{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:06:36Z","timestamp":1790139996550,"version":"4.0.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH NIGMS","doi-asserted-by":"publisher","award":["1R01 GM130915"],"award-info":[{"award-number":["1R01 GM130915"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["1R01AI143884"],"award-info":[{"award-number":["1R01AI143884"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR002551"],"award-info":[{"award-number":["TL1TR002551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002550"],"award-info":[{"award-number":["UL1TR002550"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["G-2108-04793"],"award-info":[{"award-number":["G-2108-04793"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003187","name":"NSF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"NIDDK Division of Diabetes Endocrinology and Metabolic Diseases","doi-asserted-by":"publisher","award":["1R01DK117138"],"award-info":[{"award-number":["1R01DK117138"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"NIDDK Division of Diabetes Endocrinology and Metabolic Diseases","doi-asserted-by":"publisher","award":["UH3 DK122639"],"award-info":[{"award-number":["UH3 DK122639"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2400220"],"award-info":[{"award-number":["2400220"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["UG3DK1421188"],"award-info":[{"award-number":["UG3DK1421188"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","award":["5-SRA-2018-557-Q-R"],"award-info":[{"award-number":["5-SRA-2018-557-Q-R"]}],"id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.celrep.2025.116189","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:08:39Z","timestamp":1756433319000},"page":"116189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A vascular-associated fibroblastic cell controls pancreatic islet immunity"],"prefix":"10.1016","volume":"44","author":[{"given":"Don","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley W.","family":"Moremen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Pettus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Domissy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Vy","family":"Nguyen-Ngoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Berti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.W.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Teyton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2025.116189_bib1","first-page":"141","article-title":"Pancreatic Extracts in the Treatment of Diabetes Mellitus","volume":"12","author":"Banting","year":"1922","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.celrep.2025.116189_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2337\/diab.14.10.619","article-title":"Pathologic anatomy of the pancreas in juvenile diabetes mellitus","volume":"14","author":"Gepts","year":"1965","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116189_bib3","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0140-6736(74)90140-8","article-title":"Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies","volume":"2","author":"Bottazzo","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2025.116189_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/329599a0","article-title":"HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus","volume":"329","author":"Todd","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116189_bib5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrg3069","article-title":"Understanding type 1 diabetes through genetics: advances and prospects","volume":"12","author":"Polychronakos","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2025.116189_bib6","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1073\/pnas.84.8.2435","article-title":"The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique","volume":"84","author":"Acha-Orbea","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-Related Adverse Events Associated with Immune Checkpoint Blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib8","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.2337\/dc18-1465","article-title":"Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes","volume":"41","author":"Wright","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.celrep.2025.116189_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.20022125","article-title":"The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice","volume":"198","author":"Ansari","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib10","article-title":"Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency","volume":"221","author":"Johnson","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib11","doi-asserted-by":"crossref","first-page":"E10418","DOI":"10.1073\/pnas.1713543114","article-title":"Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice","volume":"114","author":"Carrero","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib12","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1073\/pnas.0801973105","article-title":"Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules","volume":"105","author":"Calderon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib13","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.20150496","article-title":"The pancreas anatomy conditions the origin and properties of resident macrophages","volume":"212","author":"Calderon","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib14","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"Gautier","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib15","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4049\/jimmunol.2300769","article-title":"Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature","volume":"212","author":"Costanzo","year":"2024","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJM198508083130604","article-title":"In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis","volume":"313","author":"Bottazzo","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib17","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1093\/ejendo\/lvae002","article-title":"Insulitis in human type 1 diabetes: lessons from an enigmatic lesion","volume":"190","author":"Morgan","year":"2024","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.celrep.2025.116189_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.20111187","article-title":"Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients","volume":"209","author":"Coppieters","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib19","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/modpathol.2012.68","article-title":"Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease","volume":"25","author":"Li","year":"2012","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.celrep.2025.116189_bib20","first-page":"11","article-title":"Structural aspects of the permeability of the microvascular endothelium","volume":"463","author":"Palade","year":"1979","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.celrep.2025.116189_bib21","article-title":"Inflammation and the blood microvascular system","volume":"7","author":"Pober","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2025.116189_bib22","first-page":"803","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nature reviews"},{"key":"10.1016\/j.celrep.2025.116189_bib23","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2337\/diab.31.10.883","article-title":"New perspectives on the microvasculature of the islets of Langerhans in the rat","volume":"31","author":"Bonner-Weir","year":"1982","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116189_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.immunol.21.120601.141110","article-title":"T cell anergy","volume":"21","author":"Schwartz","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.20040254","article-title":"Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes","volume":"200","author":"Katakai","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib26","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/eji.202149263","article-title":"Collagen type VI is the antigen recognized by the ER-TR7 antibody","volume":"51","author":"Schiavinato","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12915-017-0381-7","article-title":"Differential DARC\/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues","volume":"15","author":"Thiriot","year":"2017","journal-title":"BMC Biol."},{"key":"10.1016\/j.celrep.2025.116189_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nprot.2014.006","article-title":"Full-length RNA-seq from single cells using Smart-seq2","volume":"9","author":"Picelli","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2025.116189_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41587-020-0442-2","article-title":"Dissecting cellular crosstalk by sequencing physically interacting cells","volume":"38","author":"Giladi","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2025.116189_bib30","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1096\/fj.201903188R","article-title":"Origin and functional heterogeneity of fibroblasts","volume":"34","author":"LeBleu","year":"2020","journal-title":"Faseb J"},{"key":"10.1016\/j.celrep.2025.116189_bib31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2020.09.048","article-title":"Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation","volume":"183","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116189_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.174.1.80","article-title":"Peptide-specific intercellular transfer of MHC class II to CD4+ T cells directly from the immunological synapse upon cellular dissociation","volume":"174","author":"Wetzel","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib33","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.3389\/fimmu.2018.02800","article-title":"IFNgamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration","volume":"9","author":"Scott","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.4049\/jimmunol.172.2.871","article-title":"MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice","volume":"172","author":"Serreze","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw6329","article-title":"Position beta57 of I-A(g7) controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset","volume":"4","author":"Gioia","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4939-7514-3_14","article-title":"Gene Profiling and T Cell Receptor Sequencing from Antigen-Specific CD4 T Cells","volume":"1712","author":"Holt","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2025.116189_bib37","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1073\/pnas.1205850109","article-title":"Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection","volume":"109","author":"Ng","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.celrep.2025.116189_bib39","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2025.116189_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59067","article-title":"Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development","volume":"10","author":"Geusz","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2025.116189_bib41","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic beta cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2025.116189_bib42","first-page":"347","article-title":"Immunoglobulin A: interaction with complement, phagocytic cells and endothelial cells","volume":"8","author":"Bogers","year":"1991","journal-title":"Complement Inflamm."},{"key":"10.1016\/j.celrep.2025.116189_bib43","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/pcmedi\/pby015","article-title":"Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation","volume":"1","author":"Wan","year":"2018","journal-title":"Precis. Clin. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41590-020-0623-7","article-title":"The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides","volume":"21","author":"Wan","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41586-018-0341-6","article-title":"Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides","volume":"560","author":"Wan","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2025.116189_bib46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/imr.12748","article-title":"Fibroblastic reticular cells at the nexus of innate and adaptive immune responses","volume":"289","author":"Perez-Shibayama","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2025.116189_bib47","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fimmu.2012.00285","article-title":"Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes","volume":"3","author":"Siegert","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade3614","article-title":"Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells","volume":"15","author":"Sharma","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2025.116189_bib49","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1073\/pnas.0505497102","article-title":"Establishment of NOD-Pdcd1-\/- mice as an efficient animal model of type I diabetes","volume":"102","author":"Wang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib50","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1073\/pnas.96.1.185","article-title":"A two-step, two-signal model for the primary activation of precursor helper T cells","volume":"96","author":"Bretscher","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib51","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.immuni.2015.06.023","article-title":"Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity","volume":"43","author":"Sckisel","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2025.116189_bib52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1073\/pnas.98.1.241","article-title":"Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells","volume":"98","author":"Ragazzo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib53","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.4049\/jimmunol.164.6.2987","article-title":"Induction of T cell anergy in the absence of CTLA-4\/B7 interaction","volume":"164","author":"Frauwirth","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib54","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.4049\/jimmunol.138.11.3704","article-title":"Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness","volume":"138","author":"Quill","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4049\/jimmunol.144.1.16","article-title":"Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody","volume":"144","author":"Jenkins","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib57","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1172\/JCI41502","article-title":"The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity","volume":"120","author":"Yoshida","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116189_bib58","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166185","article-title":"Pancreatic regional blood flow links the endocrine and exocrine diseases","volume":"133","author":"Rizk","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2025.116189_bib59","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2337\/db23-0760","article-title":"Local Dialogues Between the Endocrine and Exocrine Cells in the Pancreas","volume":"73","author":"Slak Rupnik","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116189_bib60","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2337\/diab.46.11.1701","article-title":"Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers","volume":"46","author":"Bingley","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2025.116189_bib61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/cei.13360","article-title":"Birth and coming of age of islet autoantibodies","volume":"198","author":"Bonifacio","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2025.116189_bib62","doi-asserted-by":"crossref","first-page":"15140","DOI":"10.1073\/pnas.1814558116","article-title":"Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes","volume":"116","author":"Sorini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2025.116189_bib63","doi-asserted-by":"crossref","first-page":"98","DOI":"10.34172\/hpp.2020.18","article-title":"Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis","volume":"10","author":"Mobasseri","year":"2020","journal-title":"Health Promot. Perspect."},{"key":"10.1016\/j.celrep.2025.116189_bib64","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis","volume":"162","author":"Iannuzzi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2025.116189_bib65","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S2468-1253(19)30323-1","article-title":"Pancreatic cancer: a growing burden","volume":"4","author":"Klein","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2025.116189_bib66","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2147\/DMSO.S223618","article-title":"Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges","volume":"14","author":"Vilarrasa","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.celrep.2025.116189_bib67","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 fatty acids and inflammatory processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2025.116189_bib70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jim.2018.08.011","article-title":"Development of T cell lines sensitive to antigen stimulation","volume":"462","author":"Williams","year":"2018","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.celrep.2025.116189_bib71","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nmeth858","article-title":"Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice","volume":"3","author":"Holst","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2025.116189_bib72","article-title":"Generating Primary Fibroblast Cultures from Mouse Ear and Tail Tissues","volume":"10","author":"Khan","year":"2016","journal-title":"J. Vis. Exp."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500960X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472500960X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:39:45Z","timestamp":1790138385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472500960X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S221112472500960X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116189","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A vascular-associated fibroblastic cell controls pancreatic islet immunity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2025.116189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116189"}}