{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:16:03Z","timestamp":1783174563013,"version":"3.54.6"},"reference-count":85,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen Municipality","doi-asserted-by":"publisher","award":["3502Z202371005"],"award-info":[{"award-number":["3502Z202371005"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470750"],"award-info":[{"award-number":["32470750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400715"],"award-info":[{"award-number":["32400715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170873"],"award-info":[{"award-number":["32170873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720240116"],"award-info":[{"award-number":["20720240116"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J02002"],"award-info":[{"award-number":["2024J02002"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J08010"],"award-info":[{"award-number":["2024J08010"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.celrep.2025.116076","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:49:39Z","timestamp":1753523379000},"page":"116076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis"],"prefix":"10.1016","volume":"44","author":[{"given":"Xiawei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-7503","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116076_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mib.2015.10.003","article-title":"Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence","volume":"29","author":"Zhao","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.celrep.2025.116076_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib5","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360 degrees view of the inflammasome: Mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib6","doi-asserted-by":"crossref","first-page":"21119","DOI":"10.1074\/jbc.C200179200","article-title":"The PYRIN-CARD protein ASC is an activating adaptor for caspase-1","volume":"277","author":"Srinivasula","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116076_bib7","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.4049\/jimmunol.171.11.6154","article-title":"Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation","volume":"171","author":"Stehlik","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116076_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2014.01.063","article-title":"Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation","volume":"156","author":"Cai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11929","article-title":"ASC filament formation serves as a signal amplification mechanism for inflammasomes","volume":"7","author":"Dick","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib14","doi-asserted-by":"crossref","first-page":"33835","DOI":"10.1074\/jbc.274.48.33835","article-title":"ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells","volume":"274","author":"Masumoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116076_bib15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116076_bib16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2025.116076_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-immunol-032712-095944","article-title":"Recognition of bacteria by inflammasomes","volume":"31","author":"von Moltke","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tibs.2008.12.003","article-title":"Autoregulatory feedback loops terminating the NF-kappaB response","volume":"34","author":"Renner","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2025.116076_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib21","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb1050","article-title":"Hippo promotes proliferation arrest and apoptosis in the Salvador\/Warts pathway","volume":"5","author":"Udan","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116076_bib22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/ncb1051","article-title":"The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila","volume":"5","author":"Pantalacci","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2025.116076_bib24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.devcel.2019.06.003","article-title":"The Hippo Signaling Pathway in Development and Disease","volume":"50","author":"Zheng","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","article-title":"Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer","volume":"163","author":"Yu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: growth control and beyond","volume":"138","author":"Halder","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.celrep.2025.116076_bib27","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011288","article-title":"The hippo pathway","volume":"4","author":"Harvey","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2025.116076_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/dev.167106","article-title":"Hippo signalling during development","volume":"146","author":"Davis","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.celrep.2025.116076_bib29","doi-asserted-by":"crossref","first-page":"21049","DOI":"10.1074\/jbc.271.35.21049","article-title":"The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain","volume":"271","author":"Creasy","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116076_bib30","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.str.2013.07.008","article-title":"Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5","volume":"21","author":"Ni","year":"2013","journal-title":"Structure"},{"key":"10.1016\/j.celrep.2025.116076_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/BJ20040025","article-title":"Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras","volume":"381","author":"Praskova","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2025.116076_bib32","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.devcel.2011.09.012","article-title":"The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway","volume":"21","author":"Poon","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib33","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.devcel.2011.08.028","article-title":"Tao-1 phosphorylates Hippo\/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway","volume":"21","author":"Boggiano","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib34","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1093\/emboj\/17.8.2224","article-title":"Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1","volume":"17","author":"Graves","year":"1998","journal-title":"The EMBO journal"},{"key":"10.1016\/j.celrep.2025.116076_bib35","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1038\/sj.onc.1201840","article-title":"Proteolytic activation of MST\/Krs, STE20-related protein kinase, by caspase during apoptosis","volume":"16","author":"Lee","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2025.116076_bib36","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1074\/jbc.M005109200","article-title":"MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation","volume":"276","author":"Lee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116076_bib37","doi-asserted-by":"crossref","first-page":"14909","DOI":"10.1074\/jbc.M010905200","article-title":"Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95\/Fas-induced apoptosis","volume":"276","author":"Graves","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116076_bib38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0092-8674(03)00355-6","article-title":"Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase","volume":"113","author":"Cheung","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib39","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1182\/blood-2011-09-378364","article-title":"MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival","volume":"119","author":"Nehme","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116076_bib40","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1182\/blood-2011-09-378158","article-title":"The phenotype of human STK4 deficiency","volume":"119","author":"Abdollahpour","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2025.116076_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.15698\/cst2018.01.119","article-title":"MST kinases in innate immune signaling","volume":"2","author":"Shi","year":"2017","journal-title":"Cell Stress"},{"key":"10.1016\/j.celrep.2025.116076_bib42","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fimmu.2020.00323","article-title":"The Crosstalk Between Hippo-YAP Pathway and Innate Immunity","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib43","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41423-018-0007-1","article-title":"Role of Hippo signaling in regulating immunity","volume":"15","author":"Hong","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib44","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fimmu.2020.01473","article-title":"The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116076_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116076_bib47","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116076_bib48","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/s41467-021-22987-3","article-title":"YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib49","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1038\/ncomms9357","article-title":"MAP4K family kinases act in parallel to MST1\/2 to activate LATS1\/2 in the Hippo pathway","volume":"6","author":"Meng","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib50","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.devcel.2015.08.014","article-title":"Identification of Happyhour\/MAP4K as Alternative Hpo\/Mst-like Kinases in the Hippo Kinase Cascade","volume":"34","author":"Zheng","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.devcel.2014.09.012","article-title":"The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila","volume":"31","author":"Li","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib52","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molcel.2016.10.034","article-title":"Characterization of Hippo Pathway Components by Gene Inactivation","volume":"64","author":"Plouffe","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib53","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116076_bib55","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1038\/s41467-018-07573-4","article-title":"NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway","volume":"9","author":"Hafner-Bratkovic","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib56","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.immuni.2023.02.014","article-title":"Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity","volume":"56","author":"Wu","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116076_bib57","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ni.2749","article-title":"Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity","volume":"14","author":"Hara","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib58","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.4049\/jimmunol.2000969","article-title":"cAbl Kinase Regulates Inflammasome Activation and Pyroptosis via ASC Phosphorylation","volume":"206","author":"Gavrilin","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib59","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nmeth1048","article-title":"A semisynthetic epitope for kinase substrates","volume":"4","author":"Allen","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116076_bib60","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2025.116076_bib61","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature13449","article-title":"Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome","volume":"513","author":"Xu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116076_bib62","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2025.116076_bib63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imr.12294","article-title":"Negative regulation of the inflammasome: keeping inflammation under control","volume":"265","author":"Pedraza-Alva","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.116076_bib64","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ni.3772","article-title":"Limiting inflammation-the negative regulation of NF-kappaB and the NLRP3 inflammasome","volume":"18","author":"Afonina","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib65","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1038\/ncomms5977","article-title":"IKKalpha negatively regulates ASC-dependent inflammasome activation","volume":"5","author":"Martin","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib66","doi-asserted-by":"crossref","first-page":"10148","DOI":"10.1073\/pnas.181161698","article-title":"Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation","volume":"98","author":"Ura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116076_bib67","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1073\/pnas.162172899","article-title":"Caspase 3 activity is required for skeletal muscle differentiation","volume":"99","author":"Fernando","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116076_bib68","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1101\/gad.264929.115","article-title":"Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling","volume":"29","author":"Ni","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116076_bib69","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2010.08.002","article-title":"Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling","volume":"39","author":"Ribeiro","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib70","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1016\/j.celrep.2017.11.076","article-title":"Homeostatic Control of Hpo\/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex","volume":"21","author":"Zheng","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116076_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004712","article-title":"Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions","volume":"6","author":"Couzens","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2025.116076_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073874","article-title":"Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase","volume":"8","author":"Tomiyama","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116076_bib73","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.4049\/jimmunol.1301060","article-title":"Mst1\/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1\/Foxo3 stability in autoimmune disease","volume":"192","author":"Du","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib74","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/ni1374","article-title":"Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion","volume":"7","author":"Katagiri","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib75","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.20111692","article-title":"The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes","volume":"209","author":"Mou","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116076_bib76","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.4049\/jimmunol.0900678","article-title":"A cell-intrinsic role for Mst1 in regulating thymocyte egress","volume":"183","author":"Dong","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116076_bib77","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/emboj.2009.82","article-title":"Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes","volume":"28","author":"Katagiri","year":"2009","journal-title":"The EMBO journal"},{"key":"10.1016\/j.celrep.2025.116076_bib78","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ncomms2105","article-title":"Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus","volume":"3","author":"Ueda","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116076_bib79","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1172\/JCI81203","article-title":"STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116076_bib80","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1101\/gad.277533.116","article-title":"Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116076_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100246","article-title":"Preparation and culture of bone marrow-derived macrophages from mice for functional analysis","volume":"2","author":"Toda","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.116076_bib82","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1073\/pnas.0810773105","article-title":"The Nore1B\/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells","volume":"105","author":"Zhou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116076_bib83","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116076_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111143","article-title":"A dRASSF-STRIPAK-Imd-JAK\/STAT axis controls antiviral immune response in Drosophila","volume":"40","author":"Shen","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2025.116076_bib85","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.immuni.2022.10.021","article-title":"IKKbeta primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network","volume":"55","author":"Schmacke","year":"2022","journal-title":"Immunity"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725008472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:21:14Z","timestamp":1783171274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725008472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":85,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2211124725008472"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116076","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116076"}}