{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:08:48Z","timestamp":1788988128686,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM145279"],"award-info":[{"award-number":["R35GM145279"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM007088"],"award-info":[{"award-number":["T32GM007088"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson&apos;s Research","doi-asserted-by":"publisher","award":["R01NS109858"],"award-info":[{"award-number":["R01NS109858"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG000222-23"],"award-info":[{"award-number":["T32AG000222-23"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS113574"],"award-info":[{"award-number":["F31NS113574"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS125018"],"award-info":[{"award-number":["R01NS125018"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS032527"],"award-info":[{"award-number":["NS032527"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS128142"],"award-info":[{"award-number":["R01NS128142"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS064928"],"award-info":[{"award-number":["T32NS064928"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS036630"],"award-info":[{"award-number":["NS036630"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS119690"],"award-info":[{"award-number":["R01NS119690"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS109858"],"award-info":[{"award-number":["R01NS109858"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-20-060-01-RMC"],"award-info":[{"award-number":["RSG-20-060-01-RMC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR001875"],"award-info":[{"award-number":["TL1TR001875"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005904","name":"NC State University Institute for Emerging Issues","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014434","name":"New York-Presbyterian\/Columbia University Irving Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson&apos;s Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD016167"],"award-info":[{"award-number":["S10OD016167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA251753-01"],"award-info":[{"award-number":["R01CA251753-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019274","name":"National Institute of Mental Health and Neurosciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020488","name":"Columbia University Vagelos College of Physicians and Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","award":["R01CA251753-01"],"award-info":[{"award-number":["R01CA251753-01"]}],"id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.celrep.2025.116145","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T23:53:59Z","timestamp":1755129239000},"page":"116145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1"],"prefix":"10.1016","volume":"44","author":[{"given":"Maximilian","family":"Cabaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro G.","family":"Mazzara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Gaertner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela M.","family":"Pauers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Gouveia","family":"Roque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Feeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Raimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"de Prisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Chemiakine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari K.","family":"Yalamanchili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Hengst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwar","family":"Awatramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-6991","authenticated-orcid":false,"given":"Vincenzo A.","family":"Gennarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116145_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40478-022-01364-1","article-title":"The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade","volume":"10","author":"Hickman","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2025.116145_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archneurol.2008.555","article-title":"Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms","volume":"66","author":"Ibanez","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.celrep.2025.116145_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biom14080949","article-title":"Novel Therapeutic Horizons: SNCA Targeting in Parkinson's Disease","volume":"14","author":"Caramiello","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.celrep.2025.116145_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archneur.58.2.186","article-title":"Synucleinopathies: clinical and pathological implications","volume":"58","author":"Galvin","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.celrep.2025.116145_bib5","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","article-title":"alpha-Synucleinopathy phenotypes","volume":"20","author":"McCann","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.celrep.2025.116145_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2017.04.004","article-title":"Deregulation of alpha-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA","volume":"154","author":"Guhathakurta","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2025.116145_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nbd.2011.12.046","article-title":"MicroRNAs in Parkinson's disease","volume":"46","author":"Mouradian","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2025.116145_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275235","article-title":"Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells","volume":"17","author":"Snoderly-Foster","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116145_bib9","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.0906277106","article-title":"Repression of alpha-synuclein expression and toxicity by microRNA-7","volume":"106","author":"Junn","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116145_bib10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2018.05.009","article-title":"MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy","volume":"678","author":"Choi","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2025.116145_bib11","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.ymthe.2017.08.017","article-title":"Loss of MicroRNA-7 Regulation Leads to alpha-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo","volume":"25","author":"McMillan","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2025.116145_bib12","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1093\/nar\/gkx1048","article-title":"Discovering the 3\u2032 UTR-mediated regulation of alpha-synuclein","volume":"45","author":"Marchese","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2025.116145_bib13","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.230158","article-title":"RNA binding protein AUF1\/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts","volume":"13","author":"Kattan","year":"2023","journal-title":"Open Biol."},{"key":"10.1016\/j.celrep.2025.116145_bib14","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ncomms2032","article-title":"Alternative alpha-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology","volume":"3","author":"Rhinn","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116145_bib15","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.cell.2015.02.012","article-title":"Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels","volume":"160","author":"Gennarino","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.cell.2018.02.006","article-title":"A mild PUM1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures","volume":"172","author":"Gennarino","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib17","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.tig.2018.09.006","article-title":"Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins","volume":"34","author":"Goldstrohm","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.celrep.2025.116145_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003164","article-title":"Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system","volume":"3","author":"Galgano","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116145_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1261\/rna.078436.120","article-title":"Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome","volume":"27","author":"Enwerem","year":"2021","journal-title":"RNA"},{"key":"10.1016\/j.celrep.2025.116145_bib20","doi-asserted-by":"crossref","first-page":"36370","DOI":"10.1074\/jbc.M112.373522","article-title":"Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs","volume":"287","author":"Van Etten","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2025.116145_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2025.116145_bib22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/ana.20017","article-title":"UCHL1 is a Parkinson's disease susceptibility gene","volume":"55","author":"Maraganore","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2025.116145_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00018-024-05262-8","article-title":"PRKN-linked familial Parkinson's disease: cellular and molecular mechanisms of disease-linked variants","volume":"81","author":"Clausen","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2025.116145_bib24","article-title":"The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of alpha-Synuclein in Parkinson's Disease","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2025.116145_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13041-018-0371-x","article-title":"A novel extended form of alpha-synuclein 3\u2032UTR in the human brain","volume":"11","author":"Je","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.celrep.2025.116145_bib26","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1101\/gad.298752.117","article-title":"Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins","volume":"31","author":"Zhang","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2025.116145_bib27","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112721","article-title":"Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms","volume":"42","author":"Botta","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2025.116145_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2025.116145_bib29","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.neuron.2019.08.035","article-title":"Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body","volume":"104","author":"Martinez","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116145_bib30","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.cell.2022.05.008","article-title":"The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability","volume":"185","author":"Hallacli","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib31","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1016\/j.neuron.2024.06.002","article-title":"Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of alpha-synuclein inclusions","volume":"112","author":"Lam","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2025.116145_bib32","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jnr.490320407","article-title":"Expression of the class III beta-tubulin isotype in developing neurons in culture","volume":"32","author":"Ferreira","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.celrep.2025.116145_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116145_bib34","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"Vierbuchen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116145_bib35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41593-022-01061-1","article-title":"Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease","volume":"25","author":"Kamath","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2025.116145_bib36","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.celrep.2025.116145_bib37","article-title":"The broken Alzheimer's disease genome","volume":"4","author":"Gouveia Roque","year":"2024","journal-title":"Cell Genom."},{"key":"10.1016\/j.celrep.2025.116145_bib38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/brain\/awaa401","article-title":"Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations","volume":"144","author":"Rudakou","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2025.116145_bib39","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jalz.2017.03.001","article-title":"Genetic analysis of alpha-synuclein 3\u2032 untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies","volume":"13","author":"Tagliafierro","year":"2017","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.celrep.2025.116145_bib40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3389\/fgene.2019.00584","article-title":"The Landscape of SNCA Transcripts Across Synucleinopathies: New Insights From Long Reads Sequencing Analysis","volume":"10","author":"Tseng","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.celrep.2025.116145_bib41","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1523\/JNEUROSCI.3047-16.2016","article-title":"Hippocampal alpha-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology","volume":"37","author":"Adamowicz","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2025.116145_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40478-025-01944-x","article-title":"Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson's disease","volume":"13","author":"Otero-Jimenez","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2025.116145_bib43","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.cell.2014.07.001","article-title":"Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions","volume":"158","author":"Baleriola","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib44","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.molcel.2023.06.021","article-title":"mRNA stability and m(6)A are major determinants of subcellular mRNA localization in neurons","volume":"83","author":"Loedige","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/biom12081108","article-title":"Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation","volume":"12","author":"Pieger","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.celrep.2025.116145_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031812","article-title":"Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells","volume":"23","author":"Seebauer","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2025.116145_bib47","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ejhg.2015.61","article-title":"Mutation in the 3\u2032 untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy","volume":"24","author":"Nicolas","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2025.116145_bib48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41531-024-00791-2","article-title":"MicroRNAs regulation in Parkinson's disease, and their potential role as diagnostic and therapeutic targets","volume":"10","author":"Shaheen","year":"2024","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.celrep.2025.116145_bib49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/dvdy.20441","article-title":"Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform","volume":"234","author":"Yaylaoglu","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2025.116145_bib50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2818.2005.01450.x","article-title":"A method for automated detection of gene expression required for the establishment of a digital transcriptome-wide gene expression atlas","volume":"217","author":"Carson","year":"2005","journal-title":"J. Microsc."},{"key":"10.1016\/j.celrep.2025.116145_bib51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116145_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101150","article-title":"Identifying patients and assessing variant pathogenicity for an autosomal dominant disease-driving gene","volume":"3","author":"Lee","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.116145_bib53","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cub.2012.01.039","article-title":"Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis","volume":"22","author":"Chen","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2025.116145_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026159","article-title":"SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate alpha-synuclein and are susceptible to oxidative stress","volume":"6","author":"Byers","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2025.116145_bib55","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.1245296","article-title":"Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons","volume":"342","author":"Chung","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116145_bib56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2015.12.017","article-title":"Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins","volume":"164","author":"Lee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116145_bib57","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1038\/s41467-020-17954-3","article-title":"Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons","volume":"11","author":"Mazzara","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2025.116145_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101232","article-title":"Determining the effects of loss of function mutations in human cell lines","volume":"3","author":"de Prisco","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2025.116145_bib59","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ng0595-94","article-title":"Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals","volume":"10","author":"Servadio","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2025.116145_bib60","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/nprot.2006.316","article-title":"Microfluidic culture platform for neuroscience research","volume":"1","author":"Park","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116145_bib61","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nmeth777","article-title":"A microfluidic culture platform for CNS axonal injury, regeneration and transport","volume":"2","author":"Taylor","year":"2005","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116145_bib62","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725009167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124725009167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:34:05Z","timestamp":1788986045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124725009167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2211124725009167"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116145","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116145"}}