{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:53:19Z","timestamp":1783723999566,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY032029"],"award-info":[{"award-number":["EY032029"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY034456"],"award-info":[{"award-number":["EY034456"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY032566"],"award-info":[{"award-number":["EY032566"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY032752"],"award-info":[{"award-number":["EY032752"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","award":["P30EY001730"],"award-info":[{"award-number":["P30EY001730"]}],"id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM124246"],"award-info":[{"award-number":["GM124246"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM152641"],"award-info":[{"award-number":["R01GM152641"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.celrep.2025.116045","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:26:44Z","timestamp":1753144004000},"page":"116045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas"],"prefix":"10.1016","volume":"44","author":[{"given":"Nicol\u00e1s M.","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell N.","family":"Van Gelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-6644","authenticated-orcid":false,"given":"Ethan D.","family":"Buhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116045_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.1957.sp005758","article-title":"The structure and transparency of the cornea","volume":"136","author":"Maurice","year":"1957","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2025.116045_bib2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2007.10.011","article-title":"The transparent lens and cornea in the mouse and zebra fish eye","volume":"19","author":"Greiling","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1442-9071.1992.tb00718.x","article-title":"Epidemiological patterns of ocular trauma","volume":"20","author":"Thylefors","year":"1992","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"10.1016\/j.celrep.2025.116045_bib4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/archopht.1992.01080180110037","article-title":"Ocular trauma in the United States. Eye injuries resulting in hospitalization, 1984 through 1987","volume":"110","author":"Klopfer","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.celrep.2025.116045_bib5","volume":"NBK459283","author":"Willman","year":"2025"},{"key":"10.1016\/j.celrep.2025.116045_bib6","doi-asserted-by":"crossref","first-page":"26633","DOI":"10.1073\/pnas.1912260116","article-title":"Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury","volume":"116","author":"Park","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archopht.1960.01840010538009","article-title":"Cell production and migration in the epithelial layer of the cornea","volume":"64","author":"Hanna","year":"1960","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.celrep.2025.116045_bib8","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2025.116045_bib9","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1167\/iovs.16-21154","article-title":"Modulation of Circadian Rhythms Affects Corneal Epithelium Renewal and Repair in Mice","volume":"58","author":"Xue","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2025.116045_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.32.3.677","article-title":"Circadian phase relationships of thymidine-3H uptake, labeled nuclei, grain counts, and cell division rate in rat corneal epithelium","volume":"32","author":"Scheving","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib11","first-page":"181","article-title":"Circadian-dependent response in DNA synthesis to epidermal growth factor in spleen, bone marrow, and lung and in mitotic index of corneal epithelium in ad libitum-fed and fasted CD2F1 mice","volume":"227A","author":"Scheving","year":"1987","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.celrep.2025.116045_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107709","article-title":"Corneal injury: Clinical and molecular aspects","volume":"186","author":"Barrientez","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2025.116045_bib13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.1086179","article-title":"Melanopsin is required for non-image-forming photic responses in blind mice","volume":"301","author":"Panda","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116045_bib14","doi-asserted-by":"crossref","first-page":"13093","DOI":"10.1073\/pnas.1516259112","article-title":"Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea","volume":"112","author":"Buhr","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/cne.25272","article-title":"Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells","volume":"530","author":"D'Souza","year":"2021","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116045_bib16","article-title":"Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments","volume":"15","author":"Ramanujam","year":"2023","journal-title":"J. Photochem. Photobiol., A"},{"key":"10.1016\/j.celrep.2025.116045_bib17","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41586-020-2683-0","article-title":"Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons","volume":"585","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116045_bib18","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1016\/j.cub.2019.08.063","article-title":"Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin","volume":"29","author":"Buhr","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/iovs.61.6.37","article-title":"Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea","volume":"61","author":"D\u00edaz","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2025.116045_bib20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018840118","article-title":"Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice","volume":"118","author":"Jiang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109414","article-title":"Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia","volume":"228","author":"Jeong","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2025.116045_bib22","article-title":"Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye","volume":"19","author":"Kato","year":"2019","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.celrep.2025.116045_bib23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41556-019-0301-x","article-title":"An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye","volume":"21","author":"Nguyen","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature11823","article-title":"A direct and melanopsin-dependent fetal light response regulates mouse eye development","volume":"494","author":"Rao","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116045_bib25","doi-asserted-by":"crossref","DOI":"10.1017\/S0952523817000359","article-title":"Melanopsin expression in the cornea","volume":"35","author":"Delwig","year":"2018","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.celrep.2025.116045_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fncir.2016.00060","article-title":"Peripheral Sensory Neurons Expressing Melanopsin Respond to Light","volume":"10","author":"Matynia","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.celrep.2025.116045_bib27","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1038\/srep05352","article-title":"Light-induced rapid Ca(2+) response and MAPK phosphorylation in the cells heterologously expressing human OPN5","volume":"4","author":"Sugiyama","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116045_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/gtc.12751","article-title":"OPN4 belongs to the photosensitive system of the human skin","volume":"25","author":"Kusumoto","year":"2020","journal-title":"Genes Cells"},{"key":"10.1016\/j.celrep.2025.116045_bib29","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1073\/pnas.1902825116","article-title":"Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor","volume":"116","author":"Ozdeslik","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib30","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3390\/cimb43030101","article-title":"Loss of Melanopsin (OPN4) Leads to a Faster Cell Cycle Progression and Growth in Murine Melanocytes","volume":"43","author":"de Assis","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib31","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.celrep.2019.12.043","article-title":"Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing","volume":"30","author":"Nayak","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116045_bib32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.exer.2014.02.007","article-title":"Wounding the cornea to learn how it heals","volume":"121","author":"Stepp","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2025.116045_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026388","article-title":"UV-sensitive photoreceptor protein OPN5 in humans and mice","volume":"6","author":"Kojima","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116045_bib34","doi-asserted-by":"crossref","first-page":"8625","DOI":"10.1073\/pnas.1323350111","article-title":"Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin","volume":"111","author":"Buhr","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13101584","article-title":"Gene Expression as a Potential Biomarker for In Vitro Prediction of Ocular Toxicity","volume":"13","author":"Hwang","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celrep.2025.116045_bib36","first-page":"1575","article-title":"Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells","volume":"14","author":"Benko","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.celrep.2025.116045_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jbm.a.32056","article-title":"Bioactive interpenetrating polymer network hydrogels that support corneal epithelial wound healing","volume":"90","author":"Myung","year":"2009","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.celrep.2025.116045_bib38","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1074\/jbc.275.4.2607","article-title":"Role of lumican in the corneal epithelium during wound healing","volume":"275","author":"Saika","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116045_bib39","first-page":"499","article-title":"Disruption of circadian rhythms inhibits wound healing of corneal epithelium in mice","volume":"31","author":"Liu","year":"2015","journal-title":"Chin. J. Pathophysiol."},{"key":"10.1016\/j.celrep.2025.116045_bib40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/074873001129001791","article-title":"MPer1 and mper2 are essential for normal resetting of the circadian clock","volume":"16","author":"Albrecht","year":"2001","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.celrep.2025.116045_bib41","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0896-6273(00)80417-1","article-title":"Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei","volume":"19","author":"Shearman","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116045_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232748","article-title":"Altered light induced EGR1 expression in the SCN of PACAP deficient mice","volume":"15","author":"Riedel","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116045_bib43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0014-5793(02)03616-5","article-title":"Amphioxus homologs of Go-coupled rhodopsin and peropsin having 11-cis- and all-trans-retinals as their chromophores","volume":"531","author":"Koyanagi","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2025.116045_bib44","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1098\/rstb.2009.0051","article-title":"Evolution of opsins and phototransduction","volume":"364","author":"Shichida","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2025.116045_bib45","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1074\/jbc.M113.514075","article-title":"Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation","volume":"289","author":"Yamashita","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116045_bib46","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1073\/pnas.1219416110","article-title":"Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue","volume":"110","author":"Koyanagi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib47","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1038\/s41598-018-21946-1","article-title":"An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor","volume":"8","author":"Nagata","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116045_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0748730421999870","article-title":"Evolutionary Constraint on Visual and Nonvisual Mammalian Opsins","volume":"36","author":"Upton","year":"2021","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.celrep.2025.116045_bib49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41374-018-0118-4","article-title":"Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4","volume":"99","author":"Okada","year":"2019","journal-title":"Lab. Invest."},{"key":"10.1016\/j.celrep.2025.116045_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100974","article-title":"The two-faced effects of nerves and neuropeptides in corneal diseases","volume":"86","author":"Lasagni Vitar","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.celrep.2025.116045_bib51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature01761","article-title":"Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice","volume":"424","author":"Hattar","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116045_bib52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1077293","article-title":"Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice","volume":"299","author":"Lucas","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116045_bib53","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116045_bib54","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1126\/science.1076848","article-title":"Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting","volume":"298","author":"Panda","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116045_bib55","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116045_bib56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature06829","article-title":"Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision","volume":"453","author":"Guler","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116045_bib57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0076-6879(00)16730-8","article-title":"Cultured amphibian melanophores: a model system to study melanopsin photobiology","volume":"316","author":"Rollag","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2025.116045_bib58","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1073\/pnas.95.1.340","article-title":"Melanopsin: An opsin in melanophores, brain, and eye","volume":"95","author":"Provencio","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0749.1990.tb00260.x","article-title":"Action of light on frog pigment cells in culture","volume":"3","author":"Daniolos","year":"1990","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.celrep.2025.116045_bib60","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejcb.2018.01.004","article-title":"Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin","volume":"97","author":"de Assis","year":"2018","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/php.12354","article-title":"Opsin expression in human epidermal skin","volume":"91","author":"Haltaufderhyde","year":"2015","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.celrep.2025.116045_bib62","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1523\/JNEUROSCI.19-10-03681.1999","article-title":"Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain","volume":"19","author":"Blackshaw","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116045_bib63","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0014-5793(03)01212-2","article-title":"Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue","volume":"554","author":"Tarttelin","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2025.116045_bib64","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0107-20.2020","article-title":"Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model","volume":"7","author":"Olinski","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2025.116045_bib65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1165\/rcmb.2020-0392OC","article-title":"Opsin 3-Gs promotes airway smooth muscle relaxation modulated by G protein receptor kinase 2","volume":"64","author":"Wu","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116045_bib66","doi-asserted-by":"crossref","first-page":"L82","DOI":"10.1152\/ajplung.00135.2018","article-title":"Airway smooth muscle photorelaxation via opsin receptor activation","volume":"316","author":"Yim","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2025.116045_bib67","doi-asserted-by":"crossref","first-page":"L93","DOI":"10.1152\/ajplung.00091.2017","article-title":"Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition","volume":"314","author":"Barreto Ortiz","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2025.116045_bib68","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.1420258111","article-title":"Melanopsin mediates light-dependent relaxation in blood vessels","volume":"111","author":"Sikka","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116045_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/life13020575","article-title":"Photobiomodulation with Blue Light on Wound Healing: A Scoping Review","volume":"13","author":"Prado","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.celrep.2025.116045_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2774","article-title":"Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing","volume":"9","author":"Hoyle","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116045_bib71","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00410983","article-title":"Diurnal rhythm of mitosis in rabbit corneal epithelium","volume":"213","author":"Fogle","year":"1980","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.celrep.2025.116045_bib73","doi-asserted-by":"crossref","first-page":"W345","DOI":"10.1093\/nar\/gkac247","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update","volume":"50","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:36:24Z","timestamp":1783172184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725008162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2211124725008162"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116045","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116045"}}