false,"given":"David A.","family":"Cheresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116010_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13050986","article-title":"Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy","volume":"13","author":"Aboelella","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.116010_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.686792","article-title":"The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition","volume":"11","author":"G\u00f3mez-Valenzuela","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2025.116010_bib3","article-title":"The Role of Oxidative Stress in Tumorigenesis and Progression","volume":"13","author":"Li","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116010_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells14070488","article-title":"The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis","volume":"14","author":"Nishida","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116010_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020603","article-title":"The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy","volume":"22","author":"Tolomeo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116010_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154425","article-title":"STAT3 signaling in pancreatic ductal adenocarcinoma: a candidate therapeutic target","volume":"245","author":"Al-Hetty","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.celrep.2025.116010_bib7","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/0008-5472.CAN-11-0908","article-title":"STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis","volume":"71","author":"Corcoran","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116010_bib8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13046-023-02693-2","article-title":"Pancreatic cancer stemness: dynamic status in malignant progression","volume":"42","author":"Zhao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116010_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ncb2953","article-title":"An integrin \u03b23-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition","volume":"16","author":"Seguin","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib10","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/nm.2009","article-title":"An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression","volume":"15","author":"Desgrosellier","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116010_bib11","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ccell.2017.10.016","article-title":"Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma","volume":"32","author":"Cosset","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bax028","article-title":"GeneHancer: genome-wide integration of enhancers and target genes in GeneCards","volume":"2017","author":"Fishilevich","year":"2017","journal-title":"Database"},{"key":"10.1016\/j.celrep.2025.116010_bib14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.devcel.2014.06.005","article-title":"Integrin \u03b1v\u03b23 drives slug activation and stemness in the pregnant and neoplastic mammary gland","volume":"30","author":"Desgrosellier","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib15","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1158\/0008-5472.CAN-23-2700","article-title":"Integrin \u03b1v\u03b23 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity","volume":"84","author":"Nam","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116010_bib16","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1158\/2159-8290.CD-17-0539","article-title":"Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers","volume":"7","author":"Seguin","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116010_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13059-020-01957-w","article-title":"Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells","volume":"21","author":"Zhang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib18","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-023-36296-4","article-title":"Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment","volume":"14","author":"Werba","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116010_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu15245104","article-title":"Oxidative Stress Induced by Chemotherapy: Evaluation of Glutathione and Its Related Antioxidant Enzyme Dynamics in Patients with Colorectal Cancer","volume":"15","author":"Chiang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2025.116010_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106899","article-title":"Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo","volume":"26","author":"Reyes-Castellanos","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2025.116010_bib21","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116010_bib22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm.2344","article-title":"Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy","volume":"17","author":"Collisson","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116010_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nm.4082","article-title":"Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression","volume":"22","author":"Laklai","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116010_bib24","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1158\/2159-8290.CD-15-0120","article-title":"Pancreatic Cancer Metastases Harbor Evidence of Polyclonality","volume":"5","author":"Maddipati","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2025.116010_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137486","article-title":"Enhanced Expression of Integrin \u03b1v\u03b23 Induced by TGF-\u03b2 Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-\u03b2-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells","volume":"10","author":"Mori","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116010_bib26","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/s41375-018-0117-x","article-title":"Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer","volume":"32","author":"Wingelhofer","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2025.116010_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ije.2021.5","article-title":"HAT\/HDAC: The epigenetic regulators of inflammatory gene expression (Review)","volume":"1","author":"Swaroop","year":"2021","journal-title":"Int. J. Epigen."},{"key":"10.1016\/j.celrep.2025.116010_bib28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/19491034.2022.2143106","article-title":"Chromatin accessibility: methods, mechanisms, and biological insights","volume":"13","author":"Mansisidor","year":"2022","journal-title":"Nucleus"},{"key":"10.1016\/j.celrep.2025.116010_bib29","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a Cancer Dependency Map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/sj.neo.7900005","article-title":"In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice","volume":"1","author":"Bruns","year":"1999","journal-title":"Neoplasia"},{"key":"10.1016\/j.celrep.2025.116010_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41586-020-2969-2","article-title":"A metastasis map of human cancer cell lines","volume":"588","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116010_bib32","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2025.116010_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13073-020-00776-9","article-title":"Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions","volume":"12","author":"Lin","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2025.116010_bib34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116010_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","article-title":"Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment","volume":"7","author":"Yu","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116010_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091280","article-title":"STAT3, a Master Regulator of Anti-Tumor Immune Response","volume":"11","author":"R\u00e9b\u00e9","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.116010_bib37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gad.311852.118","article-title":"STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis","volume":"32","author":"D'Amico","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116010_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.37349\/etat.2024.00202","article-title":"Role of STAT3 in pancreatic cancer","volume":"5","author":"Hamel","year":"2024","journal-title":"Explor Target Antitumor Ther."},{"key":"10.1016\/j.celrep.2025.116010_bib40","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41419-018-0322-6","article-title":"G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.116010_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13046-019-1455-x","article-title":"Interleukin-8 promotes integrin \u03b23 upregulation and cell invasion through PI3K\/Akt pathway in hepatocellular carcinoma","volume":"38","author":"Sun","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2025.116010_bib42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tcb.2014.12.006","article-title":"Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance","volume":"25","author":"Seguin","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib43","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.18632\/oncotarget.6730","article-title":"EGFRvIII\/integrin \u03b23 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116010_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tranon.2017.11.008","article-title":"IFN-\u03b3 Induces Gastric Cancer Cell Proliferation and Metastasis Through Upregulation of Integrin \u03b23-Mediated NF-\u03baB Signaling","volume":"11","author":"Xu","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.celrep.2025.116010_bib45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.canlet.2018.10.015","article-title":"Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin \u03b23-p38 MAPK signalling","volume":"442","author":"Wen","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2025.116010_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/jsre.1996.0242","article-title":"Beta3 integrin expression in melanoma predicts subsequent metastasis","volume":"63","author":"Hieken","year":"1996","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.celrep.2025.116010_bib47","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.2147\/OTT.S157331","article-title":"A Phase Ib study of ruxolitinib + gemcitabine \u00b1 nab-paclitaxel in patients with advanced solid tumors","volume":"11","author":"Bauer","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.celrep.2025.116010_bib48","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10637-018-0580-2","article-title":"Ruxolitinib + capecitabine in advanced\/metastatic pancreatic cancer after disease progression\/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies","volume":"36","author":"Hurwitz","year":"2018","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.celrep.2025.116010_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101073","article-title":"Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors","volume":"25","author":"Lee","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib50","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2022.07.076","article-title":"Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer","volume":"163","author":"Datta","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2025.116010_bib51","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S1470-2045(14)70379-1","article-title":"Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial","volume":"15","author":"Stupp","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.celrep.2025.116010_bib52","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3390\/cancers11070978","article-title":"Are Integrins Still Practicable Targets for Anti-Cancer Therapy?","volume":"11","author":"Alday-Parejo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2025.116010_bib53","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/s41467-018-04383-6","article-title":"Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes","volume":"9","author":"Lomberk","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116010_bib54","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.celrep.2018.10.051","article-title":"TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma","volume":"25","author":"Somerville","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116010_bib55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s43018-020-00134-z","article-title":"Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer","volume":"2","author":"Li","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2025.116010_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107625","article-title":"HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer","volume":"31","author":"Brunton","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116010_bib57","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ccell.2019.04.001","article-title":"The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer","volume":"35","author":"Todoric","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib58","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature14590","article-title":"Single-cell chromatin accessibility reveals principles of regulatory variation","volume":"523","author":"Buenrostro","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116010_bib59","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.molcel.2017.11.026","article-title":"AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection","volume":"68","author":"Vierbuchen","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41586-020-03147-x","article-title":"A gene-environment-induced epigenetic program initiates tumorigenesis","volume":"590","author":"Alonso-Curbelo","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116010_bib61","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s43018-021-00258-w","article-title":"TNF-\u03b1-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer","volume":"2","author":"Tu","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.celrep.2025.116010_bib62","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/gutjnl-2021-325811","article-title":"Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells","volume":"72","author":"Alfarano","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116010_bib63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-023-05891-2","article-title":"Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer","volume":"616","author":"Lee","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116010_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2003014118","article-title":"Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1","volume":"118","author":"Tsai","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116010_bib65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41698-022-00337-w","article-title":"The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells","volume":"6","author":"Criscione","year":"2022","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.celrep.2025.116010_bib66","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41556-021-00728-4","article-title":"LKB1 inactivation modulates chromatin accessibility to drive metastatic progression","volume":"23","author":"Pierce","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib67","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1096\/fj.09-138420","article-title":"Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit","volume":"24","author":"Morgan","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2025.116010_bib68","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/0008-5472.CAN-19-1246","article-title":"Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression","volume":"79","author":"Wettersten","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2025.116010_bib69","doi-asserted-by":"crossref","first-page":"31.1.1","DOI":"10.1002\/0471142727.mb3101s107","article-title":"CRISPR\/Cas9-Directed Genome Editing of Cultured Cells","volume":"107","author":"Yang","year":"2014","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116010_bib71","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116010_bib72","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.celrep.2025.116010_bib73","doi-asserted-by":"crossref","first-page":"W187","DOI":"10.1093\/nar\/gku365","article-title":"deepTools: a flexible platform for exploring deep-sequencing data","volume":"42","author":"Ram\u00edrez","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116010_bib74","article-title":"Improved peak-calling with MACS2","author":"Gaspar","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2025.116010_bib75","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib76","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.celrep.2025.116010_bib77","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12859-018-2435-4","article-title":"Single sample scoring of molecular phenotypes","volume":"19","author":"Foroutan","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.116010_bib78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116010_bib79","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41587-021-01206-w","article-title":"A Python library for probabilistic analysis of single-cell omics data","volume":"40","author":"Gayoso","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116010_bib80","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1016\/j.cell.2023.11.026","article-title":"Automatic cell-type harmonization and integration across Human Cell Atlas datasets","volume":"186","author":"Xu","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116010_bib81","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"10.1016\/j.celrep.2025.116010_bib82","series-title":"inferCNV of the Trinity CTAT Project","author":"Tickle","year":"2019"},{"key":"10.1016\/j.celrep.2025.116010_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100358","article-title":"An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells","volume":"2","author":"Texari","year":"2021","journal-title":"STAR Protoc."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725007818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:25:55Z","timestamp":1783171555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725007818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":82,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2211124725007818"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116010","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A STAT3\/integrin axis accelerates pancreatic cancer initiation and progression","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116010"}}