{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:51:56Z","timestamp":1790844716833,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR073665"],"award-info":[{"award-number":["R01AR073665"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR073752"],"award-info":[{"award-number":["P30AR073752"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5T32GM146694"],"award-info":[{"award-number":["5T32GM146694"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010062","name":"Towson University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.celrep.2025.116054","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:56:21Z","timestamp":1753347381000},"page":"116054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march"],"prefix":"10.1016","volume":"44","author":[{"given":"Sabrina N.","family":"Kline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laine E.","family":"Feller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshine","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Dikeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Jen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pontaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junela C.","family":"Hunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine T.N.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-8985","authenticated-orcid":false,"given":"Nathan K.","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116054_bib1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/all.13401","article-title":"Epidemiology of atopic dermatitis in adults: Results from an international survey","volume":"73","author":"Barbarot","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2025.116054_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116054_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2025.116054_bib5","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1111\/all.15058","article-title":"A new era of atopic eczema research: Advances and highlights","volume":"76","author":"Hulpusch","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib6","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1111\/all.14304","article-title":"Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?","volume":"75","author":"Brough","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib7","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3389\/fimmu.2020.01907","article-title":"Research Progress in Atopic March","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/jamapediatrics.2017.0556","article-title":"Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood","volume":"171","author":"Roduit","year":"2017","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.celrep.2025.116054_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000497383","article-title":"Atopic Dermatitis: Collegium Internationale Allergologicum (CIA) Update 2019","volume":"178","author":"Simon","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1939-4551-7-12","article-title":"Allergic diseases and asthma: a global public health concern and a call to action","volume":"7","author":"Pawankar","year":"2014","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.celrep.2025.116054_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaci.2018.11.015","article-title":"The microbiome in patients with atopic dermatitis","volume":"143","author":"Paller","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal4651","article-title":"Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis","volume":"9","author":"Byrd","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib13","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.jid.2018.03.1517","article-title":"Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype","volume":"138","author":"Simpson","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.celrep.2025.116054_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143334","article-title":"Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease","volume":"131","author":"Patrick","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116054_bib15","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jaci.2016.01.010","article-title":"Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis","volume":"137","author":"Jones","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav2685","article-title":"The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype","volume":"11","author":"Leung","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum","volume":"11","author":"Simpson","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.celrep.2025.116054_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.10.011","article-title":"Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis","volume":"133","author":"Moore","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11882-015-0529-x","article-title":"The Complex Type 2 Endotype in Allergy and Asthma: From Laboratory to Bedside","volume":"15","author":"Agache","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116054_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/17476348.2017.1268919","article-title":"Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations","volume":"11","author":"Chang","year":"2017","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144336","article-title":"IL-36 in chronic inflammation and fibrosis - bridging the gap?","volume":"131","author":"Elias","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116054_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/imr.12610","article-title":"Regulation and function of interleukin-36 cytokines","volume":"281","author":"Bassoy","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.116054_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155890","article-title":"The IL-1 cytokine family as custodians of barrier immunity","volume":"154","author":"Matarazzo","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2025.116054_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/cells13090787","article-title":"Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues","volume":"13","author":"Tongmuang","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2025.116054_bib27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaci.2016.08.056","article-title":"IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis","volume":"140","author":"Johnston","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMc1811317","article-title":"Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis","volume":"380","author":"Bachelez","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib29","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJMoa1013068","article-title":"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis","volume":"365","author":"Marrakchi","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib30","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jaci.2021.08.024","article-title":"Netherton syndrome subtypes share IL-17\/IL-36 signature with distinct IFN-alpha and allergic responses","volume":"149","author":"Barbieux","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib31","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/mi.2015.134","article-title":"IL-36alpha expression is elevated in ulcerative colitis and promotes colonic inflammation","volume":"9","author":"Russell","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106200","article-title":"Interleukin-36 receptor antagonist alleviates airway inflammation in asthma via inhibiting the activation of Interleukin-36 pathway","volume":"81","author":"Liu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2025.116054_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13223-023-00868-2","article-title":"Different expression levels of interleukin-36 in asthma phenotypes","volume":"20","author":"Li","year":"2024","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11882-020-00937-1","article-title":"The Role of New IL-1 Family Members (IL-36 and IL-38) in Atopic Dermatitis, Allergic Asthma, and Allergic Rhinitis","volume":"20","author":"Tsang","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cyto.2019.02.008","article-title":"The role of IL-36gamma and its regulation in eosinophilic inflammation in allergic rhinitis","volume":"117","author":"Qin","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2025.116054_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.154992","article-title":"IL-36alpha contributes to enhanced T helper 17 type responses in allergic rhinitis","volume":"128","author":"Qin","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2025.116054_bib37","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.jaci.2016.03.056","article-title":"IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells","volume":"138","author":"Galand","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib38","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.immuni.2019.03.023","article-title":"Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion","volume":"50","author":"Leyva-Castillo","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116054_bib39","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jaci.2015.03.003","article-title":"RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications","volume":"135","author":"Suarez-Farinas","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib40","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.chom.2017.10.006","article-title":"Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses. Cell","volume":"22","author":"Liu","year":"2017","journal-title":"Host Microbe"},{"key":"10.1016\/j.celrep.2025.116054_bib41","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309243121","article-title":"Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation","volume":"121","author":"Kline","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116054_bib42","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1161\/ATVBAHA.116.307786","article-title":"Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation","volume":"36","author":"Yan","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2025.116054_bib43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fimmu.2016.00261","article-title":"Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps","volume":"7","author":"Majewski","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib44","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1164\/rccm.201810-1869OC","article-title":"Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma","volume":"199","author":"Lachowicz-Scroggins","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116054_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cea.12859","article-title":"Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma","volume":"47","author":"Pham","year":"2017","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib46","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib47","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116054_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.836278","article-title":"Molecular Prerequisites for Neutrophil Extracellular Trap Formation and Evasion Mechanisms of Staphylococcus aureus","volume":"13","author":"von Kockritz-Blickwede","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib49","doi-asserted-by":"crossref","first-page":"20149","DOI":"10.1038\/s41598-020-76864-y","article-title":"Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice","volume":"10","author":"Watanabe","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib50","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1038\/s41598-022-16449-z","article-title":"Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice","volume":"12","author":"Hasegawa","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib51","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jdv.18727","article-title":"Spesolimab, an anti-interleukin-36 receptor antibody, in patients with moderate-to-severe atopic dermatitis: Results from a multicentre, randomized, double-blind, placebo-controlled, phase IIa study","volume":"37","author":"Bissonnette","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.celrep.2025.116054_bib52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4168\/aair.2023.15.2.231","article-title":"Incidence of Cardiovascular Disease After Atopic Dermatitis Development: A Nationwide, Population-Based Study","volume":"15","author":"Lee","year":"2023","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.celrep.2025.116054_bib53","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/jamadermatol.2023.2875","article-title":"Risk of Inflammatory Bowel Disease in Patients With Atopic Dermatitis","volume":"159","author":"Chiesa Fuxench","year":"2023","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.celrep.2025.116054_bib54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/bjd.19624","article-title":"Association between atopic dermatitis and autoimmune diseases: a population-based case-control study","volume":"185","author":"Ivert","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.celrep.2025.116054_bib55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.alit.2023.12.005","article-title":"Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis","volume":"73","author":"Ahn","year":"2024","journal-title":"Allergol. Int."},{"key":"10.1016\/j.celrep.2025.116054_bib56","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gutjnl-2014-307477","article-title":"Comparing histological activity indexes in UC","volume":"64","author":"Bressenot","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2025.116054_bib57","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/jcm5120118","article-title":"The Dual Role of Neutrophils in Inflammatory Bowel Diseases","volume":"5","author":"Wera","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib58","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.18632\/oncotarget.22814","article-title":"IL-36 cytokines in autoimmunity and inflammatory disease","volume":"9","author":"Ding","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2025.116054_bib59","article-title":"The Role of IL-36 in the Pathophysiological Processes of Autoimmune Diseases","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116054_bib60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12890-024-03078-7","article-title":"Association between psoriasis and asthma: a systematic review and bidirectional meta-analysis","volume":"24","author":"Wu","year":"2024","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155897","article-title":"Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions","volume":"156","author":"Sachen","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2025.116054_bib62","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaci.2019.09.006","article-title":"Asthma and psoriasis: What do they have in common? IL-17A","volume":"144","author":"Busse","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib63","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2019.03.027","article-title":"IL-17-high asthma with features of a psoriasis immunophenotype","volume":"144","author":"Ostling","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib64","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/thoraxjnl-2020-215986","article-title":"Neutrophils in asthma: the good, the bad and the bacteria","volume":"76","author":"Crisford","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.celrep.2025.116054_bib65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13223-020-00504-3","article-title":"Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma","volume":"17","author":"Wei","year":"2021","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib66","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jaci.2010.02.008","article-title":"Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes","volume":"125","author":"Hastie","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib67","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155581","article-title":"IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD","volume":"7","author":"Baker","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2025.116054_bib68","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ajpath.2023.12.008","article-title":"Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease","volume":"194","author":"Haynes","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2025.116054_bib69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13223-023-00834-y","article-title":"Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis","volume":"19","author":"Gu","year":"2023","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib70","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.3390\/ijms25105492","article-title":"Neutrophil-Derived Proteases in Lung Inflammation: Old Players and New Prospects","volume":"25","author":"Cheetham","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116054_bib71","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1136\/thx.2010.157719","article-title":"Systemic upregulation of neutrophil alpha-defensins and serine proteases in neutrophilic asthma","volume":"66","author":"Baines","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.celrep.2025.116054_bib72","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/jcm7090244","article-title":"Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease","volume":"7","author":"Dey","year":"2018","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib73","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.celrep.2015.12.072","article-title":"Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines","volume":"14","author":"Henry","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000639","article-title":"Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans","volume":"5","author":"Urban","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2025.116054_bib75","article-title":"Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase","volume":"8","author":"O'Donoghue","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116054_bib76","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1164\/rccm.200707-1134OC","article-title":"Clarithromycin targets neutrophilic airway inflammation in refractory asthma","volume":"177","author":"Simpson","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2025.116054_bib77","article-title":"Macrolides for chronic asthma","volume":"\u25aa\u25aa","author":"Kew","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.celrep.2025.116054_bib78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1465-9921-14-8","article-title":"Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses","volume":"14","author":"Koga","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.celrep.2025.116054_bib79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI5844","article-title":"Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions","volume":"104","author":"Wan","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116054_bib80","doi-asserted-by":"crossref","first-page":"26667","DOI":"10.1074\/jbc.M110.193987","article-title":"The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116054_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/srep42341","article-title":"Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation","volume":"7","author":"Kale","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib82","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/all.15678","article-title":"Protease allergens as initiators-regulators of allergic inflammation","volume":"78","author":"Soh","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.879029","article-title":"IL-1alpha and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases","volume":"13","author":"Frezza","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib84","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1476-5381.2009.00449.x","article-title":"Protease-activated receptors and prostaglandins in inflammatory lung disease","volume":"158","author":"Peters","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2025.116054_bib85","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jaci.2003.08.050","article-title":"Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulated kinase","volume":"112","author":"Page","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib86","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-9255-9-32","article-title":"The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen","volume":"9","author":"Lutfi","year":"2012","journal-title":"J. Inflamm."},{"key":"10.1016\/j.celrep.2025.116054_bib87","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1042\/BST20200191","article-title":"The development of proteinase-activated receptor-2 modulators and the challenges involved","volume":"48","author":"McIntosh","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.celrep.2025.116054_bib88","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/labinvest.2015.72","article-title":"Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)","volume":"95","author":"Guest","year":"2015","journal-title":"Lab. Invest."},{"key":"10.1016\/j.celrep.2025.116054_bib89","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1378\/chest.126.1.205","article-title":"Airway mucosal thickening and bronchial hyperresponsiveness induced by inhaled beta 2-agonist in mice","volume":"126","author":"Tamaoki","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.celrep.2025.116054_bib90","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/all.12944","article-title":"Enhanced Th2 cell differentiation and function in the absence of Nox2","volume":"72","author":"Kwon","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib91","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4110\/in.2011.11.3.169","article-title":"Enhancement of Allergen-induced Airway Inflammation by NOX2 Deficiency","volume":"11","author":"Won","year":"2011","journal-title":"Immune Netw."},{"key":"10.1016\/j.celrep.2025.116054_bib92","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","article-title":"The activation and function of IL-36gamma in neutrophilic inflammation in chronic rhinosinusitis","volume":"141","author":"Wang","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib93","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162088","article-title":"Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions","volume":"133","author":"Roy","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116054_bib94","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/resp.12730","article-title":"Neutrophil extracellular traps are associated with inflammation in chronic airway disease","volume":"21","author":"Wright","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.celrep.2025.116054_bib95","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.3389\/fimmu.2019.02376","article-title":"Neutrophils in Psoriasis","volume":"10","author":"Chiang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib96","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa2111563","article-title":"Trial of Spesolimab for Generalized Pustular Psoriasis","volume":"385","author":"Bachelez","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116054_bib97","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaci.2020.06.024","article-title":"Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis","volume":"147","author":"Cau","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib98","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/cne.21529","article-title":"Fate mapping Nkx2.1-lineage cells in the mouse telencephalon","volume":"506","author":"Xu","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.celrep.2025.116054_bib99","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1172\/JCI42090","article-title":"Epithelium-specific deletion of TGF-beta receptor type II protects mice from bleomycin-induced pulmonary fibrosis","volume":"121","author":"Li","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116054_bib100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0165-5728(03)00130-9","article-title":"IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells","volume":"139","author":"Berglof","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.celrep.2025.116054_bib101","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.chom.2017.10.008","article-title":"Staphylococcus aureus Virulent PSMalpha Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation","volume":"22","author":"Nakagawa","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2025.116054_bib102","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/exd.14605","article-title":"Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis","volume":"31","author":"Timms","year":"2022","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.celrep.2025.116054_bib103","doi-asserted-by":"crossref","first-page":"e00537","DOI":"10.1128\/mBio.00537-12","article-title":"A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes","volume":"4","author":"Fey","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.celrep.2025.116054_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059232","article-title":"Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging","volume":"8","author":"Plaut","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116054_bib105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nature12655","article-title":"Staphylococcus delta-toxin induces allergic skin disease by activating mast cells","volume":"503","author":"Nakamura","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116054_bib106","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116054_bib107","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/nar\/gkp1137","article-title":"The Sanger FASTQ file format for sequences with quality scores, and the Solexa\/Illumina FASTQ variants","volume":"38","author":"Cock","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116054_bib108","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.celrep.2025.116054_bib109","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2025.116054_bib110","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.4049\/jimmunol.1303461","article-title":"Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma","volume":"192","author":"Gao","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116054_bib111","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/all.12827","article-title":"Cockroach allergen exposure and risk of asthma","volume":"71","author":"Do","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.celrep.2025.116054_bib112","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2025.116054_bib113","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116054_bib114","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116054_bib115","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/19420862.2017.1353853","article-title":"Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies","volume":"9","author":"Ganesan","year":"2017","journal-title":"mAbs"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:28:22Z","timestamp":1783171702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725008253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":115,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2211124725008253"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116054","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116054"}}